Expression and Function of BMP and Activin Membrane-Bound Inhibitor (BAMBI) in Chronic Liver Diseases and Hepatocellular Carcinoma

Microvascular significance of TGF-β axis activation in COVID-19

(2023) Lauren M. Arguinchona et al.   Frontiers in Cardiovascular Medicine

TJ-M2010-5, A self-developed MyD88 inhibitor, attenuates liver fibrosis by inhibiting the NF-κB pathway

(2022) Yalong Xie et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Tumor Microenvironment of Hepatocellular Carcinoma: Challenges and Opportunities for New Treatment Options

(2022) Zuzanna Sas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protection of the Prodomain α1-Helix Correlates with Latency in the Transforming Growth Factor-β Family

(2022) Viet Q. Le et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of cell type specific ACE2 modifiers by CRISPR screening

(2022) Emily J. Sherman et al.   PLoS Pathogens

The Love-Hate Relationship Between TGF-β Signaling and the Immune System During Development and Tumorigenesis

(2022) Baode Chen et al.   Frontiers in Immunology

Targeting Wnt/β-Catenin Pathways in Primary Liver Tumours: From Microenvironment Signaling to Therapeutic Agents

(2022) Federico Selvaggi et al.   Cancers

The Complex Roles of Adipokines in Polycystic Ovary Syndrome and Endometriosis

(2022) Susanne Schüler-Toprak et al.   Biomedicines

Secondary hemophagocytic lymphohistiocytosis and severe liver injury induced by hepatic SARS-CoV-2 infection unmasking Wilson’s disease: Balancing immunosuppression

(2021) Matthias Lubnow et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Hepcidin and Iron Metabolism in Experimental Liver Injury

(2021) Steven A. Bloomer et al.   AMERICAN JOURNAL OF PATHOLOGY

The Evolving Role of Fetuin-A in Nonalcoholic Fatty Liver Disease: An Overview from Liver to the Heart

(2021) Teoman Dogru et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The TGF-β Pathway: A Pharmacological Target in Hepatocellular Carcinoma?

(2021) Ester Gonzalez-Sanchez et al.   Cancers

Correlation analysis of tumor mutation burden of hepatocellular carcinoma based on data mining

(2021) Weijie Zhou et al.   Journal of Gastrointestinal Oncology

General Features and Novel Gene Signatures That Identify Epstein-Barr Virus-Associated Epithelial Cancers

(2021) Chukkris Heawchaiyaphum et al.   Cancers

TAK1: A Molecular Link Between Liver Inflammation, Fibrosis, Steatosis, and Carcinogenesis

(2021) Weijun Wang et al.   Frontiers in Cell and Developmental Biology

Potential Effects of Coronaviruses on the Liver: An Update

(2021) Xinyi Wang et al.   Frontiers in Medicine

Wnt/β-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasis on Molecular Pathways

(2021) Mahshid Deldar Abad Paskeh et al.   Journal of Hepatocellular Carcinoma

Screening of a novel autophagy-related prognostic signature and therapeutic targets in hepatocellular carcinoma

(2021) Wei Chen et al.   Journal of Gastrointestinal Oncology

Autophagy and autophagy-related proteins in cancer

(2020) Xiaohua Li et al.   Molecular Cancer

CTNNB1/β-catenin dysfunction contributes to adiposity by regulating the cross-talk of mature adipocytes and preadipocytes

(2020) Maopei Chen et al.   Science Advances

Role of lipids in pathophysiology, diagnosis and therapy of hepatocellular carcinoma

(2020) Christa Buechler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Differential effectiveness of tyrosine kinase inhibitors in 2D/3D culture according to cell differentiation, p53 status and mitochondrial respiration in liver cancer cells

(2020) María A. Rodríguez-Hernández et al.   Cell Death & Disease

The hepatic lipidome: From basic science to clinical translation

(2020) Marit ten Hove et al.   ADVANCED DRUG DELIVERY REVIEWS

Study on the relationship between hepatic fibrosis and epithelial-mesenchymal transition in intrahepatic cells

(2020) Yang Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Receptor binding competition: A paradigm for regulating TGF-β family action

(2020) Erik Martinez-Hackert et al.   CYTOKINE & GROWTH FACTOR REVIEWS

LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-β1/Smad3 pathway

(2020) Ya-ru Yang et al.   MOLECULAR IMMUNOLOGY

Intrahepatic TH17/TReg Cells in Homeostasis and Disease—It’s All About the Balance

(2020) Hannah K. Drescher et al.   Frontiers in Pharmacology

Unfolded protein response is an early, non-critical event during hepatic stellate cell activation

(2019) Inge Mannaerts et al.   Cell Death & Disease

Transforming Growth Factor-β Signaling in Immunity and Cancer

(2019) Eduard Batlle et al.   IMMUNITY

Defective fibrin deposition and thrombus stability in Bambi ‐/‐ mice is mediated by elevated anticoagulant function

(2019) James T.B. Crawley et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Growth differentiation factor 11 attenuates liver fibrosis via expansion of liver progenitor cells

(2019) Zhen Dai et al.   GUT

The gut-liver axis in liver disease: pathophysiological basis for therapy

(2019) Agustín Albillos et al.   JOURNAL OF HEPATOLOGY

Niemann–Pick type C disease: cellular pathology and pharmacotherapy

(2019) Simon Wheeler et al.   JOURNAL OF NEUROCHEMISTRY

Tumour evolution in hepatocellular carcinoma

(2019) Amanda J. Craig et al.   Nature Reviews Gastroenterology & Hepatology

TGF-β1 – A truly transforming growth factor in fibrosis and immunity

(2019) Monika Lodyga et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Activin-A causes Hepatic stellate cell activation via the induction of TNFα and TGFβ in Kupffer cells

(2018) Foteini Kiagiadaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Targeting autophagy in cancer

(2018) Angelique V. Onorati et al.   CANCER

Revisiting asthma therapeutics: focus on WNT signal transduction

(2018) Tim Koopmans et al.   DRUG DISCOVERY TODAY

The EpCAM overexpression is associated with clinicopathological significance and prognosis in hepatocellular carcinoma patients: A systematic review and meta-analysis

(2018) Linhua Zhou et al.   International Journal of Surgery

MicroRNA-942 mediates hepatic stellate cell activation by regulating BAMBI expression in human liver fibrosis

(2018) Le Tao et al.   ARCHIVES OF TOXICOLOGY

Sparstolonin B (SSnB) attenuates liver fibrosisvia a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent

(2018) Diptadip Dattaroy et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours

(2018) Zeribe C. Nwosu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

BMP Signalling at the Crossroad of Liver Fibrosis and Regeneration

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Adipokines and Non-Alcoholic Fatty Liver Disease: Multiple Interactions

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Adipokines in Liver Cirrhosis

(2017) Christa Buechler et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Thrombin promotes diet-induced obesity through fibrin-driven inflammation

(2017) Anna K. Kopec et al.   JOURNAL OF CLINICAL INVESTIGATION

Liver inflammation and fibrosis

(2017) Yukinori Koyama et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunity and Fibrogenesis: The Role of Th17/IL-17 Axis in HBV and HCV-induced Chronic Hepatitis and Progression to Cirrhosis

(2017) Feliciano Chanana Paquissi   Frontiers in Immunology

Obesity is Independently Associated With Increased Risk of Hepatocellular Cancer–related Mortality

(2017) Arjun Gupta et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

TGF-β and Hepatocellular Carcinoma: When A Friend Becomes An Enemy

(2017) Marco Arrese et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Liver Cancer: Connections with Obesity, Fatty Liver, and Cirrhosis

(2016) Andrea Marengo et al.   Annual Review of Medicine

Fibrin deposition following bile duct injury limits fibrosis through an  M 2-dependent mechanism

(2016) N. Joshi et al.   BLOOD

On the Dependency of Cellular Protein Levels on mRNA Abundance

(2016) Yansheng Liu et al.   CELL

Common mutations in ALK2/ACVR1, a multi-faceted receptor, have roles in distinct pediatric musculoskeletal and neural orphan disorders

(2016) Maurizio Pacifici et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Oxymatrine attenuates CCl 4 -induced hepatic fibrosis via modulation of TLR4-dependent inflammatory and TGF-β1 signaling pathways

(2016) Hong-wei Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis

(2016) Fengyun Xu et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

TLR4-dependent signaling pathway modulation: A novel mechanism by which pioglitazone protects against nutritional fibrotic steatohepatitis in mice

(2016) JINGHUA DU et al.   Molecular Medicine Reports

Ethanol and High Cholesterol Diet Causes Severe Steatohepatitis and Early Liver Fibrosis in Mice

(2016) Yasodha Krishnasamy et al.   PLoS One

Effect of Exogenous Fetuin-A on TGF-β/Smad Signaling in Hepatic Stellate Cells

(2016) Yulai Zhou et al.   Biomed Research International

Bone Morphogenetic Protein and Activin Membrane-Bound Inhibitor, a Transforming Growth Factor β Rheostat That Controls Murine Treg Cell/Th17 Cell Differentiation and the Development of Autoimmune Arthritis by Reducing Interleukin-2 Signaling

(2016) Jorge Postigo et al.   Arthritis & Rheumatology

BMP and activin membrane-bound inhibitor (BAMBI) inhibits the adipogenesis of porcine preadipocytes through Wnt/β-catenin signaling pathway

(2014) Yin Mai et al.   Biochemistry and Cell Biology

Vessel wall BAMBI contributes to hemostasis and thrombus stability

(2014) I. I. Salles-Crawley et al.   BLOOD

Characterization and prognosis of patients with hepatocellular carcinoma (HCC) in the non-cirrhotic liver

(2014) Kerstin Schütte et al.   BMC GASTROENTEROLOGY

The Role of Snail in EMT and Tumorigenesis

(2014) Yifan Wang et al.   CURRENT CANCER DRUG TARGETS

The Pathogenesis of Hepatocellular Carcinoma

(2014) Martha M. Kirstein et al.   DIGESTIVE DISEASES

Roles for Chemokines in Liver Disease

(2014) Fabio Marra et al.   GASTROENTEROLOGY

Enhanced expression of BMP6 inhibits hepatic fibrosis in non-alcoholic fatty liver disease

(2014) Stephanie Arndt et al.   GUT

Potential Roles of BMP9 in Liver Fibrosis

(2014) Jianjun Bi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transcriptional Repression of the Transforming Growth Factor β (TGF-β) Pseudoreceptor BMP and Activin Membrane-bound Inhibitor (BAMBI) by Nuclear Factor κB (NF-κB) p50 Enhances TGF-β Signaling in Hepatic Stellate Cells

(2014) Cheng Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Platelets and fibrin in progression of liver disease: friends or foes?

(2014) T. Lisman   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Fetuin-A negatively correlates with liver and vascular fibrosis in nonalcoholic fatty liver disease subjects

(2014) Motoya Sato et al.   LIVER INTERNATIONAL

Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte

(2014) Carla Cicchini et al.   LIVER INTERNATIONAL

ALK1-Smad1/5 signaling pathway in fibrosis development: Friend or foe?

(2013) José M. Muñoz-Félix et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Chemerin is highly expressed in hepatocytes and is induced in non-alcoholic steatohepatitis liver

(2013) Sabrina Krautbauer et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice

(2013) Kengo Tomita et al.   HEPATOLOGY

Transforming Growth Factor-β (TGF-β)-mediated Connective Tissue Growth Factor (CTGF) Expression in Hepatic Stellate Cells Requires Stat3 Signaling Activation

(2013) Yan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bermuda Triangle for the liver: Alcohol, obesity, and viral hepatitis

(2013) Samir Zakhari   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

CellMinerHCC: a microarray-based expression database for hepatocellular carcinoma cell lines

(2013) Frank Staib et al.   LIVER INTERNATIONAL

BAMBI (BMP and activin membrane-bound inhibitor) protects the murine heart from pressure-overload biomechanical stress by restraining TGF-β signaling

(2012) Ana V. Villar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Effect of intracellular lipid accumulation in a new model of non-alcoholic fatty liver disease

(2012) Norberto C Chavez-Tapia et al.   BMC GASTROENTEROLOGY

Metformin-Mediated Bambi Expression in Hepatic Stellate Cells Induces Prosurvival Wnt/ -Catenin Signaling

(2012) N. Subramaniam et al.   Cancer Prevention Research

Subset of Suz12/PRC2 target genes is activated during hepatitis B virus replication and liver carcinogenesis associated with HBV X protein

(2012) Leo L. Studach et al.   HEPATOLOGY

Oral Administration of Recombinant Adeno-associated Virus-mediated Bone Morphogenetic Protein-7 Suppresses CCl4-induced Hepatic Fibrosis in Mice

(2012) Zhi-Ming Hao et al.   MOLECULAR THERAPY

TGF-β and NF-κB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers

(2012) C Freudlsperger et al.   ONCOGENE

BAMBI Regulates Angiogenesis and Endothelial Homeostasis through Modulation of Alternative TGFβ Signaling

(2012) Nicolas Guillot et al.   PLoS One

Inhibition of TGF-β/Smad Signaling by BAMBI Blocks Differentiation of Human Mesenchymal Stem Cells to Carcinoma-Associated Fibroblasts and Abolishes their Protumor Effects

(2012) Lei Shangguan et al.   STEM CELLS

Bone morphogenetic protein-7 regulates Snail signaling in carbon tetrachloride-induced fibrosis in the rat liver

(2012) WAN-RONG BI et al.   Experimental and Therapeutic Medicine

Regulation of TGF-β receptor activity

(2012) Fei Huang et al.   Cell and Bioscience

Coactivation of AKT and  -Catenin in Mice Rapidly Induces Formation of Lipogenic Liver Tumors

(2011) J. K. Stauffer et al.   CANCER RESEARCH

Identification of BMP and Activin Membrane-Bound Inhibitor (BAMBI) as a Potent Negative Regulator of Adipogenesis and Modulator of Autocrine/Paracrine Adipogenic Factors

(2011) X. Luo et al.   DIABETES

Adiponectin induces the transforming growth factor decoy receptor BAMBI in human hepatocytes

(2011) Josef Wanninger et al.   FEBS LETTERS

A High-Cholesterol Diet Exacerbates Liver Fibrosis in Mice via Accumulation of Free Cholesterol in Hepatic Stellate Cells

(2011) Toshiaki Teratani et al.   GASTROENTEROLOGY

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

Diverse roles of TGF-β receptor II in renal fibrosis and inflammation in vivo and in vitro

(2011) Xiao-Ming Meng et al.   JOURNAL OF PATHOLOGY

Lipid accumulation impairs adiponectin-mediated induction of activin A by increasing TGFbeta in primary human hepatocytes

(2010) Josef Wanninger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Role of Cytokines in Non-Alcoholic Fatty Liver Disease

(2010) Herbert Tilg   DIGESTIVE DISEASES

Animal Models of Non-Alcoholic Steatohepatitis: Of Mice and Man

(2010) J.M. Schattenberg et al.   DIGESTIVE DISEASES

Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases

(2010) Olav A. Gressner et al.   LIVER INTERNATIONAL

BAMBI Is Expressed in Endothelial Cells and Is Regulated by Lysosomal/Autolysosomal Degradation

(2010) Sandhya Xavier et al.   PLoS One

Snail

(2010) Yadi Wu et al.   Cell Adhesion & Migration

Protective roles of adiponectin in obesity-related fatty liver diseases: mechanisms and therapeutic implications

(2009) Yu Wang et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

Anti-inflammatory and pro-inflammatory roles of TGF-β, IL-10, and IL-22 in immunity and autoimmunity

(2009) Shomyseh Sanjabi et al.   CURRENT OPINION IN PHARMACOLOGY

VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice

(2009) Arumugam Velayudham et al.   HEPATOLOGY

Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis

(2009) Gakuhei Son et al.   HEPATOLOGY

Human BAMBI Cooperates with Smad7 to Inhibit Transforming Growth Factor-β Signaling

(2009) Xiaohua Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low Serum Adiponectin Levels Are Predictive of Advanced Hepatic Fibrosis in Patients With NAFLD

(2009) Savvoula Savvidou et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Effects of atherogenic diet on hepatic gene expression across mouse strains

(2009) Keith R. Shockley et al.   PHYSIOLOGICAL GENOMICS

EpCAM and  -Fetoprotein Expression Defines Novel Prognostic Subtypes of Hepatocellular Carcinoma

(2008) T. Yamashita et al.   CANCER RESEARCH

Immune Interactions in Hepatic Fibrosis

(2008) Andrew P. Holt et al.   Clinics in Liver Disease

The Pseudoreceptor BMP and Activin Membrane-bound Inhibitor Positively Modulates Wnt/β-Catenin Signaling

(2008) Zhenghong Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipocytokines and liver disease

(2008) Yoshihiro Kamada et al.   JOURNAL OF GASTROENTEROLOGY

Atherogenic diet-induced hepatitis is partially dependent on murine TLR4

(2008) M. S. Desai et al.   JOURNAL OF LEUKOCYTE BIOLOGY

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(2008) Katja Rabe et al.   MOLECULAR MEDICINE

Regulation of CCN2 mRNA expression and promoter activity in activated hepatic stellate cells

(2008) Andrew Leask et al.   Journal of Cell Communication and Signaling