SLC1 glutamate transporters

Regional regulation of glutamate signaling during cuprizone-induced demyelination in the brain

(2013) Abolfazl Azami Tameh et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

(2013) Undine E. Lang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Neuronal Exosomal miRNA-dependent Translational Regulation of Astroglial Glutamate Transporter GLT1

(2013) Lydie Morel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric Modulation of an Excitatory Amino Acid Transporter: The Subtype-Selective Inhibitor UCPH-101 Exerts Sustained Inhibition of EAAT1 through an Intramonomeric Site in the Trimerization Domain

(2013) B. Abrahamsen et al.   JOURNAL OF NEUROSCIENCE

Transport dynamics in a glutamate transporter homologue

(2013) Nurunisa Akyuz et al.   NATURE

Conformational heterogeneity of the aspartate transporter GltPh

(2013) Inga Hänelt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Neurotransmitter Transporters: Structure Meets Function

(2013) Paul J. Focke et al.   STRUCTURE

Protonation State of a Conserved Acidic Amino Acid Involved in Na+ Binding to the Glutamate Transporter EAAC1

(2012) Juddy Mwaura et al.   ACS Chemical Neuroscience

Mechanism of Inhibition of the Glutamate Transporter EAAC1 by the Conformationally Constrained Glutamate Analogue (+)-HIP-B

(2012) Randolph Callender et al.   BIOCHEMISTRY

Neuroprotection by lowering cholesterol: A decrease in membrane cholesterol content reduces transporter-mediated glutamate release from brain nerve terminals

(2012) N. Krisanova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A point mutation associated with episodic ataxia 6 increases glutamate transporter anion currents

(2012) Natalie Winter et al.   BRAIN

Translational control by 3'-UTR-binding proteins

(2012) E. Szostak et al.   Briefings in Functional Genomics

Transcriptional Regulation of the GLAST/EAAT-1 Gene in Rat and Man

(2012) Tina Unger et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

NMDA and AMPA receptor mediated excitotoxicity in cerebral cortex of streptozotocin induced diabetic rat: Ameliorating effects of curcumin

(2012) S. Jayanarayanan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Glutamate Transporter 1: Target for the Treatment of Alcohol Dependence

(2012) P.S.S. Rao et al.   CURRENT MEDICINAL CHEMISTRY

The CpG island shore of the GLT-1 gene acts as a methylation-sensitive enhancer

(2012) Tatjana Perisic et al.   GLIA

Cell surface turnover of the glutamate transporter GLT-1 is mediated by ubiquitination/deubiquitination

(2012) Jaime Martínez-Villarreal et al.   GLIA

Charge Compensation Mechanism of a Na+-coupled, Secondary Active Glutamate Transporter

(2012) Christof Grewer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase C (PKC)-promoted Endocytosis of Glutamate Transporter GLT-1 Requires Ubiquitin Ligase Nedd4-2-dependent Ubiquitination but Not Phosphorylation

(2012) Noemí García-Tardón et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cysteine Scanning Mutagenesis of Transmembrane Helix 3 of a Brain Glutamate Transporter Reveals Two Conformationally Sensitive Positions

(2012) Nechama Silverstein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure–Activity Relationship Study of Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitor 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101) and Absolute Configurational Assignment Using Infrared and Vibrational Circular Dichroism Spectroscopy in Combination with ab Initio Hartree–Fock Calculations

(2012) Tri H. V. Huynh et al.   JOURNAL OF MEDICINAL CHEMISTRY

A novel cross-talk between endothelin and ErbB receptors controlling glutamate transporter expression in astrocytes

(2012) Darko Glisic et al.   JOURNAL OF NEUROCHEMISTRY

The Density of EAAC1 (EAAT3) Glutamate Transporters Expressed by Neurons in the Mammalian CNS

(2012) S. Holmseth et al.   JOURNAL OF NEUROSCIENCE

Structural Intermediates in a Model of the Substrate Translocation Path of the Bacterial Glutamate Transporter Homologue GltPh

(2012) Sebastian Stolzenberg et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Glutamate system, amyloid β peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology

(2012) Timothy Revett et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Crystal structure of an asymmetric trimer of a bacterial glutamate transporter homolog

(2012) Grégory Verdon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reduced alcohol intake and reward associated with impaired endocannabinoid signaling in mice with a deletion of the glutamate transporter GLAST

(2012) Rose-Marie Karlsson et al.   NEUROPHARMACOLOGY

Position of the Third Na+ Site in the Aspartate Transporter GltPh and the Human Glutamate Transporter, EAAT1

(2012) Turgut Bastug et al.   PLoS One

The role of the 3' untranslated region in post-transcriptional regulation of protein expression in mammalian cells.

(2012) Eva Matoulkova et al.   RNA Biology

High-fat diets induce changes in hippocampal glutamate metabolism and neurotransmission

(2011) Ismael Valladolid-Acebes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Discovery of Slowness: Low-Capacity Transport and Slow Anion Channel Gating by the Glutamate Transporter EAAT5

(2011) Armanda Gameiro et al.   BIOPHYSICAL JOURNAL

Changes in glutamate transporter expression in mouse forebrain areas following focal ischemia

(2011) Pirusha Ketheeswaranathan et al.   BRAIN RESEARCH

MicroRNAs and epigenetics

(2011) Fumiaki Sato et al.   FEBS Journal

Neuronal activity regulates glutamate transporter dynamics in developing astrocytes

(2011) Adrienne M. Benediktsson et al.   GLIA

A Conserved Aspartate Residue Located at the Extracellular End of the Binding Pocket Controls Cation Interactions in Brain Glutamate Transporters

(2011) Noa Rosental et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Factor Erythroid 2-Related Factor 2 Facilitates Neuronal Glutathione Synthesis by Upregulating Neuronal Excitatory Amino Acid Transporter 3 Expression

(2011) C. Escartin et al.   JOURNAL OF NEUROSCIENCE

Large collective motions regulate the functional properties of glutamate transporter trimers

(2011) J. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic and functional studies of a missense variant in a glutamate transporter, SLC1A3, in Tourette syndrome

(2011) Abby Adamczyk et al.   PSYCHIATRIC GENETICS

Current hypotheses for the underlying biology of amyotrophic lateral sclerosis

(2010) Jeffrey D. Rothstein   ANNALS OF NEUROLOGY

Na+:Aspartate Coupling Stoichiometry in the Glutamate Transporter Homologue GltPh

(2010) Maarten Groeneveld et al.   BIOCHEMISTRY

Identification of the Third Na+ Site and the Sequence of Extracellular Binding Events in the Glutamate Transporter

(2010) Zhijian Huang et al.   BIOPHYSICAL JOURNAL

Hetero-oligomerization of Neuronal Glutamate Transporters

(2010) Doreen Nothmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reconstructing a Chloride-binding Site in a Bacterial Neurotransmitter Transporter Homologue

(2010) Sotiria Tavoulari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Cation Binding to the Glutamate Transporter EAAC1 Probed with Mutation of the Conserved Amino Acid Residue Thr101

(2010) Zhen Tao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Excitatory Amino Acid Transporter-2 (EAAT2) and glutamate in neurodegeneration: Opportunities for developing novel therapeutics

(2010) Keetae Kim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Glutamate Transporter Type 3 Knockout Reduces Brain Tolerance to Focal Brain Ischemia in MICE

(2010) Liaoliao Li et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Loss-of-function mutations in the glutamate transporter SLC1A1 cause human dicarboxylic aminoaciduria

(2010) Charles G. Bailey et al.   JOURNAL OF CLINICAL INVESTIGATION

Structure−Activity Relationship Study of First Selective Inhibitor of Excitatory Amino Acid Transporter Subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101)

(2010) Mette N. Erichsen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Increased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimer’s disease

(2010) Guilian Tian et al.   JOURNAL OF NEUROCHEMISTRY

The mechanism of substrate release by the aspartate transporter GltPh: insights from simulations

(2010) Jason DeChancie et al.   Molecular BioSystems

Revitalizing membrane rafts: new tools and insights

(2010) Kai Simons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Time-dependent changes in GLT-1 functioning in striatum of hemi-Parkinson rats

(2010) Ann Massie et al.   NEUROCHEMISTRY INTERNATIONAL

Quantitative analysis of EAAT4 promoter activity in neurons and astrocytes of mouse somatic sensory cortex

(2010) Luisa de Vivo et al.   NEUROSCIENCE LETTERS

Evidence for a third sodium-binding site in glutamate transporters suggests an ion/substrate coupling model

(2010) H. P. Larsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural perspectives on secondary active transporters

(2010) Olga Boudker et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Small but influential: the role of microRNAs on gene regulatory network and 3′UTR evolution

(2009) Rui Zhang et al.   Journal of Genetics and Genomics

Estrogen and tamoxifen reverse manganese-induced glutamate transporter impairment in astrocytes

(2009) Eun-Sook Y. Lee et al.   JOURNAL OF NEUROCHEMISTRY

Disrupted Glutamate Transporter Expression in the Spinal Cord With Acute Flaccid Paralysis Caused by West Nile Virus Infection

(2009) Pennelope K. Blakely et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The Four Major N- and C-Terminal Splice Variants of the Excitatory Amino Acid Transporter GLT-1 Form Cell Surface Homomeric and Heteromeric Assemblies

(2009) E. Peacey et al.   MOLECULAR PHARMACOLOGY

Transport mechanism of a bacterial homologue of glutamate transporters

(2009) Nicolas Reyes et al.   NATURE

Endothelin-1 reverses the histone deacetylase inhibitor-induced increase in glial glutamate transporter transcription without affecting histone acetylation levels

(2009) Claudia Allritz et al.   NEUROCHEMISTRY INTERNATIONAL

Valproate and Amitriptyline Exert Common and Divergent Influences on Global and Gene Promoter-Specific Chromatin Modifications in Rat Primary Astrocytes

(2009) Tatjana Perisic et al.   NEUROPSYCHOPHARMACOLOGY

Molecular simulations elucidate the substrate translocation pathway in a glutamate transporter

(2009) Yan Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inward-facing conformation of glutamate transporters as revealed by their inverted-topology structural repeats

(2009) T. J. Crisman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Glial Glutamate and Aspartate Transporter (Excitatory Amino Acid Transporter 1) Causes Locomotor Hyperactivity and Exaggerated Responses to Psychotomimetics: Rescue by Haloperidol and Metabotropic Glutamate 2/3 Agonist

(2008) Rose-Marie Karlsson et al.   BIOLOGICAL PSYCHIATRY

Dynamics of the Extracellular Gate and Ion-Substrate Coupling in the Glutamate Transporter

(2008) Zhijian Huang et al.   BIOPHYSICAL JOURNAL

Detergent-Insoluble EAAC1/EAAT3 Aberrantly Accumulates in Hippocampal Neurons of Alzheimer's Disease Patients

(2008) Kevin Duerson et al.   BRAIN PATHOLOGY

PKC-dependent endocytosis of the GLT1 glutamate transporter depends on ubiquitylation of lysines located in a C-terminal cluster

(2008) Inmaculada M. González-gonzález et al.   GLIA

Differential involvement of TNFα in hypoxic suppression of astrocyte glutamate transporters

(2008) Hannah E. Boycott et al.   GLIA

Glutamate forward and reverse transport: From molecular mechanism to transporter-mediated release after ischemia

(2008) Christof Grewer et al.   IUBMB LIFE

Time-resolved Mechanism of Extracellular Gate Opening and Substrate Binding in a Glutamate Transporter

(2008) Indira H. Shrivastava et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Ceftriaxone Induction of Excitatory Amino Acid Transporter-2 Expression and Glutamate Uptake in Primary Human Astrocytes

(2008) Seok-Geun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assembly and forward trafficking of NMDA receptors (Review)

(2008) F. Anne Stephenson et al.   MOLECULAR MEMBRANE BIOLOGY

Gene Transfer of GLT-1, a Glial Glutamate Transporter, into the Spinal cord by Recombinant Adenovirus Attenuates Inflammatory and Neuropathic Pain in Rats

(2008) Sanae Maeda et al.   Molecular Pain

Ubiquitination-mediated internalization and degradation of the astroglial glutamate transporter, GLT-1

(2008) Amanda L. Sheldon et al.   NEUROCHEMISTRY INTERNATIONAL

Electrophysiology of cerebral ischemia

(2008) Krešimir Krnjević   NEUROPHARMACOLOGY

Assessment of Glutamate Transporter GLAST (EAAT1)-Deficient Mice for Phenotypes Relevant to the Negative and Executive/Cognitive Symptoms of Schizophrenia

(2008) Rose-Marie Karlsson et al.   NEUROPSYCHOPHARMACOLOGY

A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: New insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2)

(2008) D.N. Furness et al.   NEUROSCIENCE

Regulation of AMPA receptors and synaptic plasticity

(2008) S.D. Santos et al.   NEUROSCIENCE

Role of endothelins as mediators of injury-induced alterations of glial glutamate turnover

(2007) Claudia Lehmann et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Transporters for L-glutamate: An update on their molecular pharmacology and pathological involvement

(2006) P M Beart et al.   BRITISH JOURNAL OF PHARMACOLOGY