ZBP1 Protects Against mtDNA-Induced Myocardial Inflammation in Failing Hearts

ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1

(2021) Hayley I. Muendlein et al.   Nature Communications

Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease

(2020) Luca Liberale et al.   EUROPEAN HEART JOURNAL

The disruption of invariant natural killer T cells exacerbates cardiac hypertrophy and failure caused by pressure overload in mice

(2020) Masashige Takahashi et al.   EXPERIMENTAL PHYSIOLOGY

Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease

(2020) Antonio Abbate et al.   CIRCULATION RESEARCH

Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

(2020) Huipeng Jiao et al.   NATURE

mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion

(2020) Xufei Zhang et al.   Cell Death & Disease

Anti-Inflammatory Therapy with Canakinumab for the Prevention of Hospitalization for Heart Failure

(2019) Brendan M. Everett et al.   CIRCULATION

The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons

(2019) Brian P. Daniels et al.   IMMUNITY

The clinical significance of interleukin‐6 in heart failure: results from the BIOSTAT‐CHF study

(2019) George Markousis‐Mavrogenis et al.   EUROPEAN JOURNAL OF HEART FAILURE

Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction

(2019) Jean-Claude Tardif et al.   NEW ENGLAND JOURNAL OF MEDICINE

Necroptosis in pulmonary macrophages mediates lipopolysaccharide-induced lung inflammatory injury by activating ZBP-1

(2019) Xue-ke Du et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mitochondrial DNA as an inflammatory mediator in cardiovascular diseases

(2018) Hiroyuki Nakayama et al.   BIOCHEMICAL JOURNAL

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

(2018) Kate McArthur et al.   SCIENCE

Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells

(2018) Bartosz Szczesny et al.   Scientific Reports

TLR9 Regulates the NF-κB–NLRP3–IL-1β Pathway Negatively inSalmonella-Induced NKG2D-Mediated Intestinal Inflammation

(2017) Yan Li et al.   JOURNAL OF IMMUNOLOGY

Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis

(2017) Kelby W. Wegner et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Necroptosis-independent signaling by the RIP kinases in inflammation

(2016) Kenta Moriwaki et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Chronic Heart Failure and Inflammation

(2016) Sarah A. Dick et al.   CIRCULATION RESEARCH

Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans

(2016) Krishnaraj S. Rathod et al.   JOURNAL OF CLINICAL INVESTIGATION

The Akt-mTOR axis is a pivotal regulator of eccentric hypertrophy during volume overload

(2015) Masataka Ikeda et al.   Scientific Reports

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

(2014) James A. Rickard et al.   CELL

The Necroptosis Adaptor RIPK3 Promotes Injury-Induced Cytokine Expression and Tissue Repair

(2014) Kenta Moriwaki et al.   IMMUNITY

Direct uptake and degradation of DNA by lysosomes

(2013) Yuuki Fujiwara et al.   Autophagy

Recent insights into the complexity of Tank-binding kinase 1 signaling networks: The emerging role of cellular localization in the activation and substrate specificity of TBK1

(2013) Elizabeth Helgason et al.   FEBS LETTERS

RIP3: a molecular switch for necrosis and inflammation

(2013) K. Moriwaki et al.   GENES & DEVELOPMENT

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

(2013) William J. Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Natural Killer T Cells Ameliorates Postinfarct Cardiac Remodeling and Failure in Mice

(2012) Mochamad Ali Sobirin et al.   CIRCULATION RESEARCH

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

Cardiac Inflammation Contributes to Changes in the Extracellular Matrix in Patients With Heart Failure and Normal Ejection Fraction

(2010) Dirk Westermann et al.   Circulation-Heart Failure

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Bifurcation of Toll-Like Receptor 9 Signaling by Adaptor Protein 3

(2010) M. Sasai et al.   SCIENCE

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-κB

(2009) Manuele Rebsamen et al.   EMBO REPORTS

Anakinra, a Recombinant Human Interleukin-1 Receptor Antagonist, Inhibits Apoptosis in Experimental Acute Myocardial Infarction

(2008) Antonio Abbate et al.   CIRCULATION

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

(2008) Ken J. Ishii et al.   NATURE