Glutamate transporter EAAT2: regulation, function, and potential as a therapeutic target for neurological and psychiatric disease

Targeting metabotropic glutamate receptors (mGluRs) in Parkinson's disease

(2015) Marianne Amalric   CURRENT OPINION IN PHARMACOLOGY

Targeting glutamatergic synapses in Parkinson's disease

(2015) Fabrizio Gardoni et al.   CURRENT OPINION IN PHARMACOLOGY

Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer’s disease

(2015) Kou Takahashi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ceftriaxone prevents and reverses behavioral and neuronal deficits in an MPTP-induced animal model of Parkinson's disease dementia

(2015) Chao-Yu Hsu et al.   NEUROPHARMACOLOGY

Effects of ceftriaxone on the behavioral and neuronal changes in an MPTP-induced Parkinson's disease rat model

(2014) Shih-Chun Ho et al.   BEHAVIOURAL BRAIN RESEARCH

Mechanism of raloxifene-induced upregulation of glutamate transporters in rat primary astrocytes

(2014) Pratap Karki et al.   GLIA

Sumoylation of the astroglial glutamate transporter EAAT2 governs its intracellular compartmentalization

(2014) E. Foran et al.   GLIA

Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection

(2014) Qiongman Kong et al.   JOURNAL OF CLINICAL INVESTIGATION

Glutamate transporter 1-mediated antidepressant-like effect in a rat model of chronic unpredictable stress

(2014) Jian-xin Chen et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

High-affinity glutamate transporters in chronic pain: an emerging therapeutic target

(2014) Georgi Gegelashvili et al.   JOURNAL OF NEUROCHEMISTRY

Ceftriaxone modulates uptake activity of glial glutamate transporter-1 against global brain ischemia in rats

(2014) Yu-Yan Hu et al.   JOURNAL OF NEUROCHEMISTRY

Glial Dysfunction in the Mouse Habenula Causes Depressive-Like Behaviors and Sleep Disturbance

(2014) Wanpeng Cui et al.   JOURNAL OF NEUROSCIENCE

EAAT2 (GLT-1; slc1a2) Glutamate Transporters Reconstituted in Liposomes Argues against Heteroexchange Being Substantially Faster than Net Uptake

(2014) Y. Zhou et al.   JOURNAL OF NEUROSCIENCE

Synaptic Glutamate Spillover Due to Impaired Glutamate Uptake Mediates Heroin Relapse

(2014) H.-w. Shen et al.   JOURNAL OF NEUROSCIENCE

Safety and efficacy of ceftriaxone for amyotrophic lateral sclerosis: a multi-stage, randomised, double-blind, placebo-controlled trial

(2014) Merit E Cudkowicz et al.   LANCET NEUROLOGY

Yin Yang 1 Is a Repressor of Glutamate Transporter EAAT2, and It Mediates Manganese-Induced Decrease of EAAT2 Expression in Astrocytes

(2014) P. Karki et al.   MOLECULAR AND CELLULAR BIOLOGY

Extrasynaptic NMDA Receptor Involvement in Central Nervous System Disorders

(2014) Matthew P. Parsons et al.   NEURON

A Local Glutamate-Glutamine Cycle Sustains Synaptic Excitatory Transmitter Release

(2014) Hiroaki Tani et al.   NEURON

Attenuation of Ethanol Withdrawal by Ceftriaxone-Induced Upregulation of Glutamate Transporter EAAT2

(2014) Osama A Abulseoud et al.   NEUROPSYCHOPHARMACOLOGY

Ceftriaxone mediated rescue of nigral oxidative damage and motor deficits in MPTP model of Parkinson's disease in rats

(2014) Rohit Bisht et al.   NEUROTOXICOLOGY

The effects of the β-lactam antibiotic, ceftriaxone, on forepaw stepping and l-DOPA-induced dyskinesia in a rodent model of Parkinson’s disease

(2014) John E. Kelsey et al.   PSYCHOPHARMACOLOGY

Effects of ceftriaxone on ethanol intake: a possible role for xCT and GLT-1 isoforms modulation of glutamate levels in P rats

(2014) Hasan Alhaddad et al.   PSYCHOPHARMACOLOGY

Antihyperalgesic/Antinociceptive Effects of Ceftriaxone and Its Synergistic Interactions with Different Analgesics in Inflammatory Pain in Rodents

(2013) Radica M. Stepanovic´-Petrovic´ et al.   ANESTHESIOLOGY

From Pathophysiology to Novel Antidepressant Drugs: Glial Contributions to the Pathology and Treatment of Mood Disorders

(2013) Gerard Sanacora et al.   BIOLOGICAL PSYCHIATRY

Glutamate transporters in the biology of malignant gliomas

(2013) Stephanie M. Robert et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Astrocyte Pathology in Major Depressive Disorder: Insights from Human Postmortem Brain Tissue

(2013) Grazyna Rajkowska et al.   CURRENT DRUG TARGETS

Functional Modulation of the Glutamate Transporter Variant GLT1b by the PDZ Domain Protein PICK1

(2013) Rikke Sogaard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

cAMP Response Element-binding Protein (CREB) and Nuclear Factor κB Mediate the Tamoxifen-induced Up-regulation of Glutamate Transporter 1 (GLT-1) in Rat Astrocytes

(2013) Pratap Karki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal Exosomal miRNA-dependent Translational Regulation of Astroglial Glutamate Transporter GLT1

(2013) Lydie Morel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The GLT-1 (EAAT2; slc1a2) glutamate transporter is essential for glutamate homeostasis in the neocortex of the mouse

(2013) Lars Petter Bjørnsen et al.   JOURNAL OF NEUROCHEMISTRY

Allosteric Modulation of an Excitatory Amino Acid Transporter: The Subtype-Selective Inhibitor UCPH-101 Exerts Sustained Inhibition of EAAT1 through an Intramonomeric Site in the Trimerization Domain

(2013) B. Abrahamsen et al.   JOURNAL OF NEUROSCIENCE

Ceftriaxone Treatment after Traumatic Brain Injury Restores Expression of the Glutamate Transporter, GLT-1, Reduces Regional Gliosis, and Reduces Post-Traumatic Seizures in the Rat

(2013) Grant S. Goodrich et al.   JOURNAL OF NEUROTRAUMA

Ceftriaxone, a beta-lactam antibiotic, attenuates relapse-like ethanol-drinking behavior in alcohol-preferring rats

(2013) Abeer M Qrunfleh et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Ceftriaxone increases glutamate uptake and reduces striatal tyrosine hydroxylase loss in 6-OHDA Parkinson's model

(2013) Tanya Chotibut et al.   MOLECULAR NEUROBIOLOGY

Neuroprotective effect of ceftriaxone in a rat model of traumatic brain injury

(2013) Changmeng Cui et al.   NEUROLOGICAL SCIENCES

Predictable Chronic Mild Stress in Adolescence Increases Resilience in Adulthood

(2013) Lin Suo et al.   NEUROPSYCHOPHARMACOLOGY

Chronic Administration of the Methylxanthine Propentofylline Impairs Reinstatement to Cocaine by a GLT-1-Dependent Mechanism

(2013) Kathryn J Reissner et al.   NEUROPSYCHOPHARMACOLOGY

Neuroprotective effect of ceftriaxone on the penumbra in a rat venous ischemia model

(2013) T. Inui et al.   NEUROSCIENCE

SLC1 glutamate transporters

(2013) Christof Grewer et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Mechanisms of Glutamate Transport

(2013) Robert J. Vandenberg et al.   PHYSIOLOGICAL REVIEWS

A  induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

(2013) M. Talantova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reinstatement of nicotine seeking is mediated by glutamatergic plasticity

(2013) C. D. Gipson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Excitotoxicity and stroke: Identifying novel targets for neuroprotection

(2013) Ted Weita Lai et al.   PROGRESS IN NEUROBIOLOGY

Effects of the beta-lactam antibiotic ceftriaxone on nicotine withdrawal and nicotine-induced reinstatement of preference in mice

(2013) M. Alajaji et al.   PSYCHOPHARMACOLOGY

SLC1 Glutamate Transporters and Diseases: Psychiatric Diseases and Pathological Pain

(2013) Takayuki Nakagawa et al.   Current Molecular Pharmacology

Functional Neuroimaging of Major Depressive Disorder: A Meta-Analysis and New Integration of Baseline Activation and Neural Response Data

(2012) J. Paul Hamilton et al.   AMERICAN JOURNAL OF PSYCHIATRY

Mechanism of Inhibition of the Glutamate Transporter EAAC1 by the Conformationally Constrained Glutamate Analogue (+)-HIP-B

(2012) Randolph Callender et al.   BIOCHEMISTRY

Ceftriaxone upregulates the glutamate transporter in medial prefrontal cortex and blocks reinstatement of methamphetamine seeking in a condition place preference paradigm

(2012) Osama A. Abulseoud et al.   BRAIN RESEARCH

Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases

(2012) Chien-Liang Glenn Lin et al.   Future Medicinal Chemistry

The CpG island shore of the GLT-1 gene acts as a methylation-sensitive enhancer

(2012) Tatjana Perisic et al.   GLIA

Astrocytic regulation of glutamate homeostasis in epilepsy

(2012) Douglas A. Coulter et al.   GLIA

Protein Kinase C (PKC)-promoted Endocytosis of Glutamate Transporter GLT-1 Requires Ubiquitin Ligase Nedd4-2-dependent Ubiquitination but Not Phosphorylation

(2012) Noemí García-Tardón et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPR30 Regulates Glutamate Transporter GLT-1 Expression in Rat Primary Astrocytes

(2012) Eunsook Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Density of EAAC1 (EAAT3) Glutamate Transporters Expressed by Neurons in the Mammalian CNS

(2012) S. Holmseth et al.   JOURNAL OF NEUROSCIENCE

Ceftriaxone Normalizes Nucleus Accumbens Synaptic Transmission, Glutamate Transport, and Export following Cocaine Self-Administration and Extinction Training

(2012) H. Trantham-Davidson et al.   JOURNAL OF NEUROSCIENCE

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Christopher J L Murray et al.   LANCET

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

Relationship between increase in astrocytic GLT-1 glutamate transport and late-LTP

(2012) J. D. Pita-Almenar et al.   LEARNING & MEMORY

Increased glial glutamate transporter EAAT2 expression reduces epileptogenic processes following pilocarpine-induced status epilepticus

(2012) Qiongman Kong et al.   NEUROBIOLOGY OF DISEASE

Substrate Competition Studies Demonstrate Oxidative Metabolism of Glucose, Glutamate, Glutamine, Lactate and 3-Hydroxybutyrate in Cortical Astrocytes from Rat Brain

(2012) Mary C. McKenna   NEUROCHEMICAL RESEARCH

Blockade of Astrocytic Glutamate Uptake in the Prefrontal Cortex Induces Anhedonia

(2012) Catherine S John et al.   NEUROPSYCHOPHARMACOLOGY

Differential effects of cocaine access and withdrawal on glutamate type 1 transporter expression in rat nucleus accumbens core and shell

(2012) K.D. Fischer-Smith et al.   NEUROSCIENCE

Ceftriaxone Ameliorates Motor Deficits and Protects Dopaminergic Neurons in 6-Hydroxydopamine-Lesioned Rats

(2011) T. C. H. Leung et al.   ACS Chemical Neuroscience

Ceftriaxone, a Beta-Lactam Antibiotic, Reduces Ethanol Consumption in Alcohol-Preferring Rats

(2011) Y. Sari et al.   ALCOHOL AND ALCOHOLISM

Ceftriaxone prevents the induction of cocaine sensitization and produces enduring attenuation of cue- and cocaine-primed reinstatement of cocaine-seeking

(2011) Ilan Sondheimer et al.   BEHAVIOURAL BRAIN RESEARCH

Structure–activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators

(2011) Xuechao Xing et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Discovery of Slowness: Low-Capacity Transport and Slow Anion Channel Gating by the Glutamate Transporter EAAT5

(2011) Armanda Gameiro et al.   BIOPHYSICAL JOURNAL

Hippocampal glutamate transporter 1 (GLT-1) complex levels are paralleling memory training in the Multiple T-Maze in C57BL/6J mice

(2011) Seok Heo et al.   Brain Structure & Function

Neuronal activity regulates glutamate transporter dynamics in developing astrocytes

(2011) Adrienne M. Benediktsson et al.   GLIA

A morphometric study of glia and neurons in the anterior cingulate cortex in mood disorder

(2011) Rebecca A. Gittins et al.   JOURNAL OF AFFECTIVE DISORDERS

Nuclear Factor- B Contributes to Neuron-Dependent Induction of Glutamate Transporter-1 Expression in Astrocytes

(2011) M. Ghosh et al.   JOURNAL OF NEUROSCIENCE

Co-compartmentalization of the Astroglial Glutamate Transporter, GLT-1, with Glycolytic Enzymes and Mitochondria

(2011) E. N. Genda et al.   JOURNAL OF NEUROSCIENCE

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

Amyotrophic lateral sclerosis

(2011) Matthew C Kiernan et al.   LANCET

Mechanisms of epileptogenesis and potential treatment targets

(2011) Asla Pitkänen et al.   LANCET NEUROLOGY

New medications for drug addiction hiding in glutamatergic neuroplasticity

(2011) P W Kalivas et al.   MOLECULAR PSYCHIATRY

Preferential accumulation of amyloid-beta in presynaptic glutamatergic terminals (VGluT1 and VGluT2) in Alzheimer's disease cortex

(2011) Sophie Sokolow et al.   NEUROBIOLOGY OF DISEASE

Alcohol-seeking behavior is associated with increased glutamate transmission in basolateral amygdala and nucleus accumbens as measured by glutamate-oxidase-coated biosensors

(2010) Justin T. Gass et al.   ADDICTION BIOLOGY

Current hypotheses for the underlying biology of amyotrophic lateral sclerosis

(2010) Jeffrey D. Rothstein   ANNALS OF NEUROLOGY

Riluzole rapidly attenuates hyperemotional responses in olfactory bulbectomized rats, an animal model of depression

(2010) Kou Takahashi et al.   BEHAVIOURAL BRAIN RESEARCH

β-Lactam antibiotic inhibits development of morphine physical dependence in rats

(2010) Scott M. Rawls et al.   BEHAVIOURAL PHARMACOLOGY

Amygdala astrocyte reduction in subjects with major depressive disorder but not bipolar disorder

(2010) Lori L Altshuler et al.   BIPOLAR DISORDERS

Astrocytic function and its alteration in the epileptic brain

(2010) Ronald Jabs et al.   EPILEPSIA

Pharmacological evaluation of glutamate transporter 1 (GLT-1) mediated neuroprotection following cerebral ischemia/reperfusion injury

(2010) Rajkumar Verma et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Glial and glutamatergic markers in depression, alcoholism, and their comorbidity

(2010) José Javier Miguel-Hidalgo et al.   JOURNAL OF AFFECTIVE DISORDERS

Hetero-oligomerization of Neuronal Glutamate Transporters

(2010) Doreen Nothmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotective Drug Riluzole Amplifies the Heat Shock Factor 1 (HSF1)- and Glutamate Transporter 1 (GLT1)-dependent Cytoprotective Mechanisms for Neuronal Survival

(2010) Alice Y. C. Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure−Activity Relationship Study of First Selective Inhibitor of Excitatory Amino Acid Transporter Subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101)

(2010) Mette N. Erichsen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Increased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimer’s disease

(2010) Guilian Tian et al.   JOURNAL OF NEUROCHEMISTRY

Group II Metabotropic Glutamate Receptor Stimulation Triggers Production and Release of Alzheimer's Amyloid  42 from Isolated Intact Nerve Terminals

(2010) S. H. Kim et al.   JOURNAL OF NEUROSCIENCE

Activation of Extrasynaptic, But Not Synaptic, NMDA Receptors Modifies Amyloid Precursor Protein Expression Pattern and Increases Amyloid-  Production

(2010) K. Bordji et al.   JOURNAL OF NEUROSCIENCE

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

Glutamate transporter variants reduce glutamate uptake in Alzheimer's disease

(2010) Heather A. Scott et al.   NEUROBIOLOGY OF AGING

Modulation of astrocyte glutamate transporters decreases seizures in a mouse model of Tuberous Sclerosis Complex

(2010) Ling-Hui Zeng et al.   NEUROBIOLOGY OF DISEASE

Palmitoylation and function of glial glutamate transporter-1 is reduced in the YAC128 mouse model of Huntington disease

(2010) Kun Huang et al.   NEUROBIOLOGY OF DISEASE

Acute Restraint Stress Enhances Calcium Mobilization and Glutamate Exocytosis in Cerebrocortical Synaptosomes from Mice

(2010) Eiki Satoh et al.   NEUROCHEMICAL RESEARCH

New views of glutamate transporter structure and function: Advances and challenges

(2010) Jie Jiang et al.   NEUROPHARMACOLOGY

Blockade of Astrocytic Glutamate Uptake in Rats Induces Signs of Anhedonia and Impaired Spatial Memory

(2010) Anita J Bechtholt-Gompf et al.   NEUROPSYCHOPHARMACOLOGY

Spinal upregulation of glutamate transporter GLT-1 by ceftriaxone: therapeutic efficacy in a range of experimental nervous system disorders

(2010) K.M. Ramos et al.   NEUROSCIENCE

Organization of NMDA receptors at extrasynaptic locations

(2010) R.S. Petralia et al.   NEUROSCIENCE

Acute Stress Increases Depolarization-Evoked Glutamate Release in the Rat Prefrontal/Frontal Cortex: The Dampening Action of Antidepressants

(2010) Laura Musazzi et al.   PLoS One

Excitatory amino acid transporters EAAT-1 and EAAT-2 in temporal lobe and hippocampus in intractable temporal lobe epilepsy

(2009) SINAN SARAC et al.   APMIS

Ceftriaxone Restores Glutamate Homeostasis and Prevents Relapse to Cocaine Seeking

(2009) Lori A. Knackstedt et al.   BIOLOGICAL PSYCHIATRY

Excitatory amino acid transporters as potential drug targets

(2009) Lennart Bunch et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Discovery of the First Selective Inhibitor of Excitatory Amino Acid Transporter Subtype 1

(2009) Anders A. Jensen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Upregulation of Glt1 Attenuates Cue-Induced Reinstatement of Cocaine-Seeking Behavior in Rats

(2009) Y. Sari et al.   JOURNAL OF NEUROSCIENCE

Reverse glial glutamate uptake triggers neuronal cell death through extrasynaptic NMDA receptor activation

(2009) E. Gouix et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Predictable chronic mild stress improves mood, hippocampal neurogenesis and memory

(2009) V K Parihar et al.   MOLECULAR PSYCHIATRY

Transport mechanism of a bacterial homologue of glutamate transporters

(2009) Nicolas Reyes et al.   NATURE

Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport

(2009) Alessandro Filosa et al.   NATURE NEUROSCIENCE

The glutamate homeostasis hypothesis of addiction

(2009) Peter W. Kalivas   NATURE REVIEWS NEUROSCIENCE

Astrocyte-neuron interactions: Implications for epilepsy

(2009) E. E. Benarroch   NEUROLOGY

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

Presynaptic Regulation of Astroglial Excitatory Neurotransmitter Transporter GLT1

(2009) Yongjie Yang et al.   NEURON

Reduced expression of glutamate transporters vGluT1, EAAT2 and EAAT4 in learned helpless rats, an animal model of depression

(2009) M. Zink et al.   NEUROPHARMACOLOGY

Valproate and Amitriptyline Exert Common and Divergent Influences on Global and Gene Promoter-Specific Chromatin Modifications in Rat Primary Astrocytes

(2009) Tatjana Perisic et al.   NEUROPSYCHOPHARMACOLOGY

The concentrations and distributions of three C-terminal variants of the GLT1 (EAAT2; slc1a2) glutamate transporter protein in rat brain tissue suggest differential regulation

(2009) S. Holmseth et al.   NEUROSCIENCE

An anti-nociceptive role for ceftriaxone in chronic neuropathic pain in rats

(2009) Yuyan Hu et al.   PAIN

Glial ephrin-A3 regulates hippocampal dendritic spine morphology and glutamate transport

(2009) M. A. Carmona et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GLT-1 up-regulation enhances the effect of PCP on prepulse inhibition of the startle reflex in adult rats

(2009) Marcello Melone et al.   SCHIZOPHRENIA RESEARCH

Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like Behaviors

(2008) Mounira Banasr et al.   BIOLOGICAL PSYCHIATRY

Beneficial Effects of Ceftriaxone Against Pentylenetetrazole-Evoked Convulsions

(2008) Ankica V. Jelenkovic et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

PKC-dependent endocytosis of the GLT1 glutamate transporter depends on ubiquitylation of lysines located in a C-terminal cluster

(2008) Inmaculada M. González-gonzález et al.   GLIA

Glutamate forward and reverse transport: From molecular mechanism to transporter-mediated release after ischemia

(2008) Christof Grewer et al.   IUBMB LIFE

Mechanism of Ceftriaxone Induction of Excitatory Amino Acid Transporter-2 Expression and Glutamate Uptake in Primary Human Astrocytes

(2008) Seok-Geun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-affinity Na+/K+-dependent glutamate transporter EAAT4 is expressed throughout the rat fore- and midbrain

(2008) Ann Massie et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Downregulation of glial glutamate transporters after dopamine denervation in the striatum of 6-hydroxydopamine-lesioned rats

(2008) E.K.Y. Chung et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The β-lactam antibiotic, ceftriaxone, dramatically improves survival, increases glutamate uptake and induces neurotrophins in stroke

(2008) Christa Thöne-Reineke et al.   JOURNAL OF HYPERTENSION

Glutamate Release in the Nucleus Accumbens Core Is Necessary for Heroin Seeking

(2008) R. T. LaLumiere et al.   JOURNAL OF NEUROSCIENCE

Neuroprotective Effects of the Novel Glutamate Transporter Inhibitor (-)-3-Hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]-isoxazole-4-carboxylic Acid, Which Preferentially Inhibits Reverse Transport (Glutamate Release) Compared with Glutamate Reuptake

(2008) S. Colleoni et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Stroke

(2008) Geoffrey A Donnan et al.   LANCET

Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole

(2008) M Banasr et al.   MOLECULAR PSYCHIATRY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

β-Amyloid-related peptides potentiate K+-evoked glutamate release from adult rat hippocampal slices

(2008) D. Kabogo et al.   NEUROBIOLOGY OF AGING

Ubiquitination-mediated internalization and degradation of the astroglial glutamate transporter, GLT-1

(2008) Amanda L. Sheldon et al.   NEUROCHEMISTRY INTERNATIONAL

Astrocytes in the Epileptic Brain

(2008) Jonathon Wetherington et al.   NEURON

Selective overexpression of excitatory amino acid transporter 2 (EAAT2) in astrocytes enhances neuroprotection from moderate but not severe hypoxia–ischemia

(2008) M.L. Weller et al.   NEUROSCIENCE

Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse

(2008) B.R. Miller et al.   NEUROSCIENCE

A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: New insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2)

(2008) D.N. Furness et al.   NEUROSCIENCE

A β-Lactam Antibiotic Dampens Excitotoxic Inflammatory CNS Damage in a Mouse Model of Multiple Sclerosis

(2008) Nico Melzer et al.   PLoS One

Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1

(2007) Elena Fumagalli et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Loss of VGLUT1 and VGLUT2 in the prefrontal cortex is correlated with cognitive decline in Alzheimer disease

(2007) Alireza Kashani et al.   NEUROBIOLOGY OF AGING

Transporters for L-glutamate: An update on their molecular pharmacology and pathological involvement

(2006) P M Beart et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transgenic SOD1 G93A mice develop reduced GLT-1 in spinal cord without alterations in cerebrospinal fluid glutamate levels

(2003) Caterina Bendotti et al.   JOURNAL OF NEUROCHEMISTRY