Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry

N-glycosylation heterogeneity and the influence on structure, function and pharmacokinetics of monoclonal antibodies and Fc fusion proteins

(2016) Fabian Higel et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Effects of Sucrose and Benzyl Alcohol on GCSF Conformational Dynamics Revealed by Hydrogen Deuterium Exchange Mass Spectrometry

(2015) Jun Zhang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Rapid characterization of biotherapeutic proteins by size-exclusion chromatography coupled to native mass spectrometry

(2015) Markus Haberger et al.   mAbs

Hydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody

(2015) Jayant Arora et al.   mAbs

Fc fusion as a platform technology: potential for modulating immunogenicity

(2015) Ditza Levin et al.   TRENDS IN BIOTECHNOLOGY

Higher order structure characterization of protein therapeutics by hydrogen/deuterium exchange mass spectrometry

(2014) Richard Y.-C. Huang et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Conformation and Dynamics of Interchain Cysteine-Linked Antibody-Drug Conjugates as Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry

(2014) Lucy Yan Pan et al.   ANALYTICAL CHEMISTRY

Understanding the Conformational Impact of Chemical Modifications on Monoclonal Antibodies with Diverse Sequence Variation Using Hydrogen/Deuterium Exchange Mass Spectrometry and Structural Modeling

(2014) Aming Zhang et al.   ANALYTICAL CHEMISTRY

Predicting Protein Aggregation during Storage in Lyophilized Solids Using Solid State Amide Hydrogen/Deuterium Exchange with Mass Spectrometric Analysis (ssHDX-MS)

(2014) Balakrishnan S. Moorthy et al.   MOLECULAR PHARMACEUTICS

Effects of Salts from the Hofmeister Series on the Conformational Stability, Aggregation Propensity, and Local Flexibility of an IgG1 Monoclonal Antibody

(2013) Ranajoy Majumdar et al.   BIOCHEMISTRY

Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications

(2013) Hui Wei et al.   DRUG DISCOVERY TODAY

Investigating Monoclonal Antibody Aggregation Using a Combination of H/DX-MS and Other Biophysical Measurements

(2013) Roxana E. Iacob et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Improved Protein Hydrogen/Deuterium Exchange Mass Spectrometry Platform with Fully Automated Data Processing

(2012) Zhongqi Zhang et al.   ANALYTICAL CHEMISTRY

Accessing the reproducibility and specificity of pepsin and other aspartic proteases

(2012) Joomi Ahn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Fc-fusion proteins: new developments and future perspectives

(2012) Daniel M. Czajkowsky et al.   EMBO Molecular Medicine

Hydrogen Exchange Mass Spectrometry: Are We Out of the Quicksand?

(2012) Roxana E. Iacob et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Using Hydrogen/Deuterium Exchange Mass Spectrometry to Study Conformational Changes in Granulocyte Colony Stimulating Factor upon PEGylation

(2012) Hui Wei et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

HDX Workbench: Software for the Analysis of H/D Exchange MS Data

(2012) Bruce D. Pascal et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Protein dynamics viewed by hydrogen exchange

(2012) John J. Skinner et al.   PROTEIN SCIENCE

Aggregates in monoclonal antibody manufacturing processes

(2011) María Vázquez-Rey et al.   BIOTECHNOLOGY AND BIOENGINEERING

Differential hydrogen/deuterium exchange mass spectrometry analysis of protein–ligand interactions

(2011) Michael J Chalmers et al.   Expert Review of Proteomics

Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies

(2011) Weirong Wang et al.   MOLECULAR IMMUNOLOGY

Distinct Aggregation Mechanisms of Monoclonal Antibody Under Thermal and Freeze-Thaw Stresses Revealed by Hydrogen Exchange

(2011) Aming Zhang et al.   PHARMACEUTICAL RESEARCH

The Utility of Hydrogen/Deuterium Exchange Mass Spectrometry in Biopharmaceutical Comparability Studies

(2010) Damian Houde et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Prediction of Aggregation Prone Regions of Therapeutic Proteins

(2010) Naresh Chennamsetty et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Post-translational Modifications Differentially Affect IgG1 Conformation and Receptor Binding

(2010) Damian Houde et al.   MOLECULAR & CELLULAR PROTEOMICS

The use of native cation-exchange chromatography to study aggregation and phase separation of monoclonal antibodies

(2010) Shuang Chen et al.   PROTEIN SCIENCE

Characterization of IgG1 Conformation and Conformational Dynamics by Hydrogen/Deuterium Exchange Mass Spectrometry

(2009) Damian Houde et al.   ANALYTICAL CHEMISTRY

Analysis of Protein Conformation and Dynamics by Hydrogen/Deuterium Exchange MS

(2009) John R. Engen   ANALYTICAL CHEMISTRY

Aggregation-Prone Motifs in Human Immunoglobulin G

(2009) Naresh Chennamsetty et al.   JOURNAL OF MOLECULAR BIOLOGY

Design of therapeutic proteins with enhanced stability

(2009) N. Chennamsetty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epitope mapping by amide hydrogen/deuterium exchange coupled with immobilization of antibody, on-line proteolysis, liquid chromatography and mass spectrometry

(2009) Stephen J. Coales et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

High-Speed and High-Resolution UPLC Separation at Zero Degrees Celsius

(2008) Thomas E. Wales et al.   ANALYTICAL CHEMISTRY

Protein aggregation: Pathways, induction factors and analysis

(2008) Hanns-Christian Mahler et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Assessment of the repeatability and reproducibility of hydrogen/deuterium exchange mass spectrometry measurements

(2008) William Burkitt et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY