Dynorphin 1-17 biotransformation peptides: properties, challenges and solutions for future therapeutics development

Intracerebroventricular Administration of Dermorphin-Dynorphin Analogs Producing Antidepressant-Like Effects through Activation of μ₁- and κ-Opioid Receptors in Mice

(2022) Osamu Nakagawasai et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Dynorphin/KOR inhibits neuronal autophagy by activating mTOR signaling pathway to prevent acute seizure epilepsy

(2022) Lin Liu et al.   CELL BIOLOGY INTERNATIONAL

Dynorphin/kappa opioid receptor system regulation on amygdaloid circuitry: Implications for neuropsychiatric disorders

(2022) Aaron Limoges et al.   Frontiers in Systems Neuroscience

The dynorphin/kappa opioid receptor mediates adverse immunological and behavioral outcomes induced by repetitive blast trauma

(2022) Suhjung Janet Lee et al.   Journal of Neuroinflammation

Dichotomous regulation of striatal plasticity by dynorphin

(2022) Renzhi Yang et al.   MOLECULAR PSYCHIATRY

Conformational Constraint between Aromatic Residue Side Chains in the “Message” Sequence of the Peptide Arodyn Using Ring Closing Metathesis Results in a Potent and Selective Kappa Opioid Receptor Antagonist

(2021) Solomon A. Gisemba et al.   JOURNAL OF MEDICINAL CHEMISTRY

Improving the Utility of a Dynorphin Peptide Analogue Using Mannosylated Glycoliposomes

(2021) Jordan D. Lewicky et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Design of a Stable Cyclic Peptide Analgesic Derived from Sunflower Seeds that Targets the κ-Opioid Receptor for the Treatment of Chronic Abdominal Pain

(2021) Edin Muratspahić et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analogs of the κ opioid receptor antagonist arodyn cyclized by ring-closing metathesis retain κ opioid receptor affinity, selectivity and κ opioid receptor antagonism

(2021) Wei-Jie Fang et al.   MEDICINAL CHEMISTRY RESEARCH

Using PCG-Arginine nanoparticle mediated intranasal delivery of dynorphin A (1–8) to improve neuroprotection in MCAO rats

(2021) Mengying Chen et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Endogenous Opioid Dynorphin Is a Potential Link between Traumatic Brain Injury, Chronic Pain, and Substance Use Disorder

(2021) Kaitlin M. Best et al.   JOURNAL OF NEUROTRAUMA

Dynorphin A induces membrane permeabilization by formation of proteolipidic pores. Insights from electrophysiology and computational simulations

(2021) D. Aurora Perini et al.   Computational and Structural Biotechnology Journal

Mannosylated glycoliposomes for the delivery of a peptide kappa opioid receptor antagonist to the brain

(2020) Jordan D. Lewicky et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Food-Derived Opioid Peptides in Human Health: A Review

(2020) Akanksha Tyagi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A new painkiller nanomedicine to bypass the blood-brain barrier and the use of morphine

(2019) Jiao Feng et al.   Science Advances

Design, synthesis, and opioid activity of arodyn analogs cyclized by ring-closing metathesis involving Tyr(allyl)

(2018) Wei-Jie Fang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New concepts in opioid analgesia

(2018) Christoph Stein   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The efficacy of Dynorphin fragments at the κ, μ and δ opioid receptor in transfected HEK cells and in an animal model of unilateral peripheral inflammation

(2017) M. Morgan et al.   PEPTIDES

Inhibitory effects of dynorphin 3-14 on the lipopolysaccharide-induced toll-like receptor 4 signalling pathway

(2017) Siti Sarah Fazalul Rahiman et al.   PEPTIDES

Discovery of Stable Non-opioid Dynorphin A Analogues Interacting at the Bradykinin Receptors for the Treatment of Neuropathic Pain

(2016) Sara M. Hall et al.   ACS Chemical Neuroscience

Cyclic non-opioid dynorphin A analogues for the bradykinin receptors

(2016) Yeon Sun Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dynorphin A analogs for the treatment of chronic neuropathic pain

(2016) Sara M Hall et al.   Future Medicinal Chemistry

Structure–Activity Relationships of [des-Arg7]Dynorphin A Analogues at the κ Opioid Receptor

(2016) Cyf N. Ramos-Colon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neuropeptide Y (NPY) in cerebrospinal fluid from patients with Huntington's Disease: increased NPY levels and differential degradation of the NPY1-30fragment

(2016) Leona Wagner et al.   JOURNAL OF NEUROCHEMISTRY

Dynorphin 1-17 and Its N-Terminal Biotransformation Fragments Modulate Lipopolysaccharide-Stimulated Nuclear Factor-kappa B Nuclear Translocation, Interleukin-1beta and Tumor Necrosis Factor-alpha in Differentiated THP-1 Cells

(2016) Siti Sarah Fazalul Rahiman et al.   PLoS One

Structure–Activity Relationships of the Peptide Kappa Opioid Receptor Antagonist Zyklophin

(2015) Anand A. Joshi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure–activity relationships of non-opioid [des-Arg7]-dynorphin A analogues for bradykinin receptors

(2014) Yeon Sun Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effect of three peptidase inhibitors on antinociceptive potential and toxicity with intracerebroventricular administration of dynorphin A (1–17) or (1–13) in the rat

(2014) Junko Ajimi et al.   Journal of Anesthesia

Discovery of Amphipathic Dynorphin A Analogues to Inhibit the Neuroexcitatory Effects of Dynorphin A through Bradykinin Receptors in the Spinal Cord

(2014) Yeon Sun Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Neuropeptides: Metabolism to Bioactive Fragments and the Pharmacology of Their Receptors

(2014) Mathias Hallberg   MEDICINAL RESEARCH REVIEWS

Biotransformation of beta-endorphin and possible therapeutic implications

(2014) Naghmeh H. Asvadi et al.   Frontiers in Pharmacology

Dynorphin A 1–17 biotransformation in inflamed tissue, serum and trypsin solution analysed by liquid chromatography–tandem mass spectrometry

(2012) M. Morgan et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue

(2012) Anja Schreiter et al.   FASEB JOURNAL

Whyin vivomay not equalin vitro- new effectors revealed by measurement of enzymatic activities under the samein vivo-like assay conditions

(2012) Rodolfo García-Contreras et al.   FEBS Journal

Endogenous opioid systems: Current concepts and clinical correlations

(2012) E. E. Benarroch   NEUROLOGY

The permeation of dynorphin A 1–6 across the blood brain barrier and its effect on bovine brain microvessel endothelial cell monolayer permeability

(2012) Courtney D. Kuhnline Sloan et al.   PEPTIDES

Perivascular Expression and Potent Vasoconstrictor Effect of Dynorphin A in Cerebral Arteries

(2012) Éva Ruisanchez et al.   PLoS One

Suppressive effects by cysteine protease inhibitors on naloxone-precipitated withdrawal jumping in morphine-dependent mice

(2010) Koichi Tan-No et al.   NEUROPEPTIDES

Comparative studies of the neuro-excitatory behavioural effects of morphine-3-glucuronide and dynorphin A(2-17) following spinal and supraspinal routes of administration

(2009) Kamondanai Hemstapat et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Zyklophin, a systemically active selective kappa opioid receptor peptide antagonist with short duration of action

(2009) J. V. Aldrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cysteine protease inhibitors suppress the development of tolerance to morphine antinociception

(2008) Koichi Tan-No et al.   NEUROPEPTIDES