AMPK phosphorylates and stabilises copper transporter 1 to synergise metformin and copper chelator for breast cancer therapy

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SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions

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Copper Promotes Tumorigenesis by Activating the PDK1‐AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner

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(2021) Divya Ramchandani et al.   Nature Communications

Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma

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Cancer Pro-oxidant Therapy Through Copper Redox Cycling: Repurposing Disulfiram and Tetrathiomolybdate

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Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion

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A genome-scale CRISPR-Cas9 screening method for protein stability reveals novel regulators of Cdc25A

(2016) Yuanzhong Wu et al.   Cell Discovery

AMPK Protects Leukemia-Initiating Cells in Myeloid Leukemias from Metabolic Stress in the Bone Marrow

(2015) Yusuke Saito et al.   Cell Stem Cell

Anti-diabetic Drug Metformin: Challenges and Perspectives for Cancer Therapy

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Copper is required for oncogenic BRAF signalling and tumorigenesis

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AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

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Metformin induces unique biological and molecular responses in triple negative breast cancer cells

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