Effects of the Edaravone, a Drug Approved for the Treatment of Amyotrophic Lateral Sclerosis, on Mitochondrial Function and Neuroprotection

Doxorubicin Induces Endotheliotoxicity and Mitochondrial Dysfunction via ROS/eNOS/NO Pathway

(2020) Huan He et al.   Frontiers in Pharmacology

Edaravone Improves Intermittent Hypoxia-Induced Cognitive Impairment and Hippocampal Damage in Rats

(2020) Jizu Ling et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Amyotrophic lateral sclerosis: a clinical review

(2020) P. Masrori et al.   EUROPEAN JOURNAL OF NEUROLOGY

Edaravone reduces Aβ-induced oxidative damage in SH-SY5Y cells by activating the Nrf2/ARE signaling pathway

(2019) Lei Zhang et al.   LIFE SCIENCES

Edaravone for the treatment of amyotrophic lateral sclerosis

(2019) Hiide Yoshino   Expert Review of Neurotherapeutics

Nrf2 mediates the protective effect of edaravone after chlorpyrifos-induced nervous system toxicity

(2019) Limeng Shou et al.   ENVIRONMENTAL TOXICOLOGY

Activation of anti-oxidant of curcumin pyrazole derivatives through preservation of mitochondria function and Nrf2 signaling pathway

(2019) Liping Liao et al.   NEUROCHEMISTRY INTERNATIONAL

Parkin expression reverses mitochondrial dysfunction in fused in sarcoma‐induced amyotrophic lateral sclerosis

(2019) S. J. Cha et al.   INSECT MOLECULAR BIOLOGY

Protective effect of edaravone on blood-brain barrier by affecting NRF-2/HO-1 signaling pathway

(2019) Jing Liu et al.   Experimental and Therapeutic Medicine

Edaravone and benidipine protect myocardial damage by regulating mitochondrial stress, apoptosis signalling and cardiac biomarkers against doxorubicin-induced cardiotoxicity

(2019) Md Quamrul Hassan et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Long‐term edaravone efficacy in amyotrophic lateral sclerosis: Post‐hoc analyses of Study 19 (MCI186‐19)

(2019) Jeremy Shefner et al.   MUSCLE & NERVE

Quercetin protects the vascular endothelium against iron overload damages via ROS/ADMA/DDAHⅡ/eNOS/NO pathway

(2019) Xuepiao Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Improvement in mitochondrial function underlies the effects of ANNAO tablets on attenuating cerebral ischemia-reperfusion injuries

(2019) Yi Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Edaravone attenuates experimental asthma in mice through induction of HO‑1 and the Keap1/Nrf2 pathway

(2019) Yuting Pan et al.   Experimental and Therapeutic Medicine

Edaravone, a free radical scavenger, protects neuronal cells’ mitochondria from ischemia by inactivating another new critical factor of the 5-lipoxygenase pathway affecting the arachidonic acid metabolism

(2018) Ying Song et al.   BRAIN RESEARCH

How is edaravone effective against acute ischemic stroke and amyotrophic lateral sclerosis?

(2018) Kazutoshi Watanabe et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Neuroprotection of edaravone on the hippocampus of kainate-induced epilepsy rats through Nrf2/HO-1 pathway

(2018) Zhiguang Liu et al.   NEUROCHEMISTRY INTERNATIONAL

Mitochondrial regulation by pyrroloquinoline quinone prevents rotenone-induced neurotoxicity in Parkinson’s disease models

(2018) Jinli Lu et al.   NEUROSCIENCE LETTERS

Four-octyl itaconate activates Keap1-Nrf2 signaling to protect neuronal cells from hydrogen peroxide

(2018) Hua Liu et al.   Cell Communication and Signaling

Epidemiology of ALS in Korea using nationwide big data

(2018) Kyo Yeon Jun et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Genetic epidemiology of amyotrophic lateral sclerosis: a systematic review and meta-analysis

(2017) Zhang-Yu Zou et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial

(2017) Koji Abe et al.   LANCET NEUROLOGY

The role of mitochondria in amyotrophic lateral sclerosis

(2017) Emma F. Smith et al.   NEUROSCIENCE LETTERS

Edaravone protects against hyperosmolarity-induced oxidative stress and apoptosis in primary human corneal epithelial cells

(2017) Yanwei Li et al.   PLoS One

Imbalance of mitochondrial dynamics in Drosophila models of amyotrophic lateral sclerosis

(2016) Volodya Altanbyek et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ALS/FTD‐associated FUS activates GSK‐3β to disrupt the VAPB–PTPIP51 interaction and ER–mitochondria associations

(2016) Radu Stoica et al.   EMBO REPORTS

Protection by Edaravone, a Radical Scavenger, against Manganese-Induced Neurotoxicity in Rats

(2016) Melda Apaydin et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity

(2016) Wenzhang Wang et al.   NATURE MEDICINE

Miro sculpts mitochondrial dynamics in neuronal health and disease

(2016) Michael J. Devine et al.   NEUROBIOLOGY OF DISEASE

Gene-specific mitochondria dysfunctions in human TARDBP and C9ORF72 fibroblasts

(2016) Elisa Onesto et al.   Acta Neuropathologica Communications

Protective effects of edaravone, a free radical scavenger, on lipopolysaccharide-induced acute kidney injury in a rat model of sepsis

(2015) Lin Liu et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Edaravone protects osteoblastic cells from dexamethasone through inhibiting oxidative stress and mPTP opening

(2015) Wen-xiao Sun et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Miro1 deficiency in amyotrophic lateral sclerosis

(2015) Fan Zhang et al.   Frontiers in Aging Neuroscience

FUS Interacts with HSP60 to Promote Mitochondrial Damage

(2015) Jianwen Deng et al.   PLoS Genetics

ER–mitochondria associations are regulated by the VAPB–PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43

(2014) Radu Stoica et al.   Nature Communications

The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons

(2013) Wenzhang Wang et al.   HUMAN MOLECULAR GENETICS

Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models

(2013) Jordi Magrané et al.   HUMAN MOLECULAR GENETICS

Protective effects of edaravone against cisplatin-induced hair cell damage in zebrafish

(2013) Seok Jin Hong et al.   INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY

Protective role of edaravone against neomycin-induced ototoxicity in zebrafish

(2013) June Choi et al.   JOURNAL OF APPLIED TOXICOLOGY

Edaravone Ameliorates Oxidative Damage Associated with Aβ25-35 Treatment in PC12 Cells

(2013) Gui-lian Zhang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Edaravone Prevents Neurotoxicity of Mutant L166P DJ-1 in Parkinson’s Disease

(2013) Bing Li et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Mitochondrial dysfunction in human TDP-43 transfected NSC34 cell lines and the protective effect of dimethoxy curcumin

(2012) Jinsheng Lu et al.   BRAIN RESEARCH BULLETIN

Edaravone Protects Cortical Neurons From Apoptosis by Inhibiting the Translocation of BAX and Increasing the Interaction Between 14-3-3 and p-BAD

(2012) Jin Fan et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Mitochondrial complex I deficiency and ATP/ADP ratio in lymphocytes of amyotrophic lateral sclerosis patients

(2012) Parisa Ghiasi et al.   NEUROLOGICAL RESEARCH

Full-length TDP-43 and its C-terminal fragments activate mitophagy in NSC34 cell line

(2012) Kun Hong et al.   NEUROSCIENCE LETTERS

Protective effect of edaravone against Alzheimer's disease-relevant insults in neuroblastoma N2a cells

(2012) Yufang Yan et al.   NEUROSCIENCE LETTERS

Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutations

(2011) Miranda L. Tradewell et al.   HUMAN MOLECULAR GENETICS

Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson’s disease model

(2011) Won-Seok Choi et al.   JOURNAL OF CELL BIOLOGY

Parkinson disease: Insights in clinical, genetic and pathological features of monogenic disease subtypes

(2011) David Crosiers et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Free-Radical Scavenger Edaravone Treatment Confers Neuroprotection Against Traumatic Brain Injury in Rats

(2011) Guo-Hua Wang et al.   JOURNAL OF NEUROTRAUMA

PS234. Edaravone Suppresses Reperfusion Injury following Leg Ischemia in Rats: Transmission Electro Microscopic Study

(2011) Mitsuhiro Yamamaura et al.   JOURNAL OF VASCULAR SURGERY

Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice

(2011) Ya-Fei Xu et al.   Molecular Neurodegeneration

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

(2011) Laura Ferraiuolo et al.   Nature Reviews Neurology

Neuroprotective mechanisms of SMTP-7 in cerebral infarction model in mice

(2011) Keita Shibata et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Edaravone Guards Dopamine Neurons in a Rotenone Model for Parkinson's Disease

(2011) Nian Xiong et al.   PLoS One

Glutaredoxin 2 prevents aggregation of mutant SOD1 in mitochondria and abolishes its toxicity

(2010) Alberto Ferri et al.   HUMAN MOLECULAR GENETICS

Review of the Use of the Glutamate Antagonist Riluzole in Psychiatric Disorders and a Description of Recent Use in Childhood Obsessive-Compulsive Disorder

(2010) Paul Grant et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

Misfolded Mutant SOD1 Directly Inhibits VDAC1 Conductance in a Mouse Model of Inherited ALS

(2010) Adrian Israelson et al.   NEURON

Dynamic NAD(P)H post-synaptic autofluorescence signals for the assessment of mitochondrial function in a neurodegenerative disease: Monitoring the primary motor cortex of G93A mice, an amyotrophic lateral sclerosis model

(2009) Stefano Loizzo et al.   MITOCHONDRION

Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS mice

(2008) Hidefumi Ito et al.   EXPERIMENTAL NEUROLOGY