A Genetically Encoded Fluorosulfonyloxybenzoyl-l-lysine for Expansive Covalent Bonding of Proteins via SuFEx Chemistry

Developing Covalent Protein Drugs via Proximity-Enabled Reactive Therapeutics

(2020) Qingke Li et al.   CELL

Covalent peptides and proteins for therapeutics

(2020) Viktoriya Y. Berdan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Genetically Encoding Photocaged Quinone Methide to Multitarget Protein Residues Covalently in Vivo

(2019) Jun Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase

(2019) Qinheng Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Site-Specific Incorporation of a Thioester Containing Amino Acid into Proteins

(2018) Weimin Xuan et al.   ACS Chemical Biology

SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization

(2018) Zilei Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-Specific Incorporation of Selenocysteine Using an Expanded Genetic Code and Palladium-Mediated Chemical Deprotection

(2018) Jun Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genetically Encoding Fluorosulfate-l-tyrosine To React with Lysine, Histidine, and Tyrosine via SuFEx in Proteins in Vivo

(2018) Nanxi Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Emerging Utility of Fluorosulfate Chemical Probes

(2018) Lyn H. Jones   ACS Medicinal Chemistry Letters

Genetically encoding new bioreactivity

(2017) Lei Wang   New Biotechnology

Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions

(2017) Bing Yang et al.   Nature Communications

Using Protein-Confined Proximity To Determine Chemical Reactivity

(2016) Tomonori Kobayashi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue

(2016) Wentao Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Situ Formation of an Azo Bridge on Proteins Controllable by Visible Light

(2015) Christian Hoppmann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genetically Encoding an Electrophilic Amino Acid for Protein Stapling and Covalent Binding to Native Receptors

(2014) Xiao-Hua Chen et al.   ACS Chemical Biology

Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry

(2014) Jiajia Dong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Proximity-Enabled Protein Crosslinking through Genetically Encoding Haloalkane Unnatural Amino Acids

(2014) Zheng Xiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genetically Encoding Photoswitchable Click Amino Acids inEscherichia coliand Mammalian Cells

(2014) Christian Hoppmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Genetically Encoded aza-Michael Acceptor for Covalent Cross-Linking of Protein–Receptor Complexes

(2014) Jennifer L. Furman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genetically Encoded Chemical Probes in Cells Reveal the Binding Path of Urocortin-I to CRF Class B GPCR

(2013) Irene Coin et al.   CELL

The thioredoxin antioxidant system

(2013) Jun Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Adding an unnatural covalent bond to proteins through proximity-enhanced bioreactivity

(2013) Zheng Xiang et al.   NATURE METHODS

Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains

(2013) Karl R. Schmitz et al.   STRUCTURE

Stereochemical Basis for Engineered Pyrrolysyl-tRNA Synthetase and the Efficientin VivoIncorporation of Structurally Divergent Non-native Amino Acids

(2011) Jeffrey K. Takimoto et al.   ACS Chemical Biology