Apt-clean: aptamer-mediated cleavage of extracellular antigens for the inhibition of membrane protein functions

PROTAC targeted protein degraders: the past is prologue

(2022) Miklós Békés et al.   NATURE REVIEWS DRUG DISCOVERY

Modular cytokine receptor-targeting chimeras for targeted degradation of cell surface and extracellular proteins

(2022) Katarina Pance et al.   NATURE BIOTECHNOLOGY

Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1

(2021) Adam D. Cotton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bispecific Aptamer Chimeras Enable Targeted Protein Degradation on Cell Membranes

(2021) Da Han et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of Triantennary N-Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins

(2021) Yaxian Zhou et al.   ACS Central Science

LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation

(2021) Green Ahn et al.   Nature Chemical Biology

Characterization of a DNA Aptamer with High Specificity toward Fibroblast Growth Factor Receptor 1

(2021) Junya Hoshiyama et al.   CHEMISTRY LETTERS

Exosite Binding in Thrombin: A Global Structural/Dynamic Overview of Complexes with Aptamers and Other Ligands

(2021) Romualdo Troisi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Covalently Engineered Nanobody Chimeras for Targeted Membrane Protein Degradation

(2021) Heng Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Binding and Structural Properties of DNA Aptamers with VEGF-A-Mimic Activity

(2020) Toru Yoshitomi et al.   Molecular Therapy-Nucleic Acids

Lysosome-targeting chimaeras for degradation of extracellular proteins

(2020) Steven M. Banik et al.   NATURE

Targeted glycan degradation potentiates the anticancer immune response in vivo

(2020) Melissa A. Gray et al.   Nature Chemical Biology

Fibroblast growth factor receptors in cancer: genetic alterations, diagnostics, therapeutic targets and mechanisms of resistance

(2020) Melanie A. Krook et al.   BRITISH JOURNAL OF CANCER

Targeted protein degradation: expanding the toolbox

(2019) Matthieu Schapira et al.   NATURE REVIEWS DRUG DISCOVERY

High throughput protease profiling comprehensively defines active site specificity for thrombin and ADAMTS13

(2018) Colin A. Kretz et al.   Scientific Reports

A comprehensive map of molecular drug targets

(2016) Rita Santos et al.   NATURE REVIEWS DRUG DISCOVERY

Precision glycocalyx editing as a strategy for cancer immunotherapy

(2016) Han Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Insulin Receptor with a Novel Internalizing Aptamer

(2016) Margherita Iaboni et al.   Molecular Therapy-Nucleic Acids

DNA Aptamer Assembly as a Vascular Endothelial Growth Factor Receptor Agonist

(2015) Vidhya Ramaswamy et al.   Nucleic Acid Therapeutics

Inhibition of Receptor Signaling and of Glioblastoma-derived Tumor Growth by a Novel PDGFRβ Aptamer

(2014) Simona Camorani et al.   MOLECULAR THERAPY

Aptamer-based single-molecule imaging of insulin receptors in living cells

(2013) Minhyeok Chang et al.   JOURNAL OF BIOMEDICAL OPTICS

The Extended Cleavage Specificity of Human Thrombin

(2012) Maike Gallwitz et al.   PLoS One

Inhibition of Cell Proliferation by an Anti-EGFR Aptamer

(2011) Na Li et al.   PLoS One

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Long Range Communication between Exosites 1 and 2 Modulates Thrombin Function

(2009) Nicolas S. Petrera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The FGF family: biology, pathophysiology and therapy

(2009) Andrew Beenken et al.   NATURE REVIEWS DRUG DISCOVERY