Repurposed Edaravone, Metformin, and Perampanel as a Potential Treatment for Hypoxia–Ischemia Encephalopathy: An In Vitro Study

Effects of the Edaravone, a Drug Approved for the Treatment of Amyotrophic Lateral Sclerosis, on Mitochondrial Function and Neuroprotection

(2022) Sun Joo Cha et al.   Antioxidants

Perampanel, an AMPAR antagonist, alleviates experimental intracerebral hemorrhage‑induced brain injury via necroptosis and neuroinflammation

(2021) Lixiang Yang et al.   Molecular Medicine Reports

Current Therapies for Neonatal Hypoxic–Ischaemic and Infection-Sensitised Hypoxic–Ischaemic Brain Damage

(2021) Konstantina Tetorou et al.   Frontiers in Synaptic Neuroscience

Behavioral and brain morphological analysis of non-inflammatory and inflammatory rat models of preterm brain injury

(2021) Ruben Rocha et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Metformin Inhibits Propofol-Induced Apoptosis of Mouse Hippocampal Neurons HT-22 Through Downregulating Cav-1

(2020) Jianyun Ge et al.   Drug Design Development and Therapy

Optimization of cell viability assays to improve replicability and reproducibility of cancer drug sensitivity screens

(2020) Peter Larsson et al.   Scientific Reports

Edaravone Improves Intermittent Hypoxia-Induced Cognitive Impairment and Hippocampal Damage in Rats

(2020) Jizu Ling et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Drug Repurposing: Promises of Edaravone Target Drug in Traumatic Brain Injury

(2020) Zaynab Shakkour et al.   CURRENT MEDICINAL CHEMISTRY

Protective effects of combined treatment with mild hypothermia and edaravone against cerebral ischemia/reperfusion injury via oxidative stress and Nrf2 pathway regulation

(2020) Hang Yu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Low doses of Perampanel protect striatal and hippocampal neurons against in vitro ischemia by reversing the ischemia-induced alteration of AMPA receptor subunit composition

(2020) Petra Mazzocchetti et al.   NEUROBIOLOGY OF DISEASE

Preterm Brain Injury, Antenatal Triggers, and Therapeutics: Timing Is Key

(2020) Daan R.M.G. Ophelders et al.   Cells

The impact of perampanel and targeting AMPA transmission on anti-seizure drug discovery

(2019) Simona Lattanzi et al.   Expert Opinion on Drug Discovery

Edaravone for the treatment of amyotrophic lateral sclerosis

(2019) Hiide Yoshino   Expert Review of Neurotherapeutics

Effects of Edaravone on Nitric Oxide, Hydroxyl Radicals and Neuronal Nitric Oxide Synthase During Cerebral Ischemia and Reperfusion in Mice

(2019) Hitoshi Kawasaki et al.   Journal of Stroke & Cerebrovascular Diseases

Edaravone attenuates neuronal apoptosis in hypoxic-ischemic brain damage rat model via suppression of TRAIL signaling pathway

(2018) Chunyi Li et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Neonatal hypoxic–ischemic encephalopathy: emerging therapeutic strategies based on pathophysiologic phases of the injury

(2018) Qiuli Wang et al.   Journal of Maternal-Fetal & Neonatal Medicine

Metformin: An Old Drug with New Applications

(2018) Joseph Zhou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metformin: a review of its potential indications

(2017) Yi-Wei Wang et al.   Drug Design Development and Therapy

Regulation of cell proliferation by hypoxia-inducible factors

(2015) Maimon E. Hubbi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Neuroprotective Strategies after Neonatal Hypoxic Ischemic Encephalopathy

(2015) Brandon Dixon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective effect of Edaravone against hypoxia-induced cytotoxicity in osteoblasts MC3T3-E1 cells

(2015) Bo Cao et al.   IUBMB LIFE

Neuroglobin Overexpression Inhibits AMPK Signaling and Promotes Cell Anabolism

(2015) Bin Cai et al.   MOLECULAR NEUROBIOLOGY

Anti-inflammatory effects of Edaravone and Scutellarin in activated microglia in experimentally induced ischemia injury in rats and in BV-2 microglia

(2014) Yun Yuan et al.   BMC NEUROSCIENCE

Chronic metformin treatment improves post-stroke angiogenesis and recovery after experimental stroke

(2014) Venugopal R. Venna et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Curcumin abates hypoxia-induced oxidative stress based-ER stress-mediated cell death in mouse hippocampal cells (HT22) by controlling Prdx6 and NF-κB regulation

(2013) Bhavana Chhunchha et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Pharmacologic Neuroprotective Strategies in Neonatal Brain Injury

(2013) Sandra E. Juul et al.   CLINICS IN PERINATOLOGY

Edaravone Protects HT22 Neurons from H2O2-induced Apoptosis by Inhibiting the MAPK Signaling Pathway

(2012) Zhong-Yan Zhao et al.   CNS Neuroscience & Therapeutics

Free-Radical Scavenger Edaravone Treatment Confers Neuroprotection Against Traumatic Brain Injury in Rats

(2011) Guo-Hua Wang et al.   JOURNAL OF NEUROTRAUMA