Dual targeting of EZH1 and EZH2 for the treatment of malignant rhabdoid tumors

Human Pluripotent Stem Cell-Derived Tumor Model Uncovers the Embryonic Stem Cell Signature as a Key Driver in Atypical Teratoid/Rhabdoid Tumor

(2019) Yukinori Terada et al.   Cell Reports

Clinical and Prognostic Characteristics of 53 Cases of Extracranial Malignant Rhabdoid Tumor in Children. A Single‐Institute Experience from 2007 to 2017

(2019) Haiyan Cheng et al.   ONCOLOGIST

Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas

(2019) Makoto Yamagishi et al.   Cell Reports

Tazemetostat, an EZH2 inhibitor, in relapsed or refractory B-cell non-Hodgkin lymphoma and advanced solid tumours: a first-in-human, open-label, phase 1 study

(2018) Antoine Italiano et al.   LANCET ONCOLOGY

Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation

(2018) Serap Erkek et al.   CANCER CELL

Dual inhibition of enhancer of zeste homolog 1/2 overactivates WNT signaling to deplete cancer stem cells in multiple myeloma

(2018) Makoto Nakagawa et al.   CANCER SCIENCE

Prognostic factors and survival in non-central nervous system rhabdoid tumors

(2017) Benjamin A. Farber et al.   JOURNAL OF PEDIATRIC SURGERY

Dual inhibition of EZH1/2 breaks the quiescence of leukemia stem cells in acute myeloid leukemia

(2017) S Fujita et al.   LEUKEMIA

Cancer-Specific Energy Metabolism in Rhabdomyosarcoma Cells Is Regulated by MicroRNA

(2017) Nobuhiko Sugito et al.   Nucleic Acid Therapeutics

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors

(2016) Jonathon Torchia et al.   CANCER CELL

Perturbation of energy metabolism by fatty-acid derivative AIC-47 and imatinib in BCR-ABL-harboring leukemic cells

(2016) Haruka Shinohara et al.   CANCER LETTERS

Targeting EZH2 in cancer

(2016) Kimberly H Kim et al.   NATURE MEDICINE

Initial testing (stage 1) of tazemetostat (EPZ-6438), a novel EZH2 inhibitor, by the Pediatric Preclinical Testing Program

(2016) Raushan T. Kurmasheva et al.   PEDIATRIC BLOOD & CANCER

Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia

(2014) B. Xu et al.   BLOOD

Vulnerabilities of Mutant SWI/SNF Complexes in Cancer

(2014) Katherine C. Helming et al.   CANCER CELL

EZH2 Inhibitor Efficacy in Non-Hodgkin’s Lymphoma Does Not Require Suppression of H3K27 Monomethylation

(2014) William D. Bradley et al.   CHEMISTRY & BIOLOGY

SNF5 Reexpression in Malignant Rhabdoid Tumors Regulates Transcription of Target Genes by Recruitment of SWI/SNF Complexes and RNAPII to the Transcription Start Site of Their Promoters

(2013) Yasumichi Kuwahara et al.   MOLECULAR CANCER RESEARCH

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2

(2013) S. K. Knutson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

(2012) Michael T. McCabe et al.   NATURE

Clinicopathologic prognostic factors in childhood atypical teratoid and rhabdoid tumor of the central nervous system

(2011) Christelle Dufour et al.   CANCER

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Epigenetic Antagonism between Polycomb and SWI/SNF Complexes during Oncogenic Transformation

(2010) Boris G. Wilson et al.   CANCER CELL

Reexpression of hSNF5 in Malignant Rhabdoid Tumor Cell Lines Causes Cell Cycle Arrest through a p21CIP1/WAF1-Dependent Mechanism

(2010) Y. Kuwahara et al.   CANCER RESEARCH

Rhabdoid tumor: gene expression clues to pathogenesis and potential therapeutic targets

(2010) Samantha Gadd et al.   LABORATORY INVESTIGATION

MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1α/HIF-1β

(2010) Paul Cao et al.   Molecular Cancer

EZH1 Mediates Methylation on Histone H3 Lysine 27 and Complements EZH2 in Maintaining Stem Cell Identity and Executing Pluripotency

(2008) Xiaohua Shen et al.   MOLECULAR CELL