Neuroinflammation and Oxidative Stress in the Pathogenesis of Autism Spectrum Disorder

Prenatal Sex Hormone Exposure Is Associated with the Development of Autism Spectrum Disorder

(2023) Mengwei Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autism Spectrum Disorder: Neurodevelopmental Risk Factors, Biological Mechanism, and Precision Therapy

(2023) Ling Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2

(2022) Valeria Garcia-Flores et al.   Nature Communications

Influence of Prenatal Drug Exposure, Maternal Inflammation, and Parental Aging on the Development of Autism Spectrum Disorder

(2022) Atsushi Sato et al.   Frontiers in Psychiatry

Differential effects of early or late exposure to prenatal maternal immune activation on mouse embryonic neurodevelopment

(2022) Elisa Guma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prenatal Environment and Neurodevelopmental Disorders

(2022) Miyuki Doi et al.   Frontiers in Endocrinology

Social Communication of Maternal Immune Activation-Affected Offspring Is Improved by Si-Based Hydrogen-Producing Agent

(2022) Noriyoshi Usui et al.   Frontiers in Psychiatry

A Comprehensive Overview of the Complex Role of Oxidative Stress in Aging, The Contributing Environmental Stressors and Emerging Antioxidant Therapeutic Interventions

(2022) Evripides Iakovou et al.   Frontiers in Aging Neuroscience

Deleterious effects of nervous system in the offspring following maternal SARS-CoV-2 infection during the COVID-19 pandemic

(2022) Ruting Wang et al.   Translational Psychiatry

What we know about the role of corticosteroids in psychiatric disorders; evidence from animal and clinical studies

(2022) Fadwa Dabbah-Assadi et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Prenatal immune stress blunts microglia reactivity, impairing neurocircuitry

(2022) Lindsay N. Hayes et al.   NATURE

Relationship of Nonsteroidal Anti-Inflammatory Drug Use During Pregnancy with Autism Spectrum Disorder and Intellectual Disability Among Offspring

(2022) Mohiuddin Ahsanul Kabir Chowdhury et al.   JOURNAL OF WOMENS HEALTH

Maternal acute and chronic inflammation in pregnancy is associated with common neurodevelopmental disorders: a systematic review

(2021) Velda X. Han et al.   Translational Psychiatry

Developmental regulation of barrier‐ and non‐barrier blood vessels in the CNS

(2021) A. Ben‐Zvi et al.   JOURNAL OF INTERNAL MEDICINE

Prenatal maternal infection and risk for autism in offspring: A meta‐analysis

(2021) Nina Tioleco et al.   Autism Research

Early or late gestational exposure to maternal immune activation alters neurodevelopmental trajectories in mice: an integrated neuroimaging, behavioural, and transcriptional study

(2021) Elisa Guma et al.   BIOLOGICAL PSYCHIATRY

Mitochondrial biogenesis in developing astrocytes regulates astrocyte maturation and synapse formation

(2021) Tamara Zehnder et al.   Cell Reports

Molecular Basis of Late-Life Depression

(2021) Chien-Yi Kuo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Maternal immune activation and neuroinflammation in human neurodevelopmental disorders

(2021) Velda X. Han et al.   Nature Reviews Neurology

The Role of Oxidative Stress and Antioxidant Balance in Pregnancy

(2021) Tarique Hussain et al.   MEDIATORS OF INFLAMMATION

Mitochondrial morphology is associated with respiratory chain uncoupling in autism spectrum disorder

(2021) Richard E. Frye et al.   Translational Psychiatry

Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2018

(2021) Matthew J. Maenner et al.   MMWR Surveillance Summaries

Early Identification of Autism Spectrum Disorder Among Children Aged 4 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2018

(2021) Kelly A. Shaw et al.   MMWR Surveillance Summaries

Oxidative Stress in Autism Spectrum Disorder

(2020) Geir Bjørklund et al.   MOLECULAR NEUROBIOLOGY

Therapeutic glucocorticoids: mechanisms of actions in rheumatic diseases

(2020) Rowan S. Hardy et al.   Nature Reviews Rheumatology

Autism spectrum disorder

(2020) Catherine Lord et al.   Nature Reviews Disease Primers

Oxidative Stress and Immune System Dysfunction in Autism Spectrum Disorders

(2020) Luca Pangrazzi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cardiovascular effects and safety of (non-aspirin) NSAIDs

(2020) Anne-Marie Schjerning et al.   Nature Reviews Cardiology

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Assessment of oxidative stress in autism spectrum disorder using reactive oxygen metabolites and biological antioxidant potential

(2020) Masahito Morimoto et al.   PLoS One

Renoprotective and neuroprotective effects of enteric hydrogen generation from Si-based agent

(2020) Yuki Kobayashi et al.   Scientific Reports

Intraventricular IL-17A administration activates microglia and alters their localization in the mouse embryo cerebral cortex

(2020) Tetsuya Sasaki et al.   Molecular Brain

Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases

(2020) Mehdi Sharifi-Rad et al.   Frontiers in Physiology

VLDL-specific increases of fatty acids in autism spectrum disorder correlate with social interaction

(2020) Noriyoshi Usui et al.   EBioMedicine

Plasma and Fecal Metabolite Profiles in Autism Spectrum Disorder

(2020) Brittany D. Needham et al.   BIOLOGICAL PSYCHIATRY

Maternal immune conditions are increased in males with autism spectrum disorders and are associated with behavioural and emotional but not cognitive co-morbidity

(2020) Shrujna Patel et al.   Translational Psychiatry

Vitamin C Attenuates Oxidative Stress and Behavioral Abnormalities Triggered by Fipronil and Pyriproxyfen Insecticide Chronic Exposure on Zebrafish Juvenile

(2020) Madalina Andreea Robea et al.   Antioxidants

NOX1/NADPH oxidase affects the development of autism-like behaviors in a maternal immune activation model

(2020) Xueqing Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Behavioral, neuroanatomical, and molecular correlates of resilience and susceptibility to maternal immune activation

(2020) Flavia S. Mueller et al.   MOLECULAR PSYCHIATRY

Maternal immune activation in mice disrupts proteostasis in the fetal brain

(2020) Brian T. Kalish et al.   NATURE NEUROSCIENCE

Simultaneous evaluation of antioxidative serum profiles facilitates the diagnostic screening of autism spectrum disorder in under-6-year-old children

(2020) Aki Hirayama et al.   Scientific Reports

Natural Antioxidants: A Novel Therapeutic Approach to Autism Spectrum Disorders?

(2020) Luca Pangrazzi et al.   Antioxidants

The Role of Vitamins in Autism Spectrum Disorder: What Do We Know?

(2019) Geir Bjørklund et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Mitochondria: the indispensable players in innate immunity and guardians of the inflammatory response

(2019) Abhishek Mohanty et al.   Journal of Cell Communication and Signaling

Sex-dependent behavioral deficits and neuropathology in a maternal immune activation model of autism

(2019) Obelia Haida et al.   Translational Psychiatry

Oral probiotic administration during pregnancy prevents autism-related behaviors in offspring induced by maternal immune activation via anti-inflammation in mice

(2019) Xiao Wang et al.   Autism Research

The influence of neuroinflammation in Autism Spectrum Disorder

(2019) Samantha M. Matta et al.   BRAIN BEHAVIOR AND IMMUNITY

A New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress

(2019) Tyler W. LeBaron et al.   MOLECULES

Serum cytokine levels in children with spectrum autism disorder: Differences in pro- and anti-inflammatory balance

(2019) Natalia Karolina Kordulewska et al.   JOURNAL OF NEUROIMMUNOLOGY

Neurodevelopmental Resilience and Susceptibility to Maternal Immune Activation

(2019) Urs Meyer   TRENDS IN NEUROSCIENCES

Microglial regional heterogeneity and its role in the brain

(2019) Yun-Long Tan et al.   MOLECULAR PSYCHIATRY

Review of Clinical Studies Targeting Inflammatory Pathways for Individuals With Autism

(2019) Sina Hafizi et al.   Frontiers in Psychiatry

Persistently High Levels of Maternal Antenatal Inflammation Are Associated With and Mediate the Effect of Prenatal Environmental Adversities on Neurodevelopmental Delay in the Offspring

(2019) Polina Girchenko et al.   BIOLOGICAL PSYCHIATRY

IL-17a promotes sociability in mouse models of neurodevelopmental disorders

(2019) Michael Douglas Reed et al.   NATURE

Cytokine Alterations in Schizophrenia: An Updated Review

(2019) Sara Momtazmanesh et al.   Frontiers in Psychiatry

Maternal IL-6 during pregnancy can be estimated from newborn brain connectivity and predicts future working memory in offspring

(2018) Marc D. Rudolph et al.   NATURE NEUROSCIENCE

S-adenosyl methionine prevents ASD like behaviors triggered by early postnatal valproic acid exposure in very young mice

(2018) Asher Ornoy et al.   NEUROTOXICOLOGY AND TERATOLOGY

Coenzyme Q 10 supplementation reduces oxidative stress and decreases antioxidant enzyme activity in children with autism spectrum disorders

(2018) Elham Mousavinejad et al.   PSYCHIATRY RESEARCH

Autism spectrum disorder

(2018) Catherine Lord et al.   LANCET

Hydrogen-Rich Water Ameliorates Autistic-Like Behavioral Abnormalities in Valproic Acid-Treated Adolescent Mice Offspring

(2018) Qingjun Guo et al.   Frontiers in Behavioral Neuroscience

Oxidative stress: Normal pregnancy versus preeclampsia

(2018) Delia I. Chiarello et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Neuroinflammation in preterm babies and autism spectrum disorders

(2018) Cindy Bokobza et al.   PEDIATRIC RESEARCH

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

(2018) Bee Ling Tan et al.   Frontiers in Pharmacology

Foxp1 regulation of neonatal vocalizations via cortical development

(2017) Noriyoshi Usui et al.   GENES & DEVELOPMENT

The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism

(2017) William Parker et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Hydrogen generation by reaction of Si nanopowder with neutral water

(2017) Yuki Kobayashi et al.   JOURNAL OF NANOPARTICLE RESEARCH

N-acetylcysteine ameliorates repetitive/stereotypic behavior due to its antioxidant properties without activation of the canonical Wnt pathway in a valproic acid-induced rat model of autism

(2017) Yinghua Zhang et al.   Molecular Medicine Reports

Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorder

(2017) M V Lombardo et al.   MOLECULAR PSYCHIATRY

Reversing behavioural abnormalities in mice exposed to maternal inflammation

(2017) Yeong Shin Yim et al.   NATURE

Tumor necrosis factor-alpha expression in peripheral blood mononuclear cells correlates with early childhood social interaction in autism spectrum disorder

(2017) Manabu Makinodan et al.   NEUROCHEMISTRY INTERNATIONAL

Embryo implantation evolved from an ancestral inflammatory attachment reaction

(2017) Oliver W. Griffith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isolated Mitochondria Transfer Improves Neuronal Differentiation of Schizophrenia-Derived Induced Pluripotent Stem Cells and Rescues Deficits in a Rat Model of the Disorder

(2017) Odile Robicsek et al.   SCHIZOPHRENIA BULLETIN

Reaction of Si nanopowder with water investigated by FT-IR and XPS

(2017) Kentaro Imamura et al.   AIP Advances

Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment

(2017) D Mattei et al.   Translational Psychiatry

Metabolic Dysfunction Underlying Autism Spectrum Disorder and Potential Treatment Approaches

(2017) Ning Cheng et al.   Frontiers in Molecular Neuroscience

Ketogenic diet improves behaviors in a maternal immune activation model of autism spectrum disorder

(2017) David N. Ruskin et al.   PLoS One

Maternal infection during pregnancy and risk of autism spectrum disorders: A systematic review and meta-analysis

(2016) Hai-yin Jiang et al.   BRAIN BEHAVIOR AND IMMUNITY

Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program

(2016) Mireille Khacho et al.   Cell Stem Cell

Advancing the understanding of autism disease mechanisms through genetics

(2016) Luis de la Torre-Ubieta et al.   NATURE MEDICINE

Maternal immune activation: Implications for neuropsychiatric disorders

(2016) M. L. Estes et al.   SCIENCE

The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring

(2016) G. B. Choi et al.   SCIENCE

Atopic diseases and inflammation of the brain in the pathogenesis of autism spectrum disorders

(2016) T C Theoharides et al.   Translational Psychiatry

Oxidative Stress: Placenta Function and Dysfunction

(2015) Fan Wu et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Astaxanthin improves behavioral disorder and oxidative stress in prenatal valproic acid-induced mice model of autism

(2015) Md. Mamun Al-Amin et al.   BEHAVIOURAL BRAIN RESEARCH

A review on the possible molecular mechanism of action of N-acetylcysteine against insulin resistance and type-2 diabetes development

(2015) Mohamed Montassar Lasram et al.   CLINICAL BIOCHEMISTRY

N-Acetylcysteine as an Adjunctive Therapy to Risperidone for Treatment of Irritability in Autism

(2015) Mohammadali Nikoo et al.   CLINICAL NEUROPHARMACOLOGY

Influence of vitamin C and vitamin E on redox signaling: Implications for exercise adaptations

(2015) James N. Cobley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats

(2015) Theresa A. Lusardi et al.   NEUROPHARMACOLOGY

Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review

(2015) Deepmala et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state

(2015) Ergul Belge Kurutas   Nutrition Journal

The Poly(I:C)-induced maternal immune activation model in preclinical neuropsychiatric drug discovery

(2015) Sonali Reisinger et al.   PHARMACOLOGY & THERAPEUTICS

Children with autism spectrum disorders, who improved with a luteolin-containing dietary formulation, show reduced serum levels of TNF and IL-6

(2015) I Tsilioni et al.   Translational Psychiatry

The different effects of LPS and poly I:C prenatal immune challenges on the behavior, development and inflammatory responses in pregnant mice and their offspring

(2014) Dany Arsenault et al.   BRAIN BEHAVIOR AND IMMUNITY

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine

(2014) Shigeo Ohta   PHARMACOLOGY & THERAPEUTICS

Gender-Dependent Effects of Maternal Immune Activation on the Behavior of Mouse Offspring

(2014) Ingrid C. Y. Xuan et al.   PLoS One

Sulforaphane treatment of autism spectrum disorder (ASD)

(2014) K. Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preterm labor: One syndrome, many causes

(2014) R. Romero et al.   SCIENCE

Maternal immune activation promotes hippocampal kindling epileptogenesis in mice

(2013) Eduardo Pineda et al.   ANNALS OF NEUROLOGY

A randomized double blind placebo controlled clinical trial of N-Acetylcysteine added to risperidone for treating autistic disorders

(2013) Ahmad Ghanizadeh et al.   BMC Psychiatry

An Open-Label Pilot Study of a Formulation Containing the Anti-Inflammatory Flavonoid Luteolin and Its Effects on Behavior in Children With Autism Spectrum Disorders

(2013) Anilia Taliou et al.   CLINICAL THERAPEUTICS

Prenatal Valproate Exposure and Risk of Autism Spectrum Disorders and Childhood Autism

(2013) Jakob Christensen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Focal brain inflammation and autism

(2013) Theoharis C Theoharides et al.   Journal of Neuroinflammation

Stereotypical Alterations in Cortical Patterning Are Associated with Maternal Illness-Induced Placental Dysfunction

(2013) Pamela A. Carpentier et al.   JOURNAL OF NEUROSCIENCE

Existing and potential therapeutic uses for N-acetylcysteine: The need for conversion to intracellular glutathione for antioxidant benefits

(2013) Gordon F. Rushworth et al.   PHARMACOLOGY & THERAPEUTICS

Maternal immune activation and strain specific interactions in the development of autism-like behaviors in mice

(2013) J J Schwartzer et al.   Translational Psychiatry

A Randomized Controlled Pilot Trial of Oral N-Acetylcysteine in Children with Autism

(2012) Antonio Y. Hardan et al.   BIOLOGICAL PSYCHIATRY

Maternal immune activation by LPS selectively alters specific gene expression profiles of interneuron migration and oxidative stress in the fetus without triggering a fetal immune response

(2012) Devon B. Oskvig et al.   BRAIN BEHAVIOR AND IMMUNITY

Placental regulation of maternal-fetal interactions and brain development

(2012) Elaine Y. Hsiao et al.   Developmental Neurobiology

Oxidative stress-related biomarkers in autism: Systematic review and meta-analyses

(2012) Alessandra Frustaci et al.   FREE RADICAL BIOLOGY AND MEDICINE

Early Behavioral Intervention Is Associated With Normalized Brain Activity in Young Children With Autism

(2012) Geraldine Dawson et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Effects of a Brief Early Start Denver Model (ESDM)–Based Parent Intervention on Toddlers at Risk for Autism Spectrum Disorders: A Randomized Controlled Trial

(2012) Sally J. Rogers et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Brain Region-Specific Glutathione Redox Imbalance in Autism

(2012) Abha Chauhan et al.   NEUROCHEMICAL RESEARCH

The role of pro-inflammatory cytokines in the neuroinflammation and neurogenesis of schizophrenia

(2012) Kyoung-Sae Na et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Celecoxib as adjunctive treatment to risperidone in children with autistic disorder: a randomized, double-blind, placebo-controlled trial

(2012) Mahtab Asadabadi et al.   PSYCHOPHARMACOLOGY

Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain

(2012) S Rose et al.   Translational Psychiatry

Oxidative Stress and Antioxidant Defense

(2012) Esra Birben et al.   World Allergy Organization Journal

Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases

(2011) Shigeo Ohta   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Amelioration of behavioral aberrations and oxidative markers by green tea extract in valproate induced autism in animals

(2011) David Banji et al.   BRAIN RESEARCH

Recent Progress Toward Hydrogen Medicine: Potential of Molecular Hydrogen for Preventive and Therapeutic Applications

(2011) Shigeo Ohta   CURRENT PHARMACEUTICAL DESIGN

Melatonin in autism spectrum disorders: a systematic review and meta-analysis

(2011) DANIEL A ROSSIGNOL et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Brain region-specific deficit in mitochondrial electron transport chain complexes in children with autism

(2011) Abha Chauhan et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis

(2011) D A Rossignol et al.   MOLECULAR PSYCHIATRY

Altered object-in-place recognition memory, prepulse inhibition, and locomotor activity in the offspring of rats exposed to a viral mimetic during pregnancy

(2011) J.G. Howland et al.   NEUROSCIENCE

Activation of the maternal immune system induces endocrine changes in the placenta via IL-6

(2010) Elaine Y. Hsiao et al.   BRAIN BEHAVIOR AND IMMUNITY

Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome

(2010) Paul Ashwood et al.   BRAIN BEHAVIOR AND IMMUNITY

Linking oxidative stress to inflammation: Toll-like receptors

(2010) Roop Gill et al.   FREE RADICAL BIOLOGY AND MEDICINE

Decreased serum levels of adiponectin in subjects with autism

(2010) Azusa Fujita-Shimizu et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Increase in Cerebellar Neurotrophin-3 and Oxidative Stress Markers in Autism

(2009) Elizabeth M. Sajdel-Sulkowska et al.   CEREBELLUM

Elevated immune response in the brain of autistic patients

(2009) Xiaohong Li et al.   JOURNAL OF NEUROIMMUNOLOGY

Functional interleukin-17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis

(2009) Jayasri Sarma et al.   Journal of Neuroinflammation

Oligodendroglial differentiation induces mitochondrial genes and inhibition of mitochondrial function represses oligodendroglial differentiation

(2009) Robert Schoenfeld et al.   MITOCHONDRION

Epidemiology of Pervasive Developmental Disorders

(2009) Eric Fombonne   PEDIATRIC RESEARCH

Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism

(2008) S Jill James et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A Prospective Study of Transsulfuration Biomarkers in Autistic Disorders

(2008) David A. Geier et al.   NEUROCHEMICAL RESEARCH

Attenuation of Lipopolysaccharide-Induced Inflammatory Response and Phospholipids Metabolism at the Feto-Maternal Interface by N-Acetyl Cysteine

(2008) Manjeet K Paintlia et al.   PEDIATRIC RESEARCH