PNPLA3 Genotype and Diabetes Identify Patients With Nonalcoholic Fatty Liver Disease at High Risk of Incident Cirrhosis

NAFLD‐related gene polymorphisms and all‐cause and cause‐specific mortality in an Asian population: the Shanghai Changfeng Study

(2022) Mingfeng Xia et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Accuracy of Non-invasive Indices for Diagnosing Hepatic Steatosis Compared to Imaging in a Real-World Cohort

(2022) Jacob V. DiBattista et al.   DIGESTIVE DISEASES AND SCIENCES

Risk of liver‐related events by age and diabetes duration in patients with diabetes and nonalcoholic fatty liver disease

(2022) Xinrong Zhang et al.   HEPATOLOGY

A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation

(2022) Marijana Vujkovic et al.   NATURE GENETICS

Synergistic Associations of PNPLA3 I148M Variant, Alcohol Intake, and Obesity With Risk of Cirrhosis, Hepatocellular Carcinoma, and Mortality

(2022) Hyun-seok Kim et al.   JAMA Network Open

Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology

(2021) Vincent L. Chen et al.   Nature Communications

Allele-specific variation at APOE increases nonalcoholic fatty liver disease and obesity but decreases risk of Alzheimer’s disease and myocardial infarction

(2021) Nicholette D Palmer et al.   HUMAN MOLECULAR GENETICS

Clinical Care Pathway for the Risk Stratification and Management of Patients With Nonalcoholic Fatty Liver Disease

(2021) Fasiha Kanwal et al.   GASTROENTEROLOGY

Accuracy of International Classification of Diseases-10 Codes for Cirrhosis and Portal Hypertensive Complications

(2021) Daniel A. Burkholder et al.   DIGESTIVE DISEASES AND SCIENCES

Metabolic risk factors and incident advanced liver disease in non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis of population-based observational studies

(2020) Helen Jarvis et al.   PLOS MEDICINE

Validating a non-invasive, ALT-based non-alcoholic fatty liver phenotype in the million veteran program

(2020) Marina Serper et al.   PLoS One

Association of genetic variation with cirrhosis: a multi-trait genome-wide association and gene-environment interaction study

(2020) Connor A. Emdin et al.   GASTROENTEROLOGY

Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk scores

(2020) Cristiana Bianco et al.   JOURNAL OF HEPATOLOGY

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

Association Between PNPLA3 rs738409 C>G Variant and Liver-Related Outcomes in Patients with Non-alcoholic Fatty Liver Disease

(2019) Stefania Grimaudo et al.   Clinical Gastroenterology and Hepatology

Effect of Metabolic Traits on the Risk of Cirrhosis and Hepatocellular Cancer in Non‐alcoholic Fatty Liver Disease

(2019) Fasiha Kanwal et al.   HEPATOLOGY

Attributable Fractions of NAFLD for Mortality in the United States: Results From NHANES III With 27 Years of Follow‐up

(2019) Christian S. Alvarez et al.   HEPATOLOGY

Direct-to-consumer genetic testing

(2019) Rachel Horton et al.   BMJ-British Medical Journal

Genetic variants that associate with cirrhosis have pleiotropic effects on human traits

(2019) Vincent L. Chen et al.   LIVER INTERNATIONAL

Genetic variants in PNPLA3 and TM6SF2 predispose to the development of hepatocellular carcinoma in individuals with alcohol-related cirrhosis

(2018) Felix Stickel et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Positive Predictive Value of International Classification of Diseases, 10th Revision, Codes for Cirrhosis and Its Related Complications

(2018) Srikar Mapakshi et al.   Clinical Gastroenterology and Hepatology

Fibrosis Severity as a Determinant of Cause-Specific Mortality in Patients With Advanced Nonalcoholic Fatty Liver Disease

(2018) Eduardo Vilar-Gomez et al.   GASTROENTEROLOGY

Nonalcoholic fatty liver disease incidence and impact on metabolic burden and death: A 20 year-community study

(2018) Alina M. Allen et al.   HEPATOLOGY

A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease

(2018) Noura S. Abul-Husn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Risk of Hepatocellular Cancer in Patients With Non-Alcoholic Fatty Liver Disease

(2018) Fasiha Kanwal et al.   GASTROENTEROLOGY

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

Comparison of laboratory tests, ultrasound, or magnetic resonance elastography to detect fibrosis in patients with nonalcoholic fatty liver disease: A meta-analysis

(2017) Guangqin Xiao et al.   HEPATOLOGY

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

Fibrosis stage but not NASH predicts mortality and time to development of severe liver disease in biopsy-proven NAFLD

(2017) Hannes Hagström et al.   JOURNAL OF HEPATOLOGY

Progression and Natural History of Nonalcoholic Fatty Liver Disease in Adults

(2016) Andrea Marengo et al.   Clinics in Liver Disease

The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study

(2015) Rohit Loomba et al.   GASTROENTEROLOGY

Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up

(2015) Mattias Ekstedt et al.   HEPATOLOGY

A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis

(2015) Stephan Buch et al.   NATURE GENETICS

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

Association of polymorphisms in GCKR and TRIB1 with nonalcoholic fatty liver disease and metabolic syndrome traits

(2014) Aya Kitamoto et al.   ENDOCRINE JOURNAL

Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

(2011) Elizabeth K. Speliotes et al.   PLoS Genetics

Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease

(2010) Luca Valenti et al.   HEPATOLOGY