SESN1 is a FOXO3 effector that counteracts human skeletal muscle ageing

A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body

(2023) Shuhui Sun et al.   Innovation(United States)

The functions and roles of sestrins in regulating human diseases

(2022) Yitong Chen et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor

(2022) Zunpeng Liu et al.   Cell Discovery

Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration

(2022) Victoria Moiseeva et al.   NATURE

Single-nucleus profiling unveils a geroprotective role of the FOXO3 in primate skeletal muscle aging

(2022) Ying Jing et al.   Protein & Cell

Fibro-adipogenic progenitors in skeletal muscle homeostasis, regeneration and diseases

(2021) Thomas Molina et al.   Open Biology

Large-scale integration of single-cell transcriptomic data captures transitional progenitor states in mouse skeletal muscle regeneration

(2021) David W. McKellar et al.   Communications Biology

Single-Cell Transcriptomic Atlas of Primate Ovarian Aging

(2020) Si Wang et al.   CELL

ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin

(2020) Huifang Hu et al.   NUCLEIC ACIDS RESEARCH

Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration

(2020) Chuqian Liang et al.   CELL RESEARCH

Single-cell transcriptomic atlas of primate cardiopulmonary aging

(2020) Shuai Ma et al.   CELL RESEARCH

FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age

(2020) Laura García-Prat et al.   NATURE CELL BIOLOGY

FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocardial infarction

(2020) Jinghui Lei et al.   Protein & Cell

Protective response of Sestrin under stressful conditions in aging

(2020) Nitish Rai et al.   AGEING RESEARCH REVIEWS

Senescent cells and macrophages: key players for regeneration?

(2020) Sonia S. Elder et al.   Open Biology

Sestrins in Physiological Stress Responses

(2020) Myungjin Kim et al.   Annual Review of Physiology

FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration

(2019) Pengze Yan et al.   Cell Stem Cell

Update zur Diagnose und Therapie der Sarkopenie

(2019) S. Goisser et al.   INTERNIST

DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors

(2019) Christopher S. McGinnis et al.   Cell Systems

Sarcopenia

(2019) Alfonso J Cruz-Jentoft et al.   LANCET

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis

(2019) Liping Deng et al.   Nature Communications

Voluntary exercise normalizes the proteomic landscape in muscle and brain and improves the phenotype of progeroid mice

(2019) Jaime M. Ross et al.   AGING CELL

DJ-1 is dispensable for human stem cell homeostasis

(2019) Fang Cheng et al.   Protein & Cell

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

The exerkine apelin reverses age-associated sarcopenia

(2018) Claire Vinel et al.   NATURE MEDICINE

SCENIC: single-cell regulatory network inference and clustering

(2017) Sara Aibar et al.   NATURE METHODS

Skeletal muscle performance and ageing

(2017) Michael Tieland et al.   Journal of Cachexia Sarcopenia and Muscle

Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice

(2016) Laura Lukjanenko et al.   NATURE MEDICINE

Using single nuclei for RNA-seq to capture the transcriptome of postmortem neurons

(2016) Suguna Rani Krishnaswami et al.   Nature Protocols

Biochemical Basis of Sestrin Physiological Activities

(2016) Allison Ho et al.   TRENDS IN BIOCHEMICAL SCIENCES

Impact of creatine supplementation in combination with resistance training on lean mass in the elderly

(2016) Camila Lemos Pinto et al.   Journal of Cachexia Sarcopenia and Muscle

Effects of a Vitamin D and Leucine-Enriched Whey Protein Nutritional Supplement on Measures of Sarcopenia in Older Adults, the PROVIDE Study: A Randomized, Double-Blind, Placebo-Controlled Trial

(2015) Jürgen M. Bauer et al.   Journal of the American Medical Directors Association

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Efficient derivation and inducible differentiation of expandable skeletal myogenic cells from human ES and patient-specific iPS cells

(2015) Sara M Maffioletti et al.   Nature Protocols

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Sestrins Orchestrate Cellular Metabolism to Attenuate Aging

(2013) Jun Hee Lee et al.   Cell Metabolism

Muscle protein synthesis in response to nutrition and exercise

(2012) P. J. Atherton et al.   JOURNAL OF PHYSIOLOGY-LONDON

FoxOs Inhibit mTORC1 and Activate Akt by Inducing the Expression of Sestrin3 and Rictor

(2010) Chia-Chen Chen et al.   DEVELOPMENTAL CELL