Transcription-Coupled Nucleotide Excision Repair and the Transcriptional Response to UV-Induced DNA Damage

Active DNA damage eviction by HLTF stimulates nucleotide excision repair

(2022) Marvin van Toorn et al.   MOLECULAR CELL

Crucial role and mechanism of transcription-coupled DNA repair in bacteria

(2022) Binod K. Bharati et al.   NATURE

Bacterial DNA excision repair pathways

(2022) Katherine J. Wozniak et al.   NATURE REVIEWS MICROBIOLOGY

CSB-independent, XPC-dependent transcription-coupled repair in Drosophila

(2022) Nazli Deger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1

(2022) Anna E. Herlihy et al.   DNA REPAIR

DNA damage-induced transcription stress triggers the genome-wide degradation of promoter-bound Pol II

(2022) Barbara Steurer et al.   Nature Communications

A CSB-PAF1C axis restores processive transcription elongation after DNA damage repair

(2021) Diana van den Heuvel et al.   Nature Communications

The 7SK/P-TEFb snRNP controls ultraviolet radiation-induced transcriptional reprogramming

(2021) Cécilia Studniarek et al.   Cell Reports

Structural basis of human transcription–DNA repair coupling

(2021) Goran Kokic et al.   NATURE

Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability

(2021) Marit E. Geijer et al.   NATURE CELL BIOLOGY

ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation

(2021) Yana van der Weegen et al.   NATURE CELL BIOLOGY

Dissecting regulatory pathways for transcription recovery following DNA damage reveals a non-canonical function of the histone chaperone HIRA

(2021) Déborah Bouvier et al.   Nature Communications

Cryo-EM structure of TFIIH/Rad4–Rad23–Rad33 in damaged DNA opening in nucleotide excision repair

(2021) Trevor van Eeuwen et al.   Nature Communications

Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response

(2021) Lee Mulderrig et al.   NATURE

Continuous transcription initiation guarantees robust repair of all transcribed genes and regulatory regions

(2020) Anastasios Liakos et al.   Nature Communications

Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair

(2020) Yuka Nakazawa et al.   CELL

Regulation of the RNAPII Pool Is Integral to the DNA Damage Response

(2020) Ana Tufegdžić Vidaković et al.   CELL

The 6-4 photoproduct is the trigger of UV-induced replication blockage and ATR activation

(2020) Kai-Feng Hung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II

(2020) Yana van der Weegen et al.   Nature Communications

A Genetic Map of the Response to DNA Damage in Human Cells

(2020) Michele Olivieri et al.   CELL

Nucleolar RNA polymerase II drives ribosome biogenesis

(2020) Karan J. Abraham et al.   NATURE

The involvement of nucleotide excision repair proteins in the removal of oxidative DNA damage

(2020) Namrata Kumar et al.   NUCLEIC ACIDS RESEARCH

Ubiquitin and TFIIH-stimulated DDB2 dissociation drives DNA damage handover in nucleotide excision repair

(2020) Cristina Ribeiro-Silva et al.   Nature Communications

Causes and consequences of RNA polymerase II stalling during transcript elongation

(2020) Melvin Noe Gonzalez et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress

(2019) Andrii Bugai et al.   MOLECULAR CELL

Analysis of RNA polymerase II ubiquitylation and proteasomal degradation

(2019) Ana Tufegdzic Vidakovic et al.   METHODS

Structural basis of TFIIH activation for nucleotide excision repair

(2019) Goran Kokic et al.   Nature Communications

De Novo Heterozygous POLR2A Variants Cause a Neurodevelopmental Syndrome with Profound Infantile-Onset Hypotonia

(2019) Hanneke A. Haijes et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Multisystem analyses of two Cockayne syndrome associated proteins CSA and CSB reveal shared and unique functions

(2019) Zhenzhen Wu et al.   DNA REPAIR

Drosophila, which lacks canonical transcription-coupled repair proteins, performs transcription-coupled repair

(2019) Nazli Deger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA damage response and repair in perspective: Aedes aegypti, Drosophila melanogaster and Homo sapiens

(2019) Maria Beatriz S. Mota et al.   Parasites & Vectors

The Integrator Complex Attenuates Promoter-Proximal Transcription at Protein-Coding Genes

(2019) Nathan D. Elrod et al.   MOLECULAR CELL

A key interaction with RPA orients XPA in NER complexes

(2019) Agnieszka M Topolska-Woś et al.   NUCLEIC ACIDS RESEARCH

The transcription-coupled DNA repair-initiating protein CSB promotes XRCC1 recruitment to oxidative DNA damage

(2018) Hervé Menoni et al.   NUCLEIC ACIDS RESEARCH

Mechanistic insights in transcription-coupled nucleotide excision repair of ribosomal DNA

(2018) Laurianne Daniel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Cellular Response to Transcription-Blocking DNA Damage

(2018) Lea H. Gregersen et al.   TRENDS IN BIOCHEMICAL SCIENCES

p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage

(2018) Marina E. Borisova et al.   Nature Communications

Single-nucleotide resolution analysis of nucleotide excision repair of ribosomal DNA in humans and mice

(2018) Yanyan Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage

(2017) Juston C. Weems et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA polymerase II is released from the DNA template during transcription-coupled repair in mammalian cells

(2017) Yi-Ying Chiou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Senataxin: Genome Guardian at the Interface of Transcription and Neurodegeneration

(2017) Matthias Groh et al.   JOURNAL OF MOLECULAR BIOLOGY

Cockayne’s Syndrome A and B Proteins Regulate Transcription Arrest after Genotoxic Stress by Promoting ATF3 Degradation

(2017) Alexey Epanchintsev et al.   MOLECULAR CELL

Structural basis for the initiation of eukaryotic transcription-coupled DNA repair

(2017) Jun Xu et al.   NATURE

Common TFIIH recruitment mechanism in global genome and transcription-coupled repair subpathways

(2017) Masahiko Okuda et al.   NUCLEIC ACIDS RESEARCH

Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate

(2017) Matthieu D. Lavigne et al.   Nature Communications

Major Roles for Pyrimidine Dimers, Nucleotide Excision Repair, and ATR in the Alternative Splicing Response to UV Irradiation

(2017) Manuel J. Muñoz et al.   Cell Reports

Nucleotide Excision Repair and Transcriptional Regulation: TFIIH and Beyond

(2016) Emmanuel Compe et al.   Annual Review of Biochemistry

Cockayne syndrome-derived neurons display reduced synapse density and altered neural network synchrony

(2016) Alexandre T. Vessoni et al.   HUMAN MOLECULAR GENETICS

Cullin–RING ubiquitin E3 ligase regulation by the COP9 signalosome

(2016) Simone Cavadini et al.   NATURE

Deep phenotyping of 89 xeroderma pigmentosum patients reveals unexpected heterogeneity dependent on the precise molecular defect

(2016) Hiva Fassihi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BMI1–UBR5 axis regulates transcriptional repression at damaged chromatin

(2016) Anthony Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SRSF10 Connects DNA Damage to the Alternative Splicing of Transcripts Encoding Apoptosis, Cell-Cycle Control, and DNA Repair Factors

(2016) Lulzim Shkreta et al.   Cell Reports

Pharmacological Bypass of Cockayne Syndrome B Function in Neuronal Differentiation

(2016) Yuming Wang et al.   Cell Reports

Multiomic Analysis of the UV-Induced DNA Damage Response

(2016) Stefan Boeing et al.   Cell Reports

Genome-wide analysis of human global and transcription-coupled excision repair of UV damage at single-nucleotide resolution

(2015) Jinchuan Hu et al.   GENES & DEVELOPMENT

The C-terminal Region and SUMOylation of Cockayne Syndrome Group B Protein Play Critical Roles in Transcription-coupled Nucleotide Excision Repair

(2015) Yooksil Sin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Photosensitive human syndromes

(2015) Graciela Spivak et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The core spliceosome as target and effector of non-canonical ATM signalling

(2015) Maria Tresini et al.   NATURE

DNA repair and recovery of RNA synthesis following exposure to ultraviolet light are delayed in long genes

(2015) Leonardo C. Andrade-Lima et al.   NUCLEIC ACIDS RESEARCH

DNA Ligases I and III Support Nucleotide Excision Repair in DT40 Cells with Similar Efficiency

(2015) Katja Paul-Konietzko et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Structural Insight into the Mechanism of TFIIH Recognition by the Acidic String of the Nucleotide Excision Repair Factor XPC

(2015) Masahiko Okuda et al.   STRUCTURE

SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair

(2015) Loes van Cuijk et al.   Nature Communications

Ubiquitin-specific Protease 7 Regulates Nucleotide Excision Repair through Deubiquitinating XPC Protein and Preventing XPC Protein from Undergoing Ultraviolet Light-induced and VCP/p97 Protein-regulated Proteolysis

(2014) Jinshan He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysregulation of gene expression as a cause of Cockayne syndrome neurological disease

(2014) Yuming Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cockayne syndrome B protein is essential for neuronal differentiation and neuritogenesis

(2014) F Ciaffardini et al.   Cell Death & Disease

Proteasome-Mediated Processing of Def1, a Critical Step in the Cellular Response to Transcription Stress

(2013) Marcus D. Wilson et al.   CELL

Transcription Recovery after DNA Damage Requires Chromatin Priming by the H3.3 Histone Chaperone HIRA

(2013) Salomé Adam et al.   CELL

DNA Quality Control by a Lesion Sensor Pocket of the Xeroderma Pigmentosum Group D Helicase Subunit of TFIIH

(2013) Nadine Mathieu et al.   CURRENT BIOLOGY

Blinded by the UV light: How the focus on transcription-coupled NER has distracted from understanding the mechanisms of Cockayne syndrome neurologic disease

(2013) P.J. Brooks   DNA REPAIR

Nucleotide Excision Repair in Human Cells

(2013) Jinchuan Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response

(2013) Sara L. Poulsen et al.   JOURNAL OF CELL BIOLOGY

Cockayne syndrome: The expanding clinical and mutational spectrum

(2013) Vincent Laugel   MECHANISMS OF AGEING AND DEVELOPMENT

Enhanced Chromatin Dynamics by FACT Promotes Transcriptional Restart after UV-Induced DNA Damage

(2013) Christoffel Dinant et al.   MOLECULAR CELL

Alternative splicing: a pivotal step between eukaryotic transcription and translation

(2013) Alberto R. Kornblihtt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A bacterial-like mechanism for transcription termination by the Sen1p helicase in budding yeast

(2013) Odil Porrua et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Comet-FISH with strand-specific probes reveals transcription-coupled repair of 8-oxoGuanine in human cells

(2013) Jia Guo et al.   NUCLEIC ACIDS RESEARCH

Regulatory interplay of Cockayne syndrome B ATPase and stress-response gene ATF3 following genotoxic stress

(2013) U. Kristensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ELL, a novel TFIIH partner, is involved in transcription restart after DNA repair

(2013) S. Mourgues et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone Methyltransferase DOT1L Drives Recovery of Gene Expression after a Genotoxic Attack

(2013) Valentyn Oksenych et al.   PLoS Genetics

Ubiquitylation and degradation of elongating RNA polymerase II: The last resort

(2012) Marcus D. Wilson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Mechanism of Release and Fate of Excised Oligonucleotides during Nucleotide Excision Repair

(2012) Michael G. Kemp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KIAA1530 Protein Is Recruited by Cockayne Syndrome Complementation Group Protein A (CSA) to Participate in Transcription-coupled Repair (TCR)

(2012) Jia Fei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Shining a Light on Xeroderma Pigmentosum

(2012) John J. DiGiovanna et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair

(2012) Yuka Nakazawa et al.   NATURE GENETICS

Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair

(2012) Xue Zhang et al.   NATURE GENETICS

UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair

(2012) Petra Schwertman et al.   NATURE GENETICS

Sirt1 suppresses RNA synthesis after UV irradiation in combined xeroderma pigmentosum group D/Cockayne syndrome (XP-D/CS) cells

(2012) R. Velez-Cruz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Molecular Basis of CRL4DDB2/CSA Ubiquitin Ligase Architecture, Targeting, and Activation

(2011) Eric S. Fischer et al.   CELL

UV-induced photolesions elicit ATR-kinase-dependent signaling in non-cycling cells through nucleotide excision repair-dependent and -independent pathways

(2011) M. G. Vrouwe et al.   JOURNAL OF CELL SCIENCE

Sub1 and RPA Associate with RNA Polymerase II at Different Stages of Transcription

(2011) Timothy W. Sikorski et al.   MOLECULAR CELL

The Ewing Sarcoma Protein Regulates DNA Damage-Induced Alternative Splicing

(2011) Maria Paola Paronetto et al.   MOLECULAR CELL

A semi-automated non-radioactive system for measuring recovery of RNA synthesis and unscheduled DNA synthesis using ethynyluracil derivatives

(2010) Yuka Nakazawa et al.   DNA REPAIR

A Ubiquitin-Binding Domain in Cockayne Syndrome B Required for Transcription-Coupled Nucleotide Excision Repair

(2010) Roy Anindya et al.   MOLECULAR CELL

Three DNA Polymerases, Recruited by Different Mechanisms, Carry Out NER Repair Synthesis in Human Cells

(2010) Tomoo Ogi et al.   MOLECULAR CELL

DNA Damage Regulates Alternative Splicing through Inhibition of RNA Polymerase II Elongation

(2009) Manuel J. Muñoz et al.   CELL

Trichothiodystrophy: From basic mechanisms to clinical implications

(2009) M. Stefanini et al.   DNA REPAIR

Coordination of dual incision and repair synthesis in human nucleotide excision repair

(2009) Lidija Staresincic et al.   EMBO JOURNAL

Two-Step Recognition of DNA Damage for Mammalian Nucleotide Excision Repair: Directional Binding of the XPC Complex and DNA Strand Scanning

(2009) Kaoru Sugasawa et al.   MOLECULAR CELL

Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation

(2009) M. Harreman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of UV DNA-Damage Recognition by the DDB1–DDB2 Complex

(2008) Andrea Scrima et al.   CELL

Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1

(2008) Takashi Yasukawa et al.   EMBO JOURNAL

Multiple Mechanisms Contribute to Inhibit Transcription in Response to DNA Damage

(2008) George F. Heine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleotide Excision Repair Driven by the Dissociation of CAK from TFIIH

(2008) Frédéric Coin et al.   MOLECULAR CELL