Comprehensive analyses of the microRNA–messenger RNA–transcription factor regulatory network in mouse and human renal fibrosis

Renal tubular PAR2 promotes interstitial fibrosis by increasing inflammatory responses and EMT process

(2022) Sugyeong Ha et al.   ARCHIVES OF PHARMACAL RESEARCH

CDKN2B antisense RNA 1 expression alleviates idiopathic pulmonary fibrosis by functioning as a competing endogenouse RNA through the miR-199a-5p/Sestrin-2 axis

(2022) Mei Yang et al.   Bioengineered

Exosomal miRNAs as Potential Biomarkers to Monitor Phosphodiesterase 5 Inhibitor Induced Anti-Fibrotic Effects on CCl4 Treated Rats

(2021) Andre Broermann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PAX5 activates telomerase activity and proliferation in keloid fibroblasts by transcriptional regulation of SND1, thus promoting keloid growth in burn-injured skin

(2021) Gaoping Qin et al.   INFLAMMATION RESEARCH

Roles of Krüppel‐like factor 5 in kidney disease

(2021) Jia Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inhibition of miR-199a-5p rejuvenates aged mesenchymal stem cells derived from patients with idiopathic pulmonary fibrosis and improves their therapeutic efficacy in experimental pulmonary fibrosis

(2021) Linli Shi et al.   Stem Cell Research & Therapy

The Expression of TRIM6 Activates the mTORC1 Pathway by Regulating the Ubiquitination of TSC1-TSC2 to Promote Renal Fibrosis

(2021) Weiwei Liu et al.   Frontiers in Cell and Developmental Biology

microRNA-29b prevents renal fibrosis by attenuating renal tubular epithelial cell–mesenchymal transition through targeting the PI3K/AKT pathway

(2021) Shuang Hu et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Pyridostigmine Protects Against Diabetic Cardiomyopathy by Regulating Vagal Activity, Gut Microbiota, and Branched-Chain Amino Acid Catabolism in Diabetic Mice

(2021) Yang Yang et al.   Frontiers in Pharmacology

DZNep, an inhibitor of the histone methyltransferase EZH2, suppresses hepatic fibrosis through regulating miR-199a-5p/SOCS7 pathway

(2021) Rongrong Ding et al.   PeerJ

Small molecules against the origin and activation of myofibroblast for renal interstitial fibrosis therapy

(2021) Ya-long Feng et al.   BIOMEDICINE & PHARMACOTHERAPY

Identification of miR-199a-5p, miR-214-3p and miR-99b-5p as Fibrosis-Specific Extracellular Biomarkers and Promoters of HSC Activation

(2021) Catherine Jane Messner et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MRTF: Basic Biology and Role in Kidney Disease

(2021) Maria Zena Miranda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transcription factors specificity protein and nuclear receptor 4A1 in pancreatic cancer

(2021) Stephen Safe et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Diverging targets mediate the pathological role of miR-199a-5p and miR-199a-3p by promoting cardiac hypertrophy and fibrosis

(2021) Ni Zeng et al.   Molecular Therapy-Nucleic Acids

Long Non-coding RNA ENST00000453774.1 Confers an Inhibitory Effect on Renal Fibrosis by Inhibiting miR-324-3p to Promote NRG1 Expression

(2021) Shumei Tang et al.   Frontiers in Cell and Developmental Biology

Endothelial autophagy deficiency induces IL6 - dependent endothelial mesenchymal transition and organ fibrosis

(2020) Yuta Takagaki et al.   Autophagy

Targeting angiogenesis and lymphangiogenesis in kidney disease

(2020) Katsuyuki Tanabe et al.   Nature Reviews Nephrology

Evaluation of profibrotic gene transcription in renal tissues from cats with naturally occurring chronic kidney disease

(2020) Bianca N. Lourenço et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Wnt signaling pathway in aging-related tissue fibrosis and therapies

(2020) He-He Hu et al.   AGEING RESEARCH REVIEWS

Extracellular matrix, integrins, and focal adhesion signaling in polycystic kidney disease

(2020) Yan Zhang et al.   CELLULAR SIGNALLING

Collagen Type III Alpha 1 chain regulated by GATA‐Binding Protein 6 affects Type II IFN response and propanoate metabolism in the recurrence of lower grade glioma

(2020) Runzhi Huang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

MiR-200b/c family inhibits renal fibrosis through modulating epithelial-to-mesenchymal transition via targeting fascin-1/CD44 axis

(2020) Hua Fu et al.   LIFE SCIENCES

MYO5B mutations in pheochromocytoma/paraganglioma promote cancer progression

(2020) Tajana Tešan Tomić et al.   PLoS Genetics

ALDH5A1 acts as a tumour promoter and has a prognostic impact in papillary thyroid carcinoma

(2020) Xing‐Yan Deng et al.   CELL BIOCHEMISTRY AND FUNCTION

WNT–β-catenin signalling — a versatile player in kidney injury and repair

(2020) Stefan J. Schunk et al.   Nature Reviews Nephrology

Comparative Toxicogenomics Database (CTD): update 2021

(2020) Allan Peter Davis et al.   NUCLEIC ACIDS RESEARCH

Late intervention in the remnant kidney model attenuates proteinuria but not glomerular filtration rate decline

(2020) Matthew R. Veitch et al.   NEPHROLOGY

The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets

(2020) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Role of the CTRP6/AMPK pathway in kidney fibrosis through the promotion of fatty acid oxidation

(2020) Yu-hong Xie et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway

(2019) Sun Ah Nam et al.   Cell Death & Disease

The role of podocyte damage in the etiology of ischemia-reperfusion acute kidney injury and post-injury fibrosis

(2019) Yi Chen et al.   BMC Nephrology

MicroRNA-34a Promotes Renal Fibrosis by Downregulation of Klotho in Tubular Epithelial Cells

(2019) Yong Liu et al.   MOLECULAR THERAPY

Caveolin-1 regulation of Sp1 controls production of the antifibrotic protein follistatin in kidney mesangial cells

(2019) Neel Mehta et al.   Cell Communication and Signaling

Markers of renal fibrosis: How do they correlate with podocyte damage in glomerular diseases?

(2019) Tiago Giulianni Lopes et al.   PLoS One

Unilateral Ureteral Obstruction as a Model to Investigate Fibrosis-Attenuating Treatments

(2019) Elena Martínez-Klimova et al.   Biomolecules

WNT1‐inducible signaling protein‐1 mediates TGF‐β1‐induced renal fibrosis in tubular epithelial cells and unilateral ureteral obstruction mouse models via autophagy

(2019) Xue Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The analysis of risk factors for diabetic nephropathy progression and the construction of a prognostic database for chronic kidney diseases

(2019) Gang Wang et al.   Journal of Translational Medicine

miRDB: an online database for prediction of functional microRNA targets

(2019) Yuhao Chen et al.   NUCLEIC ACIDS RESEARCH

miRNA‑342 suppresses renal interstitial fibrosis in diabetic nephropathy by targeting SOX6

(2019) Zhen‑Huan Jiang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

BMP-7 inhibits renal fibrosis in diabetic nephropathy via miR-21 downregulation

(2019) Lingling Liu et al.   LIFE SCIENCES

Interstitial HIF1A induces an estimated glomerular filtration rate decline through potentiating renal fibrosis in diabetic nephropathy

(2019) Xiyue Li et al.   LIFE SCIENCES

The biochemical basis of microRNA targeting efficacy

(2019) Sean E. McGeary et al.   SCIENCE

Non-canonical (non-SMAD2/3) TGF-β signaling in fibrosis: Mechanisms and targets

(2019) Kenneth W. Finnson et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mechanisms of Renal Fibrosis

(2018) Benjamin D. Humphreys   Annual Review of Physiology

Transactivation of PTGS2 by PAX5 signaling potentiates cisplatin resistance in muscle-invasive bladder cancer cells

(2018) Bing-wei Dong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice

(2018) Yunfeng Zhou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Capillary rarefaction and altered renal development: the imbalance between pro- and anti-angiogenic factors in response to angiotensin II inhibition in the developing rat kidney

(2018) Kee Hwan Yoo et al.   JOURNAL OF MOLECULAR HISTOLOGY

Role of hypoxia-inducible factor-1 in the development of renal fibrosis in mouse obstructed kidney: Special references to HIF-1 dependent gene expression of profibrogenic molecules

(2018) Kazuya Kabei et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

FP429THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM INHIBITORS AMELIORATE HYPERGLYCAEMIA INDUCED TUBULOINTERSITIAL FIBROSIS IN DIABETIC NEPHROPATHY

(2018) Agnes Molnar et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The Role of FABP5 in Radiation-Induced Human Skin Fibrosis

(2018) Jianyuan Song et al.   RADIATION RESEARCH

PAX2 may induce ADAM10 expression in renal tubular epithelial cells and contribute to epithelial-to-mesenchymal transition

(2018) Ling Hou et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

miRWalk: An online resource for prediction of microRNA binding sites

(2018) Carsten Sticht et al.   PLoS One

Pathological cardiac remodeling occurs early in CKD mice from unilateral urinary obstruction, and is attenuated by Enalapril

(2018) Onju Ham et al.   Scientific Reports

miRBase: from microRNA sequences to function

(2018) Ana Kozomara et al.   NUCLEIC ACIDS RESEARCH

Inhibitors of the renin-angiotensin system ameliorates clinical and pathological aspects of experimentally induced nephrotoxic serum nephritis

(2018) M. E. Ougaard et al.   RENAL FAILURE

IBMX protects human proximal tubular epithelial cells from hypoxic stress through suppressing hypoxia-inducible factor-1α expression

(2017) Arif Ul Hasan et al.   EXPERIMENTAL CELL RESEARCH

SP and KLF Transcription Factors in Digestive Physiology and Diseases

(2017) Chang-Kyung Kim et al.   GASTROENTEROLOGY

The MicroRNA-199a/214 Cluster Targets E-Cadherin and Claudin-2 and Promotes High Glucose-Induced Peritoneal Fibrosis

(2017) Mingwen Che et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Pirfenidone suppresses MAPK signalling pathway to reverse epithelial-mesenchymal transition and renal fibrosis

(2017) Zhenzhen Li et al.   NEPHROLOGY

DGIdb 3.0: a redesign and expansion of the drug–gene interaction database

(2017) Kelsy C Cotto et al.   NUCLEIC ACIDS RESEARCH

A subcellular map of the human proteome

(2017) Peter J. Thul et al.   SCIENCE

Pax-5 is a potent regulator of E-cadherin and breast cancer malignant processes

(2017) Sami Benzina et al.   Oncotarget

Mass Spectrometry Imaging of Kidney Tissue Sections of Rat Subjected to Unilateral Ureteral Obstruction

(2017) Huihui Liu et al.   Scientific Reports

p53 induces miR199a-3p to suppress SOCS7 for STAT3 activation and renal fibrosis in UUO

(2017) Ruhao Yang et al.   Scientific Reports

Blood capillary rarefaction and lymphatic capillary neoangiogenesis are key contributors to renal allograft fibrosis in an ACE inhibition rat model

(2016) Péter Hamar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Modulation of glycolysis and lipogenesis by novel PI3K selective molecule represses tumor angiogenesis and decreases colorectal cancer growth

(2016) Aashiq Hussain et al.   CANCER LETTERS

Regulatory Mechanisms of the Molecular Pathways in Fibrosis Induced by MicroRNAs

(2016) Si-Dao Zheng et al.   CHINESE MEDICAL JOURNAL

Mitochondrial Pathology and Glycolytic Shift during Proximal Tubule Atrophy after Ischemic AKI

(2016) R. Lan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Angiotensin-Converting Enzyme Inhibitor (ACEI)-Mediated Amelioration in Renal Fibrosis Involves Suppression of Mast Cell Degranulation

(2016) Nan Sun et al.   KIDNEY & BLOOD PRESSURE RESEARCH

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

Roles of mTOR complexes in the kidney: implications for renal disease and transplantation

(2016) Daniel Fantus et al.   Nature Reviews Nephrology

miR-21-5p renal expression is associated with fibrosis and renal survival in patients with IgA nephropathy

(2016) Marie-Flore Hennino et al.   Scientific Reports

Accumulated Metabolites of Hydroxybutyric Acid Serve as Diagnostic and Prognostic Biomarkers of Ovarian High-Grade Serous Carcinomas

(2015) M. Hilvo et al.   CANCER RESEARCH

Insights into the Mechanisms Involved in the Expression and Regulation of Extracellular Matrix Proteins in Diabetic Nephropathy

(2015) C. Hu et al.   CURRENT MEDICINAL CHEMISTRY

Discovery and validation of extracellular/circulating microRNAs during idiopathic pulmonary fibrosis disease progression

(2015) Guanghai Yang et al.   GENE

DIANA-miRPath v3.0: deciphering microRNA function with experimental support

(2015) Ioannis S. Vlachos et al.   NUCLEIC ACIDS RESEARCH

Inhibition of MiR-199a-5p Reduced Cell Proliferation in Autosomal Dominant Polycystic Kidney Disease through Targeting CDKN1C

(2015) Changlin Mei   MEDICAL SCIENCE MONITOR

miR-638 Suppresses Cell Proliferation in Gastric Cancer by Targeting Sp2

(2014) Ling Yu Zhao et al.   DIGESTIVE DISEASES AND SCIENCES

Podocyte-Specific VEGF-A Gain of Function Induces Nodular Glomerulosclerosis in eNOS Null Mice

(2014) D. Veron et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Autophagy in Acute Kidney Injury and Repair

(2014) Liyu He et al.   NEPHRON CLINICAL PRACTICE

iRegulon: From a Gene List to a Gene Regulatory Network Using Large Motif and Track Collections

(2014) Rekin's Janky et al.   PLoS Computational Biology

What is the best way to measure renal fibrosis?: A pathologist’s perspective

(2014) Alton B. Farris et al.   Kidney International Supplements

starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein–RNA interaction networks from large-scale CLIP-Seq data

(2013) Jun-Hao Li et al.   NUCLEIC ACIDS RESEARCH

DIANA-microT web server v5.0: service integration into miRNA functional analysis workflows

(2013) Maria D. Paraskevopoulou et al.   NUCLEIC ACIDS RESEARCH

Therapeutic Effects of Human Amniotic Fluid-Derived Stem Cells on Renal Interstitial Fibrosis in a Murine Model of Unilateral Ureteral Obstruction

(2013) Dong Sun et al.   PLoS One

miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1

(2013) Christian Lacks Lino Cardenas et al.   PLoS Genetics

Short-term ACE inhibition confers long-term protection against target organ damage

(2012) Taben M Hale et al.   HYPERTENSION RESEARCH

Protective effect of Phellinus linteus polysaccharide extracts against thioacetamide-induced liver fibrosis in rats: a proteomics analysis

(2012) Hualin Wang et al.   Chinese Medicine

Beneficial Effects of Enalapril on Chlorhexidine Digluconate-Induced Liver Peritoneal Fibrosis in Rats

(2011) Chung-Jen Lee   CHINESE JOURNAL OF PHYSIOLOGY

Protective effects of enalapril in streptozotocin-induced diabetic rat: studies of DNA damage, apoptosis and expression of CCN2 in the heart, kidney and liver

(2011) S. Kushwaha et al.   JOURNAL OF APPLIED TOXICOLOGY

The Progression of Liver Fibrosis Is Related with Overexpression of the miR-199 and 200 Families

(2011) Yoshiki Murakami et al.   PLoS One

Renal fibrosis: novel insights into mechanisms and therapeutic targets

(2010) Peter Boor et al.   Nature Reviews Nephrology

Wnt signaling in kidney development and disease

(2010) Kaisa Pulkkinen et al.   Organogenesis

Decreased renal expression of vascular endothelial growth factor in lupus nephritis is associated with worse prognosis

(2009) Yingyos Avihingsanon et al.   KIDNEY INTERNATIONAL

Hypoxia response and VEGF-A expression in human proximal tubular epithelial cells in stable and progressive renal disease

(2009) Michael Rudnicki et al.   LABORATORY INVESTIGATION