Article
Biochemistry & Molecular Biology
Mi Kyoung Seo, Jung An Lee, Sehoon Jeong, Dae-Hyun Seog, Jung Goo Lee, Sung Woo Park
Summary: In an animal model of chronic unpredictable stress-induced depression, chronic treatment with the mGlu2/3 receptor antagonist LY341495 showed antidepressant effects possibly through the activation of hippocampal mTORC1 signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Andre R. S. Colla, Francis L. Pazini, Vicente Lieberknecht, Anderson Camargo, Ana Lucia S. Rodrigues
Summary: The study demonstrates that ursolic acid has antidepressant-like effects in mice exposed to chronic unpredictable stress (CUS), and this effect may be associated with the modulation of Bcl-2/Bax expression in the hippocampus. Fluoxetine showed similar antidepressant effects as ursolic acid, preventing CUS-induced behavioral changes. However, the mechanisms by which ursolic acid exerts its antidepressant effects may differ from traditional antidepressants like fluoxetine.
METABOLIC BRAIN DISEASE
(2021)
Article
Behavioral Sciences
Negin Saeedi, Mahgol Darvishmolla, Zohreh Tavassoli, Shima Davoudi, Soomaayeh Heysieattalab, Narges Hosseinmardi, Mahyar Janahmadi, Gila Behzadi
Summary: Opioid abuse affects synaptic plasticity and behavior like morphine dependence, with glial cells and glutamate playing key roles. GLT-1 in the hippocampus is involved in morphine dependence, and activating it can reduce withdrawal symptoms associated with chronic morphine use.
BRAIN AND BEHAVIOR
(2021)
Article
Clinical Neurology
Shu Yang, Li Yi, Xiaodi Xia, Xiaolu Chen, Xiao Hou, Longjie Zhang, Fang Yang, Jiaxin Liao, Zhijie Han, Yixiao Fu
Summary: This study used a rat model to investigate transcriptome changes in the amygdala-hippocampal neural network under chronic unpredictable mild stress (CUMS), and identified depression-related modules. Differential gene expression and enrichment analyses revealed candidate genes associated with neuronal myelination in the amygdala and synaptic transmission in the hippocampus. Furthermore, central genes were identified in both the amygdala and hippocampus modules through module hub gene statistics, differential gene expression, and protein-protein interaction networks.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Jie Zhao, Yin Zhang, Yue Liu, Wen-Qian Tang, Chun-Hui Ji, Jiang-Hong Gu, Bo Jiang
Summary: The study found that MNA has antidepressant-like potential in mice, at least partially mediated through promoting the hippocampal BDNF signaling pathway. A single injection of MNA (100 and 200 mg/kg) displayed notable antidepressant-like effects in the FST and TST.
NEUROSCIENCE LETTERS
(2021)
Article
Food Science & Technology
Yanlan Chen, Nan Xiao, Yuxin Chen, Xinye Chen, Chunfei Zhong, Yuying Cheng, Bing Du, Pan Li
Summary: The study demonstrated that Semen Sojae Praeparatum alleviated depression-like behaviors and structural changes in the neuronal morphology of the hippocampus in rats with CUMS, through promoting neurotransmitter and BDNF levels, modulating gut microbiota, and affecting SCFAs concentration.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Denis A. Borozdenko, Darya I. Gonchar, Vlada I. Bogorodova, Dmitri V. Tarasenko, Evgeniya P. Kramarova, Svetlana S. Khovanova, Yaroslav V. Golubev, Nina M. Kiseleva, Tatiana A. Shmigol, Aiarpi A. Ezdoglian, Konstantin A. Sobyanin, Vadim V. Negrebetsky, Yuri I. Baukov
Summary: This study demonstrates that Compound I has reliable antidepressant activity, comparable to the reference antidepressant Fluoxetine, suggesting its therapeutic potential in depression treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Joanna Szala-Rycaj, Aleksandra Szewczyk, Miroslaw Zagaja, Agnieszka Kaczmarczyk-Ziemba, Maciej Maj, Marta Andres-Mach
Summary: Daily living under stress can lead to mental health problems. Studies have shown that a proper diet enriched with pre-, pro-, and synbiotics can regulate gut brain axis functioning and alleviate the negative effects of stress. This study found that supplementation with topinambur powder and chicory root inulin could mitigate anxiety, depression, and cognitive disorders in mice exposed to chronic unpredictable stress, as well as improve their gut microbiota.
Article
Neurosciences
Yan-Hui Cui, Ao Fu, Xue-Qin Wang, Bo-Xuan Tu, Kang-Zhi Chen, Yi-Kai Wang, Qiong-Gui Hu, Lai-Fa Wang, Zhao-Lan Hu, Pin-Hua Pan, Fang Li, Fang-Fang Bi, Chang-Qi Li
Summary: Substantial evidence suggests that LASP1 plays a significant role in depression by alleviating behavioral defects induced by UCMS through enhanced dendritic spine density and activated AKT-dependent signaling.
Article
Multidisciplinary Sciences
M. Maetzi Estevez-Cabrera, Fausto Sanchez-Munoz, Gilberto Perez-Sanchez, Lenin Pavon, Adrian Hernandez-Diazcouder, J. Luis Cortes Altamirano, C. Soria-Fregoso, Alfonso Alfaro-Rodriguez, Herlinda Bonilla-Jaime
Summary: The antidepressant fluoxetine has been found to have antioxidant and anti-inflammatory effects when dealing with chronic stress. It reduces corticosterone levels, increases the expression of specific miRNAs, and has an antidepressant effect on the forced swim test.
Article
Oncology
Feng Li, Ying Wang, Xue Wang, Yun Zhao, Fang Xie, Ling-Jia Qian
Summary: Stress causes changes in hippocampal gene expression, leading to alterations in hippocampal structure and function. The dynamic changes in hippocampal gene expression caused by stress of different durations are still unknown. This study analyzed the hippocampal transcriptome of rats subjected to chronic unpredictable mild stress (CUMS) of different durations using mRNA sequencing. The results showed opposing regulation patterns of differentially expressed genes (DEGs) between early and late stages of chronic stress, suggesting a functional change from adaptation to damage. GO analysis revealed significant changes in certain biological processes and functions associated with stress-induced gene expression changes. These findings highlight the importance of understanding the molecular mechanisms underlying stress-induced hippocampal alterations.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Neurosciences
M. M. Hyer, G. A. Shaw, P. Goswamee, S. K. Dyer, C. M. Burns, E. Soriano, C. S. Sanchez, S. A. Rowson, A. R. McQuiston, G. N. Neigh
Summary: Females, especially during adolescence, experiencing chronic stress are the most vulnerable to stress-induced diseases like cognitive decline and dementia. The interplay between sex and stress history influences neural dysfunction, with specific mechanisms in the hippocampus driving changes in cognitive function. Chronic adolescent stress may lead to cognitive dysfunction through modifying glutamatergic signaling pathways, particularly in females.
NEUROBIOLOGY OF STRESS
(2021)
Article
Behavioral Sciences
Melissa A. Ribeiro, Rafael P. Aguiar, Franciele F. Scarante, Eduardo J. Fusse, Rubia M. W. de Oliveira, Francisco S. Guimara, Alline C. Campos
Summary: Several pieces of evidence suggest that the monoaminergic theory of depression cannot fully explain all behavioral and neuroplastic changes observed after antidepressant chronic treatment. Other molecular targets, such as the endocannabinoid system, have been associated with the chronic effects of these drugs. In this study, the researchers hypothesized that the behavioral and neuroplastic effects observed after repeated treatment with antidepressants depend on CB1 receptor activation. However, their results showed that chronic blockade of the CB1 receptor does not attenuate the antidepressant or anxiolytic effects of the antidepressants ESC or VFX, indicating that CB1 receptors are not involved in the observed effects.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Csilla Lea Fazekas, Adrienn Szabo, Bibiana Torok, Krisztina Banrevi, Pedro Correia, Tiago Chaves, Stephanie Daumas, Dora Zelena
Summary: Glutamate, mainly regulated by VGLUT3, plays a crucial role in modulating the release of neurotransmitters and sensory processes in the central nervous system. Its presence in the hippocampus suggests potential involvement in learning and memory, although further studies are needed to confirm this hypothesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
You-Cong Yin, Xiao-hui Li, Xuan Rao, Yuan-Jian Li, Jie Du
Summary: An increasing number of studies have shown that miRNAs play an important role in regulating stress-induced ulcers. This study found that miR-143, miR-152, and miR-181 are involved in cold stimulation-induced acute gastric mucosal injury, and their regulatory effect is related to a decrease in glutamate release by reduction of cystine/glutamate transporter activity.
FRONTIERS IN PHARMACOLOGY
(2022)