Synthesis of Selectively gem‐Difluorinated Molecules; Chiral gem‐Difluorocyclopropanes via Chemo‐Enzymatic Reaction and gem‐Difluorinated Compounds via Radical Reaction

Copper‐Catalyzed Enantioselective Hydrosilylation of gem ‐Difluorocyclopropenes Leading to a Stereochemical Study of the Silylated gem ‐Difluorocyclopropanes

(2022) Keisuke Sekine et al.   CHEMISTRY-A EUROPEAN JOURNAL

Photoredox Activation of Anhydrides for the Solvent‐Controlled Switchable Synthesis of gem ‐Difluoro Compounds**

(2022) Rahul Giri et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hantzsch Ester-Mediated Visible-Light-Induced Radical Ethoxycarbonyldifluoromethylation of Aryl Alkynes: Kinetic-Controlled Stereoselective Synthesis of Z-gem-Difluoroallyl Esters

(2022) Jian Hao et al.   JOURNAL OF ORGANIC CHEMISTRY

Visible-Light-Induced Difluoroalkylation of Alkenes and Alkynes with Fluoro-Containing Hypervalent Iodane (III) Reagents Under Photo-Catalyst-Free Conditions

(2022) Ruiyue Liu et al.   Journal of Organic Chemistry

The preparation and properties of 1,1-difluorocyclopropane derivatives

(2021) Kymbat S Adekenova et al.   Beilstein Journal of Organic Chemistry

Non-innocent Radical Ion Intermediates in Photoredox Catalysis: Parallel Reduction Modes Enable Coupling of Diverse Aryl Chlorides

(2021) Alyah F. Chmiel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Radical Chain Reduction via Carbon Dioxide Radical Anion (CO2•–)

(2021) Cecilia M. Hendy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Large-Scale Cyclopropanation of Butyl Acrylate with Difluorocarbene and Classical Resolution of a Key Fluorinated Building Block

(2021) Adam E. Goetz et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Synthesis of an allylic gem-difluoromethylene building block via radical-mediated difluorocyclopropane ring opening

(2021) Kirsty Milne et al.   TETRAHEDRON LETTERS

Photochemical C–F Activation Enables Defluorinative Alkylation of Trifluoroacetates and -Acetamides

(2021) Mark W. Campbell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Where does the Fluorine come from? A review on the challenges associated with the synthesis of organofluorine compounds.

(2020) Stephane Caron   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Synthesis of organic liquid crystals containing selectively fluorinated cyclopropanes

(2020) Zeguo Fang et al.   Beilstein Journal of Organic Chemistry

Enantioselective Functionalization of Difluorocyclopropenes Catalyzed by Chiral Copper Complexes: Proposal for Chiral gem-Dimethyl and tert-Butyl Analogues

(2020) Keisuke Sekine et al.   JOURNAL OF ORGANIC CHEMISTRY

Visible-Light-Driven Direct 2,2-Difluoroacetylation Using an Organic Pigment Catalyst

(2020) Yuji Furukawa et al.   ACS Sustainable Chemistry & Engineering

Contribution of Organofluorine Compounds to Pharmaceuticals

(2020) Munenori Inoue et al.   ACS Omega

Asymmetric transfer hydrogenation of gem‐difluoro‐cyclopropenyl esters. Access to enantio‐enriched gem‐difluorocyclopropanes

(2020) Christophe Meyer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of the Pan-genotypic Hepatitis C Virus NS3/4A Protease Inhibitor Voxilaprevir (GS-9857): A Component of Vosevi ®

(2019) James G. Taylor et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of gem-Difluoromethylene Containing Cycloalkenes via the Ring-Opening Reaction of gem-Difluorocyclopropanes and Subsequent RCM Reaction

(2019) Yoshihiro Masuhara et al.   JOURNAL OF ORGANIC CHEMISTRY

Visible‐Light‐Induced Difluoroacetylation of O‐(Allyloxy)Aryl‐Aldehydes: Access to Difluoroacetylated Chroman‐4‐ones

(2019) Nengneng Zhou et al.   Asian Journal of Organic Chemistry

Synthesis of 4,4-Difluoroalkenes by Coupling of α-Substituted α,α-Difluoromethyl Halides with Allyl Sulfones under Photoredox Catalyzed Conditions

(2019) Misae Uno et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Functionalized Difluorocyclopropanes: Unique Building Blocks for Drug Discovery

(2018) Roman M. Bychek et al.   CHEMISTRY-A EUROPEAN JOURNAL

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

(2018) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Sustainable Radical Cascades to Synthesize Difluoroalkylated Pyrrolo[1,2-a]indoles

(2018) Honggui Huang et al.   JOURNAL OF ORGANIC CHEMISTRY

Visible-Light Photocatalytic Difluoroalkylation-induced 1, 2-Heteroarene Migration of Allylic Alcohols in Batch and Flow

(2018) Xiao-Jing Wei et al.   JOURNAL OF ORGANIC CHEMISTRY

Transition Metal-free gem -difluorocyclopropanation of Alkenes with CF3 SiMe3 −NaI System: a Recipe for Electron-deficient Substrates

(2018) Pavel S. Nosik et al.   ADVANCED SYNTHESIS & CATALYSIS

Synthesis of 2,2-difluoro-homoallylic alcohols via ring-opening of gem-difluorocyclopropane and aerobic oxidation by photo-irradiation in the presence of an organic pigment

(2018) Hiroaki Takenaka et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Metal-Free Visible-Light Radical Iodoperfluoroalkylation of Terminal Alkenes and Alkynes

(2017) Tomoko Yajima et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Copper-Catalyzed Radical Cascade Difluoromethylation/Cyclization of 2-(3-Arylpropioloyl)benzaldehydes: A Route to Difluoromethylated Naphthoquinones

(2017) Yan Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Sustainable Difluoroalkylation Cyclization Cascades of 1,8-Enynes

(2017) Honggui Huang et al.   JOURNAL OF ORGANIC CHEMISTRY

A Novel Convergent Synthesis of the Potent Antiglaucoma Agent Tafluprost

(2017) Małgorzata Krupa et al.   MOLECULES

Visible-Light-Enabled Decarboxylative Mono- and Difluoromethylation of Cinnamic Acids under Metal-Free Conditions

(2017) Wei-Ke Tang et al.   ORGANIC LETTERS

Ring-Opening Diarylation of Siloxydifluorocyclopropanes by Ag(I) Catalysis: Stereoselective Construction of 2-Fluoroallylic Scaffold

(2017) Xiaoning Song et al.   ORGANIC LETTERS

Photoredox-Catalyzed Cross-Coupling of Enamides for the Assembly of β-Difluoroimine Synthons

(2017) Jicheng Wu et al.   ORGANIC LETTERS

Transformations based on ring-opening of gem -difluorocyclopropanes

(2017) Xiaoning Song et al.   TETRAHEDRON LETTERS

Visible-Light Photocatalytic Decarboxylation of α,β-Unsaturated Carboxylic Acids: Facile Access to Stereoselective Difluoromethylated Styrenes in Batch and Flow

(2017) Xiao-Jing Wei et al.   ACS Catalysis

Visible-light-catalyzed Tandem Difluoroacetylation-Intramolecular Cyclization of 1,3-Diarylpropynones: Access to Difluoroacetylated Indenones

(2017) Savita B. Nagode et al.   Asian Journal of Organic Chemistry

Copper-catalyzed difluoromethylation of propargylamide-substituted indoles: synthesis of mono- and bis-difluoromethylated indoloazepinone derivatives

(2016) Hui-Liang Hua et al.   CHEMICAL COMMUNICATIONS

Merging photoredox with copper catalysis: decarboxylative difluoroacetylation of α,β-unsaturated carboxylic acids with ICF2CO2Et

(2016) Heng-Rui Zhang et al.   CHEMICAL COMMUNICATIONS

Difluorocarbene Addition to Alkenes and Alkynes in Continuous Flow

(2016) Pauline Rullière et al.   ORGANIC LETTERS

Photoredox Catalysis Mediated Application of Methyl Fluorosulfonyldifluoroacetate as the CF2CO2R Radical Source

(2016) Wei Yu et al.   ORGANIC LETTERS

KAG-308, a newly-identified EP4-selective agonist shows efficacy for treating ulcerative colitis and can bring about lower risk of colorectal carcinogenesis by oral administration

(2015) Yusuke Watanabe et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Carbomethoxydifluoromethylation of enol acetates with methyl (chlorosulfonyl)difluoroacetate using visible-light photoredox catalysis. Synthesis of 2,2-difluoro-γ-ketoesters

(2015) Charles S. Thomoson et al.   JOURNAL OF FLUORINE CHEMISTRY

Halogenative Difluorohomologation of Ketones

(2015) Oleg V. Fedorov et al.   JOURNAL OF ORGANIC CHEMISTRY

Radical Reactions of Alkyl 2-Bromo-2,2-difluoroacetates with Vinyl Ethers: “Omitted” Examples and Application for the Synthesis of 3,3-Difluoro-GABA

(2015) Ivan S. Kondratov et al.   JOURNAL OF ORGANIC CHEMISTRY

Visible-Light-Mediated Radical Aryldifluoroacetylation of Alkynes with Ethyl Bromodifluoroacetate for the Synthesis of 3-Difluoroacetylated Coumarins

(2015) Weijun Fu et al.   JOURNAL OF ORGANIC CHEMISTRY

Development of (Trifluoromethyl)zinc Reagent as Trifluoromethyl Anion and Difluorocarbene Sources

(2015) Kohsuke Aikawa et al.   ORGANIC LETTERS

Visible Light-Induced Aromatic Difluoroalkylation

(2014) Jaehun Jung et al.   ADVANCED SYNTHESIS & CATALYSIS

Selective difluoroalkylation of alkenes by using visible light photoredox catalysis

(2014) Chunghyeon Yu et al.   CHEMICAL COMMUNICATIONS

Chloro, Difluoromethylation and Chloro, Carbomethoxydifluoromethylation: Reaction of Radicals Derived from RfSO2Cl with Unactivated Alkenes under Metal-Free Conditions

(2014) Charles S. Thomoson et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of gem-Difluoromethylene Building Blocks through Regioselective Allylation of gem-Difluorocyclopropanes

(2014) Daisuke Munemori et al.   ORGANIC LETTERS

Photoredox-Catalyzed Tandem Radical Cyclization of N-Arylacrylamides: General Methods To Construct Fluorinated 3,3-Disubstituted 2-Oxindoles Using Fluoroalkylsulfonyl Chlorides

(2014) Xiao-Jun Tang et al.   ORGANIC LETTERS

Recent Advances in the Synthetic Application of Difluorocarbene

(2014) Jinbo Hu et al.   SYNTHESIS-STUTTGART

Synthesis ofgem-Difluorocyclopropa(e)nes and O-, S-, N-, and P-Difluoromethylated Compounds with TMSCF2Br

(2013) Lingchun Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metathesis Reactions: Recent Trends and Challenges

(2013) Christophe Deraedt et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Development of Preformed Pd Catalysts for Cross-Coupling Reactions, Beyond the 2010 Nobel Prize

(2012) Hongbo Li et al.   ACS Catalysis

Possible origin of modified EAG activity by point-fluorination of insect pheromones

(2009) Shuichi Hayase et al.   Future Medicinal Chemistry

Chemo-enzymatic synthesis of spiro type gem-difluorocyclopropane as core molecule candidate for liquid crystal compounds

(2009) Toshiyuki Itoh et al.   JOURNAL OF FLUORINE CHEMISTRY

A convenient AIBN-initiated radical addition of ethyl iododifluoroacetate to alkenes

(2008) Leo Leung et al.   JOURNAL OF FLUORINE CHEMISTRY

Boron-Substituted Difluorocyclopropanes:  New Building Blocks ofgem-Difluorocyclopropanes

(2008) Yasutaka Fujioka et al.   ORGANIC LETTERS

Merging Photoredox Catalysis with Organocatalysis: The Direct Asymmetric Alkylation of Aldehydes

(2008) D. A. Nicewicz et al.   SCIENCE