A New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress

Regulation of microRNAs by molecular hydrogen contributes to the prevention of radiation-induced damage in the rat myocardium

(2019) Branislav Kura et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes

(2019) Tyler W. LeBaron et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Molecular hydrogen alleviates asphyxia-induced neuronal cyclooxygenase-2 expression in newborn pigs

(2018) Viktória Varga et al.   ACTA PHARMACOLOGICA SINICA

Redox regulation of microRNAs in cancer

(2018) Jiang Lan et al.   CANCER LETTERS

Hydrogen Therapy in Cardiovascular and Metabolic Diseases: from Bench to Bedside

(2018) Yaxing Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Molecular hydrogen upregulates heat shock response and collagen biosynthesis, and downregulates cell cycles: meta-analyses of gene expression profiles

(2018) Hiroshi Nishiwaki et al.   FREE RADICAL RESEARCH

Irradiation-Induced Cardiac Connexin-43 and miR-21 Responses Are Hampered by Treatment with Atorvastatin and Aspirin

(2018) Csilla Viczenczova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway

(2018) Jia Yuan et al.   JOURNAL OF SURGICAL RESEARCH

Therapeutic efficacy of hydrogen‑rich saline alone and in combination with PI3K inhibitor in non‑small cell lung cancer

(2018) Yu Jiang et al.   Molecular Medicine Reports

Antioxidant response elements: Discovery, classes, regulation and potential applications

(2018) Azhwar Raghunath et al.   Redox Biology

Molecular hydrogen (H2): Potential in mitigating oxidative stress-induced cardiotoxicity

(2018) Branislav Kura et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Hydrogen inhibits isoproterenol-induced autophagy in cardiomyocytes in vitro and in vivo

(2017) Yaxing Zhang et al.   Molecular Medicine Reports

Reprogramming Interferon Regulatory Factor Signaling in Cardiometabolic Diseases

(2017) Yaxing Zhang et al.   PHYSIOLOGY

Molecular hydrogen: a preventive and therapeutic medical gas for various diseases

(2017) Li Ge et al.   Oncotarget

Molecular hydrogen increases resilience to stress in mice

(2017) Qiang Gao et al.   Scientific Reports

MicroRNAs Regulating Reactive Oxygen Species in Cardiovascular Diseases

(2017) Yao-Yu Gong et al.   ANTIOXIDANTS & REDOX SIGNALING

Hydrogen gas alleviates oxygen toxicity by reducing hydroxyl radical levels in PC12 cells

(2017) Junchao Yu et al.   PLoS One

Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis

(2017) Yayoi Murakami et al.   PLoS One

Hydrogen-Rich Saline Attenuates Cardiac and Hepatic Injury in Doxorubicin Rat Model by Inhibiting Inflammation and Apoptosis

(2016) Yunan Gao et al.   MEDIATORS OF INFLAMMATION

Neuroprotective Effect of Hydrogen-Rich Saline in Global Cerebral Ischemia/Reperfusion Rats: Up-Regulated Tregs and Down-Regulated miR-21, miR-210 and NF-κB Expression

(2016) Qian Li et al.   NEUROCHEMICAL RESEARCH

Current Antioxidant Treatments in Organ Transplantation

(2016) Shaojun Shi et al.   Oxidative Medicine and Cellular Longevity

Hydrogen (H2) Inhibits Isoproterenol-Induced Cardiac Hypertrophy via Antioxidative Pathways

(2016) Yaxing Zhang et al.   Frontiers in Pharmacology

Mechanisms of cardiac radiation injury and potential preventive approaches

(2015) Jan Slezak et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

ROS signaling and redox biology in endothelial cells

(2015) Emiliano Panieri et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hydrogen gas production is associated with reduced interleukin-1β mRNA in peripheral blood after a single dose of acarbose in Japanese type 2 diabetic patients

(2015) Atsuko Tamasawa et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

4-Hydroxynonenal induces Nrf2-mediated UCP3 upregulation in mouse cardiomyocytes

(2015) Elia López-Bernardo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Maternal molecular hydrogen treatment attenuates lipopolysaccharide-induced rat fetal lung injury

(2015) Y. Hattori et al.   FREE RADICAL RESEARCH

Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats

(2015) Lei Jing et al.   Heart Lung and Circulation

Can we protect from malignant arrhythmias by modulation of cardiac cell-to-cell coupling?

(2015) Narcis Tribulova et al.   JOURNAL OF ELECTROCARDIOLOGY

Cardioprotection by PI3K-mediated signaling is required for anti-arrhythmia and myocardial repair in response to ischemic preconditioning in infarcted pig hearts

(2015) Feng Su et al.   LABORATORY INVESTIGATION

Role of Hydrogen Sulfide in Ischemia-Reperfusion Injury

(2015) Dongdong Wu et al.   Oxidative Medicine and Cellular Longevity

Hydrogen gas inhalation protects against liver ischemia/reperfusion injury by activating the NF-κB signaling pathway

(2015) CHAO-BIN ZHANG et al.   Experimental and Therapeutic Medicine

Hydrogen gas attenuates embryonic gene expression and prevents left ventricular remodeling induced by intermittent hypoxia in cardiomyopathic hamsters

(2014) Ryuji Kato et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Hydrogen-Rich Saline Improves Survival and Neurological Outcome After Cardiac Arrest and Cardiopulmonary Resuscitation in Rats

(2014) Ting-ting Huo et al.   ANESTHESIA AND ANALGESIA

Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release

(2014) Yantao Liu et al.   BMC GASTROENTEROLOGY

ONOOH does not react with H2: Potential beneficial effects of H2 as an antioxidant by selective reaction with hydroxyl radicals and peroxynitrite

(2014) Jelle Penders et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective effect of inhalation of hydrogen gas on radiation-induced dermatitis and skin injury in rats

(2014) S. Watanabe et al.   JOURNAL OF RADIATION RESEARCH

Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine

(2014) Shigeo Ohta   PHARMACOLOGY & THERAPEUTICS

Gasotransmitters: growing pains and joys

(2014) Rui Wang   TRENDS IN BIOCHEMICAL SCIENCES

MicroRNA-21 is a novel promising target in cancer radiation therapy

(2014) Jia Liu et al.   TUMOR BIOLOGY

Breathing nitric oxide plus hydrogen gas reduces ischemia-reperfusion injury and nitrotyrosine production in murine heart

(2013) Toshihiro Shinbo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Pathological Ventricular Remodeling

(2013) Jana S. Burchfield et al.   CIRCULATION

Hydrogen as a New Class of Radioprotective Agent

(2013) Liren Qian et al.   International Journal of Biological Sciences

Hydrogen-rich saline attenuates vascular smooth muscle cell proliferation and neointimal hyperplasia by inhibiting reactive oxygen species production and inactivating the Ras-ERK1/2-MEK1/2 and Akt pathways

(2013) YALI CHEN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Oxidative Stress and MicroRNAs in Vascular Diseases

(2013) Alessandra Magenta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

H 2 Gas Improves Functional Outcome After Cardiac Arrest to an Extent Comparable to Therapeutic Hypothermia in a Rat Model

(2013) Kei Hayashida et al.   Journal of the American Heart Association

Statin therapy prevents expansive remodeling in venous bypass grafts

(2012) Beiping Qiang et al.   ATHEROSCLEROSIS

Targeting Heme Oxygenase-1 for Neuroprotection and Neuroinflammation in Neurodegenerative Diseases

(2012) Agnieszka Jazwa et al.   CURRENT DRUG TARGETS

Molecular hydrogen and radiation protection

(2012) Yunhai Chuai et al.   FREE RADICAL RESEARCH

Hydrogen as additive of HTK solution fortifies myocardial preservation in grafts with prolonged cold ischemia

(2012) Mengwei Tan et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Hydrogen protects rats from dermatitis caused by local radiation

(2012) Ke Mei et al.   JOURNAL OF DERMATOLOGICAL TREATMENT

A novel method of preserving cardiac grafts using a hydrogen-rich water bath

(2012) Kentaro Noda et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Chronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular hypertrophy in spontaneous hypertensive rats

(2012) Yong-Sheng Yu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Molecular Hydrogen as an Emerging Therapeutic Medical Gas for Neurodegenerative and Other Diseases

(2012) Kinji Ohno et al.   Oxidative Medicine and Cellular Longevity

Gas biology: Tiny molecules controlling metabolic systems

(2012) Mayumi Kajimura et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine

(2012) Kazuyuki Sakai et al.   SCANDINAVIAN CARDIOVASCULAR JOURNAL

Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration

(2012) Kentaro Noda et al.   TRANSPLANT INTERNATIONAL

The cytoprotective role of the Keap1–Nrf2 pathway

(2011) Liam Baird et al.   ARCHIVES OF TOXICOLOGY

Hydrogen-rich saline prevents neointima formation after carotid balloon injury by suppressing ROS and the TNF-α/NF-κB pathway

(2011) Zhe-xue Qin et al.   ATHEROSCLEROSIS

Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation

(2011) Chien-Sheng Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases

(2011) Shigeo Ohta   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Role of microRNAs in the reperfused myocardium towards post-infarct remodelling

(2011) H. Zhu et al.   CARDIOVASCULAR RESEARCH

The Principle and the Potential Approach to ROS-dependent Cytotoxicity by Non-pharmaceutical Therapies: Optimal Use of Medical Gases with Antioxidant Properties

(2011) Mami Noda et al.   CURRENT PHARMACEUTICAL DESIGN

Recent Progress Toward Hydrogen Medicine: Potential of Molecular Hydrogen for Preventive and Therapeutic Applications

(2011) Shigeo Ohta   CURRENT PHARMACEUTICAL DESIGN

The effect of ischemia reperfusion injury on skeletal muscle

(2011) Syed Gillani et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

Nanocarriers for vascular delivery of antioxidants

(2011) Elizabeth Hood et al.   Nanomedicine

Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice

(2011) Naomi Kamimura et al.   Obesity

Carbon monoxide inhibits apoptosis during cold storage and protects kidney grafts donated after cardiac death

(2011) Kikumi S. Ozaki et al.   TRANSPLANT INTERNATIONAL

Safety and efficacy of vitamin-based antioxidant therapy in patients with severe acute pancreatitis: A randomized controlled trial

(2011) Ashish Bhalla et al.   Saudi Journal of Gastroenterology

Pathogenesis of Myocardial Ischemia-Reperfusion Injury and Rationale for Therapy

(2010) Aslan T. Turer et al.   AMERICAN JOURNAL OF CARDIOLOGY

Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT

(2010) A Kitamura et al.   BRITISH JOURNAL OF RADIOLOGY

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

(2010) Michael Ristow et al.   EXPERIMENTAL GERONTOLOGY

Radioprotective effect of hydrogen in cultured cells and mice

(2010) Liren Qian et al.   FREE RADICAL RESEARCH

Recent advances in hydrogen research as a therapeutic medical gas

(2010) Chien-Sheng Huang et al.   FREE RADICAL RESEARCH

Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion

(2010) Yufeng Zhang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium

(2010) James W. Smyth et al.   JOURNAL OF CLINICAL INVESTIGATION

The protective role of hydrogen-rich saline in experimental liver injury in mice

(2010) HanYong Sun et al.   JOURNAL OF HEPATOLOGY

Melatonin protects steatotic and nonsteatotic liver grafts against cold ischemia and reperfusion injury

(2010) Mohamed Amine Zaoualí et al.   JOURNAL OF PINEAL RESEARCH

The Potential Cardioprotective Effects of Hydrogen in Irradiated Mice

(2010) Liren QIAN et al.   JOURNAL OF RADIATION RESEARCH

Estrogen Receptor-β Prevents Cardiac Fibrosis

(2010) Ali Pedram et al.   MOLECULAR ENDOCRINOLOGY

Hydrogen-rich PBS protects cultured human cells from ionizing radiation-induced cellular damage

(2010) Liren Qian et al.   Nuclear Technology & Radiation Protection

Radioprotectors and Mitigators of Radiation-Induced Normal Tissue Injury

(2010) D. Citrin et al.   ONCOLOGIST

Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning

(2010) K. F. Bell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vascular Damage as an Underlying Mechanism of Cardiac and Cerebral Toxicity in Irradiated Cancer Patients

(2010) F. A. Stewart et al.   RADIATION RESEARCH

PROTECTIVE EFFECTS OF HYDROGEN GAS ON MURINE POLYMICROBIAL SEPSIS VIA REDUCING OXIDATIVE STRESS AND HMGB1 RELEASE

(2010) Keliang Xie et al.   SHOCK

Nitric Oxide Ventilation of Rat Lungs from Non-Heart-Beating Donors Improves Posttransplant Function

(2009) B. M. Dong et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Metabolic Remodeling Induced by Mitochondrial Aldehyde Stress Stimulates Tolerance to Oxidative Stress in the Heart

(2009) Jin Endo et al.   CIRCULATION RESEARCH

Hydrogen-Rich Saline Protects Myocardium Against Ischemia/Reperfusion Injury in Rats

(2009) Qiang Sun et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Are the effects ofα-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract?

(2009) Yoshihiko Suzuki et al.   FEBS LETTERS

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both

(2009) Atsunori Nakao et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Oral hydrogen water prevents chronic allograft nephropathy in rats

(2009) Jon S. Cardinal et al.   KIDNEY INTERNATIONAL

Ionizing Radiation-Induced Oxidative Stress Alters miRNA Expression

(2009) Nicole L. Simone et al.   PLoS One

p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis

(2009) D. G. Kirsch et al.   SCIENCE

Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice

(2008) Yasunori Sato et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia–reperfusion injury

(2008) Kentaro Hayashida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inflammation and Chronic Oxidative Stress in Radiation-Induced Late Normal Tissue Injury: Therapeutic Implications

(2008) Weiling Zhao et al.   CURRENT MEDICINAL CHEMISTRY

The chemical biology of nitric oxide: Implications in cellular signaling

(2008) Douglas D. Thomas et al.   FREE RADICAL BIOLOGY AND MEDICINE

Melatonin Regulates Nitric Oxide Synthase Expression in Ischemic Brain Injury

(2008) Phil-Ok KOH   JOURNAL OF VETERINARY MEDICAL SCIENCE

Preservation of the kidney by carbon monoxide: a black swan phenomenon

(2008) Karl A. Nath   KIDNEY INTERNATIONAL