Raman Microspectroscopic Evidence for the Metabolism of a Tyrosine Kinase Inhibitor, Neratinib, in Cancer Cells

CellExpress: a comprehensive microarray-based cancer cell line and clinical sample gene expression analysis online system

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Pharmacokinetics of neratinib during coadministration with lansoprazole in healthy subjects

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Neratinib induces ErbB2 ubiquitylation and endocytic degradation via HSP90 dissociation in breast cancer cells

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Stimulated Raman scattering microscopy: an emerging tool for drug discovery

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Neratinib after trastuzumab-based adjuvant therapy in patients with HER2-positive breast cancer (ExteNET): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

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Raman microscopy for cellular investigations — From single cell imaging to drug carrier uptake visualization

(2015) Birthe Kann et al.   ADVANCED DRUG DELIVERY REVIEWS

Raman imaging of drug delivery systems

(2015) Geoffrey P.S. Smith et al.   ADVANCED DRUG DELIVERY REVIEWS

Label-Free Raman Spectroscopic Imaging Monitors the Integral Physiologically Relevant Drug Responses in Cancer Cells

(2015) Samir F. El-Mashtoly et al.   ANALYTICAL CHEMISTRY

Automated Identification of Subcellular Organelles by Coherent Anti-Stokes Raman Scattering

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Imaging the intracellular distribution of tyrosine kinase inhibitors in living cells with quantitative hyperspectral stimulated Raman scattering

(2014) Dan Fu et al.   Nature Chemistry

Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering

(2014) Lu Wei et al.   NATURE METHODS

Label-free imaging of drug distribution and metabolism in colon cancer cells by Raman microscopy

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Safety, Efficacy and Pharmacokinetics of Neratinib (HKI-272) in Japanese Patients with Advanced Solid Tumors: A Phase 1 Dose-escalation Study

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Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors

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Live Cell in Vitro and in Vivo Imaging Applications: Accelerating Drug Discovery

(2011) Beverley Isherwood et al.   Pharmaceutics

Label-free imaging of human cells: algorithms for image reconstruction of Raman hyperspectral datasets

(2010) Miloš Miljković et al.   ANALYST

Label-Free Imaging of Metal-Carbonyl Complexes in Live Cells by Raman Microspectroscopy

(2010) Konrad Meister et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pharmacokinetics of oral neratinib during co-administration of ketoconazole in healthy subjects

(2010) Richat Abbas et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

A Single-Dose, Crossover, Placebo- and Moxifloxacin-Controlled Study to Assess the Effects of Neratinib (HKI-272) on Cardiac Repolarization in Healthy Adult Subjects

(2010) B. Hug et al.   CLINICAL CANCER RESEARCH

Analytical tools for the physicochemical profiling of drug candidates to predict absorption/distribution

(2009) Yveline Henchoz et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

A Phase I Study with Neratinib (HKI-272), an Irreversible Pan ErbB Receptor Tyrosine Kinase Inhibitor, in Patients with Solid Tumors

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The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

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