Cathepsin B as a cancer target

Cathepsin B Is Involved in the Trafficking of TNF- -Containing Vesicles to the Plasma Membrane in Macrophages

(2014) S.-D. Ha et al.   JOURNAL OF IMMUNOLOGY

Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B

(2012) Thomas H. Beckham et al.   INTERNATIONAL JOURNAL OF CANCER

MUC1c Regulates Cell Survival in Pancreatic Cancer by Preventing Lysosomal Permeabilization

(2012) Sulagna Banerjee et al.   PLoS One

Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling

(2012) A. Garcia-Cattaneo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of the PI3K/Akt pathway and autophagy in TLR3 signaling-induced apoptosis and growth arrest of human prostate cancer cells

(2011) Nanae Harashima et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer

(2011) T. Shree et al.   GENES & DEVELOPMENT

Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice

(2011) Aarthi Gopinathan et al.   GUT

Toll-like Receptor 3 (TLR3) Induces Apoptosis via Death Receptors and Mitochondria by Up-regulating the Transactivating p63 Isoform α (TAP63α)

(2011) Ruili Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SPARC Promotes Cathepsin B-Mediated Melanoma Invasiveness through a Collagen I/α2β1 Integrin Axis

(2011) María R. Girotti et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons

(2011) Qiuli Liang et al.   Molecular Neurodegeneration

Mechanism mediating oligomeric Aβ clearance by naïve primary microglia

(2011) Cheng-Ning Yang et al.   NEUROBIOLOGY OF DISEASE

A novel isoform of the 8p22 tumor suppressor gene DLC1 suppresses tumor growth and is frequently silenced in multiple common tumors

(2011) J S W Low et al.   ONCOGENE

Proteolytic networks in cancer

(2011) Steven D. Mason et al.   TRENDS IN CELL BIOLOGY

Targeting MMP-9, uPAR and cathepsin B inhibits invasion, migration and activates apoptosis in prostate cancer cells

(2010) A K Nalla et al.   CANCER GENE THERAPY

Co-Depletion of Cathepsin B and uPAR Induces G0/G1 Arrest in Glioma via FOXO3a Mediated p27Kip1 Upregulation

(2010) Sreelatha Gopinath et al.   PLoS One

Downregulation of uPAR and Cathepsin B Induces Apoptosis via Regulation of Bcl-2 and Bax and Inhibition of the PI3K/Akt Pathway in Gliomas

(2010) Ramarao Malla et al.   PLoS One

Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells

(2009) A Weber et al.   CELL DEATH AND DIFFERENTIATION

Cathepsin B release after imatinib-mediated lysosomal membrane permeabilization triggers BCR–ABL cleavage and elimination of chronic myelogenous leukemia cells

(2009) A Puissant et al.   LEUKEMIA

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

(2009) Ulrich Wellner et al.   NATURE CELL BIOLOGY

Antisense, RNAi, and gene silencing strategies for therapy: Mission possible or impossible?

(2008) E RAYBURN et al.   DRUG DISCOVERY TODAY

Cancer is a Preventable Disease that Requires Major Lifestyle Changes

(2008) Preetha Anand et al.   PHARMACEUTICAL RESEARCH