Multi-omics dissection of stage-specific artemisinin tolerance mechanisms in Kelch13-mutant Plasmodium falciparum

Reflections on the 2021 World Malaria Report and the future of malaria control

(2022) April Monroe et al.   MALARIA JOURNAL

Ring-stage growth arrest: Metabolic basis of artemisinin tolerance in Plasmodium falciparum

(2022) Xinyu Yu et al.   iScience

Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival

(2021) Sachel Mok et al.   Nature Communications

Integrated analysis of multimodal single-cell data

(2021) Yuhan Hao et al.   CELL

Plasmodium falciparum resistance to ACTs: Emergence, mechanisms, and outlook

(2021) Faiza Amber Siddiqui et al.   International Journal for Parasitology-Drugs and Drug Resistance

A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites

(2020) Jakob Birnbaum et al.   SCIENCE

Uncovering the ART of antimalarial resistance

(2020) Danushka Marapana et al.   SCIENCE

Malaria eradication

(2020) Jigang Wang et al.   LANCET

Plasmodium falciparum Artemisinin Resistance: The Effect of Heme, Protein Damage, and Parasite Cell Stress Response

(2020) Melissa R. Rosenthal et al.   ACS Infectious Diseases

K13, the Cytostome, and Artemisinin Resistance

(2020) Stanley C. Xie et al.   TRENDS IN PARASITOLOGY

System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion

(2020) Carlo Giannangelo et al.   PLoS Pathogens

A Temporizing Solution to “Artemisinin Resistance”

(2019) Jigang Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Malaria Cell Atlas: Single parasite transcriptomes across the complete Plasmodium life cycle

(2019) Virginia M. Howick et al.   SCIENCE

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

(2019) Tuo Yang et al.   Cell Reports

Within-host modeling of blood-stage malaria

(2018) David S. Khoury et al.   IMMUNOLOGICAL REVIEWS

Multi-omics Based Identification of Specific Biochemical Changes Associated With PfKelch13-Mutant Artemisinin-Resistant Plasmodium falciparum

(2017) Ghizal Siddiqui et al.   JOURNAL OF INFECTIOUS DISEASES

Malaria Pathogenesis

(2017) Danny A. Milner   Cold Spring Harbor Perspectives in Medicine

Artemisinin-Resistant Plasmodium falciparum Parasites Exhibit Altered Patterns of Development in Infected Erythrocytes

(2015) Amanda Hott et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

(2015) Alassane Mbengue et al.   NATURE

Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum

(2015) Jigang Wang et al.   Nature Communications

Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

(2014) Elizabeth A. Ashley et al.   NEW ENGLAND JOURNAL OF MEDICINE

K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

(2014) J. Straimer et al.   SCIENCE

Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance

(2014) S. Mok et al.   SCIENCE

Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies

(2013) Benoit Witkowski et al.   LANCET INFECTIOUS DISEASES

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

Altered temporal response of malaria parasites determines differential sensitivity to artemisinin

(2013) N. Klonis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Plasmodium falciparum-infected red blood cell

(2011) Leann Tilley et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Heme as Trigger and Target for Trioxane-Containing Antimalarial Drugs†

(2010) Bernard Meunier et al.   ACCOUNTS OF CHEMICAL RESEARCH

Discovery, mechanisms of action and combination therapy of artemisinin

(2009) Liwang Cui et al.   Expert Review of Anti-Infective Therapy

Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria

(2009) Richard T. Eastman et al.   NATURE REVIEWS MICROBIOLOGY

Evidence of Artemisinin-Resistant Malaria in Western Cambodia

(2008) Harald Noedl et al.   NEW ENGLAND JOURNAL OF MEDICINE