Circadian rhythm disruption in critically ill patients

Circadian molecular clock disruption in chronic pulmonary diseases

(2022) Allan Giri et al.   TRENDS IN MOLECULAR MEDICINE

Foundations of circadian medicine

(2022) Achim Kramer et al.   PLOS BIOLOGY

Neutrophil Recruitment in Pneumococcal Pneumonia

(2022) Catherine S. Palmer et al.   Frontiers in Cellular and Infection Microbiology

Time to Train: The Involvement of the Molecular Clock in Exercise Adaptation of Skeletal Muscle

(2022) Shivani Mansingh et al.   Frontiers in Physiology

Intermittent feeding and circadian rhythm in critical illness

(2022) Imre W.K. Kouw et al.   Current Opinion in Critical Care

Nobiletin Attenuates Anesthesia/Surgery-Induced Neurocognitive Decline by Preserving the Expression of Clock Genes in Mice

(2022) Zhuonan Sun et al.   Frontiers in Neuroscience

The circadian immune system

(2022) Chen Wang et al.   Science Immunology

A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics

(2022) Peter Pennitz et al.   European Respiratory Review

Effects of melatonin on protecting against lung injury (Review)

(2021) Weiwei Wang et al.   Experimental and Therapeutic Medicine

A Timely Call to Arms: COVID-19, the Circadian Clock, and Critical Care

(2021) Jeffrey Haspel et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Association of Delirium during Critical Illness With Mortality: Multicenter Prospective Cohort Study

(2021) Christopher G. Hughes et al.   ANESTHESIA AND ANALGESIA

Clinical and virological characteristics of hospitalised COVID-19 patients in a German tertiary care centre during the first wave of the SARS-CoV-2 pandemic: a prospective observational study

(2021) Charlotte Thibeault et al.   INFECTION

Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling

(2021) Sarah S. Geiger et al.   Nature Communications

Circadian rhythms in septic shock patients

(2021) Gunnar Lachmann et al.   Annals of Intensive Care

Pneumonia

(2021) Antoni Torres et al.   Nature Reviews Disease Primers

Comparison of sequential feeding and continuous feeding on the blood glucose of critically ill patients: a non-inferiority randomized controlled trial

(2021) Chang-Jie Ren et al.   CHINESE MEDICAL JOURNAL

Intermittent fasting in paediatric critical illness: The properties and potential beneficial effects of an overnight fast in the PICU

(2021) Karlien Veldscholte et al.   CLINICAL NUTRITION

Autophagy in major human diseases

(2021) Daniel J Klionsky et al.   EMBO JOURNAL

The histone methyltransferase Ezh2 restrains macrophage inflammatory responses

(2021) Gareth B. Kitchen et al.   FASEB JOURNAL

Dexmedetomidine Restores Autophagic Flux, Modulates Associated microRNAs and the Cholinergic Anti-inflammatory Pathway upon LPS-Treatment in Rats

(2021) Widuri Kho et al.   Journal of Neuroimmune Pharmacology

Community-acquired pneumonia

(2021) Stefano Aliberti et al.   LANCET

Daytime variation in SARS-CoV-2 infection and cytokine production

(2021) Aïssatou Bailo Diallo et al.   MICROBIAL PATHOGENESIS

The endogenous circadian system worsens asthma at night independent of sleep and other daily behavioral or environmental cycles

(2021) Frank A. J. L. Scheer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intercellular coupling between peripheral circadian oscillators by TGF-β signaling

(2021) Anna-Marie Finger et al.   Science Advances

Molecular clock REV-ERBα regulates cigarette smoke–induced pulmonary inflammation and epithelial-mesenchymal transition

(2021) Qixin Wang et al.   JCI Insight

The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells

(2021) Xiaodong Zhuang et al.   iScience

SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis

(2021) Daniel Wendisch et al.   CELL

Severity of respiratory failure and computed chest tomography in acute COVID-19 correlates with pulmonary function and respiratory symptoms after infection with SARS-CoV-2: An observational longitudinal study over 12 months

(2021) Fridolin Steinbeis et al.   RESPIRATORY MEDICINE

Melatonin use during pregnancy and lactation: A scoping review of human studies

(2021) Tya Vine et al.   REVISTA BRASILEIRA DE PSIQUIATRIA

NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1

(2021) Yang Shen et al.   PLoS Genetics

Susceptibility rhythm to bacterial endotoxin in myeloid clock-knockout mice

(2021) Veronika Lang et al.   eLife

Circadian Rhythms in Bacterial Sepsis Pathology: What We Know and What We Should Know

(2021) Malena Lis Mul Fedele et al.   Frontiers in Cellular and Infection Microbiology

Molecular Interactions Between Components of the Circadian Clock and the Immune System

(2020) Sophia Hergenhan et al.   JOURNAL OF MOLECULAR BIOLOGY

Programmed ‘disarming’ of the neutrophil proteome reduces the magnitude of inflammation

(2020) Jose M. Adrover et al.   NATURE IMMUNOLOGY

The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia

(2020) Gareth B. Kitchen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Factors Disrupting Melatonin Secretion Rhythms During Critical Illness

(2020) Matthew B. Maas et al.   CRITICAL CARE MEDICINE

Circadian changes in the composition of human milk macronutrients depending on pregnancy duration: a cross-sectional study

(2020) Ieva Jura Paulaviciene et al.   International Breastfeeding Journal

Severe COVID-19 is marked by a dysregulated myeloid cell compartment

(2020) Jonas Schulte-Schrepping et al.   CELL

Circadian asthma airway responses are gated by REV-ERBα

(2020) Hannah J. Durrington et al.   EUROPEAN RESPIRATORY JOURNAL

Coupled network of the circadian clocks: a driving force of rhythmic physiology

(2020) Anna‐Marie Finger et al.   FEBS LETTERS

Changes in Mortality in Top 10 Causes of Death from 2011 to 2018

(2020) Jamal S. Rana et al.   JOURNAL OF GENERAL INTERNAL MEDICINE

Circadian Variation in Human Milk Composition, a Systematic Review

(2020) Merel F. Italianer et al.   Nutrients

Circadian Control of Inflammasome Pathways: Implications for Circadian Medicine

(2020) Benoit Pourcet et al.   Frontiers in Immunology

Circadian Disruption in Critical Illness

(2020) Aesha M. Jobanputra et al.   Frontiers in Neurology

Circadian Gene Expression Rhythms During Critical Illness

(2020) Matthew B. Maas et al.   CRITICAL CARE MEDICINE

Abnormal Sleep, Circadian Rhythm Disruption, and Delirium in the ICU: Are They Related?

(2020) Marietou Daou et al.   Frontiers in Neurology

An Optimal Time for Treatment—Predicting Circadian Time by Machine Learning and Mathematical Modelling

(2020) Janina Hesse et al.   Cancers

Rheostatic Balance of Circadian Rhythm and Autophagy in Metabolism and Disease

(2020) Xiang Wang et al.   Frontiers in Cell and Developmental Biology

Is Progression of Pulmonary Fibrosis Due to Ventilation-Induced Lung Injury?

(2019) Richard K Albert et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Early Time-Restricted Feeding Improves 24-Hour Glucose Levels and Affects Markers of the Circadian Clock, Aging, and Autophagy in Humans

(2019) Humaira Jamshed et al.   Nutrients

Why Lungs Keep Time: Circadian Rhythms and Lung Immunity

(2019) Charles Nosal et al.   Annual Review of Physiology

Daily Changes in The Expression of Clock Genes in Sepsis and Their Relation with Sepsis Outcome and Urinary Excretion of 6-Sulfatoximelatonin

(2019) Carlos Acuña-Fernández et al.   SHOCK

Circadian control of lung inflammation in influenza infection

(2019) Shaon Sengupta et al.   Nature Communications

The circadian clock protein REVERBα inhibits pulmonary fibrosis development

(2019) Peter S. Cunningham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia

(2018) Birgitt Gutbier et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Angiotensin II Suppresses Rev-erbα Expression in THP-1 Macrophages via the Ang II Type 1 Receptor/Liver X Receptor α Pathway

(2018) Shipeng Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The Period 2 Enhancer Nobiletin as Novel Therapy in Murine Models of Circadian Disruption Resembling Delirium*

(2018) Jennifer Gile et al.   CRITICAL CARE MEDICINE

Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation

(2018) Marie Pariollaud et al.   JOURNAL OF CLINICAL INVESTIGATION

Circadian regulation of glucose, lipid, and energy metabolism in humans

(2018) Eleonora Poggiogalle et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle

(2018) Jakob Wefers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Circadian Clock Controls Immune Checkpoint Pathway in Sepsis

(2018) Wenjun Deng et al.   Cell Reports

Regulatory and Mechanistic Actions of Glucocorticoids on T and Inflammatory Cells

(2018) Ana C. Liberman et al.   Frontiers in Endocrinology

The effect of fasting or calorie restriction on autophagy induction: A review of the literature

(2018) Mohammad Bagherniya et al.   AGEING RESEARCH REVIEWS

High-accuracy determination of internal circadian time from a single blood sample

(2018) Nicole Wittenbrink et al.   JOURNAL OF CLINICAL INVESTIGATION

Melatonin and inflammation - story of a double-edged blade

(2018) Rüdiger Hardeland   JOURNAL OF PINEAL RESEARCH

Universal method for robust detection of circadian state from gene expression

(2018) Rosemary Braun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian Rhythm Disruption and Sepsis in Severe Trauma Patients

(2018) Benjamin Coiffard et al.   SHOCK

Regulation of Leptin Methylation Not via Apoptosis by Melatonin in the Rescue of Chronic Programming Liver Steatosis

(2018) Ching-Chou Tsai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rhythms of life: circadian disruption and brain disorders across the lifespan

(2018) Ryan W. Logan et al.   NATURE REVIEWS NEUROSCIENCE

Effects of dexmedetomidine on sleep quality of patients after surgery without mechanical ventilation in ICU

(2017) Weina Lu et al.   MEDICINE

BMAL1 links the circadian clock to viral airway pathology and asthma phenotypes

(2017) A Ehlers et al.   Mucosal Immunology

Rev-erb-α regulates atrophy-related genes to control skeletal muscle mass

(2017) Alicia Mayeuf-Louchart et al.   Scientific Reports

Effects of Dim Light at Night on Food Intake and Body Mass in Developing Mice

(2017) Yasmine M. Cissé et al.   Frontiers in Neuroscience

Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice

(2017) Benjamin L. Smarr et al.   Scientific Reports

WHO/UNEP global surveys of PCDDs, PCDFs, PCBs and DDTs in human milk and benefit–risk evaluation of breastfeeding

(2016) Martin van den Berg et al.   ARCHIVES OF TOXICOLOGY

CLOCK modulates survival and acute lung injury in mice with polymicrobial sepsis

(2016) Chao-Yung Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Circadian Rhythm Disruption in the Critically Ill

(2016) Mark A. Oldham et al.   CRITICAL CARE MEDICINE

The functional and clinical significance of the 24-h rhythm of circulating glucocorticoids

(2016) Henrik Oster et al.   ENDOCRINE REVIEWS

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Transcriptional architecture of the mammalian circadian clock

(2016) Joseph S. Takahashi   NATURE REVIEWS GENETICS

Pharmacological and Genetic Modulation of REV-ERB Activity and Expression Affects Orexigenic Gene Expression

(2016) Ariadna Amador et al.   PLoS One

Cell autonomous regulation of herpes and influenza virus infection by the circadian clock

(2016) Rachel S. Edgar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian time signatures of fitness and disease

(2016) Joseph Bass et al.   SCIENCE

Circadian Macronutrients Variations over the First 7 Weeks of Human Milk Feeding of Preterm Infants

(2015) Hadar Moran-Lev et al.   Breastfeeding Medicine

Effects of Melatonin on Prenatal Dexamethasone-Induced Epigenetic Alterations in Hippocampal Morphology and Reelin and Glutamic Acid Decarboxylase 67 Levels

(2015) Chun-Chung Lui et al.   DEVELOPMENTAL NEUROSCIENCE

The Circadian System Contributes to Apnea Lengthening across the Night in Obstructive Sleep Apnea

(2015) Matthew P. Butler et al.   SLEEP

Influenza A virus-dependent remodeling of pulmonary clock function in a mouse model of COPD

(2015) Isaac K. Sundar et al.   Scientific Reports

Alterations in circadian entrainment precede the onset of depression-like behavior that does not respond to fluoxetine

(2015) S Spulber et al.   Translational Psychiatry

Timing and causes of death in septic shock

(2015) Fabrice Daviaud et al.   Annals of Intensive Care

Influence of Proton-Pump Inhibitors on the Luminal Microbiota in the Gastrointestinal Tract

(2015) Ayumi Tsuda et al.   Clinical and Translational Gastroenterology

The Circadian System Contributes to Apnea Lengthening across the Night in Obstructive Sleep Apnea

(2015) Matthew P. Butler et al.   SLEEP

Mechanical Ventilation–associated Lung Fibrosis in Acute Respiratory Distress Syndrome

(2014) Nuria E. Cabrera-Benitez et al.   ANESTHESIOLOGY

Effect of melatonin on incidence of delirium among patients with hip fracture: a multicentre, double-blind randomized controlled trial

(2014) A. de Jonghe et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Dynamics of pulmonary endothelial barrier function in acute inflammation: mechanisms and therapeutic perspectives

(2014) Holger C. Müller-Redetzky et al.   CELL AND TISSUE RESEARCH

Clock-controlled StAR’s expression and corticosterone production contribute to the endotoxemia immune response

(2014) Jiesi Wang et al.   CHRONOBIOLOGY INTERNATIONAL

Maternal citrulline supplementation prevents prenatal dexamethasone-induced programmed hypertension

(2014) Y. L. Tain et al.   FREE RADICAL RESEARCH

CLOCK:BMAL1 is a pioneer-like transcription factor

(2014) J. S. Menet et al.   GENES & DEVELOPMENT

Melatonin attenuates prenatal dexamethasone-induced blood pressure increase in a rat model

(2014) You-Lin Tain et al.   Journal of the American Society of Hypertension

An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action

(2014) Julie Gibbs et al.   NATURE MEDICINE

Cosinor-based rhythmometry

(2014) Germaine Cornelissen   Theoretical Biology and Medical Modelling

Circadian rhythm reprogramming during lung inflammation

(2014) Jeffrey A. Haspel et al.   Nature Communications

Altered Circadian Rhythmicity in Patients in the ICU

(2013) Joost A.C. Gazendam et al.   CHEST

Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway

(2013) Jae-Woong Hwang et al.   FASEB JOURNAL

A study on circadian rhythm disorder of rat lung tissue caused by mechanical ventilation induced lung injury

(2013) Huan Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy

(2013) Estelle Woldt et al.   NATURE MEDICINE

Ventilator-Induced Lung Injury

(2013) Arthur S. Slutsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Impact of Chronodisruption during Primate Pregnancy on the Maternal and Newborn Temperature Rhythms

(2013) María Serón-Ferré et al.   PLoS One

Characterisation of the Maternal Response to Chronic Phase Shifts during Gestation in the Rat: Implications for Fetal Metabolic Programming

(2013) Tamara J. Varcoe et al.   PLoS One

Designing artificial environments for preterm infants based on circadian studies on pregnant uterus

(2013) Shimpei Watanabe   Frontiers in Endocrinology

Critical Illness Myopathy and GLUT4

(2012) Steffen Weber-Carstens et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Variation in Fat, Lactose, and Protein Composition in Breast Milk over 24 Hours

(2012) Sadaf Khan et al.   JOURNAL OF HUMAN LACTATION

Peroxiredoxins are conserved markers of circadian rhythms

(2012) Rachel S. Edgar et al.   NATURE

Mechanical stress induces lung fibrosis by epithelial–mesenchymal transition*

(2011) Nuria E. Cabrera-Benítez et al.   CRITICAL CARE MEDICINE

Circadian Variation in Placental and Hepatic Clock Genes in Rat Pregnancy

(2011) Michaela D. Wharfe et al.   ENDOCRINOLOGY

Circadian clocks in human red blood cells

(2011) John S. O’Neill et al.   NATURE

The nuclear receptor REV-ERB  mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines

(2011) J. E. Gibbs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coupling governs entrainment range of circadian clocks

(2010) Ute Abraham et al.   Molecular Systems Biology

DIURNAL VARIATION IN ENDOTOXIN-INDUCED MORTALITY IN MICE: CORRELATION WITH PROINFLAMMATORY FACTORS

(2009) Luciano Marpegan et al.   CHRONOBIOLOGY INTERNATIONAL

A circadian clock in macrophages controls inflammatory immune responses

(2009) Maren Keller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

THE ABSENCE OF CIRCADIAN CUES DURING RECOVERY FROM SEPSIS MODIFIES PITUITARY-ADRENOCORTICAL FUNCTION AND IMPAIRS SURVIVAL

(2009) Drew E. Carlson et al.   SHOCK

Effects of melatonin in an experimental model of ventilator-induced lung injury

(2008) Paula R. Pedreira et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

How to assess circadian rhythm in humans: A review of literature

(2008) Wytske A. Hofstra et al.   EPILEPSY & BEHAVIOR

Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind, randomised controlled trial

(2008) Frank Buttgereit et al.   LANCET

Chronic inflammation affects the photic response of the suprachiasmatic nucleus

(2007) Maria Palomba et al.   JOURNAL OF NEUROIMMUNOLOGY