Highlights of the Recent Patent Literature─Focus on Biocatalysis Innovation

Progress in Stereoselective Construction of C–C Bonds Enabled by Aldolases and Hydroxynitrile Lyases

(2021) Mi Liu et al.   Frontiers in Bioengineering and Biotechnology

Stereoselective Synthesis of Enantiopure Oxazolidinones via Biocatalytic Asymmetric Aminohydroxylation of Alkenes

(2021) Xiao‐Ying Zhou et al.   ADVANCED SYNTHESIS & CATALYSIS

Application of Biocatalytic Reductive Amination for the Synthesis of a Key Intermediate to a CDK 2/4/6 Inhibitor

(2021) Shengquan Duan et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Streamlined Synthesis of a Bicyclic Amine Moiety Using an Enzymatic Amidation and Identification of a Novel Solid Form

(2021) Maria S. Brown et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

State-of-the-Art Biocatalysis

(2021) Joshua B. Pyser et al.   ACS Central Science

Biocatalytic reductive amination from discovery to commercial manufacturing applied to abrocitinib JAK1 inhibitor

(2021) Rajesh Kumar et al.   Nature Catalysis

Engineered Artificial Carboligases Facilitate Regioselective Preparation of Enantioenriched Aldol Adducts

(2020) Duncan S. Macdonald et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Dual-Protein Cascade Reaction for the Regioselective Synthesis of Quinoxalines

(2020) Fengxi Li et al.   ORGANIC LETTERS

Photobiocatalytic synthesis of chiral secondary fatty alcohols from renewable unsaturated fatty acids

(2020) Wuyuan Zhang et al.   Nature Communications

Biocatalysis: Enzymatic Synthesis for Industrial Applications

(2020) Shuke Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multi-enzyme cascade for improving β-hydroxy-α-amino acids production by engineering L-threonine transaldolase and combining acetaldehyde elimination system

(2020) Lian Xu et al.   BIORESOURCE TECHNOLOGY

Biocatalytic Access to 1,4-Diazepanes via Imine Reductase-Catalyzed Intramolecular Asymmetric Reductive Amination

(2020) Zefei Xu et al.   ACS Catalysis

Broadening the scope of biocatalytic C–C bond formation

(2020) Lara E. Zetzsche et al.   Nature Reviews Chemistry

Development of a Nitrene-Type Rearrangement for the Commercial Route of the JAK1 Inhibitor Abrocitinib

(2020) Christina G. Connor et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Discovery and Design of Family VIII Carboxylesterases as Highly Efficient Acyltransferases

(2020) Henrik Müller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Process Development and Protein Engineering Enhanced Nitroreductase-Catalyzed Reduction of 2-Methyl-5-nitro-pyridine

(2020) Amin Bornadel et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Hemoglobin: a new biocatalyst for the synthesis of 2-substituted benzoxazoles via oxidative cyclization

(2019) Fengxi Li et al.   ChemCatChem

Aldolase-Catalyzed Asymmetric Synthesis of N-Heterocycles by Addition of Simple Aliphatic Nucleophiles to Aminoaldehydes

(2019) Raquel Roldán et al.   ADVANCED SYNTHESIS & CATALYSIS

Biocatalysis: A Pharma Perspective

(2019) Joseph P. Adams et al.   ADVANCED SYNTHESIS & CATALYSIS

Investigating the promiscuity of the chloramphenicol nitroreductase from Haemophilus influenzae towards the reduction of 4-nitrobenzene derivatives

(2019) Keith D. Green et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Versatility of Candida antarctica lipase in the amide bond formation applied in organic synthesis and biotechnological processes

(2019) Rafaely N. Lima et al.   Molecular Catalysis

Enzyme‐catalyzed Synthesis of Secondary and Tertiary Amides

(2019) Mark Petchey et al.   ADVANCED SYNTHESIS & CATALYSIS

Comparison of L-Threonine Aldolase Variants in the Aldol and Retro-Aldol Reactions

(2019) Kateryna Fesko   Frontiers in Bioengineering and Biotechnology

Biocatalysis as Useful Tool in Asymmetric Synthesis: An Assessment of Recently Granted Patents (2014–2019)

(2019) Pablo Domínguez de María et al.   Catalysts

Biocatalysis and Pharmaceuticals: A Smart Tool for Sustainable Development

(2019) Andrés R. Alcántara   Catalysts

Chiral synthesis of LSD1 inhibitor GSK2879552 enabled by directed evolution of an imine reductase

(2019) Markus Schober et al.   Nature Catalysis

Reductive Amination in the Synthesis of Pharmaceuticals

(2019) Oleg I. Afanasyev et al.   CHEMICAL REVIEWS

Hemoglobin-Catalyzed Synthesis of Indolizines Under Mild Conditions

(2019) Fengxi Li et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Design of an in vitro biocatalytic cascade for the manufacture of islatravir

(2019) Mark A. Huffman et al.   SCIENCE

Enzymatic amidation for industrial applications

(2018) Brent M Dorr et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Informing Efforts to Develop Nitroreductase for Amine Production

(2018) Anne-Frances Miller et al.   MOLECULES

Biocatalysis in Drug Development—Highlights of the Recent Patent Literature

(2018) David L. Hughes   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Extending the application of biocatalysis to meet the challenges of drug development

(2018) Paul N. Devine et al.   Nature Reviews Chemistry

An algal photoenzyme converts fatty acids to hydrocarbons

(2017) Damien Sorigué et al.   SCIENCE

Big Data from Pharmaceutical Patents: A Computational Analysis of Medicinal Chemists’ Bread and Butter

(2016) Nadine Schneider et al.   JOURNAL OF MEDICINAL CHEMISTRY

Emergence of a catalytic tetrad during evolution of a highly active artificial aldolase

(2016) Richard Obexer et al.   Nature Chemistry

Highlights of the Recent U.S. Patent Literature: Focus on Biocatalysis

(2016) David L. Hughes   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Recent Developments in the Reduction of Aromatic and Aliphatic Nitro Compounds to Amines

(2016) Manuel Orlandi et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Identification of imine reductase-specific sequence motifs

(2016) Silvia Fademrecht et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Minimalist Protein Engineering of an Aldolase Provokes Unprecedented Substrate Promiscuity

(2016) Deniz Güclü et al.   ACS Catalysis

Constructing Biocatalytic Cascades: In Vitro and in Vivo Approaches to de Novo Multi-Enzyme Pathways

(2016) Scott P. France et al.   ACS Catalysis

Preparation of β-hydroxy-α-amino Acid Using Recombinant d-Threonine Aldolase

(2015) Steven L. Goldberg et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Simple amino acid tags improve both expression and secretion ofCandida antarcticalipase B in recombinantEscherichia coli

(2014) Sun-Ki Kim et al.   BIOTECHNOLOGY AND BIOENGINEERING

Enzyme Toolbox: Novel Enantiocomplementary Imine Reductases

(2014) Philipp N. Scheller et al.   CHEMBIOCHEM

Understanding the Broad Substrate Repertoire of Nitroreductase Based on Its Kinetic Mechanism

(2014) Warintra Pitsawong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Catalytic X–H insertion reactions based on carbenoids

(2013) Dennis Gillingham et al.   CHEMICAL SOCIETY REVIEWS

Enantioselective Synthesis of a Dual Orexin Receptor Antagonist

(2012) Ian K. Mangion et al.   ORGANIC LETTERS

Enzymatic C-terminal amidation of amino acids and peptides

(2012) Timo Nuijens et al.   TETRAHEDRON LETTERS

C−C Bond-Forming Lyases in Organic Synthesis

(2011) Margarita Brovetto et al.   CHEMICAL REVIEWS

Novel carbon–carbon bond formations for biocatalysis

(2011) Verena Resch et al.   CURRENT OPINION IN BIOTECHNOLOGY

Reaction Development and Mechanistic Study of a Ruthenium Catalyzed Intramolecular Asymmetric Reductive Amination en Route to the Dual Orexin Inhibitor Suvorexant (MK-4305)

(2011) Neil A. Strotman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enzyme activation for organic solvents made easy

(2007) Anne L. Serdakowski et al.   TRENDS IN BIOTECHNOLOGY