The Emerging Role of Raman Spectroscopy as an Omics Approach for Metabolic Profiling and Biomarker Detection toward Precision Medicine

A clinically feasible diagnostic spectro-histology built on SERS-nanotags for multiplex detection and grading of breast cancer biomarkers

(2023) Vishnu Priya Murali et al.   BIOSENSORS & BIOELECTRONICS

Physicochemical Properties and Route of Systemic Delivery Control the In Vivo Dynamics and Breakdown of Radiolabeled Gold Nanostars

(2023) Xiaona Wen et al.   Small

Standoff detection of bacterial spores by field deployable coherent Raman spectroscopy

(2023) Nicola Coluccelli et al.   Scientific Reports

High-Speed Diagnosis of Bacterial Pathogens at the Single Cell Level by Raman Microspectroscopy with Machine Learning Filters and Denoising Autoencoders

(2022) Jiabao Xu et al.   ACS Chemical Biology

Raman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by FDFT1: a review

(2022) M. Kanmalar et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

A guideline for clinicians performing clinical studies with fluorescence imaging

(2022) Wido Heeman et al.   JOURNAL OF NUCLEAR MEDICINE

Targeting Colorectal Cancer Cells with a Functionalised Calix[4]arene Receptor: Biophysical Studies

(2022) Angela F Danil de Namor et al.   MOLECULES

Hallmarks of Cancer: New Dimensions

(2022) Douglas Hanahan   Cancer Discovery

SERS Tags for Biomedical Detection and Bioimaging

(2022) Huiqiao Liu et al.   Theranostics

Prospects of Surface-Enhanced Raman Spectroscopy for Biomarker Monitoring toward Precision Medicine

(2022) Javier Plou et al.   ACS Photonics

The Complex Interplay of Inflammation, Metabolism, Epigenetics, and Sex in Calcific Disease of the Aortic Valve

(2022) Silvia Ferrari et al.   Frontiers in Cardiovascular Medicine

A Separation‐Sensing Platform Performing Accurate Diagnosis of Jaundice in Complex Biological Tear Fluids

(2022) Weidong Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multiplexed immunosensors for point-of-care diagnostic applications

(2022) Bruno Gil Rosa et al.   BIOSENSORS & BIOELECTRONICS

Surface-enhanced Raman scattering-based immunoassay for severe acute respiratory syndrome coronavirus 2

(2022) Hyunjung Cha et al.   BIOSENSORS & BIOELECTRONICS

Single-cell metabolomics: where are we and where are we going?

(2022) Ingela Lanekoff et al.   CURRENT OPINION IN BIOTECHNOLOGY

Alkyne-Tagged Raman Probes for Local Environmental Sensing by Hydrogen–Deuterium Exchange

(2022) Xiaotian Bi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Early cardiac-chamber-specific fingerprints in heart failure with preserved ejection fraction detected by FTIR and Raman spectroscopic techniques

(2022) Niki Tombolesi et al.   Scientific Reports

Highly sensitive near-infrared SERS nanoprobes for in vivo imaging using gold-assembled silica nanoparticles with controllable nanogaps

(2022) Sungje Bock et al.   JOURNAL OF NANOBIOTECHNOLOGY

Improving Cancer Immunotherapy: Exploring and Targeting Metabolism in Hypoxia Microenvironment

(2022) Jinfen Wei et al.   Frontiers in Immunology

Wearable plasmonic paper–based microfluidics for continuous sweat analysis

(2022) Umesha Mogera et al.   Science Advances

Accurate Tumor Subtype Detection with Raman Spectroscopy via Variational Autoencoder and Machine Learning

(2022) Chang He et al.   ACS Omega

Highly Sensitive Exosome Detection for Early Diagnosis of Pancreatic Cancer Using Immunoassay Based on Hierarchical Surface‐Enhanced Raman Scattering Substrate

(2022) Juan Li et al.   Small Methods

Label-Free Differentiation of Cancer and Non-Cancer Cells Based on Machine-Learning-Algorithm-Assisted Fast Raman Imaging

(2022) Qing He et al.   Biosensors-Basel

Expanding the Multiplexing Capabilities of Raman Imaging to Reveal Highly Specific Molecular Expression and Enable Spatial Profiling

(2022) Olga E. Eremina et al.   ACS Nano

Differentiation and prognostic stratification of acute myeloid leukemia by serum‐based spectroscopy coupling with metabolic fingerprints

(2022) Zhengwei Duan et al.   FASEB JOURNAL

Unraveling the Effects of Carotenoids Accumulation in Human Papillary Thyroid Carcinoma

(2022) Alessandra di Masi et al.   Antioxidants

Amino acid metabolism genes associated with immunotherapy responses and clinical prognosis of colorectal cancer

(2022) Xinyi Peng et al.   Frontiers in Molecular Biosciences

DNA-Functionalized Gold Nanorods for Perioperative Optical Imaging and Photothermal Therapy of Triple-Negative Breast Cancer

(2022) Suchetan Pal et al.   ACS Applied Nano Materials

Raman Spectroscopy Techniques for the Investigation and Diagnosis of Alzheimer's Disease

(2022) Panagis Polykretis et al.   Frontiers in Bioscience - Scholar

A fast, ultrasensitive SERS immunoassay to detect SARS-CoV-2 in saliva

(2022) Moein Mohammadi et al.   ANALYTICA CHIMICA ACTA

Tetraplex Immunophenotyping of Cell Surface Proteomes via Synthesized Plasmonic Nanotags and Portable Raman Spectroscopy

(2022) Jing Wang et al.   ANALYTICAL CHEMISTRY

Raman spectroscopy for the determination of forensically important bio-fluids

(2022) Noble George et al.   FORENSIC SCIENCE INTERNATIONAL

Etiology of IBD—Is It Still a Mystery?

(2022) Anna Kofla-Dłubacz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Image-guided Raman spectroscopy navigation system to improve transperineal prostate cancer detection. Part 2: in-vivo tumor-targeting using a classification model combining spectral and MRI-radiomics features

(2022) David Grajales et al.   JOURNAL OF BIOMEDICAL OPTICS

A non-invasive ultrasensitive diagnostic approach for COVID-19 infection using salivary label-free SERS fingerprinting and artificial intelligence

(2022) Varsha Karunakaran et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

How (Not) to Generate a Highly Predictive Biomarker Panel Using Machine Learning

(2022) Heather Desaire   JOURNAL OF PROTEOME RESEARCH

Multimodal biomedical AI

(2022) Julián N. Acosta et al.   NATURE MEDICINE

Quantification of uric acid concentration in tears by using PDMS inverse opal structure surface-enhanced Raman scattering substrates: Application in hyperuricemia

(2022) Jinming Li et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Serious adverse events of special interest following mRNA COVID-19 vaccination in randomized trials in adults

(2022) Joseph Fraiman et al.   VACCINE

Clinical cancer immunotherapy: Current progress and prospects

(2022) Chenglong Liu et al.   Frontiers in Immunology

Noninvasive cholangitis and cholangiocarcinoma screening based on serum Raman spectroscopy and support vector machine

(2022) Na Su et al.   Photodiagnosis and Photodynamic Therapy

Serum Raman spectroscopy combined with convolutional neural network for rapid diagnosis of HER2-positive and triple-negative breast cancer

(2022) Qinggang Zeng et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Fused Raman spectroscopic analysis of blood and saliva delivers high accuracy for head and neck cancer diagnostics

(2022) Hanna J. Koster et al.   Scientific Reports

Microfluidic SERS devices: brightening the future of bioanalysis

(2022) Maria João Oliveira et al.   Discover Materials

Continuous glucose monitoring: A review of the evidence in type 1 and 2 diabetes mellitus

(2021) Rose Lin et al.   DIABETIC MEDICINE

Identification of Molecular Basis for Objective Discrimination of Breast Cancer Cells (MCF-7) from Normal Human Mammary Epithelial Cells by Raman Microspectroscopy and Multivariate Curve Resolution Analysis

(2021) Keita Iwasaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evaluation of aromatic amino acids as potential biomarkers in breast cancer by Raman spectroscopy analysis

(2021) Shaymus Contorno et al.   Scientific Reports

Ultrasensitive and Highly Specific Lateral Flow Assays for Point-of-Care Diagnosis

(2021) Yilin Liu et al.   ACS Nano

SERS-Based Immunoassay Enhanced with Silver Probe for Selective Separation and Detection of Alzheimer’s Disease Biomarkers

(2021) Dan Yu et al.   International Journal of Nanomedicine

Debaryomyces is enriched in Crohn’s disease intestinal tissue and impairs healing in mice

(2021) Umang Jain et al.   SCIENCE

Ultra-bright Raman dots for multiplexed optical imaging

(2021) Zhilun Zhao et al.   Nature Communications

Raman spectroscopy and group and basis-restricted non negative matrix factorisation identifies radiation induced metabolic changes in human cancer cells

(2021) Kirsty Milligan et al.   Scientific Reports

Indication of high lipid content in epithelial-mesenchymal transitions of breast tissues

(2021) Siti Norbaini Sabtu et al.   Scientific Reports

Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors

(2021) Agnese Gagliardi et al.   Frontiers in Pharmacology

In Vivo Fiber Optic Raman Spectroscopy of Muscle in Preclinical Models of Amyotrophic Lateral Sclerosis and Duchenne Muscular Dystrophy

(2021) Maria Plesia et al.   ACS Chemical Neuroscience

Can Coupling Multiple Complementary Methods Improve the Spectroscopic Based Diagnosis of Gastrointestinal Illnesses? A Proof of Principle Ex Vivo Study Using Celiac Disease as the Model Illness

(2021) Sara J. Fraser-Miller et al.   ANALYTICAL CHEMISTRY

The Role of Raman Spectroscopy Within Quantitative Metabolomics

(2021) Cassio Lima et al.   Annual Review of Analytical Chemistry

The Complex Integration of T-cell Metabolism and Immunotherapy

(2021) Matthew Z. Madden et al.   Cancer Discovery

Non-invasive cell classification using the Paint Raman Express Spectroscopy System (PRESS)

(2021) Yuka Akagi et al.   Scientific Reports

Unveiling Cancer Metabolism through Spontaneous and Coherent Raman Spectroscopy and Stable Isotope Probing

(2021) Jiabao Xu et al.   Cancers

Single Cell Label-Free Probing of Chromatin Dynamics During B Lymphocyte Maturation

(2021) Rikke Morrish et al.   Frontiers in Cell and Developmental Biology

Designed Co-DNA-Locker and Ratiometric SERS Sensing for Accurate Detection of Exosomes Based on Gold Nanorod Arrays

(2021) Jing Wang et al.   ACS Applied Materials & Interfaces

Multispectral Fingerprinting Resolves Dynamics of Nanomaterial Trafficking in Primary Endothelial Cells

(2021) Mitchell Gravely et al.   ACS Nano

Current Challenges and Recent Developments in Mass Spectrometry–Based Metabolomics

(2021) Stephanie L. Collins et al.   Annual Review of Analytical Chemistry

Raman spectroscopy in the diagnosis of metabolic syndrome

(2021) Guadalupe Donjuán-Loredo et al.   APPLIED SPECTROSCOPY REVIEWS

Human tear fluid analysis for clinical applications: progress and prospects

(2021) Sphurti S Adigal et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Novel strategies of Raman imaging for monitoring intracellular retinoid metabolism in cancer cells

(2021) Halina Abramczyk et al.   JOURNAL OF MOLECULAR LIQUIDS

Decoding disease: from genomes to networks to phenotypes

(2021) Aaron K. Wong et al.   NATURE REVIEWS GENETICS

Raman spectroscopy accurately differentiates mucosal healing from non-healing and biochemical changes following biological therapy in inflammatory bowel disease

(2021) Samuel C. L. Smith et al.   PLoS One

Multiplexed live-cell profiling with Raman probes

(2021) Chen Chen et al.   Nature Communications

High-performance surface-enhanced Raman spectroscopy chip integrated with a micro-optical system for the rapid detection of creatinine in serum

(2021) Feng Yang et al.   Biomedical Optics Express

A Portable Ultrawideband Confocal Raman Spectroscopy System with a Handheld Probe for Skin Studies

(2021) Ruochong Zhang et al.   ACS Sensors

Revision of Commonly Accepted Warburg Mechanism of Cancer Development: Redox-Sensitive Mitochondrial Cytochromes in Breast and Brain Cancers by Raman Imaging

(2021) Halina Abramczyk et al.   Cancers

A Systematic Review of Carotenoids in the Management of Age-Related Macular Degeneration

(2021) Drake W. Lem et al.   Antioxidants

TGF-β-dependent reprogramming of amino acid metabolism induces epithelial–mesenchymal transition in non-small cell lung cancers

(2021) Fumie Nakasuka et al.   Communications Biology

Noninvasive and Highly Multiplexed Five-Color Tumor Imaging of Multicore Near-Infrared Resonant Surface-Enhanced Raman Nanoparticles In Vivo

(2021) Jung Ho Yu et al.   ACS Nano

A colorimetric and SERS dual-readout sensor for sensitive detection of tyrosinase activity based on 4-mercaptophenyl boronic acid modified AuNPs

(2021) Xiumei Zhuang et al.   ANALYTICA CHIMICA ACTA

Tear-Based Vibrational Spectroscopy Applied to Amyotrophic Lateral Sclerosis

(2021) Diletta Ami et al.   ANALYTICAL CHEMISTRY

Molecular imaging in oncology: Current impact and future directions

(2021) Steven P. Rowe et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy

(2021) Santosh Kumar Paidi et al.   CANCER RESEARCH

Recent Advances in Metallic Nanoparticle Assemblies for Surface-Enhanced Spectroscopy

(2021) Beata Tim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Integration of Raman spectra with transcriptome data in glioblastoma multiforme defines tumour subtypes and predicts patient outcome

(2021) Pierre‐Jean Le Reste et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Early upregulation of cytosolic phospholipase A2α in motor neurons is induced by misfolded SOD1 in a mouse model of amyotrophic lateral sclerosis

(2021) Yafa Fetfet Malada Edelstein et al.   Journal of Neuroinflammation

Simultaneous and ultra-sensitive SERS detection of SLPI and IL-18 for the assessment of donor kidney quality using black phosphorus/gold nanohybrids

(2021) Hui Chen et al.   OPTICS EXPRESS

Detection of glucose in diabetic tears by using gold nanoparticles and MXene composite surface-enhanced Raman scattering substrates

(2021) Xiaoyu Cui et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Photoacoustic imaging of periorbital skin cancer ex vivo: unique spectral signatures of malignant melanoma, basal, and squamous cell carcinoma

(2021) Magne Tordengren Stridh et al.   Biomedical Optics Express

Time-gated Raman spectroscopy and proteomics analyses of hypoxic and normoxic renal carcinoma extracellular vesicles

(2021) Anatoliy Samoylenko et al.   Scientific Reports

Relationship between the gut microbiota and bile acid composition in the ileal mucosa of Crohn’s disease

(2021) Shigeki Bamba et al.   Intestinal Research

Gold Nanoframeworks with Mesopores for Raman–Photoacoustic Imaging and Photo‐Chemo Tumor Therapy in the Second Near‐Infrared Biowindow

(2020) Jinping Wang et al.   ADVANCED FUNCTIONAL MATERIALS

Bioorthogonal SERS Nanotags as a Precision Theranostic Platform for in Vivo SERS Imaging and Cancer Photothermal Therapy

(2020) Jing Wang et al.   BIOCONJUGATE CHEMISTRY

Gold–silver nanoshells promote wound healing from drug-resistant bacteria infection and enable monitoring via surface-enhanced Raman scattering imaging

(2020) Jian He et al.   BIOMATERIALS

Polystyrene nanoparticles: Sources, occurrence in the environment, distribution in tissues, accumulation and toxicity to various organisms

(2020) Kinga Kik et al.   ENVIRONMENTAL POLLUTION

Axes of a revolution: challenges and promises of big data in healthcare

(2020) Smadar Shilo et al.   NATURE MEDICINE

Gut microbiota-derived metabolites as key actors in inflammatory bowel disease

(2020) Aonghus Lavelle et al.   Nature Reviews Gastroenterology & Hepatology

Deep learning and artificial intelligence methods for Raman and surface-enhanced Raman scattering

(2020) Félix Lussier et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Lipid droplets: platforms with multiple functions in cancer hallmarks

(2020) André L. S. Cruz et al.   Cell Death & Disease

Photoacoustic Imaging for Management of Breast Cancer: A Literature Review and Future Perspectives

(2020) Rao et al.   Applied Sciences-Basel

Enabling sensitive phenotypic profiling of cancer-derived small extracellular vesicles using surface-enhanced Raman spectroscopy nanotags

(2020) Wei Zhang et al.   ACS Sensors

Tracking extracellular vesicle phenotypic changes enables treatment monitoring in melanoma

(2020) Jing Wang et al.   Science Advances

Rapid optofluidic detection of biomarkers for traumatic brain injury via surface-enhanced Raman spectroscopy

(2020) Jonathan J. S. Rickard et al.   Nature Biomedical Engineering

Distinguishing metastatic triple‐negative breast cancer from nonmetastatic breast cancer using second harmonic generation imaging and resonance Raman spectroscopy

(2020) Ethan Bendau et al.   Journal of Biophotonics

Biodegradable Gold Nanoclusters with Improved Excretion Due to pH-Triggered Hydrophobic-to-Hydrophilic Transition

(2020) Elizabeth M. Higbee-Dempsey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Surface Enhanced Raman Spectroscopy Based Biosensor with a Microneedle Array for Minimally Invasive In Vivo Glucose Measurements

(2020) Jian Ju et al.   ACS Sensors

SERS spectroscopy using Au-Ag nanoshuttles and hydrophobic paper-based Au nanoflower substrate for simultaneous detection of dual cervical cancer–associated serum biomarkers

(2020) Dan Lu et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

A SERS-colorimetric dual-mode aptasensor for the detection of cancer biomarker MUC1

(2020) Na Li et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Surface-enhanced Raman spectroscopy of tears: toward a diagnostic tool for neurodegenerative disease identification

(2020) Gilda Cennamo et al.   JOURNAL OF BIOMEDICAL OPTICS

Tutorial: multivariate classification for vibrational spectroscopy in biological samples

(2020) Camilo L. M. Morais et al.   Nature Protocols

Vertical Flow Assays: Vertical Flow Assay for Inflammatory Biomarkers Based on Nanofluidic Channel Array and SERS Nanotags (Small 32/2020)

(2020) Ruipeng Chen et al.   Small

Human salivary Raman fingerprint as biomarker for the diagnosis of Amyotrophic Lateral Sclerosis

(2020) C. Carlomagno et al.   Scientific Reports

Review of hybrid PLGA nanoparticles: Future of smart drug delivery and theranostics medicine

(2020) Jana Ghitman et al.   MATERIALS & DESIGN

The Toxicity Phenomenon and the Related Occurrence in Metal and Metal Oxide Nanoparticles: A Brief Review From the Biomedical Perspective

(2020) Shokouh Attarilar et al.   Frontiers in Bioengineering and Biotechnology

PRADA: Portable Reusable Accurate Diagnostics with nanostar Antennas for multiplexed biomarker screening

(2020) Xiaona Wen et al.   Bioengineering & Translational Medicine

Immunomagnetic Capture and Multiplexed Surface Marker Detection of Circulating Tumor Cells with Magnetic Multicolor Surface-Enhanced Raman Scattering Nanotags

(2020) Raymond Edward Wilson et al.   ACS Applied Materials & Interfaces

Quantitative Drug Dynamics Visualized by Alkyne-Tagged Plasmonic-Enhanced Raman Microscopy

(2020) Kota Koike et al.   ACS Nano

Silica-Coated, Waxberry-like Surface-Enhanced Raman Resonant Scattering Tag-Pair with Near-Infrared Raman Dye Encoding: Toward In Vivo Duplexing Detection

(2020) Yingchao Yin et al.   ANALYTICAL CHEMISTRY

Visualizing Subcellular Enrichment of Glycogen in Live Cancer Cells by Stimulated Raman Scattering

(2020) Dongkwan Lee et al.   ANALYTICAL CHEMISTRY

Metabolism

(2020) Ayesha Judge et al.   Essays in Biochemistry

Machine Learning for Precision Medicine

(2020) Sarah J MacEachern et al.   GENOME

Detection of Penicillin G Produced by Penicillium chrysogenum with Raman Microspectroscopy and Multivariate Curve Resolution-Alternating Least-Squares Methods

(2020) Shumpei Horii et al.   JOURNAL OF NATURAL PRODUCTS

Raman spectroscopy reveals biochemical differences in plasma derived extracellular vesicles from sporadic Amyotrophic Lateral Sclerosis patients

(2020) Carlo F. Morasso et al.   Nanomedicine-Nanotechnology Biology and Medicine

Surface-enhanced Raman scattering holography

(2020) Matz Liebel et al.   Nature Nanotechnology

Recent advances in applications of nanoparticles in SERS in vivo imaging

(2020) Zhen Du et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Challenges in the development of nanoparticle‐based imaging agents: Characterization and biology

(2020) Rachael M. Crist et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Raman-guided subcellular pharmaco-metabolomics for metastatic melanoma cells

(2020) Jiajun Du et al.   Nature Communications

Melanin distribution from the dermal–epidermal junction to the stratum corneum: non-invasive in vivo assessment by fluorescence and Raman microspectroscopy

(2020) B. P. Yakimov et al.   Scientific Reports

Multiplex coherent anti-Stokes Raman scattering microspectroscopy detection of lipid droplets in cancer cells expressing TrkB

(2020) Tiffany Guerenne-Del Ben et al.   Scientific Reports

Raman Spectroscopy as Noninvasive Method of Diagnosis of Pediatric Onset Inflammatory Bowel Disease

(2020) Giuseppe Acri et al.   Applied Sciences-Basel

Promoting identification of amyotrophic lateral sclerosis based on label‐free plasma spectroscopy

(2020) Qi‐Jie Zhang et al.   Annals of Clinical and Translational Neurology

Oxyphospholipids in Cardiovascular Calcification

(2020) Arnaud Chignon et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Gut microbiota-derived metabolites as central regulators in metabolic disorders

(2020) Allison Agus et al.   GUT

Lysosome-Targeted Gold Nanotheranostics for In Situ SERS Monitoring pH and Multimodal Imaging-Guided Phototherapy

(2020) Changchun Wen et al.   LANGMUIR

Multivariate Curve Resolution: 50 years addressing the mixture analysis problem – A review

(2020) Anna de Juan et al.   ANALYTICA CHIMICA ACTA

Single-cell screening of tamoxifen abundance and effect using mass spectrometry and Raman-spectroscopy

(2019) Ahmed Ali et al.   ANALYTICAL CHEMISTRY

Characterization of Human Tear Fluid by Means of Surface-Enhanced Raman Spectroscopy

(2019) Carlo Camerlingo et al.   SENSORS

Volumetric chemical imaging by clearing-enhanced stimulated Raman scattering microscopy

(2019) Mian Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A review of small molecules and drug delivery applications using gold and iron nanoparticles

(2019) Hossein Jahangirian et al.   International Journal of Nanomedicine

Multicolor Raman Beads for Multiplexed Tumor Cell and Tissue Imaging and in Vivo Tumor Spectral Detection

(2019) QingQing Jin et al.   ANALYTICAL CHEMISTRY

Polystyrene Encapsulated SERS Tags as Promising Standard Tools: Simple and Universal in Synthesis, Highly Sensitive and Ultrastable for Bioimaging

(2019) Qian Yu et al.   ANALYTICAL CHEMISTRY

Nanoconjugates of Ag/Au/Carbon Nanotube for Alkyne-Meditated Ratiometric SERS Imaging of Hypoxia in Hepatic Ischemia

(2019) Xiaojie Qin et al.   ANALYTICAL CHEMISTRY

Prognostic analysis of amyotrophic lateral sclerosis based on clinical features and plasma surface‐enhanced Raman spectroscopy

(2019) Qi‐Jie Zhang et al.   Journal of Biophotonics

Metabolic regulation of cell growth and proliferation

(2019) Jiajun Zhu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Photodegradable CuS SERS Probes for Intraoperative Residual Tumor Detection, Ablation, and Self-Clearance

(2019) Yuanyuan Qiu et al.   ACS Applied Materials & Interfaces

A Multicolor Cocktail for Breast Cancer Multiplex Phenotype Targeting and Diagnosis Using Bioorthogonal SERS Nanoprobes

(2019) Jing Wang et al.   ANALYTICAL CHEMISTRY

Facile Hydrophobication of Glutathione-Protected Gold Nanoclusters and Encapsulation into Poly(lactide-co-glycolide) Nanocarriers

(2019) Alaaldin M. Alkilany et al.   Scientific Reports

Robust and Universal SERS Sensing Platform for Multiplexed Detection of Alzheimer's Disease Core Biomarkers Using PAapt-AuNPs Conjugates

(2019) Xue Zhang et al.   ACS Sensors

Alkyne-Tagged PLGA Allows Direct Visualization of Nanoparticles In Vitro and Ex Vivo by Stimulated Raman Scattering Microscopy

(2019) Sally Vanden-Hehir et al.   BIOMACROMOLECULES

The Age of Omics‐Driven Precision Medicine

(2019) Eliza R. McColl et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The Need for Multi-Omics Biomarker Signatures in Precision Medicine

(2019) Michael Olivier et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biological imaging of chemical bonds by stimulated Raman scattering microscopy

(2019) Fanghao Hu et al.   NATURE METHODS

The “All of Us” Research Program

(2019)   NEW ENGLAND JOURNAL OF MEDICINE

Gold nanoshell-localized photothermal ablation of prostate tumors in a clinical pilot device study

(2019) Ardeshir R. Rastinehad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Raman Analysis of Tear Fluid Alteration Following Contact Lense Use

(2019) Angela Capaccio et al.   SENSORS

Targeting Metabolic Reprogramming in Acute Myeloid Leukemia

(2019) Isabel Castro et al.   Cells

Optimization and Structural Stability of Gold Nanoparticle–Antibody Bioconjugates

(2019) Robert T. Busch et al.   ACS Omega

Present and Future of Surface-Enhanced Raman Scattering

(2019) Judith Langer et al.   ACS Nano

Towards Reliable and Quantitative SERS: from Key Parameters to Good Analytical Practice

(2019) Sebastian Schlücker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multiplex coherent anti-Stokes Raman scattering highlights state of chromatin condensation in CH region

(2019) Tiffany Guerenne-Del Ben et al.   Scientific Reports

A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease

(2019) Qingdong Guan   Journal of Immunology Research

Multimodal Multiplexed Immunoimaging with Nanostars to Detect Multiple Immunomarkers and Monitor Response to Immunotherapies

(2019) Yu-Chuan Ou et al.   ACS Nano

Using SERS-based microfluidic paper-based device (μPAD) for calibration-free quantitative measurement of AMI cardiac biomarkers

(2019) Wei Yin Lim et al.   BIOSENSORS & BIOELECTRONICS

Wrinkled metal based quantum sensor for In vitro cancer diagnosis

(2019) Srisankari Ganesan et al.   BIOSENSORS & BIOELECTRONICS

Step‐by‐step monitoring of a magnetic and SERS‐active immunosensor assembly for purification and detection of tau protein

(2019) Viktor Maurer et al.   Journal of Biophotonics

Recent advances in background-free Raman scattering for bioanalysis

(2019) Xuehui Liu et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Cancer Immunoimaging with Smart Nanoparticles

(2019) Yu-Chuan Ou et al.   TRENDS IN BIOTECHNOLOGY

Aberrant Protein Phosphorylation in Cancer by Using Raman Biomarkers

(2019) Halina Abramczyk et al.   Cancers

Raman Spectroscopy: An Emerging Tool in Neurodegenerative Disease Research and Diagnosis

(2018) George Devitt et al.   ACS Chemical Neuroscience

In vivo Raman spectroscopy for biochemical monitoring of the human cervix throughout pregnancy

(2018) Christine M. O’Brien et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Noninvasive and prospective diagnosis of coronary heart disease with urine using surface-enhanced Raman spectroscopy

(2018) Huinan Yang et al.   ANALYST

Raman Microspectroscopic Evidence for the Metabolism of a Tyrosine Kinase Inhibitor, Neratinib, in Cancer Cells

(2018) Karim Aljakouch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multiplex imaging of live breast cancer tumour models through tissue using handheld surface enhanced spatially offset resonance Raman spectroscopy (SESORRS)

(2018) Fay Nicolson et al.   CHEMICAL COMMUNICATIONS

SOD1 in Amyotrophic Lateral Sclerosis: “Ambivalent” Behavior Connected to the Disease

(2018) Orietta Pansarasa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Promises and pitfalls of untargeted metabolomics

(2018) Ilya Gertsman et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Challenges and emergent solutions for LC-MS/MS based untargeted metabolomics in diseases

(2018) Liang Cui et al.   MASS SPECTROMETRY REVIEWS

Diagnosis of immunomarkers in vivo via multiplexed surface enhanced Raman spectroscopy with gold nanostars

(2018) Yu-Chuan Ou et al.   Nanoscale

Integrative omics for health and disease

(2018) Konrad J. Karczewski et al.   NATURE REVIEWS GENETICS

Combining Multiplex SERS Nanovectors and Multivariate Analysis for In Situ Profiling of Circulating Tumor Cell Phenotype Using a Microfluidic Chip

(2018) Yizhi Zhang et al.   Small

Panomics for Precision Medicine

(2018) Charanjit Sandhu et al.   TRENDS IN MOLECULAR MEDICINE

Isotopic graphene–isolated-Au-nanocrystals with cellular Raman-silent signals for cancer cell pattern recognition

(2018) Yuxiu Zou et al.   Chemical Science

Magnetic nanochain integrated microfluidic biochips

(2018) Qirong Xiong et al.   Nature Communications

Linear Regression Links Transcriptomic Data and Cellular Raman Spectra

(2018) Koseki J. Kobayashi-Kirschvink et al.   Cell Systems

Rapid and sensitive biomarker detection using molecular imprinting polymer hydrogel and surface-enhanced Raman scattering

(2018) Shaona Chen et al.   Royal Society Open Science

A ratiometric Raman probe for live-cell imaging of hydrogen sulfide in mitochondria by stimulated Raman scattering

(2018) Chen Zeng et al.   ANALYST

SERS-Based Quantification of Biomarker Expression at the Single Cell Level Enabled by Gold Nanostars and Truncated Aptamers

(2018) Manjari Bhamidipati et al.   BIOCONJUGATE CHEMISTRY

VIBRATION SPECTROSCOPY AND BODY BIOFLUIDS: LITERATURE REVIEW FOR CLINICAL APPLICATIONS

(2018) L.B Leal et al.   Photodiagnosis and Photodynamic Therapy

A new method using Raman spectroscopy for in vivo targeted brain cancer tissue biopsy

(2018) Joannie Desroches et al.   Scientific Reports

Plasmon Near-Field Coupling of Bimetallic Nanostars and a Hierarchical Bimetallic SERS “Hot Field”: Toward Ultrasensitive Simultaneous Detection of Multiple Cardiorenal Syndrome Biomarkers

(2018) Yu Su et al.   ANALYTICAL CHEMISTRY

Identifying molecular contributors to autofluorescence of neoplastic and normal colon sections using excitation-scanning hyperspectral imaging

(2018) Joshua Deal et al.   JOURNAL OF BIOMEDICAL OPTICS

Clinical applications of raman spectroscopy in inflammatory bowel diseases: a review

(2018)   Journal of Gastrointestinal and Liver Diseases

Quantifying hot carrier and thermal contributions in plasmonic photocatalysis

(2018) Linan Zhou et al.   SCIENCE

EMT Transition States during Tumor Progression and Metastasis

(2018) Ievgenia Pastushenko et al.   TRENDS IN CELL BIOLOGY

Total Aqueous Synthesis of Au@Cu 2− x S Core–Shell Nanoparticles for In Vitro and In Vivo SERS/PA Imaging‐Guided Photothermal Cancer Therapy

(2018) Qian Lv et al.   Advanced Healthcare Materials

What is precision medicine?

(2017) Inke R. König et al.   EUROPEAN RESPIRATORY JOURNAL

Blood hemoglobin A1c levels and amyotrophic lateral sclerosis survival

(2017) Qian-Qian Wei et al.   Molecular Neurodegeneration

Aluminum Nanocrystals: A Sustainable Substrate for Quantitative SERS-Based DNA Detection

(2017) Shu Tian et al.   NANO LETTERS

A dual modal silver bumpy nanoprobe for photoacoustic imaging and SERS multiplexed identification of in vivo lymph nodes

(2017) Myeong Geun Cha et al.   Nanoscale

SERS- and luminescence-active Au–Au–UCNP trimers for attomolar detection of two cancer biomarkers

(2017) Aihua Qu et al.   Nanoscale

Monitoring immune-checkpoint blockade: response evaluation and biomarker development

(2017) Mizuki Nishino et al.   Nature Reviews Clinical Oncology

Drug development in the era of precision medicine

(2017) Sarah A. Dugger et al.   NATURE REVIEWS DRUG DISCOVERY

Beyond mice: Emerging and transdisciplinary models for the study of early-onset myopathies

(2017) Krzysztof Jagla et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Diagnosis of Breast Cancer Tissues Using 785 nm Miniature Raman Spectrometer and Pattern Regression

(2017) Qingbo Li et al.   SENSORS

Imaging drug uptake by bioorthogonal stimulated Raman scattering microscopy

(2017) William J. Tipping et al.   Chemical Science

Clinical characterization of in vivo inflammatory bowel disease with Raman spectroscopy

(2017) Isaac J. Pence et al.   Biomedical Optics Express

Chelator-Free Radiolabeling of SERRS Nanoparticles for Whole-Body PET and Intraoperative Raman Imaging

(2017) Matthew A. Wall et al.   Theranostics

Ultrasensitive NIR-SERRS Probes with Multiplexed Ratiometric Quantification for In Vivo Antibody Leads Validation

(2017) Homan Kang et al.   Advanced Healthcare Materials

Proteins are potent biomarkers to detect colon cancer progression

(2017) Palaniselvam Kuppusamy et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Review of SERS Substrates for Chemical Sensing

(2017) Pamela Mosier-Boss   Nanomaterials

Bioconjugation of Gold Nanobipyramids for SERS Detection and Targeted Photothermal Therapy in Breast Cancer

(2017) Jie Feng et al.   ACS Biomaterials-Science & Engineering

Surface-Enhanced Raman Spectroscopy-Based Sandwich Immunoassays for Multiplexed Detection of Zika and Dengue Viral Biomarkers

(2017) Maria Sánchez-Purrà et al.   ACS Infectious Diseases

Bioconjugation of Gold Nanobipyramids for SERS Detection and Targeted Photothermal Therapy in Breast Cancer

(2017) Jie Feng et al.   ACS Biomaterials Science & Engineering

Raman spectroscopy imaging reveals interplay between atherosclerosis and medial calcification in the human aorta

(2017) Amanda Y. F. You et al.   Science Advances

Highly Sensitive Detection of Hormone Estradiol E2 Using Surface-Enhanced Raman Scattering Based Immunoassays for the Clinical Diagnosis of Precocious Puberty

(2016) Rui Wang et al.   ACS Applied Materials & Interfaces

Plasmonic Schirmer Strip for Human Tear-Based Gouty Arthritis Diagnosis Using Surface-Enhanced Raman Scattering

(2016) Moonseong Park et al.   ACS Nano

Alkyne-Modulated Surface-Enhanced Raman Scattering-Palette for Optical Interference-Free and Multiplex Cellular Imaging

(2016) Yong Chen et al.   ANALYTICAL CHEMISTRY

Tunable, biodegradable gold nanoparticles as contrast agents for computed tomography and photoacoustic imaging

(2016) Rabee Cheheltani et al.   BIOMATERIALS

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

(2016) Annette Becker et al.   CANCER CELL

Stimulated Raman Scattering: From Bulk to Nano

(2016) Richard C. Prince et al.   CHEMICAL REVIEWS

Clinical instrumentation and applications of Raman spectroscopy

(2016) Isaac Pence et al.   CHEMICAL SOCIETY REVIEWS

Stimulated Raman scattering microscopy: an emerging tool for drug discovery

(2016) W. J. Tipping et al.   CHEMICAL SOCIETY REVIEWS

Label-free Raman spectroscopic imaging to extract morphological and chemical information from a formalin-fixed, paraffin-embedded rat colon tissue section

(2016) Riana Gaifulina et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Alkyne-Tag SERS Screening and Identification of Small-Molecule-Binding Sites in Protein

(2016) Jun Ando et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Surface-Enhanced Raman Scattering Surface Selection Rules for the Proteomic Liquid Biopsy in Real Samples: Efficient Detection of the Oncoprotein c-MYC

(2016) Elena Pazos et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting Epithelial–Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer

(2016) Bowen Du et al.   MOLECULES

Using Raman spectroscopy to characterize biological materials

(2016) Holly J Butler et al.   Nature Protocols

Towards precision medicine

(2016) Euan A. Ashley   NATURE REVIEWS GENETICS

An electrochemical aptasensor based on gold nanoparticles, thionine and hairpin structure of complementary strand of aptamer for ultrasensitive detection of lead

(2016) Seyed Mohammad Taghdisi et al.   SENSORS AND ACTUATORS B-CHEMICAL

Multiplexed Molecular Imaging of Fresh Tissue Surfaces Enabled by Convection-Enhanced Topical Staining with SERS-Coded Nanoparticles

(2016) Yu W. Wang et al.   Small

Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging

(2016) Feng Tian et al.   Nature Communications

Raman spectroscopy of endoscopic colonic biopsies from patients with ulcerative colitis to identify mucosal inflammation and healing

(2016) James Addis et al.   Biomedical Optics Express

Holographic Assessment of Lymphoma Tissue (HALT) for Global Oncology Field Applications

(2016) Divya Pathania et al.   Theranostics

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

Raman microspectroscopy of human aortic valves: investigation of the local and global biochemical changes associated with calcification in aortic stenosis

(2015) Krzysztof Czamara et al.   ANALYST

The Warburg effect: Evolving interpretations of an established concept

(2015) Xiaozhuo Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Discrimination of Breast Cancer from Normal Tissue with Raman Spectroscopy and Chemometrics

(2015) Q.-B. Li et al.   Journal of Applied Spectroscopy

Metabolomic Analysis Reveals Increased Aerobic Glycolysis and Amino Acid Deficit in a Cellular Model of Amyotrophic Lateral Sclerosis

(2015) Gabriel N. Valbuena et al.   MOLECULAR NEUROBIOLOGY

Intraoperative brain cancer detection with Raman spectroscopy in humans

(2015) Michael Jermyn et al.   Science Translational Medicine

A Colorimetric Enzyme-Linked Immunosorbent Assay (ELISA) Detection Platform for a Point-of-Care Dengue Detection System on a Lab-on-Compact-Disc

(2015) Aung Thiha et al.   SENSORS

Assessing Cholesterol Storage in Live Cells and C. elegans by Stimulated Raman Scattering Imaging of Phenyl-Diyne Cholesterol

(2015) Hyeon Jeong Lee et al.   Scientific Reports

Fast Vibrational Imaging of Single Cells and Tissues by Stimulated Raman Scattering Microscopy

(2014) Delong Zhang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Exploring Metabolic Pathways in Vivo by a Combined Approach of Mixed Stable Isotope-Labeled Raman Microspectroscopy and Multivariate Curve Resolution Analysis

(2014) Hemanth Noothalapati et al.   ANALYTICAL CHEMISTRY

Molecular monitoring of epithelial-to-mesenchymal transition in breast cancer cells by means of Raman spectroscopy

(2014) M. Marro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Classification and prediction of HCC tissues by Raman imaging with identification of fatty acids as potential lipid biomarkers

(2014) T. Tolstik et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Quantitative measurement of cancer tissue biomarkers in the lab and in the clinic

(2014) Daniel E Carvajal-Hausdorf et al.   LABORATORY INVESTIGATION

Imaging the intracellular distribution of tyrosine kinase inhibitors in living cells with quantitative hyperspectral stimulated Raman scattering

(2014) Dan Fu et al.   Nature Chemistry

Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering

(2014) Lu Wei et al.   NATURE METHODS

High-speed coherent Raman fingerprint imaging of biological tissues

(2014) Charles H. Camp Jr et al.   Nature Photonics

Ultrasensitive analyte detection with plasmonic paper dipsticks and swabs integrated with branched nanoantennas

(2014) Joseph A. Webb et al.   Journal of Materials Chemistry C

Label-free imaging of drug distribution and metabolism in colon cancer cells by Raman microscopy

(2013) Samir F. El-Mashtoly et al.   ANALYST

Computed tomography has low sensitivity for the diagnosis of early colon cancer

(2013) I-H. Lao et al.   Colorectal Disease

Validation of cell-based fluorescence assays: Practice guidelines from the ICSH and ICCS - part V - assay performance criteria

(2013) Brent Wood et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

A Comparison of Two Methods for Colorimetric in situ Hybridization Using Paraffin-Embedded Tissue Sections and Digoxigenin-Labeled Hybridization Probes

(2013) Joe Marcino   JOURNAL OF AQUATIC ANIMAL HEALTH

Role of thiol-containing polyethylene glycol (thiol-PEG) in the modification process of gold nanoparticles (AuNPs): Stabilizer or coagulant?

(2013) Wei Wang et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Raman spectra exploring breast tissues: Comparison of principal component analysis and support vector machine-recursive feature elimination

(2013) Chengxu Hu et al.   MEDICAL PHYSICS

Emerging advances in nanomedicine with engineered gold nanostructures

(2013) Joseph A. Webb et al.   Nanoscale

A community-driven global reconstruction of human metabolism

(2013) Ines Thiele et al.   NATURE BIOTECHNOLOGY

Development of a multiplex stimulated Raman microscope for spectral imaging through multi-channel lock-in detection

(2013) Keisuke Seto et al.   REVIEW OF SCIENTIFIC INSTRUMENTS

Rapid, Label-Free Detection of Brain Tumors with Stimulated Raman Scattering Microscopy

(2013) M. Ji et al.   Science Translational Medicine

Detection of Lipid-Rich Prostate Circulating Tumour Cells with Coherent Anti-Stokes Raman Scattering Microscopy

(2012) Ranjana Mitra et al.   BMC CANCER

Classification of inflammatory bowel diseases by means of Raman spectroscopic imaging of epithelium cells

(2012) Christiane Bielecki et al.   JOURNAL OF BIOMEDICAL OPTICS

Raman and coherent anti-Stokes Raman scattering microspectroscopy for biomedical applications

(2012) Christoph Krafft   JOURNAL OF BIOMEDICAL OPTICS

SERS: Materials, applications, and the future

(2012) Bhavya Sharma et al.   Materials Today

A Molecular Imaging Primer: Modalities, Imaging Agents, and Applications

(2012) Michelle L. James et al.   PHYSIOLOGICAL REVIEWS

A Hybrid Least Squares and Principal Component Analysis Algorithm for Raman Spectroscopy

(2012) Dominique Van de Sompel et al.   PLoS One

The Lipid Phenotype of Breast Cancer Cells Characterized by Raman Microspectroscopy: Towards a Stratification of Malignancy

(2012) Claudia Nieva et al.   PLoS One

Fundamentals of PET and PET/CT imaging

(2011) Sandip Basu et al.   Annals of the New York Academy of Sciences

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Serum amino acid profiles and their alterations in colorectal cancer

(2011) Alexander Benedikt Leichtle et al.   Metabolomics

Molecular Imaging with SERS-Active Nanoparticles

(2011) Yin Zhang et al.   Small

Label-Free Imaging of Metal-Carbonyl Complexes in Live Cells by Raman Microspectroscopy

(2010) Konrad Meister et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

1H-NMR-Based Metabolomic Profiling of CSF in Early Amyotrophic Lateral Sclerosis

(2010) Hélène Blasco et al.   PLoS One

Raman and CARS microspectroscopy of cells and tissues

(2009) Christoph Krafft et al.   ANALYST

Development of biomarker classifiers from high-dimensional data

(2009) Songjoon Baek et al.   BRIEFINGS IN BIOINFORMATICS

The evidence for altered RNA metabolism in amyotrophic lateral sclerosis (ALS)

(2009) Michael J. Strong   JOURNAL OF THE NEUROLOGICAL SCIENCES

Comparing coherent and spontaneous Raman scattering under biological imaging conditions

(2009) Meng Cui et al.   OPTICS LETTERS

Middle Ear Mechanics of Cartilage Tympanoplasty Evaluated by Laser Holography and Vibrometry

(2009) Antti A. Aarnisalo et al.   OTOLOGY & NEUROTOLOGY