CTLA4 prohibits T cells from cross-dressing

The CTLA ‐4 immune checkpoint protein regulates PD‐L1 : PD ‐1 interaction via transendocytosis of its ligand CD80

(2023) Alan Kennedy et al.   EMBO JOURNAL

CTLA4 depletes T cell endogenous and trogocytosed B7 ligands via cis-endocytosis

(2023) Xiaozheng Xu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation

(2022) Alan Kennedy et al.   NATURE IMMUNOLOGY

Differential trafficking of ligands trogocytosed via CD28 versus CTLA4 promotes collective cellular control of co-stimulation

(2022) Simon Zenke et al.   Nature Communications

Antigen presentation between T cells drives Th17 polarization under conditions of limiting antigen

(2021) Viola L. Boccasavia et al.   Cell Reports

Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells

(2021) Murat Tekguc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape

(2019) Mohamad Hamieh et al.   NATURE

Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses

(2019) Daisuke Sugiura et al.   SCIENCE

Coinhibitory Pathways in Immunotherapy for Cancer

(2016) Susanne H. Baumeister et al.   Annual Review of Immunology

Constitutive Clathrin-mediated Endocytosis of CTLA-4 Persists during T Cell Activation

(2012) Omar S. Qureshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Presentation of Acquired Peptide-MHC Class II Ligands by CD4+ Regulatory T Cells or Helper Cells Differentially Regulates Antigen-Specific CD4+ T Cell Response

(2011) G. Zhou et al.   JOURNAL OF IMMUNOLOGY

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

Antigen-specific T-T interactions regulate CD4 T-cell expansion

(2008) J. Helft et al.   BLOOD

A Synaptic Basis for Paracrine Interleukin-2 Signaling during Homotypic T Cell Interaction

(2008) Catherine A. Sabatos et al.   IMMUNITY