Targeted xCT‐mediated Ferroptosis and Protumoral Polarization of Macrophages Is Effective against HCC and Enhances the Efficacy of the Anti‐PD‐1/L1 Response

Blockade of beta-adrenergic receptors reduces cancer growth and enhances the response to anti-CTLA4 therapy by modulating the tumor microenvironment

(2022) Klaire Yixin Fjæstad et al.   ONCOGENE

Diurnal Expression of PD-1 on Tumor-Associated Macrophages Underlies the Dosing Time-Dependent Antitumor Effects of the PD-1/PD-L1 Inhibitor BMS-1 in B16/BL6 Melanoma-Bearing Mice

(2022) Akito Tsuruta et al.   MOLECULAR CANCER RESEARCH

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

TBX3 functions as a tumor suppressor downstream of activated CTNNB1 mutants during hepatocarcinogenesis

(2021) Binyong Liang et al.   JOURNAL OF HEPATOLOGY

Pharmacological inhibition of MELK restricts ferroptosis and the inflammatory response in colitis and colitis-propelled carcinogenesis

(2021) Bufu Tang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Prognostic Value of CD206 in Solid Malignancies: A Systematic Review and Meta-Analysis

(2021) Jens M. Debacker et al.   Cancers

Identification of critical ferroptosis regulators in lung adenocarcinoma that RRM2 facilitates tumor immune infiltration by inhibiting ferroptotic death

(2021) Bufu Tang et al.   CLINICAL IMMUNOLOGY

Integrative analysis of the molecular mechanisms, immunological features and immunotherapy response of ferroptosis regulators across 33 cancer types

(2021) Bufu Tang et al.   International Journal of Biological Sciences

Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein

(2020) Enyong Dai et al.   Autophagy

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

(2020) Guang Lei et al.   CELL RESEARCH

Advances in molecular classification and precision oncology in hepatocellular carcinoma

(2020) Sandra Rebouissou et al.   JOURNAL OF HEPATOLOGY

LncGBP9/miR-34a axis drives macrophages toward a phenotype conducive for spinal cord injury repair via STAT1/STAT6 and SOCS3

(2020) Jiahui Zhou et al.   Journal of Neuroinflammation

Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer

(2020) Hae-Ock Lee et al.   NATURE GENETICS

Targeting tumor-associated macrophages and granulocytic myeloid-derived suppressor cells augments PD-1 blockade in cholangiocarcinoma

(2020) Emilien Loeuillard et al.   JOURNAL OF CLINICAL INVESTIGATION

xCT: A Critical Molecule That Links Cancer Metabolism to Redox Signaling

(2020) Jinyun Liu et al.   MOLECULAR THERAPY

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

(2020) Pranavi Koppula et al.   Protein & Cell

Ferroptosis, a new form of cell death: opportunities and challenges in cancer

(2019) Yanhua Mou et al.   Journal of Hematology & Oncology

Individualized Precision Treatment：Targeting TAM in HCC

(2019) Zhixuan Li et al.   CANCER LETTERS

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

(2019) Yilong Zou et al.   Nature Communications

Diversity, Mechanisms, and Significance of Macrophage Plasticity

(2019) Massimo Locati et al.   Annual Review of Pathology-Mechanisms of Disease

Hepatocyte growth control by SOCS1 and SOCS3

(2019) Md Gulam Musawwir Khan et al.   CYTOKINE

Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11

(2019) Xueting Lang et al.   Cancer Discovery

Recent Progress in Ferroptosis Inducers for Cancer Therapy

(2019) Chen Liang et al.   ADVANCED MATERIALS

Activation of the IL-4/STAT6 Signaling Pathway Promotes Lung Cancer Progression by Increasing M2 Myeloid Cells

(2019) Cuiping Fu et al.   Frontiers in Immunology

Targeting the Stat6 pathway in tumor-associated macrophages reduces tumor growth and metastatic niche formation in breast cancer

(2018) Karin Binnemars-Postma et al.   FASEB JOURNAL

PPARγ is a nexus controlling alternative activation of macrophages via glutamine metabolism

(2018) Victoria L. Nelson et al.   GENES & DEVELOPMENT

Rapid activation of tumor-associated macrophages boosts preexisting tumor immunity

(2018) Sabine Hoves et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hepatocellular carcinoma

(2018) Alejandro Forner et al.   LANCET

xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression

(2018) Xiangming Ji et al.   ONCOGENE

Crosstalk between hepatic tumor cells and macrophages via Wnt/β-catenin signaling promotes M2-like macrophage polarization and reinforces tumor malignant behaviors

(2018) Yang Yang et al.   Cell Death & Disease

Annual Report to the Nation on the Status of Cancer, 1975–2014, Featuring Survival

(2017) Ahmedin Jemal et al.   JNCI-Journal of the National Cancer Institute

ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner

(2017) D Chen et al.   ONCOGENE

Annual Report to the Nation on the Status of Cancer, 1975–2014, Featuring Survival

(2017) Ahmedin Jemal et al.   JNCI-Journal of the National Cancer Institute

Multistaged Nanovaccines Based on Porous Silicon@Acetalated Dextran@Cancer Cell Membrane for Cancer Immunotherapy

(2016) Flavia Fontana et al.   ADVANCED MATERIALS

Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1/FASN pathway in mice

(2016) Junjie Hu et al.   Scientific Reports

Two-Photon Excitation of Porphyrin-Functionalized Porous Silicon Nanoparticles for Photodynamic Therapy

(2014) Emilie Secret et al.   ADVANCED MATERIALS

Hydrodynamic Transfection for Generation of Novel Mouse Models for Liver Cancer Research

(2014) Xin Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Tumor-Associated Macrophages Produce Interleukin 6 and Signal via STAT3 to Promote Expansion of Human Hepatocellular Carcinoma Stem Cells

(2014) Shanshan Wan et al.   GASTROENTEROLOGY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Mechanisms Driving Macrophage Diversity and Specialization in Distinct Tumor Microenvironments and Parallelisms with Other Tissues

(2014) Eva Van Overmeire et al.   Frontiers in Immunology

Macrophage-Specific RNA Interference Targeting via “Click”, Mannosylated Polymeric Micelles

(2013) Shann S. Yu et al.   MOLECULAR PHARMACEUTICS

Macrophage microvesicles induce macrophage differentiation and miR-223 transfer

(2012) N. Ismail et al.   BLOOD

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Transcriptional regulation by STAT6

(2011) Shreevrat Goenka et al.   IMMUNOLOGIC RESEARCH

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Biodegradable luminescent porous silicon nanoparticles for in vivo applications

(2009) Ji-Ho Park et al.   NATURE MATERIALS