Review
Chemistry, Multidisciplinary
Kaixuan Chen, Xing Guo, Mao Chen
Summary: Fluoropolymers have been widely used in industry and academia for their unique physicochemical properties over the past 80 years. Copolymerizations of fluoroalkene feedstocks provide an important pathway to obtain high-performance materials by combining the intrinsic attributes of fluorocarbons and the versatility of comonomers. This minireview discusses the challenges and recent progress in controlled radical copolymerizations of fluoroalkenes with non-fluorinated vinyl comonomers, enabling the preparation of various main-chain fluoropolymers with specific characteristics for high-tech applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Dmitry S. Belov, Gabriela Tejeda, Charlene Tsay, Konstantin V. Bukhryakov
Summary: Vanadium-based catalysts have been demonstrated to catalyze ring-closing olefin metathesis reactions by well-defined V chloride alkylidene phosphine complexes, exhibiting good functional group tolerance. The properties of the imido group and phosphine were found to play a crucial role in the stability of active intermediates.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Inorganic & Nuclear
Jiaqi Liu, Shannen C. Lorraine, Brian S. Dolinar, Jessica M. Hoover
Summary: This paper describes the synthesis and reactivity studies of three cobalt complexes with aminophenol-derived ligands without nitrogen substitution. The catalytic competency of these complexes in the aerobic oxidative cyclization reaction is demonstrated, and the oxidation process from cobalt(II) to cobalt(III) is shown to proceed through a ligand-based radical intermediate.
INORGANIC CHEMISTRY
(2022)
Article
Polymer Science
Hien The Ho, Veronique Montembault, Sagrario Pascual, Laurent Fontaine, Didier Gigmes, Trang N. T. Phan
Summary: A novel alkyl iodide compound was synthesized and used as an initiator for polymerization reactions. The new initiator showed high efficiency in producing functional polymers through thermal and photochemical activation.
Article
Polymer Science
Wei Sun, Xiang Shen, Jingrui Liu, Zhaoqiang Wu, Hong Chen
Summary: The study combines photoiniferter living free radical polymerization with organocatalytic ring-opening polymerization (ROP) to design a hydroxyl-functionalized carbamodithioate that can integrate different monomers. The results confirm that the two polymerization systems are experimentally compatible and can be used to synthesize block copolymers. This method provides a simple and efficient way to access well-defined block copolymers from a larger range of monomers, which is more advantageous from the operational, economical, and environmental points of view.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Grant A. L. Bare, Gerald F. Joyce
Summary: Informational macromolecules in biology, such as nucleic acids and proteins, typically have specific chirality. However, recent research has shown that it is possible to amplify RNA molecules of opposite chirality using a specific enzyme, providing a potential for the evolution of cross-chiral RNA polymerases.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Physical
Kyle M. Kirkpatrick, Benjamin H. Zhou, Philip C. Bunting, Jeffrey D. Rinehart
Summary: In this study, two new forms of iron oleate precursor were characterized, which can lead to reproducible and predictable reactivity, and produce tunable iron oxide nanoparticles.
CHEMISTRY OF MATERIALS
(2022)
Article
Chemistry, Inorganic & Nuclear
Keshav Paudel, Shi Xu, Oleksandr Hietsoi, Bedraj Pandey, Chuka Onuh, Keying Ding
Summary: The presence of base plays a crucial role in determining the selectivity of the imine and amine synthesis process. A catalytic amount of base leads to imine formation, while an excess loading of base results in amine product. The product selectivity also strongly depends on the organometallic catalysts used.
Article
Polymer Science
Brian J. Ree, Yusuke Satoh, Kyeong Sik Jin, Takuya Isono, Toshifumi Satoh
Summary: This study provides insights into the micellization behavior and morphologies of bicyclic amphiphiles, showing that different topologies result in distinct structural properties of nanomicelles. The findings suggest that topology-controlled bicyclic block copolymers can be used in various applications, such as drug delivery, biomedical imaging, cosmetics, coating appliances, and molecular electronics.
Article
Polymer Science
Jinfeng Shi, Zhengyang Liu, Na Zhao, Shaofeng Liu, Zhibo Li
Summary: This contribution demonstrates an efficient strategy to synthesize well-defined functional polysiloxanes using phosphazene as an organocatalyst. Linear poly(dimethylsiloxane)s (PDMSs) with different end-groups were successfully synthesized by C3N3-Me-P3-catalyzed ring-opening polymerization (ROP) and subsequent end-capping reactions. The resulting PDMSs were characterized by various techniques and showed narrow distributions and well-defined structures.
Article
Multidisciplinary Sciences
Yan Zhou, Xuexia Xu, Yifeng Wei, Yu Cheng, Yu Guo, Ivan Khudyakov, Fuli Liu, Ping He, Zhangyue Song, Zhi Li, Yan Gao, Ee Lui Ang, Huimin Zhao, Yan Zhang, Suwen Zhao
Summary: This study reports a multi-enzyme system that supports Z-genome synthesis and identifies globally widespread phages harboring such enzymes. The Z genome in phages provides evolutionary advantages in evading host restriction enzymes, and the characterization of its biosynthetic pathway enables large-scale production of Z-DNA for diverse applications.
Article
Biochemistry & Molecular Biology
So Young Bak, Youngri Jung, Jinho Park, Keewon Sung, Hyeon-Ki Jang, Sangsu Bae, Seong Keun Kim
Summary: This study utilized single-molecule FRET assay to investigate the dynamics of DNA:RNA heteroduplexation for various engineered Cas9 variants, revealing a strong correlation between their conformational structure and nuclease activity. Quantitative analysis showed that these engineered Cas9 variants exhibit a more rapid decrease in cleavage-competent state with increasing base-pair mismatch, leading to enhanced target specificity. The critical specificity enhancement step was found to be activated during DNA:RNA heteroduplexation for some variants, highlighting the importance of conformational dynamics in Cas9 target specificity.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Multidisciplinary Sciences
Yuangao Wang, Meng Wang, Mohamed Nadhir Djekidel, Huan Chen, Di Liu, Frederick W. Alt, Yi Zhang
Summary: By developing a new eccDNA purification and profiling method, the study revealed close-to-random genomic origination, mechanism of biogenesis and function of eccDNAs.
Article
Chemistry, Physical
L. Reginald Mills, David Gygi, Jacob R. Ludwig, Eric M. Simmons, Steven R. Wisniewski, Junho Kim, Paul J. Chirik
Summary: In this study, efficient precatalysts for the C(sp(2))-C(sp(3)) Suzuki-Miyaura cross-coupling reaction between alkyl bromides and neopentylglycol (hetero)arylboronic esters were generated in situ using Cobalt(II) halides in combination with phenoxyimine (FI) ligands. The protocol allowed for efficient C-C bond formation with various nucleophiles and electrophiles. The results also suggested that alkyl radicals play an important role in the catalytic reaction.
Review
Chemistry, Organic
Ernesto Rufino-Felipe, Hugo Valdes, David Morales-Morales
Summary: This review discusses the application of well-defined copper and nickel complexes in C-S bond formation reactions. Cu and Ni catalysts have the advantage of being more abundant and cheaper than precious metal-based catalysts like Pd. The catalytic activity of Cu and Ni complexes strongly depends on the nature of the ligands used, and multidentate, strong electron-donating ligands are commonly used to design highly active species. The reaction mechanisms and the role of different ligands in the catalytic processes using copper and nickel complexes as catalysts are also discussed. While there is an increasing number of reports on C-S cross coupling reactions, they are often difficult to reproduce and lack generality due to the unidentified catalytic species. Therefore, this review aims to promote the search and synthesis of new ligands for designing more active, well-defined complexes that can be used as catalysts in C-S bond formation reactions.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Puzhou Wang, Scott K. Silverman
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2016)
Article
Biochemistry & Molecular Biology
Alison J. Camden, Shannon M. Walsh, Sarah H. Suk, Scott K. Silverman
Article
Chemistry, Multidisciplinary
Cong Zhou, Joshua L. Avins, Paul C. Klauser, Benjamin M. Brandsen, Yujeong Lee, Scott K. Silverman
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2016)
Article
Biochemistry & Molecular Biology
Qingke Li, Qu Chen, Paul C. Klauser, Mengyuan Li, Feng Zheng, Nanxi Wang, Xiaoying Li, Qianbing Zhang, Xuemei Fu, Qian Wang, Yang Xu, Lei Wang
Article
Chemistry, Multidisciplinary
Jun Liu, Rujin Cheng, Ned Van Eps, Nanxi Wang, Takefumi Morizumi, Wei-Lin Ou, Paul C. Klauser, Sharon Rozovsky, Oliver P. Ernst, Lei Wang
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Biochemistry & Molecular Biology
Viktoriya Y. Berdan, Paul C. Klauser, Lei Wang
Summary: Drugs with a covalent mechanism of action have advantages in potency, selectivity, and in vivo efficacy. While traditionally limited to small molecules, recent advancements in peptide and protein therapeutics have allowed for the targeting of previously undruggable proteins and protein-protein interactions using covalent mechanisms.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Jun Liu, Li Cao, Paul C. Klauser, Rujin Cheng, Viktoriya Y. Berdan, Wei Sun, Nanxi Wang, Farid Ghelichkhani, Bingchen Yu, Sharon Rozovsky, Lei Wang
Summary: Introducing novel chemical bonds into proteins offers innovative possibilities, with the incorporation of latent bioreactive unnatural amino acids providing a powerful system for covalent targeting of natural residues. This approach has potential applications in biochemical research and protein engineering.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Multidisciplinary Sciences
Fan Lam, James Chu, Ji Sun Choi, Chang Cao, T. Kevin Hitchens, Scott K. Silverman, Zhi-Pei Liang, Ryan N. Dilger, Gene E. Robinson, King C. Li
Summary: This study presents a new method called epigenetic MRI (eMRI) that allows nondestructive measurement of global gene expression in the brain by directly imaging DNA methylation. The method uses C-13-enriched diets to label DNA through methionine metabolic pathways, and a C-13 magnetic resonance spectroscopic imaging technique to map the spatial distribution of labeled DNA. The study validated eMRI using pigs and discovered regional differences in global DNA methylation. The eMRI signal has the potential to enable new investigations of human brain function, behavior, and disease.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Organic
Shukun Yang, Scott K. Silverman
Summary: In this study, DNAzymes that catalyze reductive amination reactions were discovered. They were able to catalyze the reaction between the aliphatic amino group on DNA oligonucleotides and the benzaldehyde group on DNA molecules. However, these DNAzymes were not able to catalyze reactions with more complex substrates. These findings establish the substrate scope of DNAzyme catalysis for reductive amination.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Paul C. Klauser, Viktoriya Y. Berdan, Li Cao, Lei Wang
Summary: The introduction of new covalent bonds into proteins has provided novel avenues for protein research and applications, but generating covalent linkages remains challenging. In this study, genetically encoded mFSY selectively reacted with specific amino acids, allowing successful engineering of various proteins into covalent binders.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Tianjiong Yao, Jack J. Przybyla, Peter Yeh, Austin M. Woodard, Hannah J. Nilsson, Benjamin M. Brandsen, Scott K. Silverman
Summary: DNAzymes were identified through in vitro selection for catalyzing acylation reactions on amine groups, including lysine side chains of DNA-anchored peptides, using suitably reactive aryl ester acyl donors as electrophiles. These findings expand the catalytic scope of DNAzymes and suggest potential broader applications for sequence-selective lysine acylation of peptides and proteins in the future.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)