cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8+ T cell function and anti-tumor immunity

SNX9-induced membrane tubulation regulates CD28 cluster stability and signalling

(2022) Manuela Ecker et al.   eLife

Cis interactions between CD2 and its ligands on T cells are required for T cell activation

(2022) Bin Li et al.   Science Immunology

PI(3,4)P2-mediated membrane tubulation promotes integrin trafficking and invasive cell migration

(2021) Zhen Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic cells in cancer immunology

(2021) Theresa L. Murphy et al.   Cellular & Molecular Immunology

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors

(2021) Xiaozheng Xu et al.   eLife

Quorum Regulation via Nested Antagonistic Feedback Circuits Mediated by the Receptors CD28 and CTLA-4 Confers Robustness to T Cell Population Dynamics

(2020) Simon Zenke et al.   IMMUNITY

Light-Inducible Generation of Membrane Curvature in Live Cells with Engineered BAR Domain Proteins

(2020) Taylor Jones et al.   ACS Synthetic Biology

Performance and Its Limits in Rigid Body Protein-Protein Docking

(2020) Israel T. Desta et al.   STRUCTURE

Surfing on Membrane Waves: Microvilli, Curved Membranes, and Immune Signaling

(2020) Ron Orbach et al.   Frontiers in Immunology

Tumor-infiltrating dendritic cell states are conserved across solid human cancers

(2020) Genevieve M. Gerhard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Directed Evolution of Split APEX2 Peroxidase

(2019) Yisu Han et al.   ACS Chemical Biology

Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses

(2019) Daisuke Sugiura et al.   SCIENCE

A tessellation-based colocalization analysis approach for single-molecule localization microscopy

(2019) Florian Levet et al.   Nature Communications

Orchestration of Immunological Synapse Assembly by Vesicular Trafficking

(2019) Anna Onnis et al.   Frontiers in Cell and Developmental Biology

The ALFA-tag is a highly versatile tool for nanobody-based bioscience applications

(2019) Hansjörg Götzke et al.   Nature Communications

PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways

(2019) Yunlong Zhao et al.   IMMUNITY

Approaching infinite affinity through engineering of peptide–protein interaction

(2019) Anthony H. Keeble et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells

(2018) Yunlong Zhao et al.   Cell Reports

PD-L1 binds to B7-1 only in cis on the same cell surface

(2018) Apoorvi Chaudhri et al.   Cancer Immunology Research

LFA-1 in T Cell Migration and Differentiation

(2018) Brandon L. Walling et al.   Frontiers in Immunology

The ClusPro web server for protein–protein docking

(2017) Dima Kozakov et al.   Nature Protocols

Dynamic regulation of CD28 conformation and signaling by charged lipids and ions

(2017) Wei Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Early T cell receptor signals globally modulate ligand:receptor affinities during antigen discrimination

(2017) Rafal M. Pielak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New additions to the ClusPro server motivated by CAPRI

(2017) Sandor Vajda et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Visualizing dynamic microvillar search and stabilization during ligand detection by T cells

(2017) En Cai et al.   SCIENCE

Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent

(2017) Alice O. Kamphorst et al.   SCIENCE

Dynamic regulation of CD28 conformation and signaling by charged lipids and ions

(2017) Wei Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Critical Role for CD103 + /CD141 + Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma

(2016) Edward W. Roberts et al.   CANCER CELL

Roles of CD48 in regulating immunity and tolerance

(2016) Shannon L. McArdel et al.   CLINICAL IMMUNOLOGY

CD28 Costimulation: From Mechanism to Therapy

(2016) Jonathan H. Esensten et al.   IMMUNITY

Assessment of costimulation and coinhibition in a triple parameter T cell reporter line: Simultaneous measurement of NF-κB, NFAT and AP-1

(2016) Sabrina Jutz et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling

(2016) Jessica Dobbins et al.   Science Signaling

Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling

(2016) Jessica Dobbins et al.   Science Signaling

ThunderSTORM: a comprehensive ImageJ plug-in for PALM and STORM data analysis and super-resolution imaging

(2014) Martin Ovesný et al.   BIOINFORMATICS

Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity

(2014) Miranda L. Broz et al.   CANCER CELL

T Cell-Dendritic Cell Immunological Synapses Contain TCR-dependent CD28-CD80 Clusters That Recruit Protein Kinase C 

(2014) S.-Y. Tseng et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: A Double-Mutant Knockin of the CD28 YMNM and PYAP Motifs Reveals a Critical Role for the YMNM Motif in Regulation of T Cell Proliferation and Bcl-xL Expression

(2014) J. S. Boomer et al.   JOURNAL OF IMMUNOLOGY

How good is automated protein docking?

(2013) Dima Kozakov et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules

(2012) Jan R T van Weering et al.   EMBO JOURNAL

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

(2011) Gerritje J.W. van der Windt et al.   IMMUNITY

The immunological synapse: a focal point for endocytosis and exocytosis

(2010) Gillian M. Griffiths et al.   JOURNAL OF CELL BIOLOGY

Transmembrane domains control exclusion of membrane proteins from clathrin-coated pits

(2010) V. Mercanti et al.   JOURNAL OF CELL SCIENCE

Transient CD86 Expression on Hepatitis C Virus-Specific CD8 + T Cells in Acute Infection Is Linked to Sufficient IL-2 Signaling

(2010) Henry Radziewicz et al.   JOURNAL OF IMMUNOLOGY

An Enigmatic Tail of CD28 Signaling

(2010) J. S. Boomer et al.   Cold Spring Harbor Perspectives in Biology

Immune regulation by 4-1BB and 4-1BBL: complexities and challenges

(2009) Chao Wang et al.   IMMUNOLOGICAL REVIEWS

Sequential Cooperation of CD2 and CD48 in the Buildup of the Early TCR Signalosome

(2009) A. Muhammad et al.   JOURNAL OF IMMUNOLOGY

Targeted Knock-In Mice Expressing Mutations of CD28 Reveal an Essential Pathway for Costimulation

(2009) L. F. Dodson et al.   MOLECULAR AND CELLULAR BIOLOGY

Endocytosis and signalling: intertwining molecular networks

(2009) Alexander Sorkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CD28− T cells: their role in the age-associated decline of immune function

(2009) Nan-ping Weng et al.   TRENDS IN IMMUNOLOGY

AccPbFRET: An ImageJ plugin for semi-automatic, fully corrected analysis of acceptor photobleaching FRET images

(2008) János Roszik et al.   BMC BIOINFORMATICS

Spatiotemporal Regulation of T Cell Costimulation by TCR-CD28 Microclusters and Protein Kinase C θ Translocation

(2008) Tadashi Yokosuka et al.   IMMUNITY