Perineural Invasion in Pancreatic Ductal Adenocarcinoma: From Molecules towards Drugs of Clinical Relevance

Targeting the Endocannabinoidome in Pancreatic Cancer

(2022) Valerio Falasca et al.   Biomolecules

GPR55 and GPR119 Receptors Contribute to the Processing of Neuropathic Pain in Rats

(2022) Ángel Zúñiga-Romero et al.   Pharmaceuticals

Emerging experimental models for assessing perineural invasion in human cancers

(2022) Shu-Heng Jiang et al.   CANCER LETTERS

Perineural Invasion in Pancreatic Ductal Adenocarcinoma (PDAC): A Saboteur of Curative Intended Therapies?

(2022) Matthäus Felsenstein et al.   Journal of Clinical Medicine

The Role of Extracellular Vesicles in Cancer–Nerve Crosstalk of the Peripheral Nervous System

(2022) Yuanning Guo et al.   Cells

Capsaicin 8% Patch for Spinal Cord Injury Focal Neuropathic Pain, a Randomized Controlled Trial

(2022) Adedeji Olusanya et al.   PAIN MEDICINE

The Efficacy of Camelina sativa Defatted Seed Meal against Colitis-Induced Persistent Visceral Hypersensitivity: The Relevance of PPAR α Receptor Activation in Pain Relief

(2022) Elena Lucarini et al.   Nutrients

Serum Extracellular Vesicle Stratifin Is a Biomarker of Perineural Invasion in Patients With Colorectal Cancer and Predicts Worse Prognosis

(2022) Wenyun Hou et al.   Frontiers in Oncology

Postsynaptic glutamate response downregulates within presynaptic exaggerated glutamate release by activating TRPV1 in the spinal dorsal horn

(2022) Ming-Ming Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anti-neuropathic pain activity of Ajugarin-I via activation of Nrf2 signaling and inhibition of TRPV1/TRPM8 nociceptors in STZ-induced diabetic neuropathy

(2022) Adnan Khan et al.   PHARMACOLOGICAL RESEARCH

Neural Component of the Tumor Microenvironment in Pancreatic Ductal Adenocarcinoma

(2022) Michał Gola et al.   Cancers

N-Palmitoyl-D-Glucosamine Inhibits TLR-4/NLRP3 and Improves DNBS-Induced Colon Inflammation through a PPAR-α-Dependent Mechanism

(2022) Irene Palenca et al.   Biomolecules

The Beneficial Effects of Ultramicronized Palmitoylethanolamide in the Management of Neuropathic Pain and Associated Mood Disorders Induced by Paclitaxel in Mice

(2022) Claudia Cristiano et al.   Biomolecules

Beta-blockers have no impact on survival in pancreatic ductal adenocarcinoma prior to cancer diagnosis

(2021) Anthony Yang et al.   Scientific Reports

Nerves in the Tumor Microenvironment: Origin and Effects

(2021) Wenjun Wang et al.   Frontiers in Cell and Developmental Biology

GPR55 in the brain and chronic neuropathic pain

(2021) Sabiha Armin et al.   BEHAVIOURAL BRAIN RESEARCH

Functional Fine-Tuning of Metabolic Pathways by the Endocannabinoid System—Implications for Health and Disease

(2021) Estefanía Moreno et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pancreas Cancer‐Associated Pain Management

(2021) Andrew L. Coveler et al.   ONCOLOGIST

Tumor innervation and clinical outcome in pancreatic cancer

(2021) Aysha Ferdoushi et al.   Scientific Reports

Exosomal integrins and their influence on pancreatic cancer progression and metastasis

(2021) Ilaria Casari et al.   CANCER LETTERS

Perineural invasion as a risk factor for locoregional recurrence of invasive breast cancer

(2021) Priyanka Narayan et al.   Scientific Reports

MicroRNAs: emerging driver of cancer perineural invasion

(2021) Mei Zhang et al.   Cell and Bioscience

Cellular and molecular mechanisms of perineural invasion of pancreatic ductal adenocarcinoma

(2021) Jingbo Li et al.   Cancer Communications

Targeting neurons in the tumor microenvironment with bupivacaine nanoparticles reduces breast cancer progression and metastases

(2021) Maya Kaduri et al.   Science Advances

Honokiol Suppresses Perineural Invasion of Pancreatic Cancer by Inhibiting SMAD2/3 Signaling

(2021) Tao Qin et al.   Frontiers in Oncology

Loss of p53 drives neuron reprogramming in head and neck cancer

(2020) Moran Amit et al.   NATURE

CXCL10 and CCL21 Promote Migration of Pancreatic Cancer Cells Toward Sensory Neurons and Neural Remodeling in Tumors in Mice, Associated With Pain in Patients

(2020) Michael Hirth et al.   GASTROENTEROLOGY

Genetic variants of the peroxisome proliferator‐activated receptor (PPAR) signaling pathway genes and risk of pancreatic cancer

(2020) Xiaowen Liu et al.   MOLECULAR CARCINOGENESIS

The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities

(2020) Won Jin Ho et al.   Nature Reviews Clinical Oncology

U.S. Phase I First-in-human Study of Taletrectinib (DS-6051b/AB-106), a ROS1/TRK Inhibitor, in Patients with Advanced Solid Tumors

(2020) Kyriakos P. Papadopoulos et al.   CLINICAL CANCER RESEARCH

Pharmacology, Clinical Effects, and Therapeutic Potential of Cannabinoids for Gastrointestinal and Liver Diseases

(2020) Daniel B. Maselli et al.   Clinical Gastroenterology and Hepatology

Neoadjuvant therapy in pancreatic cancer: what is the true oncological benefit?

(2020) Lei Ren et al.   LANGENBECKS ARCHIVES OF SURGERY

Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer

(2020) Takeshi Koujima et al.   Molecular Therapy-Oncolytics

Antinociceptive Effects of the GPR55 Antagonist CID16020046 Injected into the Rat Anterior Cingulate Cortex

(2020) Bright N. Okine et al.   NEUROSCIENCE

Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines

(2020) Margherita Luongo et al.   Cancers

Nerve input to tumours: Pathophysiological consequences of a dynamic relationship

(2020) Charlotte Hutchings et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Update on cannabis and cannabinoids for cancer pain

(2020) Matthew Chung et al.   Current Opinion in Anesthesiology

Possible involvement of peripheral TRP channels in the hydrogen sulfide-induced hyperalgesia in diabetic rats

(2019) José Eduardo Roa-Coria et al.   BMC NEUROSCIENCE

First-time in-human study of VMD-928, an allosteric and irreversible TrkA selective inhibitor, in patients with solid tumors or lymphoma.

(2019) Vincent Chung et al.   JOURNAL OF CLINICAL ONCOLOGY

Signaling in the microenvironment of pancreatic cancer: Transmitting along the nerve

(2019) Noelle Jurcak et al.   PHARMACOLOGY & THERAPEUTICS

Suppression of TRPV1 and P2Y nociceptors by honokiol isolated from Magnolia officinalis in 3rd degree burn mice by inhibiting inflammatory mediators

(2019) Sidra Khalid et al.   BIOMEDICINE & PHARMACOTHERAPY

A phase 1, open-label, dose-escalation trial of oral TSR-011 in patients with advanced solid tumours and lymphomas

(2019) Chia-Chi Lin et al.   BRITISH JOURNAL OF CANCER

Nerves and Pancreatic Cancer: New Insights into a Dangerous Relationship

(2019) Gasparini et al.   Cancers

Glucose Metabolism in Pancreatic Cancer

(2019) Liang Yan et al.   Cancers

Relationship between cachexia and perineural invasion in pancreatic adenocarcinoma

(2019) Livia Petrusel et al.   World Journal of Gastrointestinal Oncology

New Technologies for Analysis of Extracellular Vesicles

(2018) Huilin Shao et al.   CHEMICAL REVIEWS

Perineural Invasion in Head and Neck Cancer

(2018) L.B. Schmitd et al.   JOURNAL OF DENTAL RESEARCH

Exosome Theranostics: Biology and Translational Medicine

(2018) Chuanjiang He et al.   Theranostics

GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine

(2018) R. Ferro et al.   ONCOGENE

Molecular Profiling of Pancreatic Cancer Patients—Response

(2018) Michael J. Pishvaian et al.   CLINICAL CANCER RESEARCH

Cancer exosomes induce tumor innervation

(2018) Marianna Madeo et al.   Nature Communications

Naturally occurring compounds as pancreatic cancer therapeutics

(2018) Ines Lohse et al.   Oncotarget

Pancreatic Ductal Adenocarcinoma: Current and Evolving Therapies

(2017) Aleksandra Adamska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The influence of neural invasion on survival and tumor recurrence in pancreatic ductal adenocarcinoma – A systematic review and meta-analysis

(2017) Stephan Schorn et al.   SURGICAL ONCOLOGY-OXFORD

The significance of Trk receptors in pancreatic cancer

(2017) Matthew D Johnson et al.   TUMOR BIOLOGY

Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer

(2017) Yifeng Lei et al.   Nature Communications

Peripheral interactions between cannabinoid and opioid receptor agonists in a model of inflammatory mechanical hyperalgesia

(2016) Q-Schick Auh et al.   BRAIN RESEARCH BULLETIN

Biologic effect of neurogenesis in pancreatic cancer

(2016) Dandan He et al.   HUMAN PATHOLOGY

Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer

(2016) Jami L. Saloman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pancreatic stellate cells contribute pancreatic cancer pain via activation of sHH signaling pathway

(2016) Liang Han et al.   Oncotarget

The concept and controversy of retroperitoneal nerve dissection in pancreatic head carcinoma (Review)

(2015) XUAN WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

Biological correlates of prostate cancer perineural invasion diameter

(2014) Adriana Olar et al.   HUMAN PATHOLOGY

Hsp70 Translocates into the Plasma Membrane after Stress and Is Released into the Extracellular Environment in a Membrane-Associated Form that Activates Macrophages

(2014) V. L. Vega et al.   JOURNAL OF IMMUNOLOGY

Outcome of superior mesenteric-portal vein resection during pancreatectomy for borderline ductal adenocarcinoma: results of a prospective comparative study

(2014) Federico Selvaggi et al.   LANGENBECKS ARCHIVES OF SURGERY

Midkine promotes perineural invasion in human pancreatic cancer

(2014) Jun Yao   WORLD JOURNAL OF GASTROENTEROLOGY

Perineural and Intraneural Invasion in Posttherapy Pancreaticoduodenectomy Specimens Predicts Poor Prognosis in Patients With Pancreatic Ductal Adenocarcinoma

(2012) Deyali Chatterjee et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Therapeutic Potential of Perineural Invasion, Hypoxia and Desmoplasia in Pancreatic Cancer

(2012) Han Liu et al.   CURRENT PHARMACEUTICAL DESIGN

A review on CXCR4/CXCL12 axis in oncology: No place to hide

(2012) Urszula M. Domanska et al.   EUROPEAN JOURNAL OF CANCER

Substance P and Neprilysin in Chronic Pancreatitis

(2012) G. Mascetta et al.   EUROPEAN SURGICAL RESEARCH

Impact of FOLFIRINOX Compared With Gemcitabine on Quality of Life in Patients With Metastatic Pancreatic Cancer: Results From the PRODIGE 4/ACCORD 11 Randomized Trial

(2012) Sophie Gourgou-Bourgade et al.   JOURNAL OF CLINICAL ONCOLOGY

Identification and proteomic profiling of exosomes in human cerebrospinal fluid

(2012) Jonathan M Street et al.   Journal of Translational Medicine

Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages

(2011) Cecilia Lässer et al.   Journal of Translational Medicine

Sustained blockade of neurotrophin receptors TrkA, TrkB and TrkC reduces non-malignant skeletal pain but not the maintenance of sensory and sympathetic nerve fibers

(2010) Joseph R. Ghilardi et al.   BONE

Electroacupuncture Increases CB2 Receptor Expression on Keratinocytes and Infiltrating Inflammatory Cells in Inflamed Skin Tissues of Rats

(2010) Jing Zhang et al.   JOURNAL OF PAIN

Neural Invasion in Pancreatic Cancer: The Past, Present and Future

(2010) Ihsan Ekin Demir et al.   Cancers

Exosomes: proteomic insights and diagnostic potential

(2009) Richard J Simpson et al.   Expert Review of Proteomics

Identification ofN,1,4,4-Tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (PHA-848125), a Potent, Orally Available Cyclin Dependent Kinase Inhibitor

(2009) Maria Gabriella Brasca et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting Nerve Growth Factor in Pain

(2008) Judy J Watson et al.   BIODRUGS

A phase I trial of CEP-701 + gemcitabine in patients with advanced adenocarcinoma of the pancreas

(2008) Emily Chan et al.   INVESTIGATIONAL NEW DRUGS