Emerging reaction technologies in pharmaceutical development: Challenges and opportunities in electrochemistry, photochemistry, and biocatalysis
Published 2023 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Emerging reaction technologies in pharmaceutical development: Challenges and opportunities in electrochemistry, photochemistry, and biocatalysis
Authors
Keywords
-
Journal
CHEMICAL ENGINEERING RESEARCH & DESIGN
Volume 192, Issue -, Pages 622-637
Publisher
Elsevier BV
Online
2023-03-03
DOI
10.1016/j.cherd.2023.02.050
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Exploring Electrochemical C(sp3)–H Oxidation for the Late-Stage Methylation of Complex Molecules
- (2022) Luiz F. T. Novaes et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Electrochemical Dearomative Dicarboxylation of Heterocycles with Highly Negative Reduction Potentials
- (2022) Yong You et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Electrochemically driven cross-electrophile coupling of alkyl halides
- (2022) Wen Zhang et al. NATURE
- Commercial-Scale Visible Light Trifluoromethylation of 2-Chlorothiophenol Using CF3I Gas
- (2022) Kaid C. Harper et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Highlights of the Recent Patent Literature─Focus on Biocatalysis Innovation
- (2022) David L. Hughes ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Data-rich process development of immobilized biocatalysts in flow
- (2022) Jacob H. Forstater et al. Reaction Chemistry & Engineering
- Liquid‐Liquid Centrifugal Extractors: Types and Recent Applications – a Review
- (2022) Zaid Alkhier Hamamah et al. ChemBioEng Reviews
- A Deep Eutectic Solvent Thermomorphic Multiphasic System for Biocatalytic Applications
- (2022) Lars-Erik Meyer et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Diverse Catalytic Reactions for the Stereoselective Synthesis of Cyclic Dinucleotide MK-1454
- (2022) Tamas Benkovics et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Chemoselective (Hetero)Arene Electroreduction Enabled by Rapid Alternating Polarity
- (2022) Kyohei Hayashi et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- A kinase-cGAS cascade to synthesize a therapeutic STING activator
- (2022) John A. McIntosh et al. NATURE
- Optimization of Metal Affinity Ketoreductase Immobilization for Application in Batch and Flow Processes
- (2022) Alessandra Basso et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Driving Aspirational Process Mass Intensity Using Simple Structure-Based Prediction
- (2022) Edward C. Sherer et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Kilo-Scale Electrochemical Oxidation of a Thioether to a Sulfone: A Workflow for Scaling up Electrosynthesis
- (2022) Cecilia Bottecchia et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Implementing Continuous Manufacturing for the Final Methylation Step in the AMG 397 Process to Deliver Key Quality Attributes
- (2021) Janine K. Tom et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Electrochemically driven desaturation of carbonyl compounds
- (2021) Samer Gnaim et al. Nature Chemistry
- Scalable Flow Electrochemical Alcohol Oxidation: Maintaining High Stereochemical Fidelity in the Synthesis of Levetiracetam
- (2021) Xing Zhong et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Green Chemistry: Electrochemical Organic Transformations via Paired Electrolysis
- (2021) Najoua Sbei et al. ACS Sustainable Chemistry & Engineering
- Chemoselective, Scalable Nickel‐Electrocatalytic O ‐Arylation of Alcohols
- (2021) Hai‐Jun Zhang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Direct Photocatalyzed Hydrogen Atom Transfer (HAT) for Aliphatic C–H Bonds Elaboration
- (2021) Luca Capaldo et al. CHEMICAL REVIEWS
- Enantioselective Photochemical Reactions Enabled by Triplet Energy Transfer
- (2021) Johannes Großkopf et al. CHEMICAL REVIEWS
- Advances in the E → Z Isomerization of Alkenes Using Small Molecule Photocatalysts
- (2021) Tomáš Neveselý et al. CHEMICAL REVIEWS
- Technological Innovations in Photochemistry for Organic Synthesis: Flow Chemistry, High-Throughput Experimentation, Scale-up, and Photoelectrochemistry
- (2021) Laura Buglioni et al. CHEMICAL REVIEWS
- Electrochemical Nozaki–Hiyama–Kishi Coupling: Scope, Applications, and Mechanism
- (2021) Yang Gao et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Electrochemical Palladium-Catalyzed Oxidative Sonogashira Carbonylation of Arylhydrazines and Alkynes to Ynones
- (2021) Yong Wu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- TEMPO-Enabled Electrochemical Enantioselective Oxidative Coupling of Secondary Acyclic Amines with Ketones
- (2021) Zhen-Hua Wang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- C–H Amination via Electrophotocatalytic Ritter-type Reaction
- (2021) Tao Shen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Aziridine synthesis by coupling amines and alkenes via an electrogenerated dication
- (2021) Dylan E. Holst et al. NATURE
- A Continuous-Flow Electrochemical Taylor Vortex Reactor: A Laboratory-Scale High-Throughput Flow Reactor with Enhanced Mixing for Scalable Electrosynthesis
- (2021) Ashley Love et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Development and Scale-Up of a Novel Photochemical C–N Oxidative Coupling
- (2021) Alan Robinson et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- High-Throughput Electrochemistry: State of the Art, Challenges, and Perspective
- (2021) Alfie G. Wills et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Electrochemical borylation of carboxylic acids
- (2021) Lisa M. Barton et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Improved iGAL 2.0 Metric Empowers Pharmaceutical Scientists to Make Meaningful Contributions to United Nations Sustainable Development Goal 12
- (2021) Frank Roschangar et al. ACS Sustainable Chemistry & Engineering
- Unlocking the Potential of High-Throughput Experimentation for Electrochemistry with a Standardized Microscale Reactor
- (2021) Jonas Rein et al. ACS Central Science
- Alkoxy Radicals See the Light: New Paradigms of Photochemical Synthesis
- (2021) Liang Chang et al. CHEMICAL REVIEWS
- Applications of Halogen-Atom Transfer (XAT) for the Generation of Carbon Radicals in Synthetic Photochemistry and Photocatalysis
- (2021) Fabio Juliá et al. CHEMICAL REVIEWS
- Metallaphotoredox: The Merger of Photoredox and Transition Metal Catalysis
- (2021) Amy Y. Chan et al. CHEMICAL REVIEWS
- Advances on the Merger of Electrochemistry and Transition Metal Catalysis for Organic Synthesis
- (2021) Christian A. Malapit et al. CHEMICAL REVIEWS
- Photoredox-Catalyzed C–H Functionalization Reactions
- (2021) Natalie Holmberg-Douglas et al. CHEMICAL REVIEWS
- Strategies to Generate Nitrogen-centered Radicals That May Rely on Photoredox Catalysis: Development in Reaction Methodology and Applications in Organic Synthesis
- (2021) Kitae Kwon et al. CHEMICAL REVIEWS
- Photochemical and Electrochemical Applications of Proton-Coupled Electron Transfer in Organic Synthesis
- (2021) Philip R. D. Murray et al. CHEMICAL REVIEWS
- Chiral Photocatalyst Structures in Asymmetric Photochemical Synthesis
- (2021) Matthew J. Genzink et al. CHEMICAL REVIEWS
- Aryl Transfer Strategies Mediated by Photoinduced Electron Transfer
- (2021) Anthony R. Allen et al. CHEMICAL REVIEWS
- Photons or Electrons? A Critical Comparison of Electrochemistry and Photoredox Catalysis for Organic Synthesis
- (2021) Nicholas E. S. Tay et al. CHEMICAL REVIEWS
- Visible Light-Induced Transition Metal Catalysis
- (2021) Kelvin Pak Shing Cheung et al. CHEMICAL REVIEWS
- Electrochemical Synthesis of Allylic Amines from Terminal Alkenes and Secondary Amines
- (2021) Diana J. Wang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Epoxide Electroreduction
- (2021) Cheng Huang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Manufacturing Process Development for Belzutifan, Part 2: A Continuous Flow Visible-Light-Induced Benzylic Bromination
- (2021) Cecilia Bottecchia et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Automated High-Throughput Partition Coefficient Determination with Image Analysis for Rapid Reaction Workup Process Development and Modeling
- (2021) Sophie Duffield et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Making Sustainability Assessment Accessible: Tools Developed by the ACS Green Chemistry Institute Pharmaceutical Roundtable
- (2021) Louis J. Diorazio et al. ACS Sustainable Chemistry & Engineering
- Electrochemical Oxidation of Organic Molecules at Lower Overpotential: Accessing Broader Functional Group Compatibility with Electron−Proton Transfer Mediators
- (2020) Fei Wang et al. ACCOUNTS OF CHEMICAL RESEARCH
- Site-Selective C–H Functionalization via Synergistic Use of Electrochemistry and Transition Metal Catalysis
- (2020) Ke-Jin Jiao et al. ACCOUNTS OF CHEMICAL RESEARCH
- Catalyzing Electrosynthesis: A Homogeneous Electrocatalytic Approach to Reaction Discovery
- (2020) Juno C. Siu et al. ACCOUNTS OF CHEMICAL RESEARCH
- Thin-Film Evaporator Model for Continuous Active Pharmaceutical Ingredient Manufacturing
- (2020) Boung Wook Lee et al. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
- Synthesis of Sterically Hindered Primary Amines by Concurrent Tandem Photoredox Catalysis
- (2020) Michael C. Nicastri et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Photon Equivalents as a Parameter for Scaling Photoredox Reactions in Flow: Translation of Photocatalytic C−N Cross‐Coupling from Lab Scale to Multikilogram Scale
- (2020) Emily B. Corcoran et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Development and Execution of a Production-Scale Continuous [2 + 2] Photocycloaddition
- (2020) Matthew G. Beaver et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Electrochemical Scaled‐up Synthesis of Cyclic Enecarbamates as Starting Materials for Medicinal Chemistry Relevant Building Bocks
- (2020) Oleksandr D. Tereshchenko et al. ADVANCED SYNTHESIS & CATALYSIS
- Biocatalysis: Enzymatic Synthesis for Industrial Applications
- (2020) Shuke Wu et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Supporting-Electrolyte-Free and Scalable Flow Process for the Electrochemical Synthesis of 3,3′,5,5′-Tetramethyl-2,2′-biphenol
- (2020) Maximilian Selt et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Electrochemical Cyclobutane Synthesis in Flow: Scale-Up of a Promising Melt-Castable Energetic Intermediate
- (2020) Longrui Chen et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Predicting Performance of Photochemical Transformations for Scaling Up in Different Platforms by Combining High-Throughput Experimentation with Computational Modeling
- (2020) Melda Sezen-Edmonds et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Progress to date in the design and operation of continuous crystallization processes for pharmaceutical applications
- (2019) Barbara Wood et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- A Laser Driven Flow Chemistry Platform for Scaling Photochemical Reactions with Visible Light
- (2019) Kaid C. Harper et al. ACS Central Science
- Scalable and safe synthetic organic electroreduction inspired by Li-ion battery chemistry
- (2019) Byron K. Peters et al. SCIENCE
- Small-Volume Continuous Manufacturing of Merestinib. Part 1. Process Development and Demonstration
- (2019) Kevin P. Cole et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Sulfonamide Synthesis through Electrochemical Oxidative Coupling of Amines and Thiols
- (2019) Gabriele Laudadio et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications
- (2019) Yu Kawamata et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Molecular Complexity as a Driver for Chemical Process Innovation in the Pharmaceutical Industry
- (2019) Seb Caille et al. JOURNAL OF ORGANIC CHEMISTRY
- Continuous Electrochemical Generator of Hypervalent Iodine Reagents: Synthetic Applications in Flow
- (2019) Mohamed Elsherbini et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Trends in clinical success rates and therapeutic focus
- (2019) Helen Dowden et al. NATURE REVIEWS DRUG DISCOVERY
- Thermomorphic Multiphase Systems - Switchable Solvent Mixtures for the Recovery of Homogeneous Catalysts in Batch and Flow Processes
- (2019) Jonas Bianga et al. CHEMISTRY-A EUROPEAN JOURNAL
- Metal-Reductant-Free Electrochemical Nickel-Catalyzed Couplings of Aryl and Alkyl Bromides in Acetonitrile
- (2019) Robert J. Perkins et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- The Fundamentals Behind the Use of Flow Reactors in Electrochemistry
- (2019) Timothy Noël et al. ACCOUNTS OF CHEMICAL RESEARCH
- Electroorganic Synthesis under Flow Conditions
- (2019) Mohamed Elsherbini et al. ACCOUNTS OF CHEMICAL RESEARCH
- Electrochemistry-Enabled Ir-Catalyzed Vinylic C–H Functionalization
- (2019) Qi-Liang Yang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- A Decade of Electrochemical Dehydrogenative C,C-Coupling of Aryls
- (2019) Johannes L. Röckl et al. ACCOUNTS OF CHEMICAL RESEARCH
- A Survival Guide for the “Electro-curious”
- (2019) Cian Kingston et al. ACCOUNTS OF CHEMICAL RESEARCH
- Continuous Flow Enables Metallaphotoredox Catalysis in a Medicinal Chemistry Setting: Accelerated Optimization and Library Execution of a Reductive Coupling between Benzylic Chlorides and Aryl Bromides
- (2019) Zachary G. Brill et al. ORGANIC LETTERS
- Large, Highly Modular Narrow-Gap Electrolytic Flow Cell and Application in Dehydrogenative Cross-Coupling of Phenols
- (2019) Barbara Gleede et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Design of an in vitro biocatalytic cascade for the manufacture of islatravir
- (2019) Mark A. Huffman et al. SCIENCE
- Continuous flow biocatalysis
- (2018) Joshua Britton et al. CHEMICAL SOCIETY REVIEWS
- Organocatalyzed, Visible-Light Photoredox-Mediated, One-Pot Minisci Reaction Using Carboxylic Acids via N-(Acyloxy)phthalimides
- (2018) Trevor C. Sherwood et al. JOURNAL OF ORGANIC CHEMISTRY
- Applications of Flow Chemistry in Drug Development: Highlights of Recent Patent Literature
- (2018) David L. Hughes ORGANIC PROCESS RESEARCH & DEVELOPMENT
- An Electrocatalytic Approach to the Radical Difunctionalization of Alkenes
- (2018) Gregory S. Sauer et al. ACS Catalysis
- Energy transfer catalysis mediated by visible light: principles, applications, directions
- (2018) Felix Strieth-Kalthoff et al. CHEMICAL SOCIETY REVIEWS
- The Evolving State of Continuous Processing in Pharmaceutical API Manufacturing: A Survey of Pharmaceutical Companies and Contract Manufacturing Organizations
- (2018) J. Christopher McWilliams et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Application of in situ-Product Crystallization and Related Techniques in Biocatalytic Processes
- (2018) Dennis Hülsewede et al. CHEMISTRY-A EUROPEAN JOURNAL
- Extending the application of biocatalysis to meet the challenges of drug development
- (2018) Paul N. Devine et al. Nature Reviews Chemistry
- Recent progress of continuous crystallization
- (2017) Ting Wang et al. JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
- Paired Electrochemical Processes: Overview, Systematization, Selection Criteria, Design Strategies, and Projection
- (2017) Jorge G. Ibanez et al. Journal of the Mexican Chemical Society
- The Enabling Technologies Consortium (ETC): Fostering Precompetitive Collaborations on New Enabling Technologies for Pharmaceutical Research and Development
- (2017) Christopher J. Welch et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Organic Electrosynthesis: From Laboratorial Practice to Industrial Applications
- (2017) David S. P. Cardoso et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- General Principles and Strategies for Salting-Out Informed by the Hofmeister Series
- (2017) Alan M. Hyde et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Highly Modular Flow Cell for Electroorganic Synthesis
- (2017) Christoph Gütz et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Metal-catalyzed electrochemical diazidation of alkenes
- (2017) Niankai Fu et al. SCIENCE
- Kilogram-scale prexasertib monolactate monohydrate synthesis under continuous-flow CGMP conditions
- (2017) Kevin P. Cole et al. SCIENCE
- Flow chemistry, continuous processing, and continuous manufacturing: A pharmaceutical perspective
- (2017) Scott A. May Journal of Flow Chemistry
- Continuous-flow photochemistry: A need for chemical engineering
- (2016) Karine Loubière et al. CHEMICAL ENGINEERING AND PROCESSING
- Scalable and sustainable electrochemical allylic C–H oxidation
- (2016) Evan J. Horn et al. NATURE
- Electrolytic Macrocyclizations: Scalable Synthesis of a Diazonamide-Based Drug Development Candidate
- (2015) Hui Ding et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Design and optimization of a multistage continuous cooling mixed suspension, mixed product removal crystallizer
- (2015) Graham Power et al. CHEMICAL ENGINEERING SCIENCE
- Integrated Upstream and Downstream Application of Wet Milling with Continuous Mixed Suspension Mixed Product Removal Crystallization
- (2015) Yang Yang et al. CRYSTAL GROWTH & DESIGN
- Current complexity: a tool for assessing the complexity of organic molecules
- (2015) Jun Li et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Development and Scale-Up of the Electrochemical Dehalogenation for the Synthesis of a Key Intermediate for NS5A Inhibitors
- (2015) Christoph Gütz et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Development of a Multi-Step Synthesis and Workup Sequence for an Integrated, Continuous Manufacturing Process of a Pharmaceutical
- (2014) Patrick L. Heider et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Semisynthetic Artemisinin, the Chemical Path to Industrial Production
- (2014) Joël Turconi et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Characterization of the anti-solvent batch, plug flow and MSMPR crystallization of benzoic acid
- (2013) Steven Ferguson et al. CHEMICAL ENGINEERING SCIENCE
- Membrane-Based, Liquid–Liquid Separator with Integrated Pressure Control
- (2013) Andrea Adamo et al. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
- Continuous Hydrolysis and Liquid–Liquid Phase Separation of an Active Pharmaceutical Ingredient Intermediate Using a Miniscale Hydrophobic Membrane Separator
- (2012) Albert E. Cervera-Padrell et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Crystallization of Cyclosporine in a Multistage Continuous MSMPR Crystallizer
- (2011) Alejandro J. Alvarez et al. CRYSTAL GROWTH & DESIGN
- Aiming for the Ideal Synthesis
- (2010) Tanja Gaich et al. JOURNAL OF ORGANIC CHEMISTRY
- Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture
- (2010) C. K. Savile et al. SCIENCE
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started