Synthesis and Characterization of Phenylalanine Amides Active against Mycobacterium abscessus and Other Mycobacteria

N-Acetyl-l-phenylalanine Racemization during TBTU Amidation: An In-Depth Study for the Synthesis of Anti-Inflammatory 2-(N-Acetyl)-l-phenylalanylamido-2-deoxy-d-glucose (NAPA)

(2023) Elisa Sturabotti et al.   MOLECULES

Drug development challenges in nontuberculous mycobacterial lung disease: TB to the rescue

(2022) Véronique Dartois et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anti-tuberculosis treatment strategies and drug development: challenges and priorities

(2022) Véronique A. Dartois et al.   NATURE REVIEWS MICROBIOLOGY

In Vitro Profiling of the Synthetic RNA Polymerase Inhibitor MMV688845 against Mycobacterium abscessus

(2022) Lea Mann et al.   Microbiology Spectrum

Rifampicin Mono-Resistant Tuberculosis—A Review of an Uncommon But Growing Challenge for Global Tuberculosis Control

(2021) Jason H Malenfant et al.   Open Forum Infectious Diseases

Tuberculosis: An Overview of the Immunogenic Response, Disease Progression, and Medicinal Chemistry Efforts in the Last Decade toward the Development of Potential Drugs for Extensively Drug-Resistant Tuberculosis Strains

(2021) Akanksha Sharma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mycobacterium abscessus complex: A Review of Recent Developments in an Emerging Pathogen

(2021) Laura Victoria et al.   Frontiers in Cellular and Infection Microbiology

Racemization-free synthesis of Nα-2-thiophenoyl-phenylalanine-2-morpholinoanilide enantiomers and their antimycobacterial activity

(2021) Lea Mann et al.   AMINO ACIDS

Blocking Bacterial Naphthohydroquinone Oxidation and ADP-Ribosylation Improves Activity of Rifamycins against Mycobacterium abscessus

(2021) Uday S. Ganapathy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Delamanid or pretomanid? A Solomonic judgement!

(2021) Saskia E. Mudde et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Mycobacterium abscessus

(2021) Yves-Marie Boudehen et al.   TRENDS IN MICROBIOLOGY

Vanishing of the atomic form factor derivatives in non-spherical structural refinement – a key approximation scrutinized in the case of Hirshfeld atom refinement

(2021) Laura Midgley et al.   Acta Crystallographica A-Foundation and Advances

Nontuberculous Mycobacterial Infections – a neglected and emerging problem

(2020) Imran Ahmed et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Treatment of Highly Drug-Resistant Pulmonary Tuberculosis

(2020) Francesca Conradie et al.   NEW ENGLAND JOURNAL OF MEDICINE

Features of the biochemistry of Mycobacterium smegmatis, as a possible model for Mycobacterium tuberculosis

(2020) Joseph Antony Sundarsingh T et al.   Journal of Infection and Public Health

General Overview of Nontuberculous Mycobacteria Opportunistic Pathogens: Mycobacterium avium and Mycobacterium abscessus

(2020) Kimberly To et al.   Journal of Clinical Medicine

A high-throughput whole cell screen to identify inhibitors of Mycobacterium tuberculosis

(2019) Juliane Ollinger et al.   PLoS One

Same meat, different gravy: ignore the new names of mycobacteria

(2019) Enrico Tortoli et al.   EUROPEAN RESPIRATORY JOURNAL

Rifabutin is active against Mycobacterium abscessus in mice

(2019) Thomas Dick et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

THP-1 and Dictyostelium Infection Models for Screening and Characterization of Anti-Mycobacterium abscessus Hit Compounds

(2019) Adrian Richter et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Screening of preselected libraries targeting Mycobacterium abscessus for drug discovery

(2018) Adrian Richter et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

1,3,5-triazaspiro[5.5]undeca-2,4-dienes as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors with potent whole cell activity

(2018) Xuan Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Metabolic Hydrolysis of Aromatic Amides in Selected Rat, Minipig, and Human In Vitro Systems

(2018) Peter R. Bradshaw et al.   Scientific Reports

Phylogenomics and Comparative Genomic Studies Robustly Support Division of the Genus Mycobacterium into an Emended Genus Mycobacterium and Four Novel Genera

(2018) Radhey S. Gupta et al.   Frontiers in Microbiology

Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition

(2017) Wei Lin et al.   MOLECULAR CELL

Screening of TB Actives for Activity against Nontuberculous Mycobacteria Delivers High Hit Rates

(2017) Jian Liang Low et al.   Frontiers in Microbiology

Synthesis and proapoptotic activity of oleanolic acid derived amides

(2016) Lucie Heller et al.   BIOORGANIC CHEMISTRY

Mycobacterial Characteristics and Treatment Outcomes inMycobacterium abscessusLung Disease

(2016) Won-Jung Koh et al.   CLINICAL INFECTIOUS DISEASES

Selective killing of cancer cells with triterpenoic acid amides - The substantial role of an aromatic moiety alignment

(2016) Sven Sommerwerk et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Intrinsic rifamycin resistance ofMycobacterium abscessusis mediated by ADP-ribosyltransferase MAB_0591

(2016) Anna Rominski et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Lack of Antimicrobial Bactericidal Activity in Mycobacterium abscessus

(2014) Florian P. Maurer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Microbiological Features and Clinical Relevance of New Species of the Genus Mycobacterium

(2014) Enrico Tortoli   CLINICAL MICROBIOLOGY REVIEWS

The epidemiologic relationship between tuberculosis and non-tuberculous mycobacterial disease: a systematic review

(2014) S. K. Brode et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Multidrug-Resistant Tuberculosis and Culture Conversion with Bedaquiline

(2014) Andreas H. Diacon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis

(2013) Lluís Ballell et al.   ChemMedChem

Metal-Free Coupling of Saturated Heterocyclic Sulfonylhydrazones with Boronic Acids

(2013) Daniel M. Allwood et al.   JOURNAL OF ORGANIC CHEMISTRY

Clinical Significance of the Differentiation Between Mycobacterium avium and Mycobacterium intracellulare in M avium Complex Lung Disease

(2012) Won-Jung Koh et al.   CHEST

Racemisation of N-Fmoc phenylglycine under mild microwave-SPPS and conventional stepwise SPPS conditions: attempts to develop strategies for overcoming this

(2012) Mohamed A. Elsawy et al.   JOURNAL OF PEPTIDE SCIENCE

Species Difference of Esterase Expression and Hydrolase Activity in Plasma

(2012) Fatma Goksin Bahar et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Pulmonary disease caused by nontuberculous mycobacteria

(2012) Curtis H Weiss et al.   Expert Review of Respiratory Medicine

Clinical and Microbiologic Outcomes in Patients Receiving Treatment for Mycobacterium abscessus Pulmonary Disease

(2011) Julie Jarand et al.   CLINICAL INFECTIOUS DISEASES

General and Scalable Amide Bond Formation with Epimerization-Prone Substrates Using T3P and Pyridine

(2011) Joshua R. Dunetz et al.   ORGANIC LETTERS

Recent development in peptide coupling reagents

(2011) Tarfah I. Al-Warhi et al.   Journal of Saudi Chemical Society

Synthesis, Encapsulation and Antitumor Activity of New Betulin Derivatives

(2010) René Csuk et al.   ARCHIV DER PHARMAZIE

Antibiotic Treatment ofMycobacterium abscessusLung Disease

(2009) Kyeongman Jeon et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Metal-free carbon–carbon bond-forming reductive coupling between boronic acids and tosylhydrazones

(2009) José Barluenga et al.   Nature Chemistry

The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis

(2009) Andreas H. Diacon et al.   NEW ENGLAND JOURNAL OF MEDICINE