Visible-light-catalyzed Tandem Difluoroacetylation-Intramolecular Cyclization of 1,3-Diarylpropynones: Access to Difluoroacetylated Indenones

Design, synthesis, in-silico and biological evaluation of novel donepezil derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease

(2017) Chandra Bhushan Mishra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Controlled Fluoroalkylation Reactions by Visible-Light Photoredox Catalysis

(2016) Tanmay Chatterjee et al.   ACCOUNTS OF CHEMICAL RESEARCH

Gold-Catalyzed Highly Selective Photoredox C(sp2 )−H Difluoroalkylation and Perfluoroalkylation of Hydrazones

(2016) Jin Xie et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible-light-promoted iminyl radical formation from vinyl azides: synthesis of 6-(fluoro)alkylated phenanthridines

(2016) Xiaoyang Sun et al.   CHEMICAL COMMUNICATIONS

Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease

(2016) Zhi-Min Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Convenient Access to Di- and Tri­fluoroethylamines for Lead Structure Research

(2016) Amrei Deutsch et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Investigation of the Structure–Activity Relationships of Aza-A-Ring Indenoisoquinoline Topoisomerase I Poisons

(2016) Daniel E. Beck et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of Potential Prodrugs Related to the Experimental Anticancer Agent Indotecan (LMP400)

(2016) Peng-Cheng Lv et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metal-Free Radical Oxidative Annulation of Ynones with Alkanes To Access Indenones

(2016) Changduo Pan et al.   JOURNAL OF ORGANIC CHEMISTRY

Photoredox-Catalyzed Intramolecular Difluoromethylation of N-Benzylacrylamides Coupled with a Dearomatizing Spirocyclization: Access to CF2H-Containing 2-Azaspiro[4.5]deca-6,9-diene-3,8-diones

(2016) Zuxiao Zhang et al.   ORGANIC LETTERS

Radical (Phenylsulfonyl)difluoromethylation of Isocyanides with PhSO2CF2H under Transition-Metal-Free Conditions

(2016) Pan Xiao et al.   ORGANIC LETTERS

Visible-Light-Mediated 1,7-Enyne Bicyclizations for Synthesis of Cyclopenta[c]quinolines and Benzo[j]phenanthridines

(2016) Fei Gao et al.   ORGANIC LETTERS

Discovery of a Highly Potent and Selective Indenoindolone Type 1 Pan-FLT3 Inhibitor

(2016) John M. Hatcher et al.   ACS Medicinal Chemistry Letters

Synthesis ofortho-(Fluoro)alkylated PyridinesviaVisible Light-Promoted Radical Isocyanide Insertion

(2015) Kun Tong et al.   ADVANCED SYNTHESIS & CATALYSIS

Visible-Light-Induced Radical Tandem Aryldifluoroacetylation of Cinnamamides: Access to Difluoroacetylated Quinolone-2-ones And 1-Azaspiro[4.5]decanes

(2015) Zhangxi Gu et al.   ADVANCED SYNTHESIS & CATALYSIS

Visible-Light Photoredox-Catalyzed C−H Difluoroalkylation of Hydrazones through an Aminyl Radical/Polar Mechanism

(2015) Pan Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Visible-Light-Mediated Radical Smiles Rearrangement and its Application to the Synthesis of a Difluoro-Substituted Spirocyclic ORL-1 Antagonist

(2015) James J. Douglas et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and comparison of the biological activity of monocyclic phosphonate, difluorophosphonate and phosphate analogs of the natural AChE inhibitor cyclophostin

(2015) Benjamin P. Martin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Visible light promoted carbodifluoroalkylation of allylic alcohols via concomitant 1,2-aryl migration

(2015) Pan Xu et al.   CHEMICAL COMMUNICATIONS

Recent Progress toward the Introduction of Functionalized Difluoromethylated Building Blocks onto C(sp2) and C(sp) Centers

(2015) Marie-Charlotte Belhomme et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent Advances in Difluoromethylation Reaction

(2015) Yang Lu et al.   CURRENT ORGANIC CHEMISTRY

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fluorous Peptide Nucleic Acids: PNA Analogues with Fluorine in Backbone (γ-CF2-apg-PNA) Enhance Cellular Uptake

(2015) Satheesh Ellipilli et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Perfluorinated Isoquinolinediones through Visible-Light-Induced Cyclization of Alkenes

(2015) Shi Tang et al.   JOURNAL OF ORGANIC CHEMISTRY

Visible-Light-Mediated Radical Aryldifluoroacetylation of Alkynes with Ethyl Bromodifluoroacetate for the Synthesis of 3-Difluoroacetylated Coumarins

(2015) Weijun Fu et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of organofluorine compounds using α-fluorine-substituted silicon reagents

(2015) Alexander D. Dilman et al.   MENDELEEV COMMUNICATIONS

Photocatalytic fluoroalkylation reactions of organic compounds

(2015) Sebastián Barata-Vallejo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Visible Light-Induced Aromatic Difluoroalkylation

(2014) Jaehun Jung et al.   ADVANCED SYNTHESIS & CATALYSIS

Selective difluoroalkylation of alkenes by using visible light photoredox catalysis

(2014) Chunghyeon Yu et al.   CHEMICAL COMMUNICATIONS

Successful fluorine-containing herbicide agrochemicals

(2014) Tomoya Fujiwara et al.   JOURNAL OF FLUORINE CHEMISTRY

Synthesis, structural, theoretical studies and biological activities of 3-(arylamino)-2-phenyl-1H-inden-1-one derivative

(2014) Hamdy S. El-Sheshtawy et al.   JOURNAL OF MOLECULAR STRUCTURE

Visible-Light-Mediated Fluoroalkylation of Isocyanides with Ethyl Bromofluoroacetates: Unified Synthesis of Mono- and Difluoromethylated Phenanthridine Derivatives

(2014) Xiaoyang Sun et al.   ORGANIC LETTERS

Synthesis of α-brominated phosphonates and their application as phosphate bioisosteres

(2014) A. Michael Downey et al.   MedChemComm

Visible-Light-Mediated Radical Aryldifluoroacetylation ofN-Arylacrylamides to give Difluoroacetylated Oxindoles

(2014) Weijun Fu et al.   Asian Journal of Organic Chemistry

Visible-light radical reaction designed by Ru- and Ir-based photoredox catalysis

(2014) Takashi Koike et al.   Inorganic Chemistry Frontiers

Synthesis of 6-Alkylated Phenanthridine Derivatives Using Photoredox Neutral Somophilic Isocyanide Insertion

(2013) Heng Jiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

A Novel Intermolecular Synthesis of γ-Lactones via Visible-Light Photoredox Catalysis

(2013) Xiao-Jing Wei et al.   ORGANIC LETTERS

Indotecan (LMP400) and AM13-55: Two Novel Indenoisoquinolines Show Potential for Treating Visceral Leishmaniasis

(2012) Rafael Balaña-Fouce et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis, Structure, and Biological Applications ofα-Fluorinatedβ-Amino Acids and Derivatives

(2012) Taryn L. March et al.   CHEMISTRY & BIODIVERSITY

Visible Light-Mediated Atom Transfer Radical Addition via Oxidative and Reductive Quenching of Photocatalysts

(2012) Carl-Johan Wallentin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Phosphonylated and Thiolated Indenones by Manganese(III)-Mediated Addition of Phosphorus- and Sulfur-Centered Radicals to 1,3-Diarylpropynones

(2011) Jun Zhou et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Stereoselective Synthesis of α-Fluorinated Amino Acid Derivatives

(2010) Atsushi Tarui et al.   ADVANCED SYNTHESIS & CATALYSIS

Manganese(iii)-mediated direct phosphonation of arylalkenes and arylalkynes

(2010) Xiang-Qiang Pan et al.   CHEMICAL COMMUNICATIONS

Selective difluoromethylation and monofluoromethylation reactions

(2009) Jinbo Hu et al.   CHEMICAL COMMUNICATIONS

Asymmetric synthesis of fluorine-containing amines, amino alcohols, α- and β-amino acids mediated by chiral sulfinyl group

(2009) Alexander E. Sorochinsky et al.   JOURNAL OF FLUORINE CHEMISTRY

Total Synthesis of Diverse Carbogenic Complexity within the Resveratrol Class from a Common Building Block

(2009) Scott A. Snyder et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages

(2009) Gabriela Molina et al.   Nature Chemical Biology

Total Synthesis of Euplectin, a Natural Product with a Chromone Fused Indenone

(2009) Dipakranjan Mal et al.   ORGANIC LETTERS

Synthetic strategies to α-trifluoromethyl and α-difluoromethyl substituted α-amino acids

(2008) René Smits et al.   CHEMICAL SOCIETY REVIEWS

Functionalized fluoroalkyl and alkenyl silanes: Preparations, reactions, and synthetic applications

(2008) Kenji Uneyama   JOURNAL OF FLUORINE CHEMISTRY

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS