Aptamer-Based Probes for Cancer Diagnostics and Treatment

Direct and indirect regulation of the tumor immune microenvironment by VEGF

(2022) Yuqing Zhang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

First-in-human phase I clinical trial of a TLR4-binding DNA aptamer, ApTOLL: Safety and pharmacokinetics in healthy volunteers

(2022) Macarena Hernández-Jiménez et al.   Molecular Therapy-Nucleic Acids

Fast detection, a precise and sensitive diagnostic agent for breast cancer

(2022) Qiong Wu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Identification of a novel RNA aptamer that selectively targets breast cancer exosomes

(2021) Carla Lucia Esposito et al.   Molecular Therapy-Nucleic Acids

Novel Complex of PD-L1 Aptamer and Holliday Junction Enhances Antitumor Efficacy in Vivo

(2021) Ting Li et al.   MOLECULES

ATP‐Responsive Smart Hydrogel Releasing Immune Adjuvant Synchronized with Repeated Chemotherapy or Radiotherapy to Boost Antitumor Immunity

(2021) Lele Sun et al.   ADVANCED MATERIALS

Recent progress in developing fluorescent probes for imaging cell metabolites

(2021) Shanni Hong et al.   Biomedical Materials

Light up multiple protein dimers on cell surface based on proximity-induced fluorescence activation of DNA-templated sliver nanoclusters

(2021) Lulu Xu et al.   BIOSENSORS & BIOELECTRONICS

Highly sensitive electrochemical detection of circulating EpCAM-positive tumor cells using a dual signal amplification strategy

(2021) Ayemeh Bagheri Hashkavayi et al.   SENSORS AND ACTUATORS B-CHEMICAL

Development of a novel ssDNA aptamer targeting cardiac troponin I and its clinical applications

(2021) Yi Cen et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Dual aptamer recognition-based G-quadruplex nanowires to selectively analyze cancer-derived exosomes

(2021) Ji Zheng et al.   TALANTA

Gold nanoparticles conjugated with DNA aptamer for photoacoustic detection of human matrix metalloproteinase-9

(2021) Jinhwan Kim et al.   Photoacoustics

Rapid and sensitive exosome detection with CRISPR/Cas12a

(2020) Xianxian Zhao et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Temperature-controlled magnetic nanoparticles hyperthermia inhibits primary tumor growth and metastases dissemination

(2020) Anastasiia S. Garanina et al.   Nanomedicine-Nanotechnology Biology and Medicine

Binding and Structural Properties of DNA Aptamers with VEGF-A-Mimic Activity

(2020) Toru Yoshitomi et al.   Molecular Therapy-Nucleic Acids

Aptamers, the Nucleic Acid Antibodies, in Cancer Therapy

(2020) Zhaoying Fu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Low sample volume origami-paper-based graphene-modified aptasensors for label-free electrochemical detection of cancer biomarker-EGFR

(2020) Yang Wang et al.   Microsystems & Nanoengineering

An amplification strategy for detecting HER2 with a quasi-targeted proteomics approach coupled with aptamer-triggered hybridization chain reaction

(2020) Jingjing Bao et al.   TALANTA

Current Perspectives on Aptamers as Diagnostic Tools and Therapeutic Agents

(2020) Prabir Kumar Kulabhusan et al.   Pharmaceutics

Unravelling the diagnostic and therapeutic potentialities of a novel RNA aptamer isolated against human pituitary tumour transforming gene 1 (PTTG1) protein

(2020) Siva Sankar Prabu et al.   ANALYTICA CHIMICA ACTA

Mechanisms of Action of EGFR Tyrosine Kinase Receptor Incorporated in Extracellular Vesicles

(2020) Laura C. Zanetti-Domingues et al.   Cells

An aptamer-based drug delivery agent (CD133-apt-Dox) selectively and effectively kills liver cancer stem-like cells

(2020) Gang Zhou et al.   CANCER LETTERS

Aptamer-integrated α-Gal liposomes as bispecific agents to trigger immune response for killing tumor cells

(2019) Shanni Hong et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Pegylated magnetic mesoporous silica nanoparticles decorated with AS1411 Aptamer as a targeting delivery system for cytotoxic agents

(2019) Ramin Sakhtianchi et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

A novel cytosensor for capture, detection and release of breast cancer cells based on metal organic framework PCN-224 and DNA tetrahedron linked dual-aptamer

(2019) Dan Ou et al.   SENSORS AND ACTUATORS B-CHEMICAL

An fluorescent aptasensor for sensitive detection of tumor marker based on the FRET of a sandwich structured QDs-AFP-AuNPs

(2019) Lu Zhou et al.   TALANTA

Black Phosphorus-Based Drug Nanocarrier for Targeted and Synergetic Chemophotothermal Therapy of Acute Lymphoblastic Leukemia

(2019) Shenfei Zong et al.   ACS Applied Materials & Interfaces

A signal-on nanobiosensor for VEGF165 detection based on supraparticle copper nanoclusters formed on bivalent aptamer

(2019) Fatemeh Mortazavi Moghadam et al.   BIOSENSORS & BIOELECTRONICS

Co-Delivery of Paclitaxel and PLK1-Targeted siRNA Using Aptamer-Functionalized Cationic Liposome for Synergistic Anti-Breast Cancer Effects In Vivo

(2019) Sheng Yu et al.   Journal of Biomedical Nanotechnology

A fluorometric aptamer nanoprobe for alpha-fetoprotein by exploiting the FRET between 5-carboxyfluorescein and palladium nanoparticles

(2019) Guiyin Li et al.   MICROCHIMICA ACTA

A Sensitive Aptasensor Based on a Hemin/G‐Quadruplex‐Assisted Signal Amplification Strategy for Electrochemical Detection of Gastric Cancer Exosomes

(2019) Rongrong Huang et al.   Small

RNA aptamers targeting integrin α5β1 as probes for cyto- and histo-fluorescence in glioblastoma

(2019) P. Fechter et al.   Molecular Therapy-Nucleic Acids

Direct quantification of cancerous exosomes via surface plasmon resonance with dual gold nanoparticle-assisted signal amplification

(2019) Qing Wang et al.   BIOSENSORS & BIOELECTRONICS

Aptamer functionalized curcumin-loaded human serum albumin (HSA) nanoparticles for targeted delivery to HER-2 positive breast cancer cells

(2019) Tayebeh Saleh et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

A dual-functional HER2 aptamer-conjugated, pH-activated mesoporous silica nanocarrier-based drug delivery system provides in vitro synergistic cytotoxicity in HER2-positive breast cancer cells

(2019) Yinxing Shen et al.   International Journal of Nanomedicine

A fluorescent aptasensor for the femtomolar detection of epidermal growth factor receptor-2 based on the proximity of G-rich sequences to Ag nanoclusters

(2019) Manman Zhang et al.   TALANTA

Near-infrared carbon dots-based fluorescence turn on aptasensor for determination of carcinoembryonic antigen in pleural effusion

(2019) Kang Shao et al.   ANALYTICA CHIMICA ACTA

Enhanced cancer therapy with pH-dependent and aptamer functionalized doxorubicin loaded polymeric (poly D, L-lactic-co-glycolic acid) nanoparticles

(2019) Kandasamy Saravanakumar et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

A nuclear targeted Dox-aptamer loaded liposome delivery platform for the circumvention of drug resistance in breast cancer

(2019) Xin Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Bispecific Aptamer Induced Artificial Protein-Pairing: A Strategy for Selective Inhibition of Receptor Function

(2019) Liping Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ultrasensitive Detection of Exosomes by Target-Triggered Three-Dimensional DNA Walking Machine and Exonuclease III-Assisted Electrochemical Ratiometric Biosensing

(2019) Li Zhao et al.   ANALYTICAL CHEMISTRY

Therapeutic applications of AS1411 aptamer, an update review

(2019) Rezvan Yazdian-Robati et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Electrochemical aptamer-based determination of protein tyrosine kinase-7 using toehold-mediated strand displacement amplification on gold nanoparticles and graphene oxide

(2019) Zongbing Li et al.   MICROCHIMICA ACTA

An aptasensor based on upconversion nanoparticles as LRET donors for the detection of exosomes

(2019) Yonghao Wang et al.   SENSORS AND ACTUATORS B-CHEMICAL

An Efficient Cell-Targeting Drug Delivery System Based on Aptamer-Modified Mesoporous Silica Nanoparticles

(2019) Yang Yang et al.   Nanoscale Research Letters

Aptamer-tagged silver nanoclusters for cell image and Mucin1 detection in vitro

(2019) Leiji Zhou et al.   TALANTA

Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles

(2019) Xiaodong Xie et al.   Nature Communications

A novel aptamer-based online magnetic solid phase extraction method for the selective determination of 8-hydroxy-2′-deoxyguanosine in human urine

(2018) Haijiao Gan et al.   ANALYTICA CHIMICA ACTA

Recent advances on aptamer-based biosensors to detection of platelet-derived growth factor

(2018) Nasrin Razmi et al.   BIOSENSORS & BIOELECTRONICS

Targeted delivery of melittin to cancer cells by AS1411 anti-nucleolin aptamer

(2018) Seyed Hossein Rajabnejad et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Targeted delivery of anti-miR-155 by functionalized mesoporous silica nanoparticles for colorectal cancer therapy

(2018) Yang Li et al.   International Journal of Nanomedicine

A Novel AS1411 Aptamer-Based Three-Way Junction Pocket DNA Nanostructure Loaded with Doxorubicin for Targeting Cancer Cells in Vitro and in Vivo

(2018) Seyed Mohammad Taghdisi et al.   MOLECULAR PHARMACEUTICS

A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo

(2018) Suping Li et al.   NATURE BIOTECHNOLOGY

A sensitive detection method of carcinoembryonic antigen based on dsDNA-templated copper nanoparticles

(2018) Mingjian Chen et al.   NEW JOURNAL OF CHEMISTRY

A fluorescent biosensor based on molybdenum disulfide nanosheets and protein aptamer for sensitive detection of carcinoembryonic antigen

(2018) Lianjing Zhao et al.   SENSORS AND ACTUATORS B-CHEMICAL

A dual-targeting DNA tetrahedron nanocarrier for breast cancer cell imaging and drug delivery

(2018) Xiaoting Liu et al.   TALANTA

DNase I enzyme-aided fluorescence signal amplification based on graphene oxide-DNA aptamer interactions for colorectal cancer exosome detection

(2018) Hui Wang et al.   TALANTA

Enzyme-free ultrasensitive fluorescence detection of epithelial cell adhesion molecules based on a toehold-aided DNA recycling amplification strategy

(2018) Jishun Chen et al.   RSC Advances

Self-assembled RNAi nanoflowers via rolling circle transcription for aptamer-targeted siRNA delivery

(2018) Hui Cheng et al.   Journal of Materials Chemistry B

Recent Advances in Subcellular Targeted Cancer Therapy Based on Functional Materials

(2018) Wei-Hai Chen et al.   ADVANCED MATERIALS

Immune lipoprotein nanostructures inspired relay drug delivery for amplifying antitumor efficiency

(2018) Yue Han et al.   BIOMATERIALS

PET imaging of EGFR expression using an 18F-labeled RNA aptamer

(2018) Siyuan Cheng et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Targeted delivery of doxorubicin to cancer cells by a cruciform DNA nanostructure composed of AS1411 and FOXM1 aptamers

(2018) Khalil Abnous et al.   Expert Opinion on Drug Delivery

Matrix Metalloproteinase-9 (MMP-9) as a Cancer Biomarker and MMP-9 Biosensors: Recent Advances

(2018) Hao Huang   SENSORS

A simple, specific and “on-off” type MUC1 fluorescence aptasensor based on exosomes for detection of breast cancer

(2018) Junli Zhang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Rapid aptasensor capable of simply detect tumor markers based on conjugated polyelectrolytes

(2018) Biqing Bao et al.   TALANTA

Dynamics and Visualization of MCF7 Adenocarcinoma Cell Death by Aptamer-C1q-Mediated Membrane Attack

(2018) John R. Stecker et al.   Nucleic Acid Therapeutics

Aptamer-conjugated multi-walled carbon nanotubes as a new targeted ultrasound contrast agent for the diagnosis of prostate cancer

(2018) Fenfen Gu et al.   JOURNAL OF NANOPARTICLE RESEARCH

Improving the fluorometric determination of the cancer biomarker 8-hydroxy-2′-deoxyguanosine by using a 3D DNA nanomachine

(2018) Wei Wei et al.   MICROCHIMICA ACTA

AS1411 aptamer-decorated cisplatin-loaded poly(lactic-co-glycolic acid) nanoparticles for targeted therapy of miR-21-inhibited ovarian cancer cells

(2018) Somayeh Vandghanooni et al.   Nanomedicine

Recent Advances in SELEX Technology and Aptamer Applications in Biomedicine

(2017) Zhenjian Zhuo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Precise glioblastoma targeting by AS1411 aptamer-functionalized poly ( l -γ-glutamylglutamine)–paclitaxel nanoconjugates

(2017) Zimiao Luo et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Inhibition of adhesion and metastasis of HepG2 hepatocellular carcinoma cells in vitro by DNA aptamer against sialyl Lewis X

(2017) Xiao-kang Wang et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Co-delivery of doxorubicin and AS1411 aptamer by poly(ethylene glycol)-poly(β-amino esters) polymeric micelles for targeted cancer therapy

(2017) Ran Zhang et al.   JOURNAL OF NANOPARTICLE RESEARCH

Inhibition of HER3 activation and tumor growth with a human antibody binding to a conserved epitope formed by domain III and IV

(2017) Lisa C. Schmitt et al.   mAbs

Anti-MUC1 aptamer: A potential opportunity for cancer treatment

(2017) Maryam Sadat Nabavinia et al.   MEDICINAL RESEARCH REVIEWS

Dual signal amplification strategy for amperometric aptasensing using hydroxyapatite nanoparticles. Application to the sensitive detection of the cancer biomarker platelet-derived growth factor BB

(2017) Wentao Jiang et al.   MICROCHIMICA ACTA

Nucleolin-Targeting AS1411-Aptamer-Modified Graft Polymeric Micelle with Dual pH/Redox Sensitivity Designed To Enhance Tumor Therapy through the Codelivery of Doxorubicin/TLR4 siRNA and Suppression of Invasion

(2017) Shudi Yang et al.   MOLECULAR PHARMACEUTICS

A label-free and enzyme-free ratiometric fluorescence biosensor for sensitive detection of carcinoembryonic antigen based on target-aptamer complex recycling amplification

(2017) Kun Wang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Dual aptamer modified dendrigraft poly-l-lysine nanoparticles for overcoming multi-drug resistance through mitochondrial targeting

(2017) Huachao Chen et al.   Journal of Materials Chemistry B

Rethinking cancer nanotheranostics

(2017) Hongmin Chen et al.   Nature Reviews Materials

A label-free ultrasensitive assay of 8-hydroxy-2′-deoxyguanosine in human serum and urine samples via polyaniline deposition and tetrahedral DNA nanostructure

(2016) Jiahui Fan et al.   ANALYTICA CHIMICA ACTA

Dual-primer self-generation SERS signal amplification assay for PDGF-BB using label-free aptamer

(2016) SuJuan Ye et al.   BIOSENSORS & BIOELECTRONICS

Voltammetric aptasensors for protein disease biomarkers detection: A review

(2016) Sofia G. Meirinho et al.   BIOTECHNOLOGY ADVANCES

Berberine as a novel light-up i-motif fluorescence ligand and its application in designing molecular logic systems

(2016) Lijun Xu et al.   CHEMICAL COMMUNICATIONS

Improvement in the drug delivery and anti-tumor efficacy of PEGylated liposomal doxorubicin by targeting RNA aptamers in mice bearing breast tumor model

(2016) Seyedeh Alia Moosavian et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Theranostic MUC-1 aptamer targeted gold coated superparamagnetic iron oxide nanoparticles for magnetic resonance imaging and photothermal therapy of colon cancer

(2016) Morteza Azhdarzadeh et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

EpCAM aptamer-functionalized mesoporous silica nanoparticles for efficient colon cancer cell-targeted drug delivery

(2016) Xiaodong Xie et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Double targeting and aptamer-assisted controlled release delivery of epirubicin to cancer cells by aptamers-based dendrimer in vitro and in vivo

(2016) Seyed Mohammad Taghdisi et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Aptamer-mediated delivery of docetaxel to prostate cancer through polymeric nanoparticles for enhancement of antitumor efficacy

(2016) Zhongjian Chen et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

ATP-Responsive Drug Delivery Systems

(2016) Wujin Sun et al.   Expert Opinion on Drug Delivery

Diagnosis of prostate cancer using anti-PSMA aptamer A10-3.2-oriented lipid nanobubbles

(2016) Xiaozhou Fan et al.   International Journal of Nanomedicine

Specific targeting delivery to MUC1 overexpressing tumors by albumin-chitosan nanoparticles conjugated to DNA aptamer

(2016) Mehdi Esfandyari-Manesh et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The Rise of PSMA Ligands for Diagnosis and Therapy of Prostate Cancer

(2016) A. Afshar-Oromieh et al.   JOURNAL OF NUCLEAR MEDICINE

A novel fluorescence aptasensor for 8-hydroxy-2′-deoxyguanosine based on the conformational switching of K + -stabilized G-quadruplex

(2016) Hui Liu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

AS1411 Aptamer-Decorated Biodegradable Polyethylene Glycol–Poly(lactic-co-glycolic acid) Nanopolymersomes for the Targeted Delivery of Gemcitabine to Non–Small Cell Lung Cancer In Vitro

(2016) Mona Alibolandi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Aptamers as targeted therapeutics: current potential and challenges

(2016) Jiehua Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

A Phase 1 Study of Intravitreous E10030 in Combination with Ranibizumab in Neovascular Age-Related Macular Degeneration

(2016) Glenn J. Jaffe et al.   OPHTHALMOLOGY

Targeted Delivery of Epirubicin to Cancer Cells by Polyvalent Aptamer System in vitro and in vivo

(2016) Rezvan Yazdian-Robati et al.   PHARMACEUTICAL RESEARCH

Aptamer-based microcantilever biosensor for ultrasensitive detection of tumor marker nucleolin

(2016) Huiyan Li et al.   TALANTA

Aptamer-guided DNA tetrahedron as a novel targeted drug delivery system for MUC1-expressing breast cancer cells in vitro

(2016) Bindong Dai et al.   Oncotarget

Targeted delivery of CRISPR/Cas9 to prostate cancer by modified gRNA using a flexible aptamer-cationic liposome

(2016) Shuai Zhen et al.   Oncotarget

Building a chimera of aptamer–antisense oligonucleotide for silencing galectin-1 gene

(2016) Shanni Hong et al.   RSC Advances

Adenosine Triphosphate-Triggered Release of Macromolecular and Nanoparticle Loads from Aptamer/DNA-Cross-Linked Microcapsules

(2015) Wei-Ching Liao et al.   ACS Nano

Nicking endonuclease-assisted signal amplification of a split molecular aptamer beacon for biomolecule detection using graphene oxide as a sensing platform

(2015) Xiang Li et al.   ANALYST

Design of a dual aptamer-based recognition strategy for human matrix metalloproteinase 9 protein by piezoelectric biosensors

(2015) S. Scarano et al.   ANALYTICA CHIMICA ACTA

2-fluoro-RNA oligonucleotide CD40 targeted aptamers for the control of B lymphoma and bone-marrow aplasia

(2015) Mario Martinez Soldevilla et al.   BIOMATERIALS

ATP-responsive DNA-graphene hybrid nanoaggregates for anticancer drug delivery

(2015) Ran Mo et al.   BIOMATERIALS

Photoinduced electron transfer (PET) based label-free aptasensor for platelet-derived growth factor-BB and its logic gate application

(2015) Guangfeng Wang et al.   BIOSENSORS & BIOELECTRONICS

Selectively assaying CEA based on a creative strategy of gold nanoparticles enhancing silver nanoclusters' fluorescence

(2015) Xiaoming Yang et al.   BIOSENSORS & BIOELECTRONICS

Aptamers as a replacement for antibodies in enzyme-linked immunosorbent assay

(2015) Saw Yi Toh et al.   BIOSENSORS & BIOELECTRONICS

Electrochemical aptamer/antibody based sandwich immunosensor for the detection of EGFR, a cancer biomarker, using gold nanoparticles as a signaling probe

(2015) Hoda Ilkhani et al.   BIOSENSORS & BIOELECTRONICS

Highly sensitive and specific colorimetric detection of cancer cells via dual-aptamer target binding strategy

(2015) Kun Wang et al.   BIOSENSORS & BIOELECTRONICS

Silver nanoparticles-enhanced time-resolved fluorescence sensor for VEGF 165 based on Mn-doped ZnS quantum dots

(2015) Dong Zhu et al.   BIOSENSORS & BIOELECTRONICS

Enzyme-free and label-free fluorescence aptasensing strategy for highly sensitive detection of protein based on target-triggered hybridization chain reaction amplification

(2015) Xiuzhong Wang et al.   BIOSENSORS & BIOELECTRONICS

Aptamer decorated hyaluronan/chitosan nanoparticles for targeted delivery of 5-fluorouracil to MUC1 overexpressing adenocarcinomas

(2015) Zahra Ghasemi et al.   CARBOHYDRATE POLYMERS

Cancer biomarker detection: recent achievements and challenges

(2015) Li Wu et al.   CHEMICAL SOCIETY REVIEWS

Cancer immunotherapy via nucleic acid aptamers

(2015) Mostafa Khedri et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

An aptamer targeting shared tumor-specific peptide antigen of MAGE-A3 in multiple cancers

(2015) Chin-Yu Wang et al.   INTERNATIONAL JOURNAL OF CANCER

An AS1411 aptamer-conjugated liposomal system containing a bubble-generating agent for tumor-specific chemotherapy that overcomes multidrug resistance

(2015) Zi-Xian Liao et al.   JOURNAL OF CONTROLLED RELEASE

Tumor targeting with a99mTc-labeled AS1411 aptamer in prostate tumor cells

(2015) Zohreh Noaparast et al.   JOURNAL OF DRUG TARGETING

18F-Labeled Single-Stranded DNA Aptamer for PET Imaging of Protein Tyrosine Kinase-7 Expression

(2015) O. Jacobson et al.   JOURNAL OF NUCLEAR MEDICINE

Successful Translation of Fluorescence Navigation During Oncologic Surgery: A Consensus Report

(2015) E. L. Rosenthal et al.   JOURNAL OF NUCLEAR MEDICINE

Mechanistic studies of anticancer aptamer AS1411 reveal a novel role for nucleolin in regulating Rac1 activation

(2015) E. Merit Reyes-Reyes et al.   Molecular Oncology

Predicting the Uncertain Future of Aptamer-Based Diagnostics and Therapeutics

(2015) John Bruno   MOLECULES

A Highlight of Recent Advances in Aptamer Technology and Its Application

(2015) Hongguang Sun et al.   MOLECULES

Multifunctional nanoparticle–EpCAM aptamer bioconjugates: A paradigm for targeted drug delivery and imaging in cancer therapy

(2015) Manasi Das et al.   Nanomedicine-Nanotechnology Biology and Medicine

Agonistic aptamer to the insulin receptor leads to biased signaling and functional selectivity through allosteric modulation

(2015) Na-Oh Yunn et al.   NUCLEIC ACIDS RESEARCH

AuNPs colorimetric sensor for detecting platelet-derived growth factor-BB based on isothermal target-triggering strand displacement amplification

(2015) Huige Zhang et al.   SENSORS AND ACTUATORS B-CHEMICAL

An aptasensor for carcinoembryonic antigen based on upconversion fluorescence resonance energy transfer

(2015) Zhengjun Wu et al.   SENSORS AND ACTUATORS B-CHEMICAL

Cardiac shockwave therapy improves myocardial function in patients with refractory coronary artery disease by promoting VEGF and IL-8 secretion to mediate the proliferation of endothelial progenitor cells

(2015) HONG-YAN CAI et al.   Experimental and Therapeutic Medicine

DNA Aptamer Assembly as a Vascular Endothelial Growth Factor Receptor Agonist

(2015) Vidhya Ramaswamy et al.   Nucleic Acid Therapeutics

Aptamer density dependent cellular uptake of lipid-capped polymer nanoparticles for polyvalent targeted delivery of vinorelbine to cancer cells

(2015) Zhenbao Liu et al.   RSC Advances

A Synthetic Aptamer-Drug Adduct for Targeted Liver Cancer Therapy

(2015) Thu Le Trinh et al.   PLoS One

Identification and Characterization of an Agonistic Aptamer Against the T Cell Costimulatory Receptor, OX40

(2015) Elizabeth D. Pratico et al.   Nucleic Acid Therapeutics

Near-Infrared Light-Triggered Drug-Delivery Vehicle for Mitochondria-Targeted Chemo-Photothermal Therapy

(2014) Enguo Ju et al.   ACS Applied Materials & Interfaces

A novel aptasensor based on MUC-1 conjugated CNSs for ultrasensitive detection of tumor cells

(2014) Hongmei Cao et al.   ANALYST

Enhanced Anticancer Efficacy by ATP-Mediated Liposomal Drug Delivery

(2014) Ran Mo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nucleolin-targeting liposomes guided by aptamer AS1411 for the delivery of siRNA for the treatment of malignant melanomas

(2014) Liyu Li et al.   BIOMATERIALS

Molecular magnetic resonance probe targeting VEGF165: preparation andin vitroandin vivoevaluation

(2014) Xiao-Guang You et al.   Contrast Media & Molecular Imaging

MUC1 aptamer conjugated to chitosan nanoparticles, an efficient targeted carrier designed for anticancer SN38 delivery

(2014) E. Sayari et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Fluorescence aggregation assay for the protein biomarker mucin 1 using carbon dot-labeled antibodies and aptamers

(2014) Nan Ma et al.   MICROCHIMICA ACTA

Maleimidyl magnetic nanoplatform for facile molecular MRI

(2014) Dan Heo et al.   NANOTECHNOLOGY

Protein tyrosine kinase 7 plays a tumor suppressor role by inhibiting ERK and AKT phosphorylation in lung cancer

(2014) JI-HEE KIM et al.   ONCOLOGY REPORTS

ATP-triggered anticancer drug delivery

(2014) Ran Mo et al.   Nature Communications

DNA-Aptamer Targeting Vimentin for Tumor Therapy In Vivo

(2014) Tatyana N. Zamay et al.   Nucleic Acid Therapeutics

Specific and Sensitive Tumor Imaging Using Biostable Oligonucleotide Aptamer Probes

(2014) Zihua Zeng et al.   Theranostics

Ultra-effective photothermal therapy for prostate cancer cells using dual aptamer-modified gold nanostars

(2014) Hunho Jo et al.   Journal of Materials Chemistry B

Oligonucleotide Aptamers: New Tools for Targeted Cancer Therapy

(2014) Hongguang Sun et al.   Molecular Therapy-Nucleic Acids

Intracellular pH-Sensitive PEG-block-Acetalated-Dextrans as Efficient Drug Delivery Platforms

(2013) Zhe Zhang et al.   ACS Applied Materials & Interfaces

Selective collection and detection of MCF-7 breast cancer cells using aptamer-functionalized magnetic beads and quantum dots based nano-bio-probes

(2013) Xin Hua et al.   ANALYTICA CHIMICA ACTA

Aptamer-based label-free detection of PDGF using ruthenium(II) complex as luminescent probe

(2013) E. Babu et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Aptamers: Molecules of great potential

(2013) Filip Radom et al.   BIOTECHNOLOGY ADVANCES

The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys

(2013) F. Schwoebel et al.   BLOOD

The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization

(2013) J. Hoellenriegel et al.   BLOOD

The development of synthetic antitumour vaccines from mucin glycopeptide antigens

(2013) Nikola Gaidzik et al.   CHEMICAL SOCIETY REVIEWS

Epirubicin loaded super paramagnetic iron oxide nanoparticle-aptamer bioconjugate for combined colon cancer therapy and imaging in vivo

(2013) Seyed Hamid Jalalian et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Aptamer-conjugated magnetic nanoparticles enable efficient targeted detection of integrin αvβ3 via magnetic resonance imaging

(2013) Eun-Kyung Lim et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Blocking the attachment of cancer cells in vivo with DNA aptamers displaying anti-adhesive properties against the carcinoembryonic antigen

(2013) Erik W. Orava et al.   Molecular Oncology

Aptamer imaging with Cu-64 labeled AS1411: Preliminary assessment in lung cancer

(2013) Junling Li et al.   NUCLEAR MEDICINE AND BIOLOGY

Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer theranostics

(2013) G. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective delivery of an anticancer drug with aptamer-functionalized liposomes to breast cancer cells in vitro and in vivo

(2013) Hang Xing et al.   Journal of Materials Chemistry B

Aptamer-modified magnetic nanoprobe for molecular MR imaging of VEGFR2 on angiogenic vasculature

(2013) Bongjune Kim et al.   Nanoscale Research Letters

CD28 Aptamers as Powerful Immune Response Modulators

(2013) Fernando Pastor et al.   Molecular Therapy-Nucleic Acids

Direct Observation of Nanoparticle–Cancer Cell Nucleus Interactions

(2012) Duncan Hieu M. Dam et al.   ACS Nano

Colorimetric and Ultrasensitive Bioassay Based on a Dual-Amplification System Using Aptamer and DNAzyme

(2012) Longhua Tang et al.   ANALYTICAL CHEMISTRY

Fluorescence resonance energy transfer aptasensor for platelet-derived growth factor detection based on upconversion nanoparticles in 30% blood serum

(2012) Fanbo Lin et al.   Analytical Methods

99mTc-MAG3-Aptamer for Imaging Human Tumors Associated with High Level of Matrix Metalloprotease-9

(2012) Sonia Da Rocha Gomes et al.   BIOCONJUGATE CHEMISTRY

AS1411 aptamer tagged PLGA-lecithin-PEG nanoparticles for tumor cell targeting and drug delivery

(2012) Athulya Aravind et al.   BIOTECHNOLOGY AND BIOENGINEERING

Aptamer-Containing Surfaces for Selective Capture of CD4 Expressing Cells

(2012) Qing Zhou et al.   LANGMUIR

ATP-Responsive Controlled Release System Using Aptamer-Functionalized Mesoporous Silica Nanoparticles

(2012) Xiaoxiao He et al.   LANGMUIR

In Vitro Transfection Mediated by Dendrigraft Poly(L-lysines): The Effect of Structure and Molecule Size

(2012) Jakub Hofman et al.   MACROMOLECULAR BIOSCIENCE

Aptamer-Conjugated DNA Icosahedral Nanoparticles As a Carrier of Doxorubicin for Cancer Therapy

(2011) Microsugar Chang et al.   ACS Nano

Epithelial cell adhesion molecule expression (CD326) in cancer: A short review

(2011) Carlo Patriarca et al.   CANCER TREATMENT REVIEWS

Self-assemble gene delivery system for molecular targeting using nucleic acid aptamer

(2011) Tomoaki Kurosaki et al.   GENE

Do all roads lead to Rome? Routes to metastasis development

(2011) Jonathan P. Sleeman et al.   INTERNATIONAL JOURNAL OF CANCER

RNA Aptamer Evolution: Two Decades of SELEction

(2011) Guillermo Aquino-Jarquin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tumor targeted quantum dot-mucin 1 aptamer-doxorubicin conjugate for imaging and treatment of cancer

(2011) Ronak Savla et al.   JOURNAL OF CONTROLLED RELEASE

Combination of an Aptamer Probe to CD4 and Antibodies for Multicolored Cell Phenotyping

(2010) Peng Zhang et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Prostate cancer cell death produced by the co-delivery of Bcl-xL shRNA and doxorubicin using an aptamer-conjugated polyplex

(2010) Eunjung Kim et al.   BIOMATERIALS

Simultaneous electrochemical detection of both PSMA (+) and PSMA (−) prostate cancer cells using an RNA/peptide dual-aptamer probe

(2010) Kyoungin Min et al.   CHEMICAL COMMUNICATIONS

Development of aptamer therapeutics

(2010) David HJ Bunka et al.   CURRENT OPINION IN PHARMACOLOGY

Advances in polymeric micelles for drug delivery and tumor targeting

(2010) Uttam Kedar et al.   Nanomedicine-Nanotechnology Biology and Medicine

Targeting cancer cells with nucleic acid aptamers

(2010) Laura Cerchia et al.   TRENDS IN BIOTECHNOLOGY

Laser ablation-based one-step generation and bio-functionalization of gold nanoparticles conjugated with aptamers

(2010) Johanna G Walter et al.   JOURNAL OF NANOBIOTECHNOLOGY

Molecular Assembly of an Aptamer-Drug Conjugate for Targeted Drug Delivery to Tumor Cells

(2009) Yu-Fen Huang et al.   CHEMBIOCHEM

Targeted delivery of daunorubicin to T-cell acute lymphoblastic leukemia by aptamer

(2009) Seyed Mohammad Taghdisi et al.   JOURNAL OF DRUG TARGETING

8-hydroxy-2′ -deoxyguanosine (8-OHdG): A Critical Biomarker of Oxidative Stress and Carcinogenesis

(2009) ATHANASIOS VALAVANIDIS et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

A Nucleolin-Targeted Multimodal Nanoparticle Imaging Probe for Tracking Cancer Cells Using an Aptamer

(2009) D. W. Hwang et al.   JOURNAL OF NUCLEAR MEDICINE

Using an RNA aptamer probe for flow cytometry detection of CD30-expressing lymphoma cells

(2009) Peng Zhang et al.   LABORATORY INVESTIGATION

In vivo selection of tumor-targeting RNA motifs

(2009) Jing Mi et al.   Nature Chemical Biology

Late Onset of Ccl2 Blockade with the Spiegelmer mNOX-E36–3′PEG Prevents Glomerulosclerosis and Improves Glomerular Filtration Rate in db/db Mice

(2008) Volha Ninichuk et al.   AMERICAN JOURNAL OF PATHOLOGY

Assembling OX40 Aptamers on a Molecular Scaffold to Create a Receptor-Activating Aptamer

(2008) Claudia M. Dollins et al.   CHEMISTRY & BIOLOGY

Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice

(2008) James O. McNamara et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell-Specific Aptamer Probes for Membrane Protein Elucidation in Cancer Cells

(2008) Dihua Shangguan et al.   JOURNAL OF PROTEOME RESEARCH

Structure and Function of the Cell Surface (Tethered) Mucins

(2007) Christine L. Hattrup et al.   Annual Review of Physiology