The hunger strikes back: an epigenetic memory for autophagy

Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice

(2023) Yuta Takahashi et al.   CELL

Autophagy: A challengeable paradox in cancer treatment

(2023) Farnaz Ahmadi‐Dehlaghi et al.   Cancer Medicine

Molecular mechanisms of transgenerational epigenetic inheritance

(2022) Maximilian H. Fitz-James et al.   NATURE REVIEWS GENETICS

Association of Prenatal Famine Exposure With Inflammatory Markers and Its Impact on Adulthood Liver Function Across Consecutive Generations

(2022) Shiwei Yan et al.   Frontiers in Nutrition

ULK3-dependent activation of GLI1 promotes DNMT3A expression upon autophagy induction

(2022) Patricia González-Rodríguez et al.   Autophagy

Association of Parental Famine Exposure With Offspring Depression and Cognition Function

(2022) Ye Liu et al.   Frontiers in Psychiatry

Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity

(2022) Zhizhen Wang et al.   GeroScience

Balancing nutrient and energy demand and supply via autophagy

(2022) Congcong He   CURRENT BIOLOGY

Sex-specific DNA methylation: impact on human health and development

(2022) Priyanka Govender et al.   MOLECULAR GENETICS AND GENOMICS

Food abundance in men before puberty predicts a range of cancers in grandsons

(2022) Denny Vågerö et al.   Nature Communications

SGLT2 inhibitors as calorie restriction-mimetics: insights on longevity pathways and age-related diseases

(2021) Caroline W S Hoong et al.   ENDOCRINOLOGY

A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing

(2021) Yu-Xuan Lu et al.   eLife

Ganoderma lucidum stimulates autophagy-dependent longevity pathways in Caenorhabditis elegans and human cells

(2021) Hsin-Hsin Peng et al.   Aging-US

Autophagy in major human diseases

(2021) Daniel J Klionsky et al.   EMBO JOURNAL

Epigenetic Regulation of Autophagy Beyond the Cytoplasm: A Review

(2021) Yin Shi et al.   Frontiers in Cell and Developmental Biology

Caloric Restriction Mimetics in Nutrition and Clinical Trials

(2021) Sebastian J. Hofer et al.   Frontiers in Nutrition

Circadian autophagy drives iTRF-mediated longevity

(2021) Matt Ulgherait et al.   NATURE

Key Regulators of Autophagosome Closure

(2021) Wenyan Jiang et al.   Cells

Transient Autophagy Inhibition Precipitates Oncogenesis: A Red Flag For Pharmacological Autophagy Inhibitors?

(2020) Lorenzo Galluzzi et al.   TRENDS IN CELL BIOLOGY

Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk

(2020) Liam D. Cassidy et al.   Nature Communications

Verapamil extends lifespan in Caenorhabditis elegans by inhibiting calcineurin activity and promoting autophagy

(2020) Wenwen Liu et al.   Aging-US

Radiation Induces Autophagy via Histone H4 Lysine 20 Trimethylation in Non-small Cell Lung Cancer Cells

(2020) TAE-GUL LEE et al.   ANTICANCER RESEARCH

Sex differences in autophagy-mediated diseases: toward precision medicine

(2020) Dangtong Shang et al.   Autophagy

Long-term treatment with spermidine increases health span of middle-aged Sprague-Dawley male rats

(2020) Madalina Filfan et al.   GeroScience

Prenatal famine exposure and estimated glomerular filtration rate across consecutive generations: association and epigenetic mediation in a population-based cohort study in Suihua China

(2020) Wenbo Jiang et al.   Aging-US

Intergenerationally Maintained Histone H4 Lysine 16 Acetylation Is Instructive for Future Gene Activation

(2020) Maria Samata et al.   CELL

The DNA methyltransferase DNMT3A contributes to autophagy long-term memory

(2020) Patricia González-Rodríguez et al.   Autophagy

A Bioactive compound Shatavarin IV-mediated longevity as revealed by dietary restriction-induced autophagy in Caenorhabditis elegans

(2020) Shachi Shuchi Smita et al.   BIOGERONTOLOGY

C. elegans interprets bacterial non-coding RNAs to learn pathogenic avoidance

(2020) Rachel Kaletsky et al.   NATURE

Understanding 'Non-genetic' Inheritance: Insights from Molecular-Evolutionary Crosstalk

(2020) Irene Adrian-Kalchhauser et al.   TRENDS IN ECOLOGY & EVOLUTION

Hallmarks of Aging: An Autophagic Perspective

(2019) María Carolina Barbosa et al.   Frontiers in Endocrinology

Suppression of autophagic activity by Rubicon is a signature of aging

(2019) Shuhei Nakamura et al.   Nature Communications

The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species

(2019) Didac Carmona-Gutierrez et al.   Nature Communications

Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension

(2019) Ben Zhou et al.   CELL

Does Autophagy Promote Longevity? It Depends.

(2019) Marzia Savini et al.   CELL

Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK

(2019) Yuan Su et al.   Aging-US

Upregulation of the Autophagy Adaptor p62/SQSTM1 Prolongs Health and Lifespan in Middle-Aged Drosophila

(2019) Ricardo Aparicio et al.   Cell Reports

NAD+ in Brain Aging and Neurodegenerative Disorders

(2019) Sofie Lautrup et al.   Cell Metabolism

Early life starvation has stronger intra-generational than transgenerational effects on key life-history traits and consumption measures in a sawfly

(2019) Sarah Catherine Paul et al.   PLoS One

The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy

(2019) Caroline Kumsta et al.   Nature Communications

Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in C. elegans

(2019) Teresa Wei-sy Lee et al.   eLife

Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension

(2018) James H. Catterson et al.   CURRENT BIOLOGY

Spermidine in health and disease

(2018) Frank Madeo et al.   SCIENCE

Alterations in sperm DNA methylation, non-coding RNA and histone retention associate with DDT-induced epigenetic transgenerational inheritance of disease

(2018) Michael K. Skinner et al.   Epigenetics & Chromatin

Aspirin Recapitulates Features of Caloric Restriction

(2018) Federico Pietrocola et al.   Cell Reports

PALTEM: What Parameters Should Be Collected in Disaster Settings to Assess the Long-Term Outcomes of Famine?

(2018) Alexandra Moraru et al.   International Journal of Environmental Research and Public Health

Exposure to famine in early life and chronic kidney diseases in adulthood

(2018) Ningjian Wang et al.   Nutrition & Diabetes

Epigenetic Transgenerational Inheritance of Altered Sperm Histone Retention Sites

(2018) Millissia Ben Maamar et al.   Scientific Reports

Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians

(2018) Fu-Hui Xiao et al.   GENOME RESEARCH

Paternal grandfather’s access to food predicts all-cause and cancer mortality in grandsons

(2018) Denny Vågerö et al.   Nature Communications

Epigenetic Control of Autophagy: Nuclear Events Gain More Attention

(2017) Sung Hee Baek et al.   MOLECULAR CELL

Prenatal stress and epigenetics

(2017) L. Cao-Lei et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Autophagy-related protein Vps34 controls the homeostasis and function of antigen cross-presenting CD8α+dendritic cells

(2017) Vrajesh V. Parekh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caloric restriction improves health and survival of rhesus monkeys

(2017) Julie A. Mattison et al.   Nature Communications

The Epigenetic Link between Prenatal Adverse Environments and Neurodevelopmental Disorders

(2017) Marija Kundakovic et al.   Genes

Transgenerational programming of longevity through E(z)-mediated histone H3K27 trimethylation in Drosophila

(2016) Brian Xia et al.   Aging-US

Prenatal exposure to famine and the development of hyperglycemia and type 2 diabetes in adulthood across consecutive generations: a population-based cohort study of families in Suihua, China

(2016) Jie Li et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A Tunable Mechanism Determines the Duration of the Transgenerational Small RNA Inheritance in C. elegans

(2016) Leah Houri-Ze’evi et al.   CELL

Aging is associated with hypermethylation of autophagy genes in macrophages

(2016) Hany Khalil et al.   Epigenetics

Transgenerational effects of maternal diet on metabolic and reproductive ageing

(2016) Catherine E. Aiken et al.   MAMMALIAN GENOME

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

(2016) Alessandro Bitto et al.   eLife

Age-Associated Decrease of the Histone Methyltransferase SUV39H1 in HSC Perturbs Heterochromatin and B Lymphoid Differentiation

(2016) Dounia Djeghloul et al.   Stem Cell Reports

Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway

(2015) Fu-Zheng Wei et al.   Autophagy

Nutrient-sensing mechanisms and pathways

(2015) Alejo Efeyan et al.   NATURE

Disruption of histone methylation in developing sperm impairs offspring health transgenerationally

(2015) K. Siklenka et al.   SCIENCE

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

Longevity pathways converge on autophagy genes to regulate life span inCaenorhabditis elegans

(2014) Márton L. Tóth et al.   Autophagy

Cracking the survival code

(2014) Jens Füllgrabe et al.   Autophagy

Change in paternal grandmothers´ early food supply influenced cardiovascular mortality of the female grandchildren

(2014) Lars Bygren et al.   BMC GENETICS

Starvation-Induced Transgenerational Inheritance of Small RNAs in C. elegans

(2014) Oded Rechavi et al.   CELL

Epigenetic modification and inheritance in sexual reversal of fish

(2014) C. Shao et al.   GENOME RESEARCH

Accidentally enucleating autophagy

(2014) Bertrand Joseph   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

(2014) Ricki J. Colman et al.   Nature Communications

Sex Differences in Constitutive Autophagy

(2014) Sara Oliván et al.   Biomed Research International

Late-life rapamycin treatment reverses age-related heart dysfunction

(2013) James M. Flynn et al.   AGING CELL

Effects ofCaenorhabditis elegans sgk-1mutations on lifespan, stress resistance, and DAF-16/FoxO regulation

(2013) Albert Tzong-Yang Chen et al.   AGING CELL

Transgenerational effects of prenatal exposure to the 1944-45 Dutch famine

(2013) MVE Veenendaal et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation

(2013) L. Serrano et al.   GENES & DEVELOPMENT

Epigenetic Regulation of Autophagy by the Methyltransferase G9a

(2013) A. Artal-Martinez de Narvajas et al.   MOLECULAR AND CELLULAR BIOLOGY

Autophagy: A critical regulator of cellular metabolism and homeostasis

(2013) Stefan W. Ryter et al.   MOLECULES AND CELLS

The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy

(2013) Jens Füllgrabe et al.   NATURE

The return of the nucleus: transcriptional and epigenetic control of autophagy

(2013) Jens Füllgrabe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Overexpression of Atg5 in mice activates autophagy and extends lifespan

(2013) Jong-Ok Pyo et al.   Nature Communications

Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model

(2013) Baohua Liu et al.   Nature Communications

Impaired autophagic function in rat islets with aging

(2012) Yu Liu et al.   AGE

Gene expression analysis of mTOR pathway: association with human longevity

(2012) Willemijn M. Passtoors et al.   AGING CELL

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice

(2012) Vladimir N. Anisimov et al.   CELL CYCLE

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

Evaluation of Resveratrol, Green Tea Extract, Curcumin, Oxaloacetic Acid, and Medium-Chain Triglyceride Oil on Life Span of Genetically Heterogeneous Mice

(2012) R. Strong et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

(2012) Julie A. Mattison et al.   NATURE

Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice

(2012) J. Halloran et al.   NEUROSCIENCE

Circadian autophagy rhythm: a link between clock and metabolism?

(2012) Di Ma et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Heterochromatin Formation Promotes Longevity and Represses Ribosomal RNA Synthesis

(2012) Kimberly Larson et al.   PLoS Genetics

Dietary restriction in rats and mice: A meta-analysis and review of the evidence for genotype-dependent effects on lifespan

(2011) William R. Swindell   AGEING RESEARCH REVIEWS

The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner

(2011) Travis J. Maures et al.   AGING CELL

On the role of autophagy in human diseases: a gender perspective

(2011) Pasquale Lista et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

(2011) Eric L. Greer et al.   NATURE

DNA Methylation of the Gonadal Aromatase (cyp19a) Promoter Is Involved in Temperature-Dependent Sex Ratio Shifts in the European Sea Bass

(2011) Laia Navarro-Martín et al.   PLoS Genetics

Glucosamine induces autophagy via an mTOR-independent pathway

(2010) Tomoya Shintani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

The RUN Domain of Rubicon Is Important for hVps34 Binding, Lipid Kinase Inhibition, and Autophagy Suppression

(2010) Qiming Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

(2010) Richard A. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

(2010) Eric L. Greer et al.   NATURE

No Differences in the Sry Gene between Males and XY Females in Akodon (Rodentia, Cricetidae)

(2010) A. Sánchez et al.   Sexual Development

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

Essential Functions of the Histone Demethylase Lid

(2010) Ling Li et al.   PLoS Genetics

Inactivation of the Sas2 histone acetyltransferase delays senescence driven by telomere dysfunction

(2009) Marina L Kozak et al.   EMBO JOURNAL

Lifespan extension by suppression of autophagy genes inCaenorhabditis elegans

(2009) Yasufumi Hashimoto et al.   GENES TO CELLS

Histone H4 lysine 16 acetylation regulates cellular lifespan

(2009) Weiwei Dang et al.   NATURE

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance

(2009) A. P. Siebold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

(2008) Randy  Strong et al.   AGING CELL

Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life

(2008) RC Painter et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY