Recent Advances and Emerging Trends in Cancer Biomarker Detection Technologies

Zwitterion-Functionalized Cuprous Oxide Nanoparticles for Highly Specific and Enzymeless Electrochemical Creatinine Biosensing in Human Serum

(2023) R. K. Rakesh Kumar et al.   ACS Applied Nano Materials

Electrochemical immunosensor utilizing a multifunctional 3D nanocomposite coating with antifouling capability for urinary bladder cancer diagnosis

(2023) R.K. Rakesh Kumar et al.   SENSORS AND ACTUATORS B-CHEMICAL

Ultrasensitive Strain Sensor Utilizing a AgF–AgNW Hybrid Nanocomposite for Breath Monitoring and Pulmonary Function Analysis

(2022) Amit Kumar et al.   ACS Applied Materials & Interfaces

DNA-Tetrahedral-Nanostructure-Based Entropy-Driven Amplifier for High-Performance Photoelectrochemical Biosensing

(2021) Hongbo Li et al.   ACS Nano

Enzyme-based amperometric biosensors for malic acid – a review

(2021) Christopher J. Matthews et al.   ANALYTICA CHIMICA ACTA

A CRISPR/Cas13a-powered catalytic electrochemical biosensor for successive and highly sensitive RNA diagnostics

(2021) Yan Sheng et al.   BIOSENSORS & BIOELECTRONICS

From Diagnosis to Treatment: Recent Advances in Patient-Friendly Biosensors and Implantable Devices

(2021) Pei Li et al.   ACS Nano

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

A Snapshot of Microfluidics in Point‐of‐Care Diagnostics: Multifaceted Integrity with Materials and Sensors

(2021) Garbis Atam Akceoglu et al.   Advanced Materials Technologies

A review of recent advances in non-enzymatic electrochemical creatinine biosensing

(2021) R.K. Rakesh Kumar et al.   ANALYTICA CHIMICA ACTA

Metal–Organic Framework-Functionalized Paper-Based Electrochemical Biosensor for Ultrasensitive Exosome Assay

(2021) Xiaojuan Liu et al.   ANALYTICAL CHEMISTRY

The ever‐increasing importance of cancer as a leading cause of premature death worldwide

(2021) Freddie Bray et al.   CANCER

Bio-inspired Track-Etched Polymeric Nanochannels: Steady-State Biosensors for Detection of Analytes

(2021) Jian Wang et al.   ACS Nano

A rapid, ultrasensitive voltammetric biosensor for determining SARS-CoV-2 spike protein in real samples

(2021) Lokman Liv et al.   BIOSENSORS & BIOELECTRONICS

Highly sensitive, flexible and biocompatible temperature sensor utilizing ultra-long Au@AgNW-based polymeric nanocomposites

(2021) Amit Kumar et al.   Nanoscale

Boron nitride quantum dots as electrochemiluminescence coreactants of rGO@Au@Ru–SiO2 for label-free detection of AFP in human serum

(2020) Dongmiao Qin et al.   ELECTROCHIMICA ACTA

Ultrasensitive Fluorescent miRNA Biosensor Based on a “Sandwich” Oligonucleotide Hybridization and Fluorescence Resonance Energy Transfer Process Using an Ln(III)-MOF and Ag Nanoparticles for Early Cancer Diagnosis: Application of Central Composite Design

(2020) Ahmad Afzalinia et al.   ACS Applied Materials & Interfaces

Electrochemical biosensors based on multienzyme systems: Main groups, advantages and limitations – A review

(2020) I.S. Kucherenko et al.   ANALYTICA CHIMICA ACTA

Aptamer-Based Field-Effect Transistor for Detection of Avian Influenza Virus in Chicken Serum

(2020) Jae Kwon et al.   ANALYTICAL CHEMISTRY

Multiplexed CRISPR technologies for gene editing and transcriptional regulation

(2020) Nicholas S. McCarty et al.   Nature Communications

Quantification of Protein Secretion from Circulating Tumor Cells in Microfluidic Chambers

(2020) Lucas Armbrecht et al.   Advanced Science

Electrochemiluminescence Biosensor for Nucleolin Imaging in a Single Tumor Cell Combined with Synergetic Therapy of Tumor

(2020) Wanxia Gao et al.   ACS Sensors

The DNA methylation landscape of advanced prostate cancer

(2020) Shuang G. Zhao et al.   NATURE GENETICS

Targeting telomerase for cancer therapy

(2020) Adam N. Guterres et al.   ONCOGENE

A Dual Antibody-modified Nanochannel Biosensor for Capture and Identification of Exosomes

(2020) Cancan Wang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Immunomagnetic Capture and Multiplexed Surface Marker Detection of Circulating Tumor Cells with Magnetic Multicolor Surface-Enhanced Raman Scattering Nanotags

(2020) Raymond Edward Wilson et al.   ACS Applied Materials & Interfaces

Clinical relevance of blood-based ctDNA analysis: mutation detection and beyond

(2020) Laura Keller et al.   BRITISH JOURNAL OF CANCER

Metal-Enhanced Fluorescence by Bifunctional Au Nanoparticles for Highly Sensitive and Simple Detection of Proteolytic Enzyme

(2020) Jin-Ha Choi et al.   NANO LETTERS

Colorimetric detection of cancer biomarker based on enzyme enrichment and pH sensing

(2020) Xiangyang Miao et al.   SENSORS AND ACTUATORS B-CHEMICAL

An integrated fluorescence biosensor for microRNA detection based on exponential amplification reaction-triggered three-dimensional bipedal DNA walkers

(2020) Liu Yang et al.   ANALYTICA CHIMICA ACTA

Electrochemically Controlled ATRP for Cleavage-Based Electrochemical Detection of the Prostate-Specific Antigen at Femtomolar Level Concentrations

(2020) Qiong Hu et al.   ANALYTICAL CHEMISTRY

Development of a simple, sensitive and selective colorimetric aptasensor for the detection of cancer-derived exosomes

(2020) Lizhou Xu et al.   BIOSENSORS & BIOELECTRONICS

CRISPR-Cas12a-Based Nucleic Acid Amplification-Free DNA Biosensor via Au Nanoparticle-Assisted Metal-Enhanced Fluorescence and Colorimetric Analysis

(2020) Jin-Ha Choi et al.   NANO LETTERS

Analysis of interactions between proteins and small-molecule drugs by a biosensor based on a graphene field-effect transistor

(2020) Shicai Xu et al.   SENSORS AND ACTUATORS B-CHEMICAL

Faradaic electrochemical impedance spectroscopy for enhanced analyte detection in diagnostics

(2020) Madison E. Strong et al.   BIOSENSORS & BIOELECTRONICS

An electrochemical biosensor for DNA methylation detection through hybridization chain amplified reaction coupled with a tetrahedral DNA nanostructure

(2019) Xi Chen et al.   ACS Applied Materials & Interfaces

On the design of deterministic dielectrophoresis for continuous separation of circulating tumor cells from peripheral blood cells

(2019) Mohammad Aghaamoo et al.   ELECTROPHORESIS

Gold-nanorod enhances dielectric voltammetry detection of c-reactive protein: A predictive strategy for cardiac failure

(2019) Iswary Letchumanan et al.   BIOSENSORS & BIOELECTRONICS

The next generation of CRISPR–Cas technologies and applications

(2019) Adrian Pickar-Oliver et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microfluidic analysis of circulating tumor cells and tumor-derived extracellular vesicles

(2019) Fei Tian et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Ribosomal RNA-Selective Light-Up Fluorescent Probe for Rapidly Imaging the Nucleolus in Live Cells

(2019) Chunyan Cao et al.   ACS Sensors

Highly sensitive fluorescence biosensor for intracellular telomerase detection based on a single patchy gold/carbon nanosphere via the combination of nanoflare and hybridization chain reaction

(2019) Xiaoxiao Wang et al.   BIOSENSORS & BIOELECTRONICS

The role of telomeres and telomerase in cirrhosis and liver cancer

(2019) Jean-Charles Nault et al.   Nature Reviews Gastroenterology & Hepatology

CRISPR–Cas in mobile genetic elements: counter-defence and beyond

(2019) Guilhem Faure et al.   NATURE REVIEWS MICROBIOLOGY

Current trends and challenges in cancer management and therapy using designer nanomaterials

(2019) P. N. Navya et al.   Nano Convergence

Dual-Signal Readout of DNA Methylation Status Based on the Assembly of a Supersandwich Electrochemical Biosensor without Enzymatic Reaction

(2019) Qiumei Feng et al.   ACS Sensors

Dual-Mode Electrochemical Assay of Prostate-Specific Antigen Based on Antifouling Peptides Functionalized with Electrochemical Probes and Internal References

(2019) Caifeng Ding et al.   ANALYTICAL CHEMISTRY

Recent Advances in Microfluidic Platforms Applied in Cancer Metastasis: Circulating Tumor Cells' (CTCs) Isolation and Tumor‐On‐A‐Chip

(2019) Zhengjie Lin et al.   Small

Luminescent carbon nanostructures for microRNA detection

(2019) O.A. Goryacheva et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Research progress of DNA walker and its recent applications in biosensor

(2019) Jing Chen et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Electrogenerated Chemiluminescence Biosensing

(2019) Honglan Qi et al.   ANALYTICAL CHEMISTRY

An enzyme-free electrochemical biosensor based on well monodisperse Au nanorods for ultra-sensitive detection of telomerase activity

(2019) Lei Wang et al.   BIOSENSORS & BIOELECTRONICS

Electrochemical biosensors for the detection of lung cancer biomarkers: A review

(2019) Akbar Khanmohammadi et al.   TALANTA

Size-based separation methods of circulating tumor cells

(2018) Si-Jie Hao et al.   ADVANCED DRUG DELIVERY REVIEWS

Proximity Hybridization-Regulated Immunoassay for Cell Surface Protein and Protein-Overexpressing Cancer Cells via Electrochemiluminescence

(2018) Xiaofei Wang et al.   ANALYTICAL CHEMISTRY

Ultrasensitive Photoelectrochemical Biosensor Based on DNA Tetrahedron as Nanocarrier for Efficient Immobilization of CdTe QDs-Methylene Blue as Signal Probe with Near-Zero Background Noise

(2018) Mengjie Li et al.   ANALYTICAL CHEMISTRY

Electrochemical ELISA-based platform for bladder cancer protein biomarker detection in urine

(2018) Sunil K. Arya et al.   BIOSENSORS & BIOELECTRONICS

Circulating tumor cell isolation, culture, and downstream molecular analysis

(2018) Sandhya Sharma et al.   BIOTECHNOLOGY ADVANCES

Electrochemical biosensor for cancer cell detection based on a surface 3D micro-array

(2018) Li An et al.   LAB ON A CHIP

Circulating tumor DNA and liquid biopsy: opportunities, challenges, and recent advances in detection technologies

(2018) Lena Gorgannezhad et al.   LAB ON A CHIP

Analysis of DNA methylation in cancer: location revisited

(2018) Alexander Koch et al.   Nature Reviews Clinical Oncology

Early stage NSCLC — challenges to implementing ctDNA-based screening and MRD detection

(2018) Christopher Abbosh et al.   Nature Reviews Clinical Oncology

Biominerized gold-Hemin@MOF composites with peroxidase-like and gold catalysis activities: A high-throughput colorimetric immunoassay for alpha-fetoprotein in blood by ELISA and gold-catalytic silver staining

(2018) Liyan Zhang et al.   SENSORS AND ACTUATORS B-CHEMICAL

An enzyme-free and label-free fluorescence biosensor for microRNA detection based on cascade amplification of DNAzyme-powered three-dimensional DNA walker and hybridization chain reaction

(2018) Rui Wang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Optically-induced-dielectrophoresis (ODEP)-based cell manipulation in a microfluidic system for high-purity isolation of integral circulating tumor cell (CTC) clusters based on their size characteristics

(2018) Tzu-Keng Chiu et al.   SENSORS AND ACTUATORS B-CHEMICAL

A review of microfluidic approaches for investigating cancer extravasation during metastasis

(2018) Yu-Heng Vivian Ma et al.   Microsystems & Nanoengineering

Multiplexed SERS Detection of Soluble Cancer Protein Biomarkers with Gold–Silver Alloy Nanoboxes and Nanoyeast Single-Chain Variable Fragments

(2018) Junrong Li et al.   ANALYTICAL CHEMISTRY

Quantum dot-based electrochemical biosensor for stripping voltammetric detection of telomerase at the single-cell level

(2018) Chen-chen Li et al.   BIOSENSORS & BIOELECTRONICS

Emerging bioanalytical applications of DNA walkers

(2018) Sean D. Mason et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Electrochemical Impedance Spectroscopy Based Biosensors: Mechanistic principles, Analytical Examples and Challenges Towards Commercialization for Assays of Protein Cancer Biomarkers

(2018) Tomas Bertok et al.   ChemElectroChem

Programmable Target-Initiated DNAzyme Walker Walking along a Spatially Isolated and Highly Hybridizable Substrate Track on a Nanoparticle Surface

(2018) Ke Yang et al.   ACS Applied Materials & Interfaces

Liquid Biopsy and Lung Cancer

(2018) Pasquale Pisapia et al.   ACTA CYTOLOGICA

Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods

(2018) J. Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Survival after Minimally Invasive Radical Hysterectomy for Early-Stage Cervical Cancer

(2018) Alexander Melamed et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functionally diverse type V CRISPR-Cas systems

(2018) Winston X. Yan et al.   SCIENCE

Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors

(2018) Sadegh Saghafinia et al.   Cell Reports

Microfluidic chip coupled with optical biosensors for simultaneous detection of multiple analytes: A review

(2018) Zerong Liao et al.   BIOSENSORS & BIOELECTRONICS

Droplet-based digital PCR and next generation sequencing for monitoring circulating tumor DNA: a cancer diagnostic perspective

(2017) Mathilde Postel et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Plasma circular RNA profiling of patients with gastric cancer and their droplet digital RT-PCR detection

(2017) Tianwen Li et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Expansion of patient-derived circulating tumor cells from liquid biopsies using a CTC microfluidic culture device

(2017) Bee Luan Khoo et al.   Nature Protocols

Circulating tumour cells and cell-free DNA in gastrointestinal cancer

(2017) Klaus Pantel et al.   Nature Reviews Gastroenterology & Hepatology

Biological Functions and Current Advances in Isolation and Detection Strategies for Exosome Nanovesicles

(2017) Kseniia Boriachek et al.   Small

A novel electrochemical biosensor based on polyadenine modified aptamer for label-free and ultrasensitive detection of human breast cancer cells

(2017) Kun Wang et al.   TALANTA

Multicolor ELISA based on alkaline phosphatase-triggered growth of Au nanorods

(2016) Yanyan Li et al.   ANALYST

Recent advances in electrochemical biosensors based on graphene two-dimensional nanomaterials

(2016) Yang Song et al.   BIOSENSORS & BIOELECTRONICS

Affinity Versus Label-Free Isolation of Circulating Tumor Cells: Who Wins?

(2016) Vasudha Murlidhar et al.   Small

Application of optically-induced-dielectrophoresis in microfluidic system for purification of circulating tumour cells for gene expression analysis- Cancer cell line model

(2016) Tzu-Keng Chiu et al.   Scientific Reports

In Situ Electrochemical ELISA for Specific Identification of Captured Cancer Cells

(2015) Tina Saberi Safaei et al.   ACS Applied Materials & Interfaces

Rapid Identification by Surface-Enhanced Raman Spectroscopy of Cancer Cells at Low Concentrations Flowing in a Microfluidic Channel

(2015) Alessia Pallaoro et al.   ACS Nano

Label-free impedance detection of cancer cells from whole blood on an integrated centrifugal microfluidic platform

(2015) Charles E. Nwankire et al.   BIOSENSORS & BIOELECTRONICS

Cancer biomarker detection: recent achievements and challenges

(2015) Li Wu et al.   CHEMICAL SOCIETY REVIEWS

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

(2015) Sonia A. Melo et al.   NATURE

Integration of Platinum Nanoparticles with a Volumetric Bar-Chart Chip for Biomarker Assays

(2014) Yujun Song et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Point-of-care biochemical assays using gold nanoparticle-implemented microfluidics

(2014) Jiashu Sun et al.   CHEMICAL SOCIETY REVIEWS

Functionalized MoS2Nanosheet-Based Field-Effect Biosensor for Label-Free Sensitive Detection of Cancer Marker Proteins in Solution

(2014) Lu Wang et al.   Small

Gold Nanoparticle-Based Activatable Probe for Sensing Ultralow Levels of Prostate-Specific Antigen

(2013) Dingbin Liu et al.   ACS Nano

Electrical biosensors and the label free detection of protein disease biomarkers

(2013) Xiliang Luo et al.   CHEMICAL SOCIETY REVIEWS

Plasmonic ELISA for the detection of analytes at ultralow concentrations with the naked eye

(2013) Roberto de la Rica et al.   Nature Protocols

Hybrids of a Genetically Engineered Antibody and a Carbon Nanotube Transistor for Detection of Prostate Cancer Biomarkers

(2012) Mitchell B. Lerner et al.   ACS Nano

Aptamer-Enabled Efficient Isolation of Cancer Cells from Whole Blood Using a Microfluidic Device

(2012) Weian Sheng et al.   ANALYTICAL CHEMISTRY

Chemoenzymatic Probes for Detecting and Imaging Fucose-α(1-2)-galactose Glycan Biomarkers

(2012) Jean-Luc Chaubard et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Microfluidic approaches for cancer cell detection, characterization, and separation

(2012) Jian Chen et al.   LAB ON A CHIP

The DNA damage response and cancer therapy

(2012) Christopher J. Lord et al.   NATURE

Multiplexed volumetric bar-chart chip for point-of-care diagnostics

(2012) Yujun Song et al.   Nature Communications

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Cancer detection using nanoparticle-based sensors

(2011) Maëlle Perfézou et al.   CHEMICAL SOCIETY REVIEWS

Electrochemical biosensors

(2010) Niina J. Ronkainen et al.   CHEMICAL SOCIETY REVIEWS

Active Metalloproteases of the A Disintegrin And Metalloprotease (ADAM) Family: Biological Function and Structure

(2010) Theo Klein et al.   JOURNAL OF PROTEOME RESEARCH

Mining the plasma proteome for cancer biomarkers

(2008) Samir M. Hanash et al.   NATURE