Recent Advances in SELEX Technology and Aptamer Applications in Biomedicine

QCM-based aptamer selection and detection of Salmonella typhimurium

(2017) Lijun Wang et al.   FOOD CHEMISTRY

Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes

(2017) Shuaijian Ni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Selection of aptamers based on a protein microarray integrated with a microfluidic chip

(2017) Xiaohui Liu et al.   LAB ON A CHIP

Liposome-based drug co-delivery systems in cancer cells

(2017) Sepideh Zununi Vahed et al.   Materials Science & Engineering C-Materials for Biological Applications

Enhanced growth inhibition of prostate cancer in vitro and in vivo by a recombinant adenovirus-mediated dual-aptamer modified drug delivery system

(2016) Pei Jing et al.   CANCER LETTERS

3D Cell-SELEX: Development of RNA aptamers as molecular probes for PC-3 tumor cell line

(2016) Aline G. Souza et al.   EXPERIMENTAL CELL RESEARCH

Pre-existing anti–polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer

(2016) Nancy J. Ganson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A combined microRNA-based targeted therapeutic approach to eradicate glioblastoma stem-like cells

(2016) Carla L. Esposito et al.   JOURNAL OF CONTROLLED RELEASE

An aptamer-antibody complex (oligobody) as a novel delivery platform for targeted cancer therapies

(2016) Kyun Heo et al.   JOURNAL OF CONTROLLED RELEASE

Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): a randomised clinical trial

(2016) A Michael Lincoff et al.   LANCET

Multivalent Aptamer-RNA Conjugates for Simple and Efficient Delivery of Doxorubicin/siRNA into Multidrug-Resistant Cells

(2016) Hyosook Jeong et al.   MACROMOLECULAR BIOSCIENCE

Studying small molecule–aptamer interactions using MicroScale Thermophoresis (MST)

(2016) Clemens Entzian et al.   METHODS

Prostate-specific membrane antigen-targeted liposomes specifically deliver the Zn2+ chelator TPEN inducing oxidative stress in prostate cancer cells

(2016) Christopher H Stuart et al.   Nanomedicine

Aptamers as targeted therapeutics: current potential and challenges

(2016) Jiehua Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

Ten years of anti-vascular endothelial growth factor therapy

(2016) Napoleone Ferrara et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of an Interfering Ligand Aptamer for EphB2/3 Receptors

(2016) Paola Amero et al.   Nucleic Acid Therapeutics

2′Fluoro Modification Differentially Modulates the Ability of RNAs to Activate Pattern Recognition Receptors

(2016) Youngju Lee et al.   Nucleic Acid Therapeutics

MRP1-CD28 bi-specific oligonucleotide aptamers: target costimulation to drug-resistant melanoma cancer stem cells

(2016) Mario Martínez Soldevilla et al.   Oncotarget

Immuno Affinity SELEX for Simple, Rapid, and Cost-Effective Aptamer Enrichment and Identification against Aflatoxin B1

(2016) Keerthana Setlem et al.   Frontiers in Microbiology

Galaxy Workflows for Web-based Bioinformatics Analysis of Aptamer High-throughput Sequencing Data

(2016) William H Thiel   Molecular Therapy-Nucleic Acids

Acousto-microfluidics for screening of ssDNA aptamer

(2016) Jee-Woong Park et al.   Scientific Reports

High throughput sequencing analysis of RNA libraries reveals the influences of initial library and PCR methods on SELEX efficiency

(2016) Mayumi Takahashi et al.   Scientific Reports

Selection of DNA aptamers for ovarian cancer biomarker HE4 using CE-SELEX and high-throughput sequencing

(2015) Rachel M. Eaton et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Evolution of DNA Aptamers through in Vitro Metastatic-Cell-Based Systematic Evolution of Ligands by Exponential Enrichment for Metastatic Cancer Recognition and Imaging

(2015) Xilan Li et al.   ANALYTICAL CHEMISTRY

2-fluoro-RNA oligonucleotide CD40 targeted aptamers for the control of B lymphoma and bone-marrow aplasia

(2015) Mario Martinez Soldevilla et al.   BIOMATERIALS

Biodistribution and in vivo toxicity of aptamer-loaded gold nanostars

(2015) Duncan Hieu M. Dam et al.   Nanomedicine-Nanotechnology Biology and Medicine

Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference–based bone anabolic strategy

(2015) Chao Liang et al.   NATURE MEDICINE

Smart functional nucleic acid chimeras: Enabling tissue specific RNA targeting therapy

(2015) Lukas J Aaldering et al.   RNA Biology

Targeting Cancer Cells Using LNA-Modified Aptamer-siRNA Chimeras

(2015) Nithya Subramanian et al.   Nucleic Acid Therapeutics

Screening and Identifying a Novel ssDNA Aptamer against Alpha-fetoprotein Using CE-SELEX

(2015) Lili Dong et al.   Scientific Reports

Targeting the PD-1/PD-L1 Immune Evasion Axis With DNA Aptamers as a Novel Therapeutic Strategy for the Treatment of Disseminated Cancers

(2015) Aaron Prodeus et al.   Molecular Therapy-Nucleic Acids

Pharmacokinetics of a Cholesterol-conjugated Aptamer Against the Hepatitis C Virus (HCV) NS5B Protein

(2015) Chang Ho Lee et al.   Molecular Therapy-Nucleic Acids

Reducing toxicity of 4–1BB costimulation: targeting 4–1BB ligands to the tumor stroma with bi-specific aptamer conjugates

(2015) B Schrand et al.   OncoImmunology

Characterizing aptamer small molecule interactions with backscattering interferometry

(2014) Michael N. Kammer et al.   ANALYST

In Vitro Selection of DNA Aptamers for Metastatic Breast Cancer Cell Recognition and Tissue Imaging

(2014) Xilan Li et al.   ANALYTICAL CHEMISTRY

Screening of DNA Aptamers against Myoglobin Using a Positive and Negative Selection Units Integrated Microfluidic Chip and Its Biosensing Application

(2014) Qing Wang et al.   ANALYTICAL CHEMISTRY

Functionalizing Liposomes with anti-CD44 Aptamer for Selective Targeting of Cancer Cells

(2014) Walhan Alshaer et al.   BIOCONJUGATE CHEMISTRY

CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells

(2014) Andreas Herrmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Multifunctional Aptamer-miRNA Conjugates for Targeted Cancer Therapy

(2014) Carla L Esposito et al.   MOLECULAR THERAPY

Identification of DNA Aptamers toward Epithelial Cell Adhesion Molecule via Cell-SELEX

(2014) Ji Won Kim et al.   MOLECULES AND CELLS

Efficient Selection of Glycoprotein-Binding DNA Aptamers via Boronate Affinity Monolithic Capillary

(2013) Hongyuan Nie et al.   ANALYTICAL CHEMISTRY

Selection of DNA Aptamers against Epithelial Cell Adhesion Molecule for Cancer Cell Imaging and Circulating Tumor Cell Capture

(2013) Yanling Song et al.   ANALYTICAL CHEMISTRY

Development of a Fluorescent Enzyme-Linked DNA Aptamer-Magnetic Bead Sandwich Assay and Portable Fluorometer for Sensitive and Rapid Leishmania Detection in Sandflies

(2013) John G. Bruno et al.   JOURNAL OF FLUORESCENCE

Structural basis for discriminatory recognition of Plasmodium lactate dehydrogenase by a DNA aptamer

(2013) Y.-W. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sol-Gel SELEX Circumventing Chemical Conjugation of Low Molecular Weight Metabolites Discovers Aptamers Selective to Xanthine

(2013) Hyunjung Bae et al.   Nucleic Acid Therapeutics

In vivo SELEX for Identification of Brain-penetrating Aptamers

(2013) Congsheng Cheng et al.   Molecular Therapy-Nucleic Acids

Sol–Gel Derived Nanoporous Compositions for Entrapping Small Molecules and Their Outlook toward Aptamer Screening

(2012) Ji-Young Ahn et al.   ANALYTICAL CHEMISTRY

Selection of bovine catalase aptamers using non-SELEX

(2012) Jon Ashley et al.   ELECTROPHORESIS

Therapeutic RNA aptamers in clinical trials

(2012) Padma Sundaram et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Isolation and Optimization of Murine IL-10 Receptor Blocking Oligonucleotide Aptamers Using High-throughput Sequencing

(2012) Alexey Berezhnoy et al.   MOLECULAR THERAPY

Targeted Delivery of Chemotherapy Agents Using a Liver Cancer-Specific Aptamer

(2012) Ling Meng et al.   PLoS One

In Vitro Selection of DNA Aptamers to Glioblastoma Multiforme

(2011) Abdullah Tahir Bayrac et al.   ACS Chemical Neuroscience

Release of Photoactivatable Drugs from Plasmonic Nanoparticles for Targeted Cancer Therapy

(2011) Yun-Ling Luo et al.   ACS Nano

Thermodynamics of Ligand Binding to a Heterogeneous RNA Population in the Malachite Green Aptamer

(2011) Joshua E. Sokoloski et al.   BIOCHEMISTRY

Isolation of DNA aptamers using micro free flow electrophoresis

(2011) Meng Jing et al.   LAB ON A CHIP

Targeting 4-1BB Costimulation to Disseminated Tumor Lesions With Bi-specific Oligonucleotide Aptamers

(2011) Fernando Pastor et al.   MOLECULAR THERAPY

A Sol–Gel-Based Microfluidics System Enhances the Efficiency of RNA Aptamer Selection

(2011) Ji-Young Ahn et al.   OLIGONUCLEOTIDES

Methods for measuring aptamer-protein equilibria: A review

(2010) Meng Jing et al.   ANALYTICA CHIMICA ACTA

Surface-Immobilized Aptamers for Cancer Cell Isolation and Microscopic Cytology

(2010) Y. Wan et al.   CANCER RESEARCH

Fluorescence-activated cell sorting for aptamer SELEX with cell mixtures

(2010) Günter Mayer et al.   Nature Protocols

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer

(2010) Anna Pasternak et al.   NUCLEIC ACIDS RESEARCH

Quantitative selection of DNA aptamers through microfluidic selection and high-throughput sequencing

(2010) M. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversible Cell-Specific Drug Delivery with Aptamer-Functionalized Liposomes

(2009) Zehui Cao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Preparation of Functional Aptamer Films Using Layer-by-Layer Self-Assembly

(2009) Yasir Sultan et al.   BIOMACROMOLECULES

Molecular Assembly of an Aptamer-Drug Conjugate for Targeted Drug Delivery to Tumor Cells

(2009) Yu-Fen Huang et al.   CHEMBIOCHEM

Inhibition of von Willebrand factor-mediated platelet activation and thrombosis by the anti-von Willebrand factor A1-domain aptamer ARC1779

(2009) J. L. DIENER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Selection and elution of aptamers using nanoporous sol-gel arrays with integrated microheaters

(2009) Seung-min Park et al.   LAB ON A CHIP

A Hybrid DNA Aptamer-Dendrimer Nanomaterial for Targeted Cell Labeling

(2009) Jing Zhou et al.   MACROMOLECULAR BIOSCIENCE

Locked nucleic acid nucleoside triphosphates and polymerases: on the way towards evolution of LNA aptamers

(2009) Rakesh N. Veedu et al.   Molecular BioSystems

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors

(2009) Justin P Dassie et al.   NATURE BIOTECHNOLOGY

In vivo selection of tumor-targeting RNA motifs

(2009) Jing Mi et al.   Nature Chemical Biology

Selection of DNA aptamers using atomic force microscopy

(2009) Yusuke Miyachi et al.   NUCLEIC ACIDS RESEARCH

Micromagnetic selection of aptamers in microfluidic channels

(2009) X. Lou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel low-cost and easy to develop functionalization platform. Case study: Aptamer-based detection of thrombin by surface plasmon resonance

(2009) Cristina Polonschii et al.   TALANTA

Study of the interaction between the G-quadruplex-forming thrombin-binding aptamer and the porphyrin 5,10,15,20-tetrakis-(N-methyl-4-pyridyl)-21,23H-porphyrin tetratosylate

(2008) Miquel del Toro et al.   ANALYTICAL BIOCHEMISTRY

Phase 1b Randomized Study of Antidote-Controlled Modulation of Factor IXa Activity in Patients With Stable Coronary Artery Disease

(2008) Mark Y. Chan et al.   CIRCULATION

Bioinformatic Analysis of the Contribution of Primer Sequences to Aptamer Structures

(2008) Matthew C. Cowperthwaite et al.   JOURNAL OF MOLECULAR EVOLUTION