Cytosolic calcium: Judge, jury and executioner of neurodegeneration in Alzheimer's disease and beyond

Oral nimodipine treatment has no effect on amyloid pathology or neuritic dystrophy in the 5XFAD mouse model of amyloidosis

(2022) Katherine R. Sadleir et al.   PLoS One

Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca 2+ efflux and disrupted by PSEN1 loss of function

(2022) Pearl P. Y. Lie et al.   Science Advances

CaMKIIβ knockdown decreases store-operated calcium entry in hippocampal dendritic spines

(2022) Nikita Zernov et al.   IBRO Neuroscience Reports

Association of AK4 Protein From Stem Cell–Derived Neurons With Cognitive Reserve: An Autopsy Study

(2022) Lei Yu et al.   NEUROLOGY

Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer’s disease

(2022) Disha Shah et al.   Cell Reports

Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer’s disease

(2022) Sarah Mustaly-Kalimi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer’s disease pathology: From antioxidant to epigenetic therapy

(2021) Christian Griñán-Ferré et al.   AGEING RESEARCH REVIEWS

Key Disease Mechanisms Linked to Alzheimer’s Disease in the Entorhinal Cortex

(2021) Virginie Bottero et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Elevating the Levels of Calcium Ions Exacerbate Alzheimer’s Disease via Inducing the Production and Aggregation of β-Amyloid Protein and Phosphorylated Tau

(2021) Pei-Pei Guan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An Unbalanced Synaptic Transmission: Cause or Consequence of the Amyloid Oligomers Neurotoxicity?

(2021) Miriam Sciaccaluga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors

(2021) Valentina N. Lagomarsino et al.   NEURON

RyR-mediated Ca2+ release elicited by neuronal activity induces nuclear Ca2+ signals, CREB phosphorylation, and Npas4/RyR2 expression

(2021) Pedro Lobos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human-Induced Neurons from Presenilin 1 Mutant Patients Model Aspects of Alzheimer’s Disease Pathology

(2020) Sean Schrank et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Opposite changes in APP processing and human Aβ levels in rats carrying either a protective or a pathogenic APP mutation

(2020) Marc D Tambini et al.   eLife

Dantrolene Ameliorates Impaired Neurogenesis and Synaptogenesis in Induced Pluripotent Stem Cell Lines Derived from Patients with Alzheimer’s Disease

(2020) Yong Wang et al.   ANESTHESIOLOGY

Transcriptomic and Network Analysis Identifies Shared and Unique Pathways across Dementia Spectrum Disorders

(2020) Jose A. Santiago et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tau‐induced upregulation of C/EBPβ‐TRPC1‐SOCE signaling aggravates tauopathies: A vicious cycle in Alzheimer neurodegeneration

(2020) Jinwang Ye et al.   AGING CELL

Dissecting Alzheimer’s disease pathogenesis in human 2D and 3D models

(2020) Giovanna Cenini et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Enhanced Neuronal Activity and Asynchronous Calcium Transients Revealed in a 3D Organoid Model of Alzheimer’s Disease

(2020) Juan Yin et al.   ACS Biomaterials-Science & Engineering

Alterations of the Endoplasmic Reticulum (ER) Calcium Signaling Molecular Components in Alzheimer’s Disease

(2020) Mounia Chami et al.   Cells

Ca2+ Dyshomeostasis Disrupts Neuronal and Synaptic Function in Alzheimer’s Disease

(2020) John McDaid et al.   Cells

Mitochondria and Calcium in Alzheimer’s Disease: From Cell Signaling to Neuronal Cell Death

(2020) Maria Calvo-Rodriguez et al.   TRENDS IN NEUROSCIENCES

Mitochondrial dysfunction in Alzheimer's disease: Role in pathogenesis and novel therapeutic opportunities

(2019) Judit M. Perez Ortiz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Computational identification of key genes that may regulate gene expression reprogramming in Alzheimer’s patients

(2019) Judith A. Potashkin et al.   PLoS One

Meta-Analysis of Gene Expression Changes in the Blood of Patients with Mild Cognitive Impairment and Alzheimer’s Disease Dementia

(2019) Virginie Bottero et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alzheimer’s Disease, Dendritic Spines, and Calcineurin Inhibitors: A New Approach?

(2018) Melissa A. O’Neal et al.   ACS Chemical Neuroscience

Calcium Signaling Deficits in Glia and Autophagic Pathways Contributing to Neurodegenerative Disease

(2018) Sarah Mustaly-Kalimi et al.   ANTIOXIDANTS & REDOX SIGNALING

The amyloid hypothesis on trial

(2018) Simon Makin   NATURE

Pathological Impacts of Chronic Hypoxia on Alzheimer’s Disease

(2018) Feng Zhang et al.   ACS Chemical Neuroscience

RyR2-Mediated Ca2+ Release and Mitochondrial ROS Generation Partake in the Synaptic Dysfunction Caused by Amyloid β Peptide Oligomers

(2017) Carol D. SanMartín et al.   Frontiers in Molecular Neuroscience

Regulation of lysosomal dynamics and autophagy by CTSB/cathepsin B

(2016) Si Ming Man et al.   Autophagy

Vitamin D, reactive oxygen species and calcium signalling in ageing and disease

(2016) Michael J. Berridge   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice

(2015) Adam C. Kaufman et al.   ANNALS OF NEUROLOGY

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

(2015) Celeste M. Karch et al.   BIOLOGICAL PSYCHIATRY

Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

(2015) Ju-Hyun Lee et al.   Cell Reports

A Voltage-Gated Calcium Channel Regulates Lysosomal Fusion with Endosomes and Autophagosomes and Is Required for Neuronal Homeostasis

(2015) Xuejun Tian et al.   PLOS BIOLOGY

Calcium and ROS: A mutual interplay

(2015) Agnes Görlach et al.   Redox Biology

Memantine Monotherapy for Alzheimer’s Disease: A Systematic Review and Meta-Analysis

(2015) Shinji Matsunaga et al.   PLoS One

Physiological release of endogenous tau is stimulated by neuronal activity

(2013) Amy M Pooler et al.   EMBO REPORTS

Calcium regulation of neural rhythms, memory and Alzheimer's disease

(2013) Michael J. Berridge   JOURNAL OF PHYSIOLOGY-LONDON

Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

(2013) Ji Won Um et al.   NEURON

The synaptic plasticity and memory hypothesis: encoding, storage and persistence

(2013) T. Takeuchi et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

Calpains, mitochondria, and apoptosis

(2012) M. A. Smith et al.   CARDIOVASCULAR RESEARCH

Common Transcriptional Signatures in Brain Tissue from Patients with HIV-Associated Neurocognitive Disorders, Alzheimer’s Disease, and Multiple Sclerosis

(2012) Alejandra Borjabad et al.   Journal of Neuroimmune Pharmacology

Age-dependent alterations in the presynaptic active zone in a Drosophila model of Alzheimer's Disease

(2012) Jian-Kang Huang et al.   NEUROBIOLOGY OF DISEASE

Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice

(2012) Jun Peng et al.   NEUROSCIENCE LETTERS

Disturbed Ca2+ Homeostasis Increases Glutaminyl Cyclase Expression; Connecting Two Early Pathogenic Events in Alzheimer’s Disease In Vitro

(2012) Line De Kimpe et al.   PLoS One

Stabilizing ER Ca2+ Channel Function as an Early Preventative Strategy for Alzheimer’s Disease

(2012) Shreaya Chakroborty et al.   PLoS One

Primary lysosomal dysfunction causes cargo-specific deficits of axonal transport leading to Alzheimer-like neuritic dystrophy

(2011) SooYeon Lee et al.   Autophagy

A Role for Calcineurin in Alzheimers Disease

(2011) Lindsay C. Reese et al.   Current Neuropharmacology

Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease

(2011) Angela M. Bruno et al.   NEUROBIOLOGY OF AGING

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

Calcium Ions Promote Formation of Amyloid β-Peptide (1–40) Oligomers Causally Implicated in Neuronal Toxicity of Alzheimer's Disease

(2011) Anna Itkin et al.   PLoS One

Mitochondria and Neuroplasticity

(2010) Aiwu Cheng et al.   ASN Neuro

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

Calpain Activation Promotes BACE1 Expression, Amyloid Precursor Protein Processing, and Amyloid Plaque Formation in a Transgenic Mouse Model of Alzheimer Disease

(2010) Bin Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium Signaling and Amyloid Toxicity in Alzheimer Disease

(2010) Angelo Demuro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gain-of-Function Enhancement of IP3 Receptor Modal Gating by Familial Alzheimer's Disease-Linked Presenilin Mutants in Human Cells and Mouse Neurons

(2010) K.-H. Cheung et al.   Science Signaling

Ryanodine Receptors: Structure, Expression, Molecular Details, and Function in Calcium Release

(2010) J. T. Lanner et al.   Cold Spring Harbor Perspectives in Biology

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

(2009) Paula I. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Tumor Necrosis Factor-α-mediated Regulation of the Inositol 1,4,5-Trisphosphate Receptor Promoter

(2009) Keigan M. Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

(2009) Diane P. Hanger et al.   TRENDS IN MOLECULAR MEDICINE

The N-terminus of presenilin-2 increases single channel activity of brain ryanodine receptors through direct protein–protein interaction

(2008) Volodya Hayrapetyan et al.   CELL CALCIUM

Ca2+ Signaling, Mitochondria and Cell Death

(2008) Paolo Pinton et al.   CURRENT MOLECULAR MEDICINE

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES