Real-time single-molecule observation of chaperone-assisted protein folding

Energy landscape remodeling mechanism of Hsp70-chaperone-accelerated protein folding

(2021) Jiajun Lu et al.   BIOPHYSICAL JOURNAL

Bacterial Hsp70 resolves misfolded states and accelerates productive folding of a multi-domain protein

(2020) Rahmi Imamoglu et al.   Nature Communications

Recent advances in understanding catalysis of protein folding by molecular chaperones

(2020) David Balchin et al.   FEBS LETTERS

Coordinated Conformational Processing of the Tumor Suppressor Protein p53 by the Hsp70 and Hsp90 Chaperone Machineries

(2019) Vinay Dahiya et al.   MOLECULAR CELL

The Hsp70 chaperone network

(2019) Rina Rosenzweig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis for client recognition and activity of Hsp40 chaperones

(2019) Yajun Jiang et al.   SCIENCE

Efficient conversion of chemical energy into mechanical work by Hsp70 chaperones

(2019) Salvatore Assenza et al.   eLife

Reliable State Identification and State Transition Detection in Fluorescence Intensity-Based Single-Molecule Förster Resonance Energy-Transfer Data

(2018) Mélodie C. A. S. Hadzic et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Hsp90 Breaks the Deadlock of the Hsp70 Chaperone System

(2018) Tania Morán Luengo et al.   MOLECULAR CELL

Conformational Activation of Argonaute by Distinct yet Coordinated Actions of the Hsp70 and Hsp90 Chaperone Systems

(2018) Kotaro Tsuboyama et al.   MOLECULAR CELL

Conserved conformational selection mechanism of Hsp70 chaperone-substrate interactions

(2018) Ashok Sekhar et al.   eLife

Chaperone-client interactions: Non-specificity engenders multifunctionality

(2017) Philipp Koldewey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Promiscuous binding by Hsp70 results in conformational heterogeneity and fuzzy chaperone-substrate ensembles

(2017) Rina Rosenzweig et al.   eLife

A Novel Method for Assessing the Chaperone Activity of Proteins

(2016) Nevena Hristozova et al.   PLoS One

Protein aggregation in Alzheimer’s disease: Aβ and τ and their potential roles in the pathogenesis of AD

(2015) Dietmar Rudolf Thal et al.   ACTA NEUROPATHOLOGICA

How Hsp70 Molecular Machines Interact with Their Substrates to Mediate Diverse Physiological Functions

(2015) Eugenia M. Clerico et al.   JOURNAL OF MOLECULAR BIOLOGY

Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation

(2015) Nadinath B. Nillegoda et al.   NATURE

Heterogeneous binding of the SH3 client protein to the DnaK molecular chaperone

(2015) Jung Ho Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping the conformation of a client protein through the Hsp70 functional cycle

(2015) Ashok Sekhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Misfolding of Luciferase at the Single-Molecule Level

(2014) Alireza Mashaghi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chaperones Rescue Luciferase Folding by Separating Its Domains

(2014) Zackary N. Scholl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-molecule spectroscopy reveals chaperone-mediated expansion of substrate protein

(2014) Ruth Kellner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hsp70 chaperones are non-equilibrium machines that achieve ultra-affinity by energy consumption

(2014) Paolo De Los Rios et al.   eLife

Chaperone machines for protein folding, unfolding and disaggregation

(2013) Helen Saibil   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hsp70 chaperone dynamics and molecular mechanism

(2013) Matthias P. Mayer   TRENDS IN BIOCHEMICAL SCIENCES

DnaK Functions as a Central Hub in the E. coli Chaperone Network

(2012) Giulia Calloni et al.   Cell Reports

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Comparing the functional properties of the Hsp70 chaperones, DnaK and BiP

(2010) Jeanne Bonomo et al.   BIOPHYSICAL CHEMISTRY

Native and Unfolded States of Phosphoglycerate Kinase Studied by Single-Molecule FRET

(2010) Tobias Rosenkranz et al.   CHEMPHYSCHEM

Role of DnaJ G/F-rich Domain in Conformational Recognition and Binding of Protein Substrates

(2010) Judit Perales-Calvo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The kinetic parameters and energy cost of the Hsp70 chaperone as a polypeptide unfoldase

(2010) Sandeep K Sharma et al.   Nature Chemical Biology

Identification of small molecules that modify the protein folding activity of heat shock protein 70

(2008) Susanne Wisén et al.   ANALYTICAL BIOCHEMISTRY

Efficient Site-Specific Labeling of Proteins via Cysteines

(2008) Younggyu Kim et al.   BIOCONJUGATE CHEMISTRY

Molecular Basis for Regulation of the Heat Shock Transcription Factor σ32 by the DnaK and DnaJ Chaperones

(2008) Fernanda Rodriguez et al.   MOLECULAR CELL