Article
Medicine, Research & Experimental
Chuanzheng Wang, Fei Cao, Jiahao Cao, Zhen Jiao, Yuting You, Yu Xiong, Wenxiu Zhao, Xiaomin Wang
Summary: CD58 is upregulated in HCC tissues and its overexpression is associated with poor prognosis in HCC patients. CD58 promotes proliferation and metastasis in HCC cells by activating the AKT/GSK-3β/β-catenin pathway, suggesting that CD58 may serve as a prognostic biomarker and therapeutic target for HCC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Feng Li, Ruya Liu, Vinny Negi, Ping Yang, Jeongkyung Lee, Rajaganapathi Jagannathan, Mousumi Moulik, Vijay K. Yechoor
Summary: In this study, TEAD1 and the mammalian Hippo pathway were found to play a regulatory role in cellular proliferation and function, particularly in 0 cells. The study identified VGLL4 and MENIN as corepressors of TEAD1 in 0 cells, which suppress the expression of target genes and inhibit 0 cell proliferation. Targeting VGLL4 and MENIN could potentially enhance proliferation in 0 cells for the treatment of diabetes.
Article
Cell Biology
Mustafa Karabicici, Yagmur Azbazdar, Gunes Ozhan, Serif Senturk, Zeynep Firtina Karagonlar, Esra Erdal
Summary: In this study, it was found that regorafenib treatment activated Wnt/beta-catenin signaling only in hepatoblast-like HCC cell lines and induced enrichment of markers associated with hepatic stem/progenitor cells. On the other hand, regorafenib resistant cells demonstrated diminished Wnt/beta-catenin signaling activity and enhanced TGF-beta signaling activity. The inhibition of TGF-beta pathway in combination with regorafenib administration might increase regorafenib-induced cell death in HCC tumors with aberrant activation in the Wnt/beta-catenin pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Srishti Kotiyal, Kimberley Jane Evason
Summary: Mutations in TERT promoter and CTNNB1 gene are common in hepatocellular carcinoma (HCC), and their interaction plays a role in promoting hepatocarcinogenesis.
Article
Cell Biology
Hong-Xiang Shi, Chao Liang, Chao-Yan Yao, Zi-Xuan Gao, Jia Qin, Jin-Lan Cao, Ming-Zhu Zhang, Ying-Ying Li, Meng-Qing Wang, Hua Sun, Song-Qiang Xie, Dong Fang
Summary: This study reveals the immunosuppressive role of spermine in hepatocellular carcinoma by activating the CaSR pathway to promote the expression of PD-L1 and reducing the infiltration of CD8(+) T cells. This discovery highlights the crucial function of spermine in establishing immune privilege.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Oncology
Cen-Shan Lin, Yuyi Liang, Shu-Guang Su, Yin-Li Zheng, Neng Jiang, Jing Zhou, Ying Zhang, Ru Deng, Chun-Hua Wang, Shi-Xun Lu, Yu-Hua Huang, Li-Li Liu, Chao Zhang, Jing-Ping Yun
Summary: The study identified elevated Nup93 expression in HCC tissues, especially in cases with metastasis, and its association with poorer prognosis. Nup93 was found to promote HCC metastasis and proliferation by regulating beta-catenin translocation, while the interaction between Nup93 and beta-catenin, as well as a positive feedback loop involving LEF1 and beta-catenin, further facilitated metastasis and proliferation in HCC. The findings suggest potential therapeutic targets in the LEF1-Nup93-beta-catenin pathway for HCC treatment.
Article
Cell Biology
Yiming Hou, Wenqian Yu, Gaoyi Wu, Zhaoling Wang, Shuai Leng, Ming Dong, Na Li, Lei Chen
Summary: The correlation between LEF1 and KDM4A is crucial for the development of oral squamous cell carcinoma (OSCC). LEF1 promotes cell proliferation and inhibits apoptosis in OSCC by suppressing the expression of LATS2. The findings suggest that LEF1 has the potential to serve as a target for early diagnosis and treatment of OSCC.
CELL DEATH & DISEASE
(2023)
Article
Medicine, Research & Experimental
Lili Zhu, Xiaobei Yang, Jingyu Feng, Jian Mao, Qidong Zhang, Mengru He, Yang Mi, Yingwu Mei, Ge Jin, Haifeng Zhang
Summary: The study reveals that CYP2E1 plays a role in hepatocarcinogenesis by manipulating the Wnt/Dvl2/beta-catenin pathway through inducing ROS accumulation, which leads to the inhibition of tumor growth and metastasis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yuan Guo, Yan-Rong Zhao, Huan Liu, Yang Xin, Jian-Zhi Yu, Yun-Jin Zang, Qing-guo Xu
Summary: The study identified EHMT2 as a critical factor in the development of hepatocellular carcinoma, showing that elevated EHMT2 expression promotes tumorigenesis and activates the Wnt-beta-catenin signaling pathway. EHMT2 was found to epigenetically silence the APC promoter through methylation, and the specific inhibitor UNC0642 demonstrated anti-tumorigenesis effects in HCC, suggesting it as a potential candidate for targeted drug therapy.
CELL AND BIOSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Fei-fei Pan, Yan-Biao Zheng, Chuan-Jian Shi, Feng-wei Zhang, Jin-fang Zhang, Wei-ming Fu
Summary: The research demonstrates that apigenin (API) can suppress tumor growth of hepatocellular carcinoma (HCC) by down-regulating the H19-mediated Wnt/beta-catenin signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Huabo Wang, Jie Lu, Frances Alencastro, Alexander Roberts, Julia Fiedor, Patrick Carroll, Robert N. Eisenman, Sarangarajan Ranganathan, Michael Torbenson, Andrew W. Duncan, Edward V. Prochownik
Summary: This study investigated the roles of the Myc and Mlx networks in the liver, with Mlx playing a crucial role in maintaining hepatocyte regenerative potential and transcriptional regulation, promoting homeostasis of proliferation, metabolism, and translation, while also serving as a suppressor of benign tumorigenesis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Oncology
Hazel M. Quinn, Regina Vogel, Oliver Popp, Philipp Mertins, Linxiang Lan, Clemens Messerschmidt, Alexandro Landshammer, Kamil Lisek, Sophie Chateau-Joubert, Elisabetta Marangoni, Elle Koren, Yaron Fuchs, Walter Birchmeier
Summary: The research reveals that in basal-like breast cancers, YAP signaling is essential for beta-catenin activity, controlling the cancer stem cell (CSC) program. Targeting the YAP/TEAD4/beta-catenin complex may offer a potential therapeutic strategy for eradicating CSCs in basal-like breast cancers.
Article
Biochemistry & Molecular Biology
Mengqi Li, Ting Li, Tingting Jin, Yi Chen, Lan Cheng, Qiheng Liang, Simiao Yan, Tingting Li, Qingzhen Ran, Wanqun Chen
Summary: This study found that TBX3 may play an important role in the development of adenomyosis (ADM). The activation of the Wnt3a/beta-catenin pathway in ADM promoted TBX3 expression and induced the occurrence of epithelial-to-mesenchymal transition (EMT), thus promoting cell proliferation and inhibiting apoptosis, ultimately accelerating the development of ADM.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Plant Sciences
Elaine da Silva Siqueira, Virginia Marcia Concato, Fernanda Tomiotto-Pellissier, Taylon Felipe Silva, Bruna Taciane da Silva Bortoleti, Manoela Daiele Goncalves, Idessania Nazareth Costa, Waldiceu Aparecido Verri Junior, Wander Rogerio Pavanelli, Carolina Panis, Mario Sergio Mantovani, Milena Menegazzo Miranda-Sapla, Ivete Conchon-Costa
Summary: The study demonstrated that trans-chalcone exerts significant cytotoxic effects on human HCC HuH7.5 cells without toxicity to non-cancerous cells. It induces mitochondrial membrane damage, G0/G1 cell cycle arrest, decreases in beta-catenin levels, and promotes autophagic cell death, ultimately reducing the metastatic capacity of HuH7.5 cells.
Article
Medicine, Research & Experimental
Jingjing Zhang, Yangliu Tong, Xun Lu, Fangming Dong, Xiaoxuan Ma, Shiyu Yin, Ying He, Yonghong Liu, Qingchao Liu, Daidi Fan
Summary: This study demonstrates the antitumor effects of a new derivative of ginsenoside CK on hepatocellular carcinoma (HCC), which can inhibit HCC progression by regulating the Hippo-YAP1-TEAD2 signaling pathway. This research provides a new direction for the use of traditional Chinese medicine in tumor therapy.
Article
Oncology
Jin Gu, Erlei Zhang, Binyong Liang, Zunyi Zhang, Xiaoping Chen, Min Xiong, Zhiyong Huang
Summary: In HCC patients with Child-Pugh grade A liver function, cirrhosis staging can be determined by measuring liver collagen contents using Collagen Proportional Area (CPA), which significantly affects the risk of Posthepatectomy Liver Failure (PHLF). The study also found a significant correlation between CPA and a non-invasive method called Cirrhotic Severity Scoring (CSS) proposed by the team, showing that higher CPA values and extent of hepatectomy are independent risk factors for PHLF, and there is a positive correlation between CPA and CSS.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Haichuan Wang, Xinhua Song, Haotian Liao, Pan Wang, Yi Zhang, Li Che, Jie Zhang, Yi Zhou, Antonio Cigliano, Cindy Ament, Daphne Superville, Silvia Ribback, Melissa Reeves, Giovanni M. Pes, Binyong Liang, Hong Wu, Matthias Evert, Diego F. Calvisi, Yong Zeng, Xin Chen
Summary: SMAD7 is up-regulated in HCC and correlates with YAP/NOTCH pathway and cholangiocellular signature.
c-Myc/MCL1/Smad7 liver tumors show increased cholangiocellular gene expression, Yap/Notch activation, and epithelial-mesenchymal transition.
In mice overexpressing myristoylated/activated AKT, coexpression of SMAD7 accelerates carcinogenesis and switches the phenotype from HCC to iCCA lesions.
Article
Pathology
Yi Zhang, Binyong Liang, Xinhua Song, Haichuan Wang, Matthias Evert, Yi Zhou, Diego F. Calvisi, Liling Tang, Xin Chen
Summary: Loss of Apc alone does not drive liver tumor formation, but synergizes with activated oncogenes (YapS127A, TazS89A, and c-Met) to induce hepatocarcinogenesis. A subset of HCC patients with loss-of-function APC mutations might benefit from therapeutic strategies targeting the Wnt/B-catenin pathway.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Gastroenterology & Hepatology
Haichuan Wang, Shanshan Zhang, Yi Zhang, Jiaoyuan Jia, Jingxiao Wang, Xianqiong Liu, Jie Zhang, Xinhua Song, Silvia Ribback, Antonio Cigliano, Matthias Evert, Bingyong Liang, Hong Wu, Diego F. Calvisi, Yong Zeng, Xin Chen
Summary: TAZ is identified as a pivotal player at the crossroad between the c-MYC and Hippo pathways in HCC, playing a critical role in c-MYC-dependent hepatocarcinogenesis and potentially being targeted for the treatment of c-MYC-driven hepatocellular carcinoma patients.
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Haichuan Wang, Yi Zhou, Hongwei Xu, Xue Wang, Yi Zhang, Runze Shang, Marie O'Farrell, Stephanie Roessler, Carsten Sticht, Andreas Stahl, Matthias Evert, Diego F. Calvisi, Yong Zeng, Xin Chen
Summary: This study evaluated the therapeutic efficacy of the FASN inhibitor TVB3664 for HCC treatment and found that it has limited effectiveness as monotherapy, but can be combined with other drugs for improved results. These combination therapies can be developed based on driver oncogenes, supporting precision medicine approaches for HCC treatment.
Article
Gastroenterology & Hepatology
Yi Zhang, Hongwei Xu, Guofei Cui, Binyong Liang, Xiangzheng Chen, Sungjin Ko, Silvia Affo, Xinhua Song, Yi Liao, Jianguo Feng, Pan Wang, Haichuan Wang, Meng Xu, Jingxiao Wang, Giovanni M. Pes, Silvia Ribback, Yong Zeng, Aatur Singhi, Robert F. Schwabe, Satdarshan P. Monga, Matthias Evert, Liling Tang, Diego F. Calvisi, Xin Chen
Summary: YAP induces cholangiocarcinogenesis through TEAD-dependent transcriptional activation and interaction with ss-Catenin. ss-Catenin binds to YAP in iCCA and is required for YAP's full transcriptional activity, revealing the functional crosstalk between YAP and ss-Catenin pathways in cholangiocarcinogenesis.
Article
Oncology
Antonio Cigliano, Shanshan Zhang, Silvia Ribback, Sara Steinmann, Marcella Sini, Cindy E. Ament, Kirsten Utpatel, Xinhua Song, Jingxiao Wang, Maria G. Pilo, Fabian Berger, Haichuan Wang, Junyan Tao, Xiaolei Li, Giovanni M. Pes, Serena Mancarella, Gianluigi Giannelli, Frank Dombrowski, Matthias Evert, Diego F. Calvisi, Xin Chen, Katja Evert
Summary: This study identified the crucial role of TAZ in cholangiocarcinogenesis and its interaction with TEAD transcription factors, as well as the impact of Notch and YAP on tumor development.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Correction
Gastroenterology & Hepatology
Haichuan Wang, Shanshan Zhang, Yi Zhang, Jiaoyuan Jia, Jingxiao Wang, Xianqiong Liu, Jie Zhang, Xinhua Song, Silvia Ribback, Antonio Cigliano, Matthias Evert, Bingyong Liang, Hong Wu, Diego F. Calvisi, Yong Zeng, Xin Chen
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Binyong Liang, Haichuan Wang, Yu Qiao, Xue Wang, Manning Qian, Xinhua Song, Yi Zhou, Yi Zhang, Runze Shang, Li Che, Yifa Chen, Zhiyong Huang, Hong Wu, Satdarshan P. Monga, Yong Zeng, Diego F. Calvisi, Xiaoping Chen, Xin Chen
Summary: This study reveals that YAP/TAZ are major signaling molecules downstream of LOF AXIN1 mutant HCCs, and targeting YAP/TAZ is an effective treatment against AXIN1 mutant human HCCs.
Review
Oncology
Simiao Yu, Jingxiao Wang, Haocheng Zheng, Ruilin Wang, Nadia Johnson, Tao Li, Ping Li, Jie Lin, Yuan Li, Jin Yan, Ying Zhang, Zhenyu Zhu, Xia Ding
Summary: This review describes the pathogenesis and underlying mechanisms of the transition from inflammation to cancer in NASH. NASH is a liver disease characterized by metabolic dysregulation, chronic inflammation, and cell death, with approximately 20-30% of cases developing into HCC, or liver cancer.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2022)