Low sulfated heparan sulfate mimetic differentially affects repair in immune‐mediated and toxin‐induced experimental models of demyelination

Human olfactory mesenchymal stromal cell transplantation ameliorates experimental autoimmune encephalomyelitis revealing an inhibitory role for IL16 on myelination

(2022) Susan L. Lindsay et al.   Acta Neuropathologica Communications

Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination

(2022) Martin Zirngibl et al.   Molecular Neurodegeneration

Zika Virus Infection Leads to Demyelination and Axonal Injury in Mature CNS Cultures

(2021) Verena Schultz et al.   Viruses-Basel

Activated microglia drive demyelination via CSF1R signaling

(2021) Dave E. Marzan et al.   GLIA

Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following experimental demyelination

(2021) Darpan Saraswat et al.   Nature Communications

Multi-target approaches to CNS repair: olfactory mucosa-derived cells and heparan sulfates

(2020) Susan L. Lindsay et al.   Nature Reviews Neurology

Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury

(2020) Elisa M. Floriddia et al.   Nature Communications

Continuous cuprizone intoxication allows active experimental autoimmune encephalomyelitis induction in C57BL/6 mice

(2019) Vladislav Yakimov et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Animal Weight Is an Important Variable for Reliable Cuprizone-Induced Demyelination

(2019) Patrizia Leopold et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The effects of developmental and current niches on oligodendrocyte precursor dynamics and fate

(2019) Linda L. Boshans et al.   NEUROSCIENCE LETTERS

Using structurally defined oligosaccharides to understand the interactions between proteins and heparan sulfate

(2018) Ding Xu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The Role of Heparan Sulfate in Inflammation, and the Development of Biomimetics as Anti-Inflammatory Strategies

(2018) Brooke L. Farrugia et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Surfen, a proteoglycan binding agent, reduces inflammation but inhibits remyelination in murine models of Multiple Sclerosis

(2018) Jordan R. Warford et al.   Acta Neuropathologica Communications

Low sulfated heparins target multiple proteins for central nervous system repair

(2018) George A. McCanney et al.   GLIA

Sulfatase-mediated manipulation of the astrocyte-Schwann cell interface

(2016) Paul O'Neill et al.   GLIA

Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline

(2016) Abbe H. Crawford et al.   Cell Reports

Single-Entity Heparan Sulfate Glycomimetic Clusters for Therapeutic Applications

(2015) Peter C. Tyler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9

(2015) Maren Lindner et al.   BRAIN

“GAG-ing with the neuron”: The role of glycosaminoglycan patterning in the central nervous system

(2015) Patrice D. Smith et al.   EXPERIMENTAL NEUROLOGY

Absence of CCL2 and CCL3 Ameliorates Central Nervous System Grey Matter But Not White Matter Demyelination in the Presence of an Intact Blood–Brain Barrier

(2015) Katharina Janssen et al.   MOLECULAR NEUROBIOLOGY

Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis

(2015) Carrie A Duckworth et al.   Oncotarget

The sphingosine 1-phosphate receptor agonist FTY720 is neuroprotective after cuprizone-induced CNS demyelination

(2014) A Slowik et al.   BRITISH JOURNAL OF PHARMACOLOGY

Synthesis and Biological Evaluation of a Unique Heparin Mimetic Hexasaccharide for Structure–Activity Relationship Studies

(2014) Sucharita Roy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cellular and molecular neuropathology of the cuprizone mouse model: Clinical relevance for multiple sclerosis

(2014) Jelle Praet et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Motor skill learning requires active central myelination

(2014) I. A. McKenzie et al.   SCIENCE

Anti–IL-17A Treatment Reduces Clinical Score and VCAM-1 Expression Detected by in Vivo Magnetic Resonance Imaging in Chronic Relapsing EAE ABH Mice

(2013) Silvy Mardiguian et al.   AMERICAN JOURNAL OF PATHOLOGY

Short-Term Cuprizone Feeding Induces Selective Amino Acid Deprivation with Concomitant Activation of an Integrated Stress Response in Oligodendrocytes

(2013) Johannes Goldberg et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Synthesis of a Targeted Library of Heparan Sulfate Hexa- to Dodecasaccharides as Inhibitors of β-Secretase: Potential Therapeutics for Alzheimer’s Disease

(2013) Ralf Schwörer et al.   CHEMISTRY-A EUROPEAN JOURNAL

Tunable Heparan Sulfate Mimetics for Modulating Chemokine Activity

(2013) Gloria J. Sheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Heparan Sulfate: A Ubiquitous Glycosaminoglycan with Multiple Roles in Immunity

(2013) David Anak Simon Davis et al.   Frontiers in Immunology

Functional identification of pathogenic autoantibody responses in patients with multiple sclerosis

(2012) Christina Elliott et al.   BRAIN

Human mesenchymal stem cells isolated from olfactory biopsies but not bone enhance CNS myelinationin vitro

(2012) Susan L. Lindsay et al.   GLIA

Regional Heterogeneity of Cuprizone-Induced Demyelination: Topographical Aspects of the Midline of the Corpus Callosum

(2012) T. Schmidt et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Inflammatory Response and Chemokine Expression in the White Matter Corpus Callosum and Gray Matter Cortex Region During Cuprizone-Induced Demyelination

(2012) J. P. Buschmann et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Differential Sulfation Remodelling of Heparan Sulfate by Extracellular 6-O-Sulfatases Regulates Fibroblast Growth Factor-Induced Boundary Formation by Glial Cells: Implications for Glial Cell Transplantation

(2012) J. R. Higginson et al.   JOURNAL OF NEUROSCIENCE

CCL5 induces a pro-inflammatory profile in microglia in vitro

(2011) Jelena Škuljec et al.   CELLULAR IMMUNOLOGY

Functional Duality of Astrocytes in Myelination

(2011) B. Nash et al.   JOURNAL OF NEUROSCIENCE

Heparan Sulfate Proteoglycans

(2011) S. Sarrazin et al.   Cold Spring Harbor Perspectives in Biology

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Heparin-derived heparan sulfate mimics to modulate heparan sulfate-protein interaction in inflammation and cancer

(2010) Benito Casu et al.   MATRIX BIOLOGY

Amyloid β1–42 oligomer inhibits myelin sheet formation in vitro

(2010) Makoto Horiuchi et al.   NEUROBIOLOGY OF AGING

VEGF and angiogenesis in acute and chronic MOG(35–55) peptide induced EAE

(2009) W.A. Roscoe et al.   JOURNAL OF NEUROIMMUNOLOGY

Cuprizone induces similar demyelination in male and female C57BL/6 mice and results in disruption of the estrous cycle

(2009) Lorelei C. Taylor et al.   JOURNAL OF NEUROSCIENCE RESEARCH

In toxic demyelination oligodendroglial cell death occurs early and is FAS independent

(2009) Amke Hesse et al.   NEUROBIOLOGY OF DISEASE

Chronic toxic demyelination in the central nervous system leads to axonal damage despite remyelination

(2009) Maren Lindner et al.   NEUROSCIENCE LETTERS

Myelinated, synapsing cultures of murine spinal cord - validation as anin vitromodel of the central nervous system

(2008) C. E. Thomson et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Heparan sulphate proteoglycans in glia and in the normal and injured CNS: expression of sulphotransferases and changes in sulphation

(2008) Francesca Properzi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Astrocytes, but not olfactory ensheathing cells or Schwann cells, promote myelination of CNS axonsin vitro

(2008) Annette Sorensen et al.   GLIA

Kinin B2 receptor regulates chemokines CCL2 and CCL5 expression and modulates leukocyte recruitment and pathology in experimental autoimmune encephalomyelitis (EAE) in mice

(2008) Adriana C Dos Santos et al.   Journal of Neuroinflammation

Activation of Inflammatory Response by a Combination of Growth Factors in Cuprizone-Induced Demyelinated Brain Leads to Myelin Repair

(2008) Juan Carlos Biancotti et al.   NEUROCHEMICAL RESEARCH

CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure

(2007) Michael T. Fitch et al.   EXPERIMENTAL NEUROLOGY