The Role of Extracellular Vesicles in Cancer–Nerve Crosstalk of the Peripheral Nervous System

Improvement of sensory neuron growth and survival via negatively regulating PTEN by miR-21-5p-contained small extracellular vesicles from skin precursor-derived Schwann cells

(2021) Meng Cong et al.   Stem Cell Research & Therapy

Nerves in the Tumor Microenvironment: Origin and Effects

(2021) Wenjun Wang et al.   Frontiers in Cell and Developmental Biology

Extracellular vesicle-encapsulated microRNA-23a from dorsal root ganglia neurons binds to A20 and promotes inflammatory macrophage polarization following peripheral nerve injury

(2021) Yamei Zhang et al.   Aging-US

Repair of peripheral nerve defects by nerve grafts incorporated with extracellular vesicles from skin-derived precursor Schwann cells

(2021) Miaomei Yu et al.   Acta Biomaterialia

Schwann cell‐derived exosomes: Janus‐faced mediators of regeneration and disease

(2021) Fang Cheng Wong et al.   GLIA

Protective effect and potential mechanism of Schwann cell‐derived exosomes on mechanical damage of rat dorsal root ganglion cells

(2021) Guotao Huang et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

Liposomes and Extracellular Vesicles as Drug Delivery Systems: A Comparison of Composition, Pharmacokinetics, and Functionalization

(2021) Luke Koog et al.   Advanced Healthcare Materials

The Biogenesis, Biological Functions, and Applications of Macrophage-Derived Exosomes

(2021) Xiaoxiao Shan et al.   Frontiers in Molecular Biosciences

Cellular and molecular mechanisms of perineural invasion of pancreatic ductal adenocarcinoma

(2021) Jingbo Li et al.   Cancer Communications

Exosomes-mediated phenotypic switch of macrophages in the immune microenvironment after spinal cord injury

(2021) Peng Peng et al.   BIOMEDICINE & PHARMACOTHERAPY

Paeoniflorin Effect of Schwann Cell-Derived Exosomes Ameliorates Dorsal Root Ganglion Neurons Apoptosis through IRE1α Pathway

(2021) Yanbo Zhu et al.   Evidence-based Complementary and Alternative Medicine

Targeting neurons in the tumor microenvironment with bupivacaine nanoparticles reduces breast cancer progression and metastases

(2021) Maya Kaduri et al.   Science Advances

Extracellular Vesicles (Exosomes) as Immunosuppressive Mediating Variables in Tumor and Chronic Inflammatory Microenvironments

(2021) Annoor Awadasseid et al.   Cells

Perineural invasion reprograms the immune microenvironment through cholinergic signaling in pancreatic ductal adenocarcinoma

(2020) Min-Wei Yang et al.   CANCER RESEARCH

Exosomes Derived From Schwann Cells Ameliorate Peripheral Neuropathy in Type II Diabetic Mice

(2020) Lei Wang et al.   DIABETES

Loss of p53 drives neuron reprogramming in head and neck cancer

(2020) Moran Amit et al.   NATURE

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Roadmap for the Emerging Field of Cancer Neuroscience

(2020) Michelle Monje et al.   CELL

Neuro-immune Interactions in the Tissues

(2020) Coco Chu et al.   IMMUNITY

Schwann cell reprogramming into repair cells increases exosome-loaded miRNA-21 promoting axonal growth

(2020) Rodrigo López-Leal et al.   JOURNAL OF CELL SCIENCE

Exosomes derived from differentiated Schwann cells inhibit Schwann cell migration via microRNAs

(2020) Eun Jung Sohn et al.   NEUROREPORT

Perineural Invasion is a Better Prognostic Indicator than Lymphovascular Invasion and a Potential Adjuvant Therapy Indicator for pN0M0 Esophageal Squamous Cell Carcinoma

(2020) Yuan-ning Guo et al.   ANNALS OF SURGICAL ONCOLOGY

Clinically Actionable Strategies for Studying Neural Influences in Cancer

(2020) Ihsan Ekin Demir et al.   CANCER CELL

Editorial overview: Brain, gut and immune system interactions

(2020) Isaac Chiu et al.   CURRENT OPINION IN NEUROBIOLOGY

Exosome Released From Schwann Cells May Be Involved in Microenergy Acoustic Pulse–Associated Cavernous Nerve Regeneration

(2020) Dongyi Peng et al.   Journal of Sexual Medicine

M1 Macrophage Derived Exosomes Aggravate Experimental Autoimmune Neuritis via Modulating Th1 Response

(2020) Tong Du et al.   Frontiers in Immunology

Schwann Cell-derived exosomes promote bone regeneration and repair by enhancing the biological activity of porous Ti6Al4V scaffolds

(2020) Zhigang Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pleomorphic Dermal Sarcoma: a clinical and histological review of 49 cases

(2020) CM Bowe et al.   BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY

Exosomes as mediators of immune regulation and immunotherapy in cancer

(2020) Fernanda G. Kugeratski et al.   FEBS Journal

Exosomes in Angiogenesis and Anti-angiogenic Therapy in Cancers

(2020) Wioletta Olejarz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Basal cell carcinoma colonized by lentigo maligna melanoma, with perineural invasion by both neoplasms

(2020) Manuel Pérez‐Pérez et al.   JOURNAL OF CUTANEOUS PATHOLOGY

Pericyte-Derived Extracellular Vesicle–Mimetic Nanovesicles Restore Erectile Function by Enhancing Neurovascular Regeneration in a Mouse Model of Cavernous Nerve Injury

(2020) Guo Nan Yin et al.   Journal of Sexual Medicine

Primary cutaneous melanoma of the scalp: Patterns of clinical, histological and epidemiological characteristics in Brazil

(2020) Ana Carolina Porto et al.   PLoS One

Cancer-associated neurogenesis and nerve-cancer crosstalk

(2020) Deborah A Silverman et al.   CANCER RESEARCH

Peripheral Nerve Regeneration and Muscle Reinnervation

(2020) Tessa Gordon   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses

(2020) Qian Hu et al.   Acta Pharmaceutica Sinica B

Extracellular vesicles from skin precursor-derived Schwann cells promote axonal outgrowth and regeneration of motoneurons via Akt/mTOR/p70S6K pathway

(2020) Xia Wu et al.   Annals of Translational Medicine

Repair Schwann cell update: Adaptive reprogramming, EMT, and stemness in regenerating nerves

(2019) Kristjan R Jessen et al.   GLIA

Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis

(2019) Hao Chen et al.   Nature Communications

The Success and Failure of the Schwann Cell Response to Nerve Injury

(2019) Kristjan R. Jessen et al.   Frontiers in Cellular Neuroscience

Proteomics analysis of Schwann cell-derived exosomes: a novel therapeutic strategy for central nervous system injury

(2019) Zhijian Wei et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Targeting pericytes for neurovascular regeneration

(2019) Mohammad Hossein Geranmayeh et al.   Cell Communication and Signaling

Melanoma-induced reprogramming of Schwann cell signaling aids tumor growth

(2019) Galina V. Shurin et al.   CANCER RESEARCH

Enteric Neurogenesis during Life Span under Physiological and Pathophysiological Conditions

(2019) David Grundmann et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Exosomal Induction of Tumor Innervation

(2019) Paola D. Vermeer   CANCER RESEARCH

Innervation of cervical carcinoma is mediated by cancer-derived exosomes

(2019) Christopher T. Lucido et al.   GYNECOLOGIC ONCOLOGY

Progenitors from the central nervous system drive neurogenesis in cancer

(2019) Philippe Mauffrey et al.   NATURE

Exosomes Derived From Pericytes Improve Microcirculation and Protect Blood–Spinal Cord Barrier After Spinal Cord Injury in Mice

(2019) Xiaochen Yuan et al.   Frontiers in Neuroscience

Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression

(2019) Atsunori Kamiya et al.   NATURE NEUROSCIENCE

Synaptic proximity enables NMDAR signalling to promote brain metastasis

(2019) Qiqun Zeng et al.   NATURE

Muscle-Derived Extracellular Vesicles Influence Motor Neuron Regeneration Accuracy

(2019) Roger D. Madison et al.   NEUROSCIENCE

Perineural Invasion as a Clue to Malignant Behavior in a Dermatofibroma

(2019) Angel Santos-Briz et al.   AMERICAN JOURNAL OF DERMATOPATHOLOGY

The pericyte secretome: Potential impact on regeneration

(2018) Abderahim Gaceb et al.   BIOCHIMIE

β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer

(2018) Bernhard W. Renz et al.   CANCER CELL

Potential roles of tumor-derived exosomes in angiogenesis

(2018) Nils Ludwig et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Exosomes derived from high-glucose–stimulated Schwann cells promote development of diabetic peripheral neuropathy

(2018) Longfei Jia et al.   FASEB JOURNAL

Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons

(2018) Arnau Hervera et al.   NATURE CELL BIOLOGY

Modulation of anti-tumor immunity by the brain’s reward system

(2018) Tamar L Ben-Shaanan et al.   Nature Communications

Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression

(2018) Eduard Willms et al.   Frontiers in Immunology

L1CAM induces perineural invasion of pancreas cancer cells by upregulation of metalloproteinase expression

(2018) Shorook Na’ara et al.   ONCOGENE

Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness

(2018) Bernhard W Renz et al.   Cancer Discovery

RET, a targetable driver of pancreatic adenocarcinoma

(2018) Moran Amit et al.   INTERNATIONAL JOURNAL OF CANCER

A Promising Biocompatible Platform: Lipid-Based and Bio-Inspired Smart Drug Delivery Systems for Cancer Therapy

(2018) Min Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cancer exosomes induce tumor innervation

(2018) Marianna Madeo et al.   Nature Communications

Effects of RSC96 Schwann Cell-Derived Exosomes on Proliferation, Senescence, and Apoptosis of Dorsal Root Ganglion Cells In Vitro

(2018) Min Zhou et al.   MEDICAL SCIENCE MONITOR

The role of perineural invasion in treatment decisions for oral cancer patients: A review of the literature

(2017) Ioannis Chatzistefanou et al.   JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY

HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers

(2017) Lada A. Koneva et al.   MOLECULAR CANCER RESEARCH

Integrated genomic and molecular characterization of cervical cancer

(2017)   NATURE

Cellular prion protein (PrPC) in the development of Merlin-deficient tumours

(2017) L Provenzano et al.   ONCOGENE

Upregulation of RET induces perineurial invasion of pancreatic adenocarcinoma

(2017) M Amit et al.   ONCOGENE

Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis

(2017) Subhash Kulkarni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adrenergic nerves activate an angio-metabolic switch in prostate cancer

(2017) Ali H. Zahalka et al.   SCIENCE

Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma

(2017) Raffaele Simeoli et al.   Nature Communications

The role of integration in oncogenic progression of HPV-associated cancers

(2017) Alison A. McBride et al.   PLoS Pathogens

CD13hi Neutrophil-like myeloid-derived suppressor cells exert immune suppression through Arginase 1 expression in pancreatic ductal adenocarcinoma

(2017) Jing Zhang et al.   OncoImmunology

Extracellular vesicle-mediated suicide mRNA/protein delivery inhibits glioblastoma tumor growth in vivo

(2016) E P Erkan et al.   CANCER GENE THERAPY

Delivery of Therapeutic Proteins via Extracellular Vesicles: Review and Potential Treatments for Parkinson’s Disease, Glioma, and Schwannoma

(2016) Justin Hall et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Origin of axonal proteins: Is the axon-schwann cell unit a functional syncytium?

(2016) Rodrigo López-Leal et al.   Cytoskeleton

Activated Schwann cells in pancreatic cancer are linked to analgesia via suppression of spinal astroglia and microglia

(2016) Ihsan Ekin Demir et al.   GUT

Schwann cells induce cancer cell dispersion and invasion

(2016) Sylvie Deborde et al.   JOURNAL OF CLINICAL INVESTIGATION

The repair Schwann cell and its function in regenerating nerves

(2016) K. R. Jessen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pericytes of the neurovascular unit: key functions and signaling pathways

(2016) Melanie D Sweeney et al.   NATURE NEUROSCIENCE

Extracellular vesicles derived from human vestibular schwannomas associated with poor hearing damage cochlear cells

(2016) Vitor Y. R. Soares et al.   NEURO-ONCOLOGY

Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer

(2016) Jami L. Saloman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury

(2015) Peiwen Chen et al.   ACTA NEUROPATHOLOGICA

Macrophage-derived microvesicles promote proliferation and migration of Schwann cell on peripheral nerve repair

(2015) Chuan Zhan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The immunomodulatory properties of adult skin-derived precursor Schwann cells: implications for peripheral nerve injury therapy

(2015) Jo Anne Stratton et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Retrospective review of symptoms and palliative care interventions in women with advanced cervical cancer

(2015) Yu Jung Kim et al.   GYNECOLOGIC ONCOLOGY

Human papillomavirus (HPV) genome status & cervical cancer outcome - A retrospective study

(2015) Rita Mulherkar et al.   INDIAN JOURNAL OF MEDICAL RESEARCH

Exosomes and their roles in immune regulation and cancer

(2015) David W. Greening et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Schwann Cells: Development and Role in Nerve Repair

(2015) Kristján R. Jessen et al.   Cold Spring Harbor Perspectives in Biology

Dependence of Intracellular and Exosomal microRNAs on Viral E6/E7 Oncogene Expression in HPV-positive Tumor Cells

(2015) Anja Honegger et al.   PLoS Pathogens

IL-10, IL-4, and STAT6 Promote an M2 Milieu Required for Termination of P0106-125-Induced Murine Experimental Autoimmune Neuritis

(2014) Anna Brunn et al.   AMERICAN JOURNAL OF PATHOLOGY

Neuroplastic Changes Occur Early in the Development of Pancreatic Ductal Adenocarcinoma

(2014) Rachelle E. Stopczynski et al.   CANCER RESEARCH

Investigation of Schwann Cells at Neoplastic Cell Sites Before the Onset of Cancer Invasion

(2014) Ihsan Ekin Demir et al.   JNCI-Journal of the National Cancer Institute

The Chemokine (CCL2–CCR2) Signaling Axis Mediates Perineural Invasion

(2014) Shizhi He et al.   MOLECULAR CANCER RESEARCH

GFR 1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling

(2014) S. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Denervation suppresses gastric tumorigenesis

(2014) C.-M. Zhao et al.   Science Translational Medicine

The role of peripheral nerve fibers and their neurotransmitters in cartilage and bone physiology and pathophysiology

(2014) Susanne Grässel   ARTHRITIS RESEARCH & THERAPY

Direct Genesis of Functional Rodent and Human Schwann Cells from Skin Mesenchymal Precursors

(2014) Matthew P. Krause et al.   Stem Cell Reports

Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors

(2013) Su Chul Jang et al.   ACS Nano

The pre-metastatic niche: finding common ground

(2013) Jaclyn Sceneay et al.   CANCER AND METASTASIS REVIEWS

Schwann cell-derived exosomes enhance axonal regeneration in the peripheral nervous system

(2013) María Alejandra Lopez-Verrilli et al.   GLIA

Nerve Physiology

(2013) Ron M.G. Menorca et al.   HAND CLINICS

Silencing of human papillomavirus (HPV)E6/E7oncogene expression affects both the contents and the amounts of extracellular microvesicles released from HPV-positive cancer cells

(2013) Anja Honegger et al.   INTERNATIONAL JOURNAL OF CANCER

Mutation of SIMPLE in Charcot–Marie–Tooth 1C alters production of exosomes

(2013) Hong Zhu et al.   MOLECULAR BIOLOGY OF THE CELL

Interaction of the Sympathetic Nerve with Pancreatic Cancer Cells Promotes Perineural Invasion through the Activation of STAT3 Signaling

(2013) K. Guo et al.   MOLECULAR CANCER THERAPEUTICS

Perineural Mast Cells Are Specifically Enriched in Pancreatic Neuritis and Neuropathic Pain in Pancreatic Cancer and Chronic Pancreatitis

(2013) Ihsan Ekin Demir et al.   PLoS One

Autonomic Nerve Development Contributes to Prostate Cancer Progression

(2013) C. Magnon et al.   SCIENCE

Endoneurial Macrophages Induce Perineural Invasion of Pancreatic Cancer Cells by Secretion of GDNF and Activation of RET Tyrosine Kinase Receptor

(2012) O. Cavel et al.   CANCER RESEARCH

The role of the immune system in the generation of neuropathic pain

(2012) Margarita Calvo et al.   LANCET NEUROLOGY

Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth

(2012) Arda Mizrak et al.   MOLECULAR THERAPY

Transfer of Vesicles From Schwann Cells to Axons: a Novel Mechanism of Communication in the Peripheral Nervous System

(2012) M. Alejandra Lopez-Verrilli et al.   Frontiers in Physiology

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Clinical impact of visceral pleural, lymphovascular and perineural invasion in completely resected non-small cell lung cancer

(2011) Aydin Yilmaz et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Morphological evidence for a transport of ribosomes from Schwann cells to regenerating axons

(2011) Felipe A. Court et al.   GLIA

Wallerian degeneration: gaining perspective on inflammatory events after peripheral nerve injury

(2011) Andrew D Gaudet et al.   Journal of Neuroinflammation

Increased growth rate of vestibular schwannoma after resection of contralateral tumor in neurofibromatosis type 2

(2011) Matthieu Peyre et al.   NEURO-ONCOLOGY

Axotomy-Induced miR-21 Promotes Axon Growth in Adult Dorsal Root Ganglion Neurons

(2011) Iain T. Strickland et al.   PLoS One

Multivesicular bodies in neurons: Distribution, protein content, and trafficking functions

(2011) Christopher S. Von Bartheld et al.   PROGRESS IN NEUROBIOLOGY

Chronic Lymphocytic Leukemia Presenting with Cholecystitis-Like Symptoms and Gallbladder Wall Invasion

(2011) Constantin A. Dasanu et al.   SOUTHERN MEDICAL JOURNAL

The neuro-immune balance in neuropathic pain: Involvement of inflammatory immune cells, immune-like glial cells and cytokines

(2010) Paul J. Austin et al.   JOURNAL OF NEUROIMMUNOLOGY

The role of cytokines in Guillain–Barré syndrome

(2010) Ming-Ou Lu et al.   JOURNAL OF NEUROLOGY

Paracrine Regulation of Pancreatic Cancer Cell Invasion by Peripheral Nerves

(2010) Ziv Gil et al.   JNCI-Journal of the National Cancer Institute

Parasympathetic Innervation Maintains Epithelial Progenitor Cells During Salivary Organogenesis

(2010) S. M. Knox et al.   SCIENCE

Neural Invasion in Pancreatic Cancer: The Past, Present and Future

(2010) Ihsan Ekin Demir et al.   Cancers

Perineural invasion in cancer

(2009) Catherine Liebig et al.   CANCER

Charcot–Marie–Tooth disease

(2009) Kinga Szigeti et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

(2009) Isabella Parolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spontaneous regression of vestibular schwannomas after resection of contralateral tumor in neurofibromatosis Type 2

(2009) Kajetan L. von Eckardstein et al.   JOURNAL OF NEUROSURGERY

Considering the evolution of regeneration in the central nervous system

(2009) Elly M. Tanaka et al.   NATURE REVIEWS NEUROSCIENCE

Schwann Cell to Axon Transfer of Ribosomes: Toward a Novel Understanding of the Role of Glia in the Nervous System

(2008) F. A. Court et al.   JOURNAL OF NEUROSCIENCE