Intratumoral Gene Transfer of mRNAs Encoding IL12 in Combination with Decoy-Resistant IL18 Improves Local and Systemic Antitumor Immunity

A tumor-specific pro-IL-12 activates preexisting cytotoxic T cells to control established tumors

(2022) Diyuan Xue et al.   Science Immunology

Novel strategies exploiting interleukin-12 in cancer immunotherapy

(2022) Assunta Cirella et al.   PHARMACOLOGY & THERAPEUTICS

19O Preliminary safety, antitumor activity and pharmacodynamics results of HIT-IT MEDI1191 (mRNA IL-12) in patients with advanced solid tumours and superficial lesions

(2021) O. Hamid et al.   ANNALS OF ONCOLOGY

Intratumoural administration and tumour tissue targeting of cancer immunotherapies

(2021) Ignacio Melero et al.   Nature Reviews Clinical Oncology

Antitumor efficacy and reduced toxicity using an anti-CD137 Probody therapeutic

(2021) Iñaki Etxeberria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local delivery of mRNA-encoding cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models

(2021) Christian Hotz et al.   Science Translational Medicine

Intratumoral co-injection of the poly I:C-derivative BO-112 and a STING agonist synergize to achieve local and distant anti-tumor efficacy

(2021) Maite Alvarez et al.   Journal for ImmunoTherapy of Cancer

Diverse immune environments in human lung tuberculosis granulomas assessed by quantitative multiplexed immunofluorescence

(2020) Marta Abengozar-Muela et al.   MODERN PATHOLOGY

IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy

(2020) Ting Zhou et al.   NATURE

An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma

(2020) Ugur Sahin et al.   NATURE

Intratumoral interleukin-12 mRNA therapy promotes TH1 transformation of the tumor microenvironment

(2020) Susannah L Hewitt et al.   CLINICAL CANCER RESEARCH

Interleukin-12 message in a bottle

(2020) Assunta Cirella et al.   CLINICAL CANCER RESEARCH

Development of an Interleukin-12 Fusion Protein That Is Activated by Cleavage with Matrix Metalloproteinase 9

(2019) Denise Skrombolas et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Amylin as a potential link between type 2 diabetes and alzheimer disease

(2019) Ivan Martinez‐Valbuena et al.   ANNALS OF NEUROLOGY

Intratumor Adoptive Transfer of IL-12 mRNA Transiently Engineered Antitumor CD8+ T Cells

(2019) Iñaki Etxeberria et al.   CANCER CELL

A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates

(2018) Staci Sabnis et al.   MOLECULAR THERAPY

Cytokines in clinical cancer immunotherapy

(2018) Pedro Berraondo et al.   BRITISH JOURNAL OF CANCER

Integrated tumor identification and automated scoring minimizes pathologist involvement and provides new insights to key biomarkers in breast cancer

(2017) Peter Bankhead et al.   LABORATORY INVESTIGATION

Elimination of large tumors in mice by mRNA-encoded bispecific antibodies

(2017) Christiane R Stadler et al.   NATURE MEDICINE

Expansion and Activation of CD103 + Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition

(2016) Hélène Salmon et al.   IMMUNITY

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Orchestrating high-throughput genomic analysis with Bioconductor

(2015) Wolfgang Huber et al.   NATURE METHODS

TCGAbiolinks: an R/Bioconductor package for integrative analysis of TCGA data

(2015) Antonio Colaprico et al.   NUCLEIC ACIDS RESEARCH

Cancer Immunotherapy with Immunomodulatory Anti-CD137 and Anti-PD-1 Monoclonal Antibodies Requires BATF3-Dependent Dendritic Cells

(2015) A. R. Sanchez-Paulete et al.   Cancer Discovery

Virotherapy with a Semliki Forest Virus–Based Vector Encoding IL12 Synergizes with PD-1/PD-L1 Blockade

(2015) José I. Quetglas et al.   Cancer Immunology Research

Intratumoral Delivery of TriMix mRNA Results in T-cell Activation by Cross-Presenting Dendritic Cells

(2015) S. Van Lint et al.   Cancer Immunology Research

The immunocytokine NHS-IL12 as a potential cancer therapeutic

(2015) Jonathan Fallon et al.   Oncotarget

Orchestrating immune check-point blockade for cancer immunotherapy in combinations

(2014) Jose Luis Perez-Gracia et al.   CURRENT OPINION IN IMMUNOLOGY

Interleukin-18 and IL-18 Binding Protein

(2013) Charles A. Dinarello et al.   Frontiers in Immunology

Multiple Injections of Electroporated Autologous T Cells Expressing a Chimeric Antigen Receptor Mediate Regression of Human Disseminated Tumor

(2010) Y. Zhao et al.   CANCER RESEARCH

Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity

(2008) K. Hildner et al.   SCIENCE