BRCA1 mediates protein homeostasis through the ubiquitination of PERK and IRE1

SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation

(2021) Elizabeth V. Minten et al.   Cell Reports

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Regulatory T Cells Support Breast Cancer Progression by Opposing IFN-γ-Dependent Functional Reprogramming of Myeloid Cells

(2020) Nicholas M. Clark et al.   Cell Reports

Genomic signatures predict the immunogenicity of BRCA-deficient breast cancer

(2019) Adam A Kraya et al.   CLINICAL CANCER RESEARCH

Vesicle-mediated secretion of misfolded prion protein molecules from cyclosporin A–treated cells

(2018) Ieshita Pan et al.   FASEB JOURNAL

Molecular mechanism of ER stress-induced pre-emptive quality control involving association of the translocon, Derlin-1, and HRD1

(2018) Hisae Kadowaki et al.   Scientific Reports

Protein Quality Control in the Endoplasmic Reticulum and Cancer

(2018) Hye Won Moon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A thiol probe for measuring unfolded protein load and proteostasis in cells

(2017) Moore Z. Chen et al.   Nature Communications

The Histone Variant MacroH2A1 Is a BRCA1 Ubiquitin Ligase Substrate

(2017) Beom-Jun Kim et al.   Cell Reports

Golgi-independent routes support protein disulfide isomerase externalization in vascular smooth muscle cells

(2017) Thaís L.S. Araujo et al.   Redox Biology

Frequency of Germline Mutations in 25 Cancer Susceptibility Genes in a Sequential Series of Patients With Breast Cancer

(2016) Nadine Tung et al.   JOURNAL OF CLINICAL ONCOLOGY

Endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls B-cell immunity through degradation of the death receptor CD95/Fas

(2016) Sinyi Kong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repair Pathway Choices and Consequences at the Double-Strand Break

(2016) Raphael Ceccaldi et al.   TRENDS IN CELL BIOLOGY

The Sel1L-Hrd1 Endoplasmic Reticulum-Associated Degradation Complex Manages a Key Checkpoint in B Cell Development

(2016) Yewei Ji et al.   Cell Reports

The Role of Endoplasmic Reticulum Stress in Human Pathology

(2015) Scott A. Oakes et al.   Annual Review of Pathology-Mechanisms of Disease

Regulation of Glutamine Carrier Proteins by RNF5 Determines Breast Cancer Response to ER Stress-Inducing Chemotherapies

(2015) Young Joo Jeon et al.   CANCER CELL

The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1 

(2015) H. Fujita et al.   EMBO JOURNAL

The BRCA1 Tumor Suppressor Binds to Inositol 1,4,5-Trisphosphate Receptors to Stimulate Apoptotic Calcium Release

(2015) Serena C. Hedgepeth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation

(2015) Shengyi Sun et al.   NATURE CELL BIOLOGY

HRD1 suppresses the growth and metastasis of breast cancer cells by promoting IGF-1R degradation

(2015) Yue-Mei Xu et al.   Oncotarget

Cleaning up in the endoplasmic reticulum: ubiquitin in charge

(2014) John C Christianson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival

(2014) Shengyi Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Der1 promotes movement of misfolded proteins through the endoplasmic reticulum membrane

(2013) Martin Mehnert et al.   NATURE CELL BIOLOGY

Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance

(2013) N. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Profile of alisporivir and its potential in the treatment of hepatitis C

(2013) Philippe Gallay et al.   Drug Design Development and Therapy

Cleaning Up: ER-Associated Degradation to the Rescue

(2012) Jeffrey L. Brodsky   CELL

Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets

(2012) Michitaka Suzuki et al.   MOLECULAR BIOLOGY OF THE CELL

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination

(2012) B H Lok et al.   ONCOGENE

STRUCTURE-FUNCTION OF THE TUMOR SUPPRESSOR BRCA1

(2012) Serena L. Clark et al.   Computational and Structural Biotechnology Journal

Cyclosporine A suppresses immunoglobulin G biosynthesis via inhibition of cyclophilin B in murine hybridomas and B cells

(2011) Jisun Lee et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The E3 Ligase Smurf1 Regulates Wolfram Syndrome Protein Stability at the Endoplasmic Reticulum

(2011) Xing Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantity Control of the ErbB3 Receptor Tyrosine Kinase at the Endoplasmic Reticulum

(2011) W. H. D. Fry et al.   MOLECULAR AND CELLULAR BIOLOGY

Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum

(2011) Ethan J Greenblatt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protein Folding and Quality Control in the ER

(2011) K. Araki et al.   Cold Spring Harbor Perspectives in Biology

Multilayered Mechanism of CD4 Downregulation by HIV-1 Vpu Involving Distinct ER Retention and ERAD Targeting Steps

(2010) Javier G. Magadán et al.   PLoS Pathogens

Substrate-specific mediators of ER associated degradation (ERAD)

(2009) Jeffrey L Brodsky et al.   CURRENT OPINION IN CELL BIOLOGY

BRCA1 and its toolbox for the maintenance of genome integrity

(2009) Michael S.Y. Huen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Overexpressed cyclophilin B suppresses apoptosis associated with ROS and Ca2+ homeostasis after ER stress

(2008) J. Kim et al.   JOURNAL OF CELL SCIENCE

OS-9 and GRP94 deliver mutant α1-antitrypsin to the Hrd1–SEL1L ubiquitin ligase complex for ERAD

(2008) John C. Christianson et al.   NATURE CELL BIOLOGY

One step at a time: endoplasmic reticulum-associated degradation

(2008) Shruthi S. Vembar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Glucose-regulated protein 78 as a novel effector of BRCA1 for inhibiting stress-induced apoptosis

(2008) B H Y Yeung et al.   ONCOGENE

The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression

(2008) R. Shakya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA