Repurposing ketamine to treat cocaine use disorder: integration of artificial intelligence‐based prediction, expert evaluation, clinical corroboration and mechanism of action analyses

COVID-19 breakthrough infections, hospitalizations and mortality in fully vaccinated patients with hematologic malignancies: A clarion call for maintaining mitigation and ramping-up research

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Comparison of mRNA-1273 and BNT162b2 Vaccines on Breakthrough SARS-CoV-2 Infections, Hospitalizations, and Death During the Delta-Predominant Period

(2022) Lindsey Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Deep learning for drug repurposing: Methods, databases, and applications

(2022) Xiaoqin Pan et al.   Wiley Interdisciplinary Reviews-Computational Molecular Science

COVID‐19 breakthrough infections and hospitalizations among vaccinated patients with dementia in the United States between December 2020 and August 2021

(2022) Lindsey Wang et al.   Alzheimers & Dementia

Incidence Rates and Clinical Outcomes of SARS-CoV-2 Infection With the Omicron and Delta Variants in Children Younger Than 5 Years in the US

(2022) Lindsey Wang et al.   JAMA Pediatrics

Breakthrough SARS-CoV-2 Infections, Hospitalizations, and Mortality in Vaccinated Patients With Cancer in the US Between December 2020 and November 2021

(2022) William Wang et al.   JAMA Oncology

Association of COVID-19 with New-Onset Alzheimer’s Disease

(2022) Lindsey Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

KG-Predict: A knowledge graph computational framework for drug repurposing

(2022) Zhenxiang Gao et al.   JOURNAL OF BIOMEDICAL INFORMATICS

Computational drug repurposing based on electronic health records: a scoping review

(2022) Nansu Zong et al.   npj Digital Medicine

Cardiovascular risk of gabapentin and pregabalin in patients with diabetic neuropathy

(2022) Yiheng Pan et al.   Cardiovascular Diabetology

Prediction and evaluation of combination pharmacotherapy using natural language processing, machine learning and patient electronic health records

(2022) Pingjian Ding et al.   JOURNAL OF BIOMEDICAL INFORMATICS

Time Trend and Association of Early-Onset Colorectal Cancer with Diverticular Disease in the United States: 2010–2021

(2022) Lindsey Wang et al.   Cancers

Association of SARS-CoV-2 Infection With New-Onset Type 1 Diabetes Among Pediatric Patients From 2020 to 2021

(2022) Ellen K. Kendall et al.   JAMA Network Open

Cocaine Use Disorder (CUD): Current Clinical Perspectives

(2022) Elizabeth K C Schwartz et al.   Substance Abuse and Rehabilitation

Association of Aspirin Use with Reduced Risk of Developing Alzheimer’s Disease in Elderly Ischemic Stroke Patients: A Retrospective Cohort Study

(2022) Maria P. Gorenflo et al.   JOURNAL OF ALZHEIMERS DISEASE

Association of COVID-19 with endocarditis in patients with cocaine or opioid use disorders in the US

(2022) Lindsey Wang et al.   MOLECULAR PSYCHIATRY

Drug repurposing for opioid use disorders: integration of computational prediction, clinical corroboration, and mechanism of action analyses

(2021) Mengshi Zhou et al.   MOLECULAR PSYCHIATRY

Anomalous collapses of Nares Strait ice arches leads to enhanced export of Arctic sea ice

(2021) G. W. K. Moore et al.   Nature Communications

Structure-based drug repurposing against COVID-19 and emerging infectious diseases: methods, resources and discoveries

(2021) Yosef Masoudi-Sobhanzadeh et al.   BRIEFINGS IN BIOINFORMATICS

Comparison of Treatments for Cocaine Use Disorder Among Adults

(2021) Brandon S. Bentzley et al.   JAMA Network Open

Decreased cocaine demand following contingency management treatment

(2021) Jin H. Yoon et al.   DRUG AND ALCOHOL DEPENDENCE

Network‐Based Approaches for Drug Repositioning

(2021) Tao Song et al.   Molecular Informatics

Increased risk for COVID ‐19 breakthrough infection in fully vaccinated patients with substance use disorders in the United States between December 2020 and August 2021

(2021) Lindsey Wang et al.   World Psychiatry

Risks of SARS-CoV-2 Breakthrough Infection and Hospitalization in Fully Vaccinated Patients With Multiple Myeloma

(2021) Lindsey Wang et al.   JAMA Network Open

Biomedical data and computational models for drug repositioning: a comprehensive review

(2020) Huimin Luo et al.   BRIEFINGS IN BIOINFORMATICS

Structure-based drug repositioning: Potential and limits

(2020) Melissa F. Adasme et al.   SEMINARS IN CANCER BIOLOGY

Combining phenome-driven drug-target interaction prediction with patients’ electronic health records-based clinical corroboration toward drug discovery

(2020) Mengshi Zhou et al.   BIOINFORMATICS

A review of computational drug repositioning: strategies, approaches, opportunities, challenges, and directions

(2020) Tamer N. Jarada et al.   Journal of Cheminformatics

Medical complications associated with substance use disorders in patients with type 2 diabetes and hypertension: Electronic health record findings

(2019) Theresa Winhusen et al.   ADDICTION

A Single Ketamine Infusion Combined With Mindfulness-Based Behavioral Modification to Treat Cocaine Dependence: A Randomized Clinical Trial

(2019) Elias Dakwar et al.   AMERICAN JOURNAL OF PSYCHIATRY

Pharmacogenetics of drug dependence: Polymorphisms of genes involved in GABA neurotransmission

(2019) Sutisa Nudmamud-Thanoi et al.   NEUROSCIENCE LETTERS

The treatment of cocaine use disorder

(2019) Kyle M. Kampman   Science Advances

Mechanisms of ketamine action as an antidepressant

(2018) P Zanos et al.   MOLECULAR PSYCHIATRY

A sub-set of psychoactive effects may be critical to the behavioral impact of ketamine on cocaine use disorder: Results from a randomized, controlled laboratory study

(2018) E. Dakwar et al.   NEUROPHARMACOLOGY

Ketamine for the treatment of addiction: Evidence and potential mechanisms

(2018) I. Ivan Ezquerra-Romano et al.   NEUROPHARMACOLOGY

In search of the mechanisms of metformin in cancer

(2018) Alan Morris   Nature Reviews Endocrinology

Drug repurposing: progress, challenges and recommendations

(2018) Sudeep Pushpakom et al.   NATURE REVIEWS DRUG DISCOVERY

Cocaine self-administration disrupted by the N-methyl-D-aspartate receptor antagonist ketamine: a randomized, crossover trial

(2016) E Dakwar et al.   MOLECULAR PSYCHIATRY

DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants

(2016) Janet Piñero et al.   NUCLEIC ACIDS RESEARCH

Multiple faces of BDNF in cocaine addiction

(2015) Xuan Li et al.   BEHAVIOURAL BRAIN RESEARCH

Cardiovascular disease among people with drug use disorders

(2015) Birgitte Thylstrup et al.   International Journal of Public Health

STITCH 5: augmenting protein–chemical interaction networks with tissue and affinity data

(2015) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

Therapeutic infusions of ketamine: Do the psychoactive effects matter?

(2014) E. Dakwar et al.   DRUG AND ALCOHOL DEPENDENCE

Cocaine-Induced Changes in NMDA Receptor Signaling

(2014) Pavel I. Ortinski   MOLECULAR NEUROBIOLOGY

New drugs cost US$2.6 billion to develop

(2014) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Gene Ontology Consortium: going forward

(2014)   NUCLEIC ACIDS RESEARCH

The Effects of Subanesthetic Ketamine Infusions on Motivation to Quit and Cue-Induced Craving in Cocaine-Dependent Research Volunteers

(2013) Elias Dakwar et al.   BIOLOGICAL PSYCHIATRY

Parallel comparison of Illumina RNA-Seq and Affymetrix microarray platforms on transcriptomic profiles generated from 5-aza-deoxy-cytidine treated HT-29 colon cancer cells and simulated datasets

(2013) Xiao Xu et al.   BMC BIOINFORMATICS

Automatic signal extraction, prioritizing and filtering approaches in detecting post-marketing cardiovascular events associated with targeted cancer drugs from the FDA Adverse Event Reporting System (FAERS)

(2013) Rong Xu et al.   JOURNAL OF BIOMEDICAL INFORMATICS

Extrasynaptic Targeting of NMDA Receptors Following D1 Dopamine Receptor Activation and Cocaine Self-Administration

(2013) P. I. Ortinski et al.   JOURNAL OF NEUROSCIENCE

Replication of Ketamine's Antidepressant Efficacy in Bipolar Depression: A Randomized Controlled Add-On Trial

(2012) Carlos A. Zarate et al.   BIOLOGICAL PSYCHIATRY

Metformin: A Diabetes Drug for Cancer, or a Cancer Drug for Diabetics?

(2012) Matthew Martin et al.   JOURNAL OF CLINICAL ONCOLOGY

GABAergic Gene Expression in Postmortem Hippocampus from Alcoholics and Cocaine Addicts; Corresponding Findings in Alcohol-Naïve P and NP Rats

(2012) Mary-Anne Enoch et al.   PLoS One

An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies

(2011) Peter C. Austin   MULTIVARIATE BEHAVIORAL RESEARCH

The Human Phenotype Ontology

(2010) PN Robinson et al.   CLINICAL GENETICS

Role of BDNF and GDNF in drug reward and relapse: A review

(2009) Udi E. Ghitza et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Association of psychiatric and substance use disorder comorbidity with cocaine dependence severity and treatment utilization in cocaine-dependent individuals

(2008) Julian D. Ford et al.   DRUG AND ALCOHOL DEPENDENCE

Research electronic data capture (REDCap)—A metadata-driven methodology and workflow process for providing translational research informatics support

(2008) Paul A. Harris et al.   JOURNAL OF BIOMEDICAL INFORMATICS

Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors

(2007) Sungho Maeng et al.   BIOLOGICAL PSYCHIATRY