Genome-Wide Characterization of SARS-CoV-2 Cytopathogenic Proteins in the Search of Antiviral Targets

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

(2022) Elisabetta Cameroni et al.   NATURE

Duration of Protection against Mild and Severe Disease by Covid-19 Vaccines

(2022) Nick Andrews et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-6, procalcitonin and neutrophil-to-lymphocyte ratio: Potential immune-inflammatory parameters to identify severe and fatal forms of COVID-19

(2021) Wafa Sayah et al.   CYTOKINE

COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation

(2021) Mohamed M. Aboudounya et al.   MEDIATORS OF INFLAMMATION

Human Safety, Tolerability, and Pharmacokinetics of Molnupiravir, a Novel Broad-Spectrum Oral Antiviral Agent with Activity Against SARS-CoV-2

(2021) Wendy P. Painter et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A trans-complementation system for SARS-CoV-2 recapitulates authentic viral replication without virulence

(2021) Xianwen Zhang et al.   CELL

Analysis of SARS-CoV-2 mutations in the United States suggests presence of four substrains and novel variants

(2021) Rui Wang et al.   Communications Biology

Pyroptotic macrophages stimulate the SARS-CoV-2-associated cytokine storm

(2021) Jinghe Zhang et al.   Cellular & Molecular Immunology

Host PDZ‐containing proteins targeted by SARS‐CoV‐2

(2021) Célia Caillet‐Saguy et al.   FEBS Journal

SARS-CoV-2 likely targets cellular PDZ proteins: a common tactic of pathogenic viruses

(2021) Andrew P Rice et al.   Future Virology

Hepatitis C virus drugs that inhibit SARS-CoV-2 papain-like protease synergize with remdesivir to suppress viral replication in cell culture

(2021) Khushboo Bafna et al.   Cell Reports

Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infection

(2021) Rukmini Mukherjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contribution of SARS-CoV-2 Accessory Proteins to Viral Pathogenicity in K18 Human ACE2 Transgenic Mice

(2021) Jesus A. Silvas et al.   JOURNAL OF VIROLOGY

Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs

(2021) David M. Kern et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SARS-CoV-2: from its discovery to genome structure, transcription, and replication

(2021) Ayslan Castro Brant et al.   Cell and Bioscience

Single-Agent and Fixed-Dose Combination HIV-1 Protease Inhibitor Drugs in Fission Yeast (Schizosaccharomyces pombe)

(2021) Jiantao Zhang et al.   Pathogens

ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egress

(2021) Di Chen et al.   DEVELOPMENTAL CELL

Characterization of the non-covalent interaction between the PF-07321332 inhibitor and the SARS-CoV-2 main protease

(2021) Marina Macchiagodena et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

(2020)   Nature Microbiology

Oxidative Stress as Key Player in Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection

(2020) Livan Delgado-Roche et al.   ARCHIVES OF MEDICAL RESEARCH

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

A distinct class of plant and animal viral proteins that disrupt mitosis by directly interrupting the mitotic entry switch Wee1-Cdc25-Cdk1

(2020) Huaibing Jin et al.   Science Advances

SARS-CoV-2 and ORF3a: Nonsynonymous Mutations, Functional Domains, and Viral Pathogenesis

(2020) Elio Issa et al.   mSystems

The ORF3a protein of SARS-CoV-2 induces apoptosis in cells

(2020) Yujie Ren et al.   Cellular & Molecular Immunology

Double-Membrane Vesicles as Platforms for Viral Replication

(2020) Georg Wolff et al.   TRENDS IN MICROBIOLOGY

Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells

(2020) Na Zhu et al.   Nature Communications

Impact of Famotidine Use on Clinical Outcomes of Hospitalized Patients With COVID-19

(2020) Jeffrey F. Mather et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis and therapies: Structural genomics approach

(2020) Ahmad Abu Turab Naqvi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities?

(2020) Simone Cristina Soares Brandão et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Effects of SARS‐CoV‐2 mutations on protein structures and intraviral protein‐protein interactions

(2020) Siqi Wu et al.   JOURNAL OF MEDICAL VIROLOGY

ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection

(2020) Asmaa Hachim et al.   NATURE IMMUNOLOGY

An inflammatory cytokine signature predicts COVID-19 severity and survival

(2020) Diane Marie Del Valle et al.   NATURE MEDICINE

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

(2020) Wayne Vuong et al.   Nature Communications

Coronavirus Proteins as Ion Channels: Current and Potential Research

(2020) Conor McClenaghan et al.   Frontiers in Immunology

Oxidative Stress and Inflammation in COVID-19-Associated Sepsis: The Potential Role of Anti-Oxidant Therapy in Avoiding Disease Progression

(2020) Jesús Beltrán-García et al.   Antioxidants

SARS-CoV-2 and Other Respiratory Viruses: What Does Oxidative Stress Have to Do with It?

(2020) Iara Grigoletto Fernandes et al.   Oxidative Medicine and Cellular Longevity

Analysis of the efficacy of HIV protease inhibitors against SARS-CoV-2′s main protease

(2020) Mohamed Mahdi et al.   Virology Journal

HIV-1 Vpr-Induced Proinflammatory Response and Apoptosis Are Mediated through the Sur1-Trpm4 Channel in Astrocytes

(2020) Ge Li et al.   mBio

Different mutations in SARS-CoV-2 associate with severe and mild outcome

(2020) Ádám Nagy et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome

(2019) I-Yin Chen et al.   Frontiers in Microbiology

Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC

(2019) Kam-Leung Siu et al.   FASEB JOURNAL

Characterization of cytopathic factors through genome-wide analysis of the Zika viral proteins in fission yeast

(2017) Ge Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of reactive oxygen species in cell signaling pathways and immune responses to viral infections

(2016) Zhenguang Li et al.   ARCHIVES OF VIROLOGY

Molecular characterization of HIV-1 genome in fission yeast Schizosaccharomyces pombe

(2015) Joseph Nkeze et al.   Cell and Bioscience

Continuous and Discontinuous RNA Synthesis in Coronaviruses

(2015) Isabel Sola et al.   Annual Review of Virology

Treatment of HCV infection with the novel NS3/4A protease inhibitors

(2014) Andrea De Luca et al.   CURRENT OPINION IN PHARMACOLOGY

Membrane rearrangements mediated by coronavirus nonstructural proteins 3 and 4

(2014) Marne C. Hagemeijer et al.   VIROLOGY

Development of chemical inhibitors of the SARS coronavirus: Viral helicase as a potential target

(2012) Young-Sam Keum et al.   BIOCHEMICAL PHARMACOLOGY

Advancing our understanding of functional genome organisation through studies in the fission yeast

(2010) Ida Olsson et al.   CURRENT GENETICS

Anti-Cancer Effect of HIV-1 Viral Protein R on Doxorubicin Resistant Neuroblastoma

(2010) Richard Y. Zhao et al.   PLoS One

HIV-1 Vpr-induced cell death in Schizosaccharomyces pombe is reminiscent of apoptosis

(2008) Sylvain Huard et al.   CELL RESEARCH

SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum

(2008) Kèvin Knoops et al.   PLOS BIOLOGY