N-Palmitoyl-D-Glucosamine Inhibits TLR-4/NLRP3 and Improves DNBS-Induced Colon Inflammation through a PPAR-α-Dependent Mechanism

Elucidating the Role of Innate and Adaptive Immune Responses in the Pathogenesis of Canine Chronic Inflammatory Enteropathy—A Search for Potential Biomarkers

(2022) Daniela Siel et al.   Animals

Management of Crohn Disease

(2021) Kelly Cushing et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

N-palmitoyl-D-glucosamine, A Natural Monosaccharide-Based Glycolipid, Inhibits TLR4 and Prevents LPS-Induced Inflammation and Neuropathic Pain in Mice

(2021) Monica Iannotta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Signaling Pathways Regulating NLRP3 Inflammasome Activation

(2021) Ming-ye Chen et al.   INFLAMMATION

Engineered Lactobacillus paracasei Producing Palmitoylethanolamide (PEA) Prevents Colitis in Mice

(2021) Giuseppe Esposito et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Palmitoylethanolamide Producing Lactobacillus paracasei Improves Clostridium difficile Toxin A-Induced Colitis

(2021) Giuseppe Esposito et al.   Frontiers in Pharmacology

Glucocorticoid Therapy in Inflammatory Bowel Disease: Mechanisms and Clinical Practice

(2021) Stefano Bruscoli et al.   Frontiers in Immunology

Endocannabinoid Levels in Ulcerative Colitis Patients Correlate With Clinical Parameters and Are Affected by Cannabis Consumption

(2021) Shelly Tartakover Matalon et al.   Frontiers in Endocrinology

Ultramicronized Palmitoylethanolamide Inhibits NLRP3 Inflammasome Expression and Pro-Inflammatory Response Activated by SARS-CoV-2 Spike Protein in Cultured Murine Alveolar Macrophages

(2021) Alessandro Del Re et al.   Metabolites

The Role of PPAR Alpha in the Modulation of Innate Immunity

(2021) Maja Grabacka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TLR4 Deficiency Affects the Microbiome and Reduces Intestinal Dysfunctions and Inflammation in Chronic Alcohol-Fed Mice

(2021) Carlos M. Cuesta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glucosamine and Chondroitin Supplements and Risk of Colorectal Adenoma and Serrated Polyp

(2020) Dong Hoon Lee et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Epidemiology and Pathogenesis of Ulcerative Colitis

(2020) Lillian Du et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Ulcerative colitis

(2020) Taku Kobayashi et al.   Nature Reviews Disease Primers

Palmitoylethanolamide and Cannabidiol Prevent Inflammation-induced Hyperpermeability of the Human Gut In Vitro and In Vivo—A Randomized, Placebo-controlled, Double-blind Controlled Trial

(2019) Daniel G Couch et al.   INFLAMMATORY BOWEL DISEASES

Modulation of Gut Microbiota by Glucosamine and Chondroitin in a Randomized, Double-Blind Pilot Trial in Humans

(2019) Sandi L. Navarro et al.   Microorganisms

Glucosamine use and risk of colorectal cancer: results from the Cancer Prevention Study II Nutrition Cohort

(2018) Elizabeth D. Kantor et al.   CANCER CAUSES & CONTROL

HIV-1 Tat-induced diarrhea is improved by the PPARalpha agonist, palmitoylethanolamide, by suppressing the activation of enteric glia

(2018) Giovanni Sarnelli et al.   Journal of Neuroinflammation

Muscadine Grape (Vitis rotundifolia) or Wine Phytochemicals Reduce Intestinal Inflammation in Mice with Dextran Sulfate Sodium-Induced Colitis

(2017) Ruiqi Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pretreatment with obestatin inhibits the development of acetic acid-induced colitis in rats

(2016) Aleksandra Matuszyk et al.   Archives of Medical Science

Adelmidrol, a palmitoylethanolamide analogue, as a new pharmacological treatment for the management of acute and chronic inflammation

(2016) Daniela Impellizzeri et al.   BIOCHEMICAL PHARMACOLOGY

Use of glucosamine and chondroitin supplements in relation to risk of colorectal cancer: Results from the Nurses' Health Study and Health Professionals follow-up study

(2016) Elizabeth D. Kantor et al.   INTERNATIONAL JOURNAL OF CANCER

Xenobiotic Metabolism and Gut Microbiomes

(2016) Anubhav Das et al.   PLoS One

Synergic Interaction of Rifaximin and Mutaflor (Escherichia coliNissle 1917) in the Treatment of Acetic Acid-Induced Colitis in Rats

(2016) Artur Dembiński et al.   Gastroenterology Research and Practice

TLR4 upregulates CBS expression through NF-κB activation in a rat model of irritable bowel syndrome with chronic visceral hypersensitivity

(2015) Bo Yuan   WORLD JOURNAL OF GASTROENTEROLOGY

The Influence of Ghrelin on the Development of Dextran Sodium Sulfate-Induced Colitis in Rats

(2015) Aleksandra Matuszyk et al.   Biomed Research International

Randomized Trial of Glucosamine and Chondroitin Supplementation on Inflammation and Oxidative Stress Biomarkers and Plasma Proteomics Profiles in Healthy Humans

(2015) Sandi L. Navarro et al.   PLoS One

Negatively regulating TLR4/NF-κB signaling via PPARα in endotoxin-induced uveitis

(2014) Wei Shen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent

(2014) Francesca Borrelli et al.   BRITISH JOURNAL OF PHARMACOLOGY

Palmitoylethanolamide normalizes intestinal motility in a model of post-inflammatory accelerated transit: involvement of CB1receptors and TRPV1 channels

(2014) Raffaele Capasso et al.   BRITISH JOURNAL OF PHARMACOLOGY

IBD and health-related quality of life — Discovering the true impact

(2014) Sanna Lönnfors et al.   Journal of Crohns & Colitis

Inflammatory bowel disease: Pathogenesis

(2014) Yi-Zhen Zhang   WORLD JOURNAL OF GASTROENTEROLOGY

Effects of dietary supplementation of glucosamine sulfate on intestinal inflammation in a mouse model of experimental colitis

(2013) Youn-Kyung Bak et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Role of TLR4/NF-κB in Damage to Intestinal Mucosa Barrier Function and Bacterial Translocation in Rats Exposed to Hypoxia

(2012) Han Luo et al.   PLoS One

Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4)

(2008) Mark R. Hutchinson et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Glial TLR4 receptor as new target to treat neuropathic pain: Efficacy of a new receptor antagonist in a model of peripheral nerve injury in mice

(2008) Isabella Bettoni et al.   GLIA