SARS‐CoV‐2 ORF3a expression in brain disrupts the autophagy–lysosomal pathway, impairs sphingolipid homeostasis, and drives neuropathogenesis

Nervous system consequences of COVID-19

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Genome-Wide Characterization of SARS-CoV-2 Cytopathogenic Proteins in the Search of Antiviral Targets

(2022) Jiantao Zhang et al.   mBio

Neurological sequela and disruption of neuron-glia homeostasis in SARS-CoV-2 infection

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SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway

(2022) Huanzhou Xu et al.   VIROLOGY

Brain Inflammation and Intracellular α-Synuclein Aggregates in Macaques after SARS-CoV-2 Infection

(2022) Ingrid H. C. H. M. Philippens et al.   Viruses-Basel

Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates

(2022) Ibolya Rutkai et al.   Nature Communications

Understanding the Role of SARS-CoV-2 ORF3a in Viral Pathogenesis and COVID-19

(2022) Jiantao Zhang et al.   Frontiers in Microbiology

Microgliosis and neuronal proteinopathy in brain persist beyond viral clearance in SARS-CoV-2 hamster model

(2022) Christopher Käufer et al.   EBioMedicine

Guillain-Barre syndrome (GBS) associated with COVID-19 infection that resolved without treatment in a child

(2022) Samir Kanou et al.   BMJ Case Reports

Association of COVID-19 with New-Onset Alzheimer’s Disease

(2022) Lindsey Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Tropism of SARS-CoV-2 for human cortical astrocytes

(2022) Madeline G. Andrews et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Morphological, cellular, and molecular basis of brain infection in COVID-19 patients

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Neuroinflammation and COVID-19

(2022) Abigail Vanderheiden et al.   CURRENT OPINION IN NEUROBIOLOGY

Upstream lipid and metabolic systems are potential causes of Alzheimer's disease, Parkinson's disease and dementias

(2022) Oliver Cooper et al.   FEBS Journal

The neurobiology of long COVID

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SARS-CoV-2 variant spike and accessory gene mutations alter pathogenesis

(2022) Marisa E. McGrath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis

(2022) Sebastian Boland et al.   Nature Communications

SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19

(2022) Danielle Beckman et al.   Cell Reports

Neuroinvasion of SARS-CoV-2 in human and mouse brain

(2021) Eric Song et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dysregulation of brain and choroid plexus cell types in severe COVID-19

(2021) Andrew C. Yang et al.   NATURE

Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs

(2021) David M. Kern et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egress

(2021) Di Chen et al.   DEVELOPMENTAL CELL

Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2

(2021) Linh Nguyen et al.   Nature Chemical Biology

Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology

(2021) Einat B Vitner et al.   Life Science Alliance

The aging lysosome: An essential catalyst for late-onset neurodegenerative diseases

(2020) Ralph A. Nixon   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

The ORF3a protein of SARS-CoV-2 induces apoptosis in cells

(2020) Yujie Ren et al.   Cellular & Molecular Immunology

Extrapulmonary manifestations of COVID-19

(2020) Aakriti Gupta et al.   NATURE MEDICINE

Increased CSF levels of IL-1β, IL-6, and ACE in SARS-CoV-2–associated encephalitis

(2020) Marta Bodro et al.   Neurology-Neuroimmunology & Neuroinflammation

Effects of COVID-19 on the Nervous System

(2020) Costantino Iadecola et al.   CELL

SARS ‐CoV‐2 targets neurons of 3D human brain organoids

(2020) Anand Ramani et al.   EMBO JOURNAL

Guillain–Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cases

(2020) Samir Abu-Rumeileh et al.   JOURNAL OF NEUROLOGY

CNS transduction benefits of AAV-PHP.eB over AAV9 are dependent on administration route and mouse strain.

(2020) Sophie N. Mathiesen et al.   Molecular Therapy-Methods & Clinical Development

ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation

(2020) Guangyan Miao et al.   DEVELOPMENTAL CELL

Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

(2020) Jenny Meinhardt et al.   NATURE NEUROSCIENCE

Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC

(2019) Kam-Leung Siu et al.   FASEB JOURNAL

Characterization of LAMP1-labeled nondegradative lysosomal and endocytic compartments in neurons

(2018) Xiu-Tang Cheng et al.   JOURNAL OF CELL BIOLOGY

Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

(2017) Ken Y Chan et al.   NATURE NEUROSCIENCE

Relative acidic compartment volume as a lysosomal storage disorder–associated biomarker

(2014) Danielle te Vruchte et al.   JOURNAL OF CLINICAL INVESTIGATION

Microglial pathology

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featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Sphingolipids: Critical players in Alzheimer’s disease

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A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia

(2010) Stephan J. Guyenet et al.   Jove-Journal of Visualized Experiments