Interfacing Materials Science and Biology for Drug Carrier Design

Self-Titrating Anticoagulant Nanocomplexes That Restore Homeostatic Regulation of the Coagulation Cascade

(2014) Kevin Y. Lin et al.   ACS Nano

Intracellularly Degradable Hydrogen-Bonded Polymer Capsules

(2014) Kristian Kempe et al.   ADVANCED FUNCTIONAL MATERIALS

Telomerase activation: A potential key modulator for human healthspan and longevity

(2014) Virginia Boccardi et al.   AGEING RESEARCH REVIEWS

Enzyme-Degradable Self-Assembled Nanostructures from Polymer–Peptide Hybrids

(2014) Daniel Bacinello et al.   BIOMACROMOLECULES

Disulfide-containing parenteral delivery systems and their redox-biological fate

(2014) Lorine Brülisauer et al.   JOURNAL OF CONTROLLED RELEASE

Applications of elastin-like polypeptides in drug delivery

(2014) Sarah R. MacEwan et al.   JOURNAL OF CONTROLLED RELEASE

Endocytic Capsule Sensors for Probing Cellular Internalization

(2014) Kang Liang et al.   Advanced Healthcare Materials

Peptide-Tunable Drug Cytotoxicity via One-Step Assembled Polymer Nanoparticles

(2013) Kang Liang et al.   ADVANCED MATERIALS

Endocytic pH-Triggered Degradation of Nanoengineered Multilayer Capsules

(2013) Kang Liang et al.   ADVANCED MATERIALS

Future of the Particle Replication in Nonwetting Templates (PRINT) Technology

(2013) Jing Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synergistic Antitumor Activity from Two-Stage Delivery of Targeted Toxins and Endosome-Disrupting Nanoparticles

(2013) Xingfang Su et al.   BIOMACROMOLECULES

In Situ Forming Reduction-Sensitive Degradable Nanogels for Facile Loading and Triggered Intracellular Release of Proteins

(2013) Wei Chen et al.   BIOMACROMOLECULES

Advanced drug delivery systems for antithrombotic agents

(2013) C. F. Greineder et al.   BLOOD

4D-networking by mitotic phosphatases

(2013) Junbin Qian et al.   CURRENT OPINION IN CELL BIOLOGY

Cathepsin B as a cancer target

(2013) Christopher S Gondi et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Telomeres and human health

(2013) S. E. Bojesen   JOURNAL OF INTERNAL MEDICINE

Collective Activation of MRI Agents via Encapsulation and Disease-Triggered Release

(2013) Mathieu L. Viger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cathepsin B Degradable Star-Shaped Peptidic Macromolecules for Delivery of 2-Methoxyestradiol

(2013) Ravi Shankar et al.   MOLECULAR PHARMACEUTICS

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

(2013) Gaurav Sahay et al.   NATURE BIOTECHNOLOGY

A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals

(2013) Yiguang Wang et al.   NATURE MATERIALS

New Fundamentals in Hemostasis

(2013) Henri H. Versteeg et al.   PHYSIOLOGICAL REVIEWS

Biology of telomeres: importance in etiology of esophageal cancer and as therapeutic target

(2013) Jagannath Pal et al.   Translational Research

N-Linked Protein Glycosylation in the Endoplasmic Reticulum

(2013) J. Breitling et al.   Cold Spring Harbor Perspectives in Biology

Engineering Cellular Degradation of Multilayered Capsules through Controlled Cross-Linking

(2012) Kang Liang et al.   ACS Nano

Engineering Particles for Therapeutic Delivery: Prospects and Challenges

(2012) Yan Yan et al.   ACS Nano

Smart Multilayered Assembly for Biocompatible siRNA Delivery Featuring Dissolvable Silica, Endosome-Disrupting Polycation, and Detachable PEG

(2012) Tomoya Suma et al.   ACS Nano

Enzyme-responsive nanoparticles for drug release and diagnostics

(2012) Roberto de la Rica et al.   ADVANCED DRUG DELIVERY REVIEWS

Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: Concepts and applications

(2012) Emanuel Fleige et al.   ADVANCED DRUG DELIVERY REVIEWS

Emerging roles of secreted phospholipase A2 enzymes: An update

(2012) Makoto Murakami et al.   BIOCHIMIE

Immobilization and Intracellular Delivery of an Anticancer Drug Using Mussel-Inspired Polydopamine Capsules

(2012) Jiwei Cui et al.   BIOMACROMOLECULES

Dendritic cell activation and T cell priming with adjuvant- and antigen-loaded oxidation-sensitive polymersomes

(2012) Evan A. Scott et al.   BIOMATERIALS

Endocytosis at the nanoscale

(2012) Irene Canton et al.   CHEMICAL SOCIETY REVIEWS

Temperature-responsive compounds as in situ gelling biomedical materials

(2012) Hyo Jung Moon et al.   CHEMICAL SOCIETY REVIEWS

Cell-penetrating peptides: classes, origin, and current landscape

(2012) Francesca Milletti   DRUG DISCOVERY TODAY

Elevated and secreted phospholipase A2 activities as new potential therapeutic targets in human epithelial ovarian cancer

(2012) Qingchun Cai et al.   FASEB JOURNAL

Protein tyrosine phosphatases - from housekeeping enzymes to master regulators of signal transduction

(2012) Nicholas K. Tonks   FEBS Journal

Targeting cancer cell mitochondria as a therapeutic approach

(2012) Shijun Wen et al.   Future Medicinal Chemistry

Evidence for distinct mechanisms of uptake and antitumor activity of secretory phospholipase A2responsive liposome in prostate cancer

(2012) J. N. Mock et al.   Integrative Biology

Single siRNA Nanocapsules for Enhanced RNAi Delivery

(2012) Ming Yan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reductively Responsive siRNA-Conjugated Hydrogel Nanoparticles for Gene Silencing

(2012) Stuart S. Dunn et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Possible “Proton Sponge ” Effect of Polyethylenimine (PEI) Does Not Include Change in Lysosomal pH

(2012) Rikke V Benjaminsen et al.   MOLECULAR THERAPY

Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics

(2012) S. Marrache et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shear-Activated Nanotherapeutics for Drug Targeting to Obstructed Blood Vessels

(2012) N. Korin et al.   SCIENCE

Cell-penetrating peptides: breaking through to the other side

(2012) Erez Koren et al.   TRENDS IN MOLECULAR MEDICINE

Redox-Responsive, Core Cross-Linked Polyester Micelles

(2012) Zhonghai Zhang et al.   ACS Macro Letters

Stimulus-Sensitive Polymeric Nanoparticles and Their Applications as Drug and Gene Carriers

(2012) Yi Li et al.   Advanced Healthcare Materials

Overcoming Endosomal Barrier by Amphotericin B-Loaded Dual pH-Responsive PDMA-b-PDPA Micelleplexes for siRNA Delivery

(2011) Haijun Yu et al.   ACS Nano

Sheddable Ternary Nanoparticles for Tumor Acidity-Targeted siRNA Delivery

(2011) Xian-Zhu Yang et al.   ACS Nano

Matrix metalloproteinase-sensitive thermogelling polymer for bioresponsive local drug delivery

(2011) Vivek Kumar Garripelli et al.   Acta Biomaterialia

Amplified release through the stimulus triggered degradation of self-immolative oligomers, dendrimers, and linear polymers

(2011) Andrew D. Wong et al.   ADVANCED DRUG DELIVERY REVIEWS

Charge-Shifting Click Capsules with Dual-Responsive Cargo Release Mechanisms

(2011) Kang Liang et al.   ADVANCED MATERIALS

Quantum-Dot-Based FRET Detection of Histone Acetyltransferase Activity

(2011) James E. Ghadiali et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Interlayer-Crosslinked Micelle with Partially Hydrated Core Showing Reduction and pH Dual Sensitivity for Pinpointed Intracellular Drug Release

(2011) Jian Dai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tunable, Ultrasensitive pH-Responsive Nanoparticles Targeting Specific Endocytic Organelles in Living Cells

(2011) Kejin Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzymatically Degradable Mussel-Inspired Adhesive Hydrogel

(2011) Carrie E. Brubaker et al.   BIOMACROMOLECULES

Controlled release of DNA from poly(vinylpyrrolidone) capsules using cleavable linkers

(2011) Sher Leen Ng et al.   BIOMATERIALS

Redox-responsive nanocapsules for intracellular protein delivery

(2011) Muxun Zhao et al.   BIOMATERIALS

Lysosomally cleavable peptide-containing polymersomes modified with anti-EGFR antibody for systemic cancer chemotherapy

(2011) Jung S. Lee et al.   BIOMATERIALS

Single-step kinase inhibitor screening using a peptide-modified gold nanoparticle platform

(2011) Shalini Gupta et al.   CHEMICAL COMMUNICATIONS

Tailoring nanocarriers for intracellular protein delivery

(2011) Zhen Gu et al.   CHEMICAL SOCIETY REVIEWS

Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting

(2011) Tomáš Etrych et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Up-regulation of AMP-activated Protein Kinase in Cancer Cell Lines Is Mediated through c-Src Activation

(2011) Sarit Mizrachy-Schwartz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biodegradable star HPMA polymer–drug conjugates: Biodegradability, distribution and anti-tumor efficacy

(2011) Tomáš Etrych et al.   JOURNAL OF CONTROLLED RELEASE

Peptides in cancer nanomedicine: Drug carriers, targeting ligands and protease substrates

(2011) Xiao-Xiang Zhang et al.   JOURNAL OF CONTROLLED RELEASE

In Vitroandin VivomRNA Delivery Using Lipid-Enveloped pH-Responsive Polymer Nanoparticles

(2011) Xingfang Su et al.   MOLECULAR PHARMACEUTICS

Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies

(2011) Tore-Geir Iversen et al.   Nano Today

The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers

(2011) Carlee E. Ashley et al.   NATURE MATERIALS

Bio-inspired, bioengineered and biomimetic drug delivery carriers

(2011) Jin-Wook Yoo et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanism mediating oligomeric Aβ clearance by naïve primary microglia

(2011) Cheng-Ning Yang et al.   NEUROBIOLOGY OF DISEASE

Synthesis and functionalization of nanoengineered materials using click chemistry

(2011) Georgina K. Such et al.   PROGRESS IN POLYMER SCIENCE

Assembly and Degradation of Low-Fouling Click-Functionalized Poly(ethylene glycol)-Based Multilayer Films and Capsules

(2011) Melissa K. M. Leung et al.   Small

Cellular Uptake, Intracellular Trafficking, and Cytotoxicity of Nanomaterials

(2011) Feng Zhao et al.   Small

Switching of self-assembly in a peptide nanostructure with a specific enzyme

(2011) Matthew J. Webber et al.   Soft Matter

Multi-enzyme systems: bringing enzymes together in vitro

(2011) Sanne Schoffelen et al.   Soft Matter

Acetal-Modified Dextran Microparticles with Controlled Degradation Kinetics and Surface Functionality for Gene Delivery in Phagocytic and Non-Phagocytic Cells

(2010) Joel A. Cohen et al.   ADVANCED MATERIALS

Fluorescent Protein-Based Redox Probes

(2010) Andreas J. Meyer et al.   ANTIOXIDANTS & REDOX SIGNALING

Hybrid Polymer Therapeutics Incorporating Bioresponsive, Coiled Coil Peptide Linkers

(2010) Bojana Apostolovic et al.   BIOMACROMOLECULES

Cytoplasmic retention of protein tyrosine kinase 6 promotes growth of prostate tumor cells

(2010) Patrick M. Brauer et al.   CELL CYCLE

Elastin-based stimuli-responsive gold nanoparticles

(2010) Vincent Lemieux et al.   CHEMICAL COMMUNICATIONS

Star polymers composed entirely of amino acid building blocks: a route towards stereospecific, biodegradable and hierarchically functionalized stars

(2010) Adrian Sulistio et al.   CHEMICAL COMMUNICATIONS

Challenges facing colloidal delivery systems: From synthesis to the clinic

(2010) Angus P.R. Johnston et al.   CURRENT OPINION IN COLLOID & INTERFACE SCIENCE

Phosphatase/temperature responsive poly(2-isopropyl-2-oxazoline)

(2010) Pier-Francesco Caponi et al.   Polymer Chemistry

pH-Sensitive Nanoflash for Tumoral Acidic pH Imaging in Live Animals

(2010) Jin Young Ko et al.   Small

Kinase-Actuated Immunoaggregation of Peptide-Conjugated Gold Nanoparticles

(2010) Shalini Gupta et al.   Small

NADPH Oxidase and Cardiac Failure

(2010) Junya Kuroda et al.   Journal of Cardiovascular Translational Research

Recent advances in the use of cell-penetrating peptides for medical and biological applications☆

(2009) Sonali B. Fonseca et al.   ADVANCED DRUG DELIVERY REVIEWS

Mechanisms of Endocytosis

(2009) Gary J. Doherty et al.   Annual Review of Biochemistry

Role of E-cadherin N-glycosylation profile in a mammary tumor model

(2009) Salomé S. Pinho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Low-Fouling Poly(N-vinyl pyrrolidone) Capsules with Engineered Degradable Properties

(2009) Cameron R. Kinnane et al.   BIOMACROMOLECULES

Biohybrid Polymer Capsules

(2009) Stijn F. M. van Dongen et al.   CHEMICAL REVIEWS

Controlled polymer synthesis—from biomimicry towards synthetic biology

(2009) George Pasparakis et al.   CHEMICAL SOCIETY REVIEWS

In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer

(2009) Emilia S. Olson et al.   Integrative Biology

Phase II studies of polymer-doxorubicin (PK1, FCE28068) in the treatment of breast, lung and colorectal cancer

(2009) Seymour   INTERNATIONAL JOURNAL OF ONCOLOGY

Monodispersed Polymeric Nanocapsules: Spontaneous Evolution and Morphology Transition from Reducible Hetero-PEG PICmicelles by Controlled Degradation

(2009) Wen-Fei Dong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aggregation Behavior of Poly(ethylene glycol-bl-propylene sulfide) Di- and Triblock Copolymers in Aqueous Solution

(2009) Simona Cerritelli et al.   LANGMUIR

Tuning the Formation and Degradation of Layer-by-Layer Assembled Polymer Hydrogel Microcapsules†

(2009) Alisa L. Becker et al.   LANGMUIR

Protein kinase Cε: an oncogene and emerging tumor biomarker

(2009) Michael A Gorin et al.   Molecular Cancer

Materials engineering for immunomodulation

(2009) Jeffrey A. Hubbell et al.   NATURE

A novel intracellular protein delivery platform based on single-protein nanocapsules

(2009) Ming Yan et al.   Nature Nanotechnology

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Subcellular targeting strategies for drug design and delivery

(2009) Lawrence Rajendran et al.   NATURE REVIEWS DRUG DISCOVERY

Controlling Cellular Uptake by Surface Chemistry, Size, and Surface Topology at the Nanoscale

(2009) Marzia Massignani et al.   Small

Systematic Research of Peptide Spacers Controlling Drug Release from Macromolecular Prodrug System, Carboxymethyldextran Polyalcohol−Peptide−Drug Conjugates

(2008) Yoshinobu Shiose et al.   BIOCONJUGATE CHEMISTRY

Duocarmycin-based prodrugs for cancer prodrug monotherapy

(2008) Lutz F. Tietze et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism

(2008) D. Trachootham et al.   BLOOD

Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers

(2008) Michèle Sabbah et al.   DRUG RESISTANCE UPDATES

Non-cytotoxic polymer vesicles for rapid and efficient intracellular delivery

(2008) Hannah Lomas et al.   FARADAY DISCUSSIONS

Acetal-Derivatized Dextran: An Acid-Responsive Biodegradable Material for Therapeutic Applications

(2008) Eric M. Bachelder et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antitumor activity of a membrane lytic peptide cyclized with a linker sensitive to membrane type 1-matrix metalloproteinase

(2008) J. Zhong et al.   MOLECULAR CANCER THERAPEUTICS

Reconciling the chemistry and biology of reactive oxygen species

(2008) Christine C Winterbourn   Nature Chemical Biology

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

Enzyme-responsive hydrogel particles for the controlled release of proteins: designing peptide actuators to match payload

(2008) Paul D. Thornton et al.   Soft Matter

Nanoimprint lithography based fabrication of shape-specific, enzymatically-triggered smart nanoparticles

(2007) Luz Cristal Glangchai et al.   JOURNAL OF CONTROLLED RELEASE